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Article
Characteristics of Mild Dengue Virus Infection in Thai Children
Institute for Immunology and Informatics Faculty Publications
  • In-Kyu Yoon
  • Anon Srikiatkhachorn
  • Laura Hermann
  • Darunee Buddhari
  • Thomas W. Scott
  • Richard G. Jarman
  • Jared Aldstadt
  • Ananda Nisalak
  • Suwich Thammapalo
  • Piraya Bhoomiboonchoo
  • Mammen P. Mammen
  • Sharone Green
  • Robert V. Gibbons
  • Timothy P. Endy
  • Alan L. Rothman, University of Rhode Island
Document Type
Article
Date of Original Version
12-1-2013
DOI
10.4269/ajtmh.13-0424
Abstract

A four-year longitudinal cohort and geographic cluster study in rural Thailand was conducted to characterize the clinical spectrum of dengue virus (DENV) infection. Symptomatic DENV infections in the cohort were detected by active school absence-based surveillance that triggered cluster investigations around ill cohort children. Data from 189 cohort children with symptomatic DENV infection and 126 contact children in the clusters with DENV infection were analyzed. Of infected contacts, only 19% were asymptomatic; 81% were symptomatic, but only 65.9% reported fever. Symptom-based case definitions were unreliable for diagnosis. Symptomatic infections in contacts were milder with lower DENV RNA levels than the cohort. Infections in contacts with fever history were more likely to have detectable DENV RNA than infections without fever history. Mild infections identified by cluster investigations account for a major proportion of all DENV infections. These findings are relevant for disease burden assessments, transmission modeling, and determination of vaccine impact.

Citation Information

Yoon, In-Kyu et al. "Characteristics of Mild Dengue Virus Infection in Thai Children." Am J Trop Med Hyg. 2013 Dec;89(6):1081-7. doi: 10.4269/ajtmh.13-0424.