Nanoparticles are widely due as Sustained Release Drug Delivery System. Due to their smaller size of controlled drug release potential, targeting ability, enhancement of therapeutic efficacy and reduction of toxicity. Nifedipine one of the calcium channel blocker use for the management of hypertension. Spray drier technique develops Nifedipine loaded nanoparticle. Primary superimulsion phase contains Drug (Nifedipine), Polymer (Ethylcellulose) & suitable non-aqueous Solvent (Dichloromethane) which are sprayed over secondary phase containing aqueous solvent with dispersing polymers (PVA) are prepared by taking drug to polymer weight ratio of 20:90. Formation of films on the surface of secondary phase dried, sieved & forward to spectroscopic analysis. SEM micrograph shows the morphology of particles. FTIR spectrometer as an analytical tool shows that the final formulation retains its chemical groups with nucleus (dihydropyridine) indicates no fluctuation at drug stability. DSC study shows the glass transition remains likely constant. X-Ray study shows the formulation looses its crystallinity.
- Drug Delivery,
- Spray drier technique
Available at: http://works.bepress.com/ajitbehera/19/