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Ovarian metabolism of xenobiotics
Experimental Biology and Medicine
  • Poulomi Bhattacharya, Iowa State University
  • Aileen F. Keating, Iowa State University
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Publication Version
Accepted Manuscript
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At birth, the mammalian ovary contains a finite number of primordial follicles, which once depleted, cannot be replaced. Xenobiotic exposures can destroy primordial follicles resulting in premature ovarian failure and, consequently, early entry into menopause. A number of chemical classes can induce premature ovarian failure, including environmental, chemotherapeutic and industrial exposures. While our knowledge on the mechanistic events that occur in the ovary with chemical exposures is increasing, our understanding of the ovary's capacity to metabolize such compounds is less established. This review will focus on three chemicals for which information on ovarian metabolism is known: trichloroethylene, 7,12-dimethylbenz[a]anthracene and 4- vinylcyclohexene. The current state of understanding of ovarian bioactivation and detoxification processes for each will be described.


This is a manuscript of an article published as Bhattacharya, Poulomi, and Aileen F. Keating. "Ovarian metabolism of xenobiotics." Experimental Biology and Medicine 236, no. 7 (2011): 765-771. doi: 10.1258/ebm.2011.011051. Posted with permission.

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Society for Experimental Biology and Medicine
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Citation Information
Poulomi Bhattacharya and Aileen F. Keating. "Ovarian metabolism of xenobiotics" Experimental Biology and Medicine Vol. 236 Iss. 7 (2011) p. 765 - 771
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