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Article
Distribution and responsiveness of rat anti-Müllerian hormone during ovarian development and VCD-induced ovotoxicity
Toxicology and Applied Pharmacology
  • Connie J. Mark-Kappeler, University of Arizona
  • Nivedita Sen, University of Arizona
  • Aileen F. Keating, Iowa State University
  • I. Glenn Sipes, University of Arizona
  • Patricia B. Hoyer, University of Arizona
Document Type
Article
Publication Version
Accepted Manuscript
Publication Date
11-15-2010
DOI
10.1016/j.taap.2010.08.024
Abstract

Anti-Müllerian hormone (AMH) is produced by granulosa cells in primary to small antral follicles of the adult ovary and helps maintain primordial follicles in a dormant state. The industrial chemical, 4-vinylcyclohexene diepoxide (VCD) causes specific ovotoxicity in primordial and small primary follicles of mice and rats. Previous studies suggest that this ovotoxicity involves acceleration of primordial to primary follicle recruitment via interactions with the Kit/Kit ligand signaling pathway. Because of its accepted role in inhibiting primordial follicle recruitment, the present study was designed to investigate a possible interaction between AMH and VCD-induced ovotoxicity. Protein distribution of AMH was compared in neonatal and adult F344 rat ovaries. AMH protein was visualized by immunofluorescence microscopy in large primary and secondary follicles of the adult ovary, but in small primary follicles in neonatal rat ovaries. In cultured postnatal day (PND) 4 F344 rat ovaries, VCD exposure (30 μM, 2-8d) decreased (P

Comments

This is a manuscript of an artilce published as Mark-Kappeler, Connie J., Nivedita Sen, Aileen F. Keating, I. Glenn Sipes, and Patricia B. Hoyer. "Distribution and responsiveness of rat anti-Müllerian hormone during ovarian development and VCD-induced ovotoxicity." Toxicology and applied pharmacology 249, no. 1 (2010): 1-7. doi; 10.1016/j.taap.2010.08.024. Posted with permission.

Creative Commons License
Creative Commons Attribution-Noncommercial-No Derivative Works 4.0
Copyright Owner
Elsevier Inc.
Language
en
File Format
application/pdf
Citation Information
Connie J. Mark-Kappeler, Nivedita Sen, Aileen F. Keating, I. Glenn Sipes, et al.. "Distribution and responsiveness of rat anti-Müllerian hormone during ovarian development and VCD-induced ovotoxicity" Toxicology and Applied Pharmacology Vol. 249 Iss. 1 (2010) p. 1 - 7
Available at: http://works.bepress.com/aileen-keating/29/