© 2017, Zarka Private University. All rights reserved. This study aims to evaluate Hospital Information Systems (HIS) and their impact on end-user performance and the health care services in two developing countries. A survey methodology was used to gather empirical data for model validation and hypothesis testing. A correlation and factor analysis were conducted to test the reliability and validity of the study instrument. The structural equation modelling technique was also used to evaluate the measurement and the structural models. The results confirmed the significance of the integrated model in explaining user performance and demonstrated that our model can better represent factors associated with user performance and health care services; our model was able to explain 74% of the variance in user performance and 52% of the variance in the health care services. The study indicated the need to consider the context of the HIS when using models like the Technology Acceptance Model (TAM) and the information systems success model. Some information systems factors have become more relevant, such as System Quality (SQ) and Task-Technology Fit (TTF). Others have different implications, including ease of use and usefulness, indicating the need to adapt these models based on the context of the system under study.