© 2017 IEEE. The aim of this study is to evaluate Healthcare Enterprise Information Systems from both system and user perspectives. The study uses a structural equation modelling to analyse the impacts of healthcare information systems on employees performance and health care service provided by hospitals. This was measured using several dimensional factors including, system quality, service quality and information quality. The study used a questionnaire survey to gather data from healthcare organizations and their staff in different departments and at different levels. The study findings indicated that Hospital Enterprise Information Systems (HEIS) helped improve service quality by providing complete and accurate information related to patients and patient service processes.