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Article
Antimicrobial resistance among Escherichia coli isolates from dogs presented with urinary tract infections at a veterinary teaching hospital in South Africa. BMC Veterinary Research.
BMC Veterinary Research (2018)
  • Daniel N Qekwana
  • Lufuno Phophi
  • Vinny Naidoo
  • James W. Oguttu
  • Agricola Odoi
Abstract
Background
This study investigated the burden and predictors of canine E. coliurinary tract infections (UTI) and antimicrobial resistance among dogs presented at a veterinary teaching hospital in South Africa, 2007–2012.
Methods
The Cochran-Armitage trend test was used to investigate temporal trends while logistic regression models were used to investigate predictors (age, sex, breed, year) of E. coli infections and antimicrobial resistance (AMR).
Results
A total of 22.3% (168/755) of the urinary specimens tested positive for E. coli. A significant (p = 0.0004) decreasing temporal trend in the percentage of E. coli positive isolates was observed over the study period. There were high levels of AMR to penicillin-G (99%), clindamycin (100%), tylosine (95%), cephalothin (84%) but relatively low levels of resistance to enrofloxacin (16%), orbifloxacin (21%). Almost all (98%, 164/167) the isolates exhibited multidrug resistance (MDR), while only 11% (19/167) and 2% (4/167) exhibited extensive drug resistance (XDR) and pan-drug resistance (PDR), respectively.
Conclusions
Although, the risk of E. coli UTI declined during the study period, the risk of AMR increased. The high levels of AMR and MDR as well as the presence of XDR and PDR is concerning as these have the potential of affecting prognosis of UTI treatments.
Keywords
  • Antimicrobial resistance,
  • E.coli,
  • Urinary tract infections,
  • Dog,
  • Canine,
  • Multidrug resistance,
  • Extensive drug resistance,
  • Pan-drug resistance
Disciplines
Publication Date
July 31, 2018
Citation Information
Daniel N Qekwana, Lufuno Phophi, Vinny Naidoo, James W. Oguttu, et al.. "Antimicrobial resistance among Escherichia coli isolates from dogs presented with urinary tract infections at a veterinary teaching hospital in South Africa. BMC Veterinary Research." BMC Veterinary Research (2018)
Available at: http://works.bepress.com/agricola_odoi/64/