The scale at which DNA sequencing technology can accomplish data generation in biology has transformed how the field must analyze and integrate datasets. We'll discuss the challenges and opportunities of heterogeneous biological data integration. Specific case studies of integrative platform efforts will be presented including the community tool provided by the Department of Energy Knowledgebase and the development of executable publications and data reuse. Through these examples, we will address some of the typical solutions, failure points, and success stories of data integration approaches.