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Article
Glossopharyngeal Neuralgia: Epidemiology, Risk factors, Pathophysiology, Differential diagnosis, and Treatment Options
Health Psychology Research
  • Andrew Han
  • Carver Montgomery
  • Alexandra Zamora
  • Emilie Winder
  • Adam M. Kaye, University of the Pacific
  • Caroline Carroll
  • Alfonzo Aquino
  • Juyeon Kakazu
  • Alan David Kaye, Louisiana State University Health Science Center
ORCiD
Adam M. Kaye: 0000-0002-7224-3322
Document Type
Article
DOI
10.52965/001c.36042
Publication Date
6-28-2022
Abstract

Purpose of Review
This is a comprehensive review of the most recent literature on glossopharyngeal neuralgia (GPN), a relatively rare form of neuropathic facial pain. It covers the epidemiology, risk factors, pathophysiology, and differential diagnosis given that glossopharyngeal neuralgia can often be confused with other facial pain syndromes. Finally, we extensively review recent findings regarding medical or conservative measures, minimally invasive, and surgical options for potentially treating and managing glossopharyngeal neuralgia.

Recent Findings
An in-depth analysis of the recent literature indicates that glossopharyngeal neuralgia is not only rare but its etiology and pathophysiology are complex and are often secondary to other disease processes. Regardless, current management options are shown to be effective in controlling pain. Conservatively, first-line management of GPN is carbamazepine, but gabapentin and eslicarbazepine acetate are suitable alternatives. In terms of current minimally invasive pain management techniques, pulsed radiofrequency ablation, nerve blocks, or percutaneous radiofrequency thermocoagulation are effective. Finally, surgical management involves microvascular decompression and rhizotomy.

Summary
While there are currently many viable options for addressing glossopharyngeal neuralgia pain ranging from conservative to surgical management, the complex nature of GPN etiology, pathophysiology, and involved anatomical structures prompts further research for more effective ways to treat the disease.

Creative Commons License
Creative Commons Attribution-NonCommercial 4.0 International
Citation Information
Andrew Han, Carver Montgomery, Alexandra Zamora, Emilie Winder, et al.. "Glossopharyngeal Neuralgia: Epidemiology, Risk factors, Pathophysiology, Differential diagnosis, and Treatment Options" Health Psychology Research Vol. 10 Iss. 2 (2022) ISSN: 2420-8124
Available at: http://works.bepress.com/adam-kaye/174/