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The use of antineuropathic medications for the treatment of chronic pain
Best Practice and Research: Clinical Anaesthesiology
  • Ivan Urits, Harvard Medical School
  • Nathan Li, Medical College of Wisconsin
  • Kevin Berardino, Georgetown University School of Medicine
  • Kimberly Aleen Artounian, University of Arizona College of Medicine – Phoenix
  • Prudhvi Bandi, Creighton University School of Medicine
  • Jai Won Jung, Georgetown University School of Medicine
  • Rachel J. Kaye, Medical University of South Carolina
  • Laxmaiah Manchikanti, Pain Management Centers of America
  • Adam M. Kaye, University of the Pacific
  • Thomas Simopoulos, Harvard Medical School
  • Alan David Kaye, Louisiana State University Health Science Center
  • Monica Torres, Envision Physician Services
  • Omar Viswanath, University of Arizona College of Medicine – Phoenix
ORCiD
Adam M. Kaye: 0000-0002-7224-3322
Document Type
Article
DOI
10.1016/j.bpa.2020.08.007
Publication Date
9-1-2020
Abstract

Chronic pain syndromes cost the US healthcare system over $600 billion per year. A subtype of chronic pain is neuropathic pain (NP), which is defined as “pain caused by a lesion or disease of the somatosensory system,” according to the International Association for the Study of Pain (IASP). The pathophysiology of neuropathic pain is very complex, and more research needs to be done to find the exact mechanism. Patients that have preexisting conditions such as cancer and diabetes are at high-risk of developing NP. Many NP patients are misdiagnosed and receive delayed treatment due to a lack of a standardized classification system that allows clinicians to identify, understand, and utilize pain management in these patients. Medications like tricyclic antidepressants, serotonin-norepinephrine reuptake Inhibitor (SNRIs), and gabapentinoids are first-line treatments followed by opioids, cannabinoids, and other drugs. There are limited studies on the treatment of NP.

Citation Information
Ivan Urits, Nathan Li, Kevin Berardino, Kimberly Aleen Artounian, et al.. "The use of antineuropathic medications for the treatment of chronic pain" Best Practice and Research: Clinical Anaesthesiology Vol. 34 Iss. 3 (2020) p. 493 - 506 ISSN: 1532-169X
Available at: http://works.bepress.com/adam-kaye/127/