Statins are used by approximately 24 million Americans. Statin drugs reduce the level of cholesterol in the blood by inhibiting the key step in the biochemical pathway for the biosynthesis of cholesterol. Also known as 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, they are commonly prescribed for patients who have hyperlipidemia with or without any evidence of cardiovascular disease (CVD). This biochemical pathway is also involved in the biosynthesis of other physiological processes including the production of Coenzyme Q10. Coenzyme Q10 is a required precursor for the synthesis of adenosine triphosphate (ATP) in the mitochondria, often referred to as the energy currency of the cell. ATP is required to power muscle contraction. With statin drugs on board, inhibition of the synthesis of Coenzyme Q10 may occur to some variable degree and less ATP could be made available to power muscle contraction during exercise. Coenzyme Q10 is often supplemented in an effort to prevent these complications.