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Article
The Mechanisms of Genetically Modified Vaccinia Viruses for the Treatment of Cancer
Critical Reviews in Oncology/Hematology
  • Artrish Jefferson
  • Valerie E. Cadet
  • Abigail Hielscher, Philadelphia College of Osteopathic Medicine
Document Type
Article
Publication Date
9-1-2015
Disciplines
Abstract

The use of oncolytic viruses for the treatment of cancer is an emerging field of cancer research and therapy. Oncolytic viruses are designed to induce tumor specific immunity while replicating selectively within cancer cells to cause lysis of the tumor cells. While there are several forms of oncolytic viruses, the use of vaccinia viruses for oncolysis may be more beneficial than other forms of oncolytic viruses. For example, vaccinia viruses have been shown to exert their anti-tumor effects through genetic engineering strategies which enhance their therapeutic efficacy. This paper will address some of the most common forms of genetically modified vaccinia viruses and will explore the mechanisms whereby they selectively target, enter and destroy cancer cells. Furthermore, this review will highlight how vaccinia viruses activate host immune responses against cancer cells and will address clinical trials evaluating the tumor-directed and killing efficacy of these viruses against solid tumors. While there are several forms of oncolytic viruses, the use of vaccinia viruses for oncolysis may be more beneficial than other forms of oncolytic viruses. For example, vaccinia viruses have been shown to exert their anti-tumor effects through genetic engineering strategies which enhance their therapeutic efficacy. This paper will address some of the most common forms of genetically modified vaccinia viruses and will explore the mechanisms whereby they selectively target, enter and destroy cancer cells. Furthermore, this review will highlight how vaccinia viruses activate host immune responses against cancer cells and will address clinical trials evaluating the tumor-directed and killing efficacy of these viruses against solid tumors.

Comments

This article was published in Critical Reviews in Oncology/Hematology, Volume 95, Issue 3, September 2015.

The published version is available at http://dx.doi.org/10.1016/j.critrevonc.2015.04.001.

Copyright ©2015 Elsevier.

Citation Information
Artrish Jefferson, Valerie E. Cadet and Abigail Hielscher. "The Mechanisms of Genetically Modified Vaccinia Viruses for the Treatment of Cancer" Critical Reviews in Oncology/Hematology (2015)
Available at: http://works.bepress.com/abigail_hielscher/3/