Article
Triflic Acid-Catalyzed Highly Stereoselective Friedel- Crafts Aminoalkylation of Indoles and Pyrroles
Organic Letters
(2008)
Abstract
A simple and efficient synthesis to both enantiomers of highly enantiomerically enriched α-trifluoromethyl-α-(heteroaryl)-glycine derivatives via highly stereoselective aminoalkylation of indoles and pyrroles is described. The triflic acid-catalyzed reaction of enantiomeric 3,3,3-trifluoro-pyruvate-α-methylbenzyl imines with indoles and pyrroles and the subsequent Pd-catalyzed hydrogenolysis of the methylbenzyl group provided the products in high yields and excellent enantioselectivities.
Keywords
- Stereoselective aminoalkylation,
- Triflic acid-catalyzed reaction
Disciplines
Publication Date
2008
Citation Information
Abid Shaikh, Liliana Teixeira and Béla Török. "Triflic Acid-Catalyzed Highly Stereoselective Friedel- Crafts Aminoalkylation of Indoles and Pyrroles" Organic Letters Vol. 10 Iss. 5 (2008) Available at: http://works.bepress.com/abid_shaikh/9/