Article
Lewis Acid-Catalyzed Csp3-H Functionalization of Methyl Azaarenes with α-Trifluoromethyl Carbonyl Compounds
Tetrahedron Letters
Document Type
Article
Publication Date
1-1-2013
DOI
10.1016/j.tetlet.2012.12.013
Disciplines
Abstract
A Lewis acid promoted Csp3–H bond functionalization of methyl azaarenes with α-trifluoromethylated carbonyl compounds is described. Catalytic amounts of Yb(OTf)3 provided a straightforward access to the corresponding trifluoromethylated alcohols in excellent yields up to 94% under mild reaction conditions.
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Citation Information
Vincent B. Graves and Abid Shaikh. "Lewis Acid-Catalyzed Csp3-H Functionalization of Methyl Azaarenes with α-Trifluoromethyl Carbonyl Compounds" Tetrahedron Letters Vol. 54 Iss. 7 (2013) p. 695 - 698 ISSN: 0040-4039 Available at: http://works.bepress.com/abid_shaikh/27/