Article
Solvent-Free Acid-Catalyzed Electrophilic Annelations: A New Green Approach for the Synthesis of Substituted Five-Membered N-Heterocycles
Advanced Synthesis and Catalysis
(2006)
Abstract
An effective microwave-induced, solid acid-catalyzed, environmentally benign synthesis of substituted pyrroles, indoles and carbazoles under solvent-free conditions is described. The new synthetic methodology is based on the use of a considerably strong solid acid, K-10 montmorillonite. Both the cyclialkylation of amines and annelation of pyrroles and indoles have been completed within minutes and provided excellent (75–98 %) yields with practically 100 % selectivity.
Keywords
- Carbazoles,
- Indoles,
- K-10 montmorillonite,
- Microwave heating,
- Pyrroles,
- Solid acids
Disciplines
Publication Date
2006
Citation Information
Abid Shaikh, Andrew Spaeth and Béla Török. "Solvent-Free Acid-Catalyzed Electrophilic Annelations: A New Green Approach for the Synthesis of Substituted Five-Membered N-Heterocycles" Advanced Synthesis and Catalysis Vol. 348 Iss. 15 (2006) Available at: http://works.bepress.com/abid_shaikh/14/