Gender- and race- based discrimination in jury selection is unconstitutional in the United States. Nevertheless, court cases and empirical evidence suggest that discrimination on such characteristics, especially race, continues to occur through peremptory challenges. Statistical evidence of the gender effect, however, is more limited and has not previously incorporated controls in race-specific analyses to address non-gender-based explanations for gender differences. The present study examines gender differences in peremptory challenges using data from criminal jury trials in Mississippi. Race-specific analyses and propensity score matching are used to isolate the impact of gender from other measurable effects. Results indicate weak and non-significant gender differences for peremptory challenges used by the prosecution, and weak-to-moderate and non-significant gender differences for peremptory challenges used by the defense. This suggests that gender differences in the use of peremptory challenges may be the result of racial differences and other factors rather than a true gender-based effect.