"Molybdopterin biosynthesis - Mechanistic studies on a novel MoaA catalyzed insertion of a purine carbon into the ribose of GTP" by Angad P. Mehta

Article

Molybdopterin biosynthesis - Mechanistic studies on a novel MoaA catalyzed insertion of a purine carbon into the ribose of GTP

Chemistry & Physics Faculty Publications

Angad P. Mehta, Texas A&M University
Sameh H. Abdelwahed, Texas A&M University
Tadhg P. Begley, Texas A&M University

Document Type

Article

Publication Date

12-20-2015

Abstract

Abstract The first step in the biosynthesis of the molybdopterin cofactor involves an unprecedented insertion of the purine C8 carbon between the C2′ and C3′ carbons of the ribose moiety of GTP. Here we review mechanistic studies on this remarkable transformation. This article is part of a Special Issue entitled: Cofactor-dependent proteins: evolution, chemical diversity and bio-applications.

Citation Information

Angad P. Mehta, Sameh H. Abdelwahed and Tadhg P. Begley. "Molybdopterin biosynthesis - Mechanistic studies on a novel MoaA catalyzed insertion of a purine carbon into the ribose of GTP" (2015)
Available at: http://works.bepress.com/Sameh-Abdelwahed/17/