Article
A Remarkable Oxidative Cascade That Replaces the Riboflavin C8 Methyl with an Amino Group during Roseoflavin Biosynthesis
Chemistry & Physics Faculty Publications
Document Type
Article
Publication Date
7-13-2016
Abstract
Roseoflavin is a naturally occurring riboflavin analogue with antibiotic properties. It is biosynthesized from riboflavin in a reaction involving replacement of the C8 methyl with a dimethylamino group. Herein we report the identification of a flavin-dependent enzyme that converts flavin mononucleotide (FMN) and glutamate to 8-amino-FMN via the intermediacy of 8-formyl-FMN. A mechanistic proposal for this remarkable transformation is proposed.
Citation Information
Isita Jhulki, Prem K. Chanani, Sameh H. Abdelwahed and Tadhg P. Begley. "A Remarkable Oxidative Cascade That Replaces the Riboflavin C8 Methyl with an Amino Group during Roseoflavin Biosynthesis" (2016) Available at: http://works.bepress.com/Sameh-Abdelwahed/16/