Article
Identification of the product of toxoflavin lyase: Degradation via a baeyer-villiger oxidation
Chemistry & Physics Faculty Publications
Document Type
Article
Publication Date
3-21-2012
Abstract
Toxoflavin (an azapteridine) is degraded to a single product by toxoflavin lyase (TflA) in a reaction dependent on reductant, Mn(II), and oxygen. The isolated product was fully characterized by NMR and MS and was identified as a triazine in which the pyrimidine ring was oxidatively degraded. A mechanism for toxoflavin degradation based on the identification of the enzymatic product and the recently determined crystal structure of toxoflavin lyase is proposed. © 2012 American Chemical Society.
Citation Information
Benjamin Philmus, Sameh Abdelwahed, Howard J. Williams, Michael K. Fenwick, et al.. "Identification of the product of toxoflavin lyase: Degradation via a baeyer-villiger oxidation" (2012) Available at: http://works.bepress.com/Sameh-Abdelwahed/11/