Hospital-based nurse educators are charged with providing an efficient orientation process, frequently with simulation, to expedite onboarding of nurses for patient care settings. The purpose of this study was to compare two different debriefing methods (DEBRIEF and 3D-DDD) in an orientation program to determine their effects on nurses’ perception of psychological safety, satisfaction with development of clinical reasoning skills, and satisfaction with learning. This quasi-experimental study used a post-test-only design to compare groups debriefed using the two different methods. Although results were not significant in the difference of the two methods, overall indicators reinforced findings from previous studies and the HSSOBP™ Debriefing about the importance of debriefing on the psychological safety of learners. More research is critical to assist hospital-based educators in finding efficient and timely methods for onboarding nurses.