Monocellular layers of tumors cultivated in vitro and mouse xenografts derived from those cells have been the standard toolkit for cancer biologists for decades. Unfortunately, continuous passage and culture of cells in vitro allows the least differentiated cells to thrive, resulting in distinct and irreversible losses of important biologic properties introduced by tumor resident cell populations, such as supporting non-tumor stroma, hematopoietic cells and other tumor microenvironmental factors. Based on this situation, mouse xenografts of human tumor cell lines have had poor predictive power in the translation of cancer therapeutics into clinical settings.
- PDX model
Publication DateSpring April 10, 2018
Citation InformationBennie Liu. "PDX model" (2018)
Available at: http://works.bepress.com/Bioarray/76/