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protein ubiquitination
(2018)
  • Bennie Liu
Abstract
Ubiquitination, also named as ubiquitylation, is a type of protein post-translational modification by adding ubiquitin to protein sequence. Ubiquitin is a universal regulatory protein that has been found in also all tissues. Ubiquitination modification is divided into two types: monoubiquitination and polyubiquitination, depending the number of ubiquitin molecule linked to proteins. The ubiquitination process contains a multiple enzymatic steps, with sequential action of ubiquitin-activating enzymes (E1), ubiquitin-conjugating enzymes (E2), and ubiquitin ligases (E3). The reaction catalyzed by each enzyme transfers a covalent bond with ubiquitin from one enzyme to the next and finally to a target protein.
Keywords
  • protein ubiquitination
Disciplines
Publication Date
Fall October 18, 2018
Citation Information
Bennie Liu. "protein ubiquitination" (2018)
Available at: http://works.bepress.com/Bioarray/26/