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peptide de novo sequencing
(2018)
  • Bennie Liu
Abstract
The sequence of peptide/protein is important to study the biological  function of the peptide/protein. However, complete characterization of  peptides/proteins, including post-translational modifications (PTMs), sequence  mutations and variants, is very challenging. There are two approaches to  determine the sequence of peptide/protein by mass spectrometry: database search  and de novo sequencing. Database search approach compares acquired mass spectra  to a database of known protein sequences to identify the protein sequences. De  novo sequencing is a process in which amino acid sequences are directly  interpreted from tandem mass spectra without the assistance of a database.
Keywords
  • peptide de novo sequencing
Disciplines
Publication Date
Spring March 9, 2018
Citation Information
Bennie Liu. "peptide de novo sequencing" (2018)
Available at: http://works.bepress.com/Bioarray/25/