Article
Vitamin D Deficiency Is Not Associated with Outcomes in Aneurysmal Subarachnoid Hemorrhage Patients: A Case Control Study
World Neurosurgery
ISBN or ISSN
1878-8750
Publication Date / Copyright Date
1-1-2017
Publisher
Elsevier
DOI Number
https://doi.org/10.1016/j.wneu.2016.10.033
Abstract
Objective: Vitamin D deficiency has been associated with increased risk and adverse outcomes in many clinical settings including cardiovascular disease, stroke, and critically ill patients. Therefore we aimed to determine whether vitamin D deficiency had any effect in aneurysmal subarachnoid hemorrhage (aSAH) clinical outcomes.
Methods: A retrospective record review was conducted in a tertiary community hospital in Puerto Rico. Adult patients admitted to the neurosurgical intensive care unit with a diagnosis of aSAH from January 2013 to July 2014, who had a 25-hydroxyvitamin-D level drawn, were included.
Results: A total of 40 patients were admitted with a diagnosis of aSAH, and 33 met the inclusion criteria. Overall, 81% of patients were vitamin D deficient or insufficient. Subjects were grouped into those with vitamin D deficiency (n = 13) and those without (n = 20). Except for a larger prevalence of coronary artery disease, all other baseline parameters were similar. No significant difference in hospital mortality was observed (P = 0.676). The percentage of vasospasms, vasopressor use, hydrocephalus, and infections was also similar. An increase in length of neurosurgical intensive care unit stay and respiratory failure was observed in the vitamin D-deficient group, but it was not statistically significant.
Conclusion: A high prevalence of vitamin D deficiency and insufficiency was found among patients admitted with a diagnosis of aSAH in this cohort. Despite this no difference in clinical outcomes was observed in patients when compared by vitamin D group. Further studies are needed to assess potential effects of vitamin D deficiency in this patient population including long term follow-up after discharge.
Disciplines
Keywords
- acute disease,
- aged,
- cohort studies,
- female,
- heart failure,
- hospitalization,
- humans,
- male,
- middle aged,
- practice guidelines as topic,
- retrospective studies,
- treatment outcome
MeSH Subject Heading
vitamin D, vitamin D deficiency, Puerto Rico, subarachnoid hemorrhage
Citation Information
Yarelis Alvarado Reyes, Alexandra Perez Rivera and Gloria Rodriguez-Vega. "Vitamin D Deficiency Is Not Associated with Outcomes in Aneurysmal Subarachnoid Hemorrhage Patients: A Case Control Study" World Neurosurgery Vol. 97 (2017) p. 501 - 504 Available at: http://works.bepress.com/AlexandraPerez/55/