This report describes trends in the high-tech sector in Northeast Ohio, focusing on the 2004-2006 time period. It is the first update to a baseline report released in February 2007 that analyzed trends between 2000 and 2005. This study follows the baseline report in that it examines the high-tech sector in Northeast Ohio from three perspectives — high-tech industries, high-tech occupations, and research and development activity. It assesses the strengths and weaknesses of high-tech industries in terms of employment, average wage, gross regional product (output), and productivity. High-tech occupations are analyzed in terms of employment levels. Research and development activity is analyzed in terms of industry R&D funding and academic R&D expenditures. Trends in Northeast Ohio are compared to the Midwest region as well as to the U.S.