Article
Reduction of Na/K-ATPase potentiates marinobufagenin-induced cardiac dysfunction and myocyte apoptosis
Biochemistry and Microbiology
Document Type
Article
Publication Date
5-11-2012
Disciplines
Abstract
Background: Na/K-ATPase decrease has been reported in patients with heart failure and is related to cardiac dysfunction.
Results: Reducing Na/K-ATPase activates caspase 9 and induces cardiac dilation when treated with marinobufagenin.
Conclusion: Reduction of Na/K-ATPase potentiates marinobufagenin-induced cardiac myocyte apoptosis.
Significance: Decreased Na/K-ATPase content together with increased cardiotonic steroids levels is a novel mechanism that may account for cardiac dysfunction.
Citation Information
Liu C, Y Bai, Y Chen, Y Wang, Y Sottejeau, L Liu, X Li, JB Lingrel, D Malhotra, CJ Cooper, JI Shapero, ZJ Xie, and J Tian. 2012. Reduction of Na/K-ATPase potentiates marinobufagenin-induced cardiac dysfunction and myocyte apoptosis. J. Biol. Chem. 287:16390-8.
The version of record is available from the publisher at http://www.jbc.org/content/287/20/16390.full.pdf+html. This research was originally published in The Journal of Biological Chemistry. Liu C, Bai Y, Chen Y, Wang Y, Sottejeau Y, et al. Journal of Biological Chemistry. 2012; 287:16390-16398. © The American Society for Biochemistry and Molecular Biology. Reprinted with permission. All rights reserved. DOI 10.1074/jbc.M111.304451