Skip to main content
profile image
Selected Works of Zengyi Shao
Article
Cloning and heterologous expression of the spectinabilin biosynthetic gene cluster from Streptomyces spectabilis
Molecular BioSystems (2010)
  • Zengyi Shao, Iowa State University
Download Find in your library
Abstract

Spectinabilin is a rare nitrophenyl-substituted polyketide metabolite. Here we report the cloning and heterologous expression of the spectinabilin gene cluster from Streptomyces spectabilis. Unexpectedly, this gene cluster is evolutionarily closer to the aureothin gene cluster than to the spectinabilin gene cluster from Streptomyces orinoci. Moreover, the two nearly identical spectinabilin gene clusters use a distinctly different regulation mechanism.

Keywords
  • aureothan,
  • bacterial protein,
  • chromone derivative,
  • pyrone derivative,
  • bacterial gene,
  • biosynthesis,
  • chemistry,
  • genetics,
  • metabolism,
  • molecular cloning,
  • pyrones
Disciplines
Publication Date
2010
Publisher Statement
Copyright The Royal Society of Chemistry 2010. Posted with permission.
Citation Information
Zengyi Shao. "Cloning and heterologous expression of the spectinabilin biosynthetic gene cluster from Streptomyces spectabilis" Molecular BioSystems Vol. 6 Iss. 2 (2010)
Available at: http://works.bepress.com/zengyi_shao/3/