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<title>Vivian C. McAlister</title>
<copyright>Copyright (c) 2013  All rights reserved.</copyright>
<link>http://works.bepress.com/vivianmcalister</link>
<description>Recent documents in Vivian C. McAlister</description>
<language>en-us</language>
<lastBuildDate>Mon, 03 Jun 2013 01:33:08 PDT</lastBuildDate>
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<item>
<title>Role of persistent processus vaginalis in hydroceles found in a tropical population</title>
<link>http://works.bepress.com/vivianmcalister/172</link>
<guid isPermaLink="true">http://works.bepress.com/vivianmcalister/172</guid>
<pubDate>Sat, 01 Jun 2013 12:39:54 PDT</pubDate>
<description>
	<![CDATA[
	<p>BACKGROUND:</p>
<p>Lymphatic obstruction by Wuchereria bancrofti is thought to be the mechanism for development of tropical hydrocele in men and for elephantiasis, mostly in women. Hydrocele prevalence is used to determine the effectiveness of para site eradication programs. METHODS:</p>
<p>We maintained a prospective log of operations performed at 1 Canadian Field Hospital during its relief mission to Léogâne, Haiti. Information regarding duration of symptoms, type of previous surgery (if any), surgical approach, associated inguinal hernia and volume and appearance of hydrocele fluid in patients with tropical hydroceles were recorded. RESULTS:</p>
<p>From January to March 2010, 4922 patients were seen, none of whom had elephantiasis. Of the 64 patients who collectively underwent 69 inguino-scrotal procedures, 5 patients had inguinal hernia repair several years after hydrocele excision via the scrotum, 19 patients with bilateral hydroceles underwent a scrotum-only approach, and 45 patients had an inguinal approach (33 unilateral and 12 bilateral) to repair 57 hydroceles. A patent processus vaginalis was present in 50 of 57 (88%) hydroceles where the groin was explored. CONCLUSION:</p>
<p>Hydroceles remain common in LÃ©ogÃ¢ne despite successful eradication of filariasis with mass drug administration using diethylcarbamazine-fortified cooking salt. Persistent patent processus vaginalis is a more likely cause than persistent filariasis. There is probably little difference between hydrocele in developed countries and tropical hydrocele other than neglect. Hydrocele prevalence is not a measure of the effectiveness of parasite eradication programs.</p>
<p>CONTEXTE:</p>
<p>On croit qu’une obstruction lymphatique par Wuchereria bancrofti serait le mécanisme à l’origine de l’hydrocèle tropicale chez les hommes et de l’éléphantiasis, surtout chez les femmes. La prévalence de l’hydrocèle est utilisée pour déterminer l’efficacité des programmes d’éradication parasitaire. MÉTHODES:</p>
<p>Nous avons tenu un registre prospectif des interventions effectuées au 1er Hôpital de campagne du Canada durant une mission humanitaire à Léogâne, en Haïti. Nous avons noté la durée des symptômes, les antécédents chirurgicaux (le cas échéant), l’approche chirurgicale, l’hernie inguinale associée, de même que le volume et l’aspect du liquide présent dans l’hydrocèle de patients atteints d’une hydrocèle tropicale. RÉSULTANTS:</p>
<p>De janvier à mars 2010, 4922 patients ont été vus et aucun ne souffrait d’éléphantiasis. Sur les 64 patients qui ont subi en tout 69 interventions inguinoscrotales, 5 ont subi une réparation d’hernie inguinale plusieurs années après l’exérèse d’une hydrocèle par voie scrotale, 19 patients porteurs d’hydrocèles bilatérales ont subi l’intervention exclusivement par approche scrotale et 45 patients, par approche inguinale (33 unilatérales et 12 bilatérales) pour la réparation de 57 hydrocèles. Une ouverture du processus vaginal a été observée dans 50 cas d’hydrocèle sur 57 (88 %) où on a procédé à un examen inguinal. CONCLUSIONS:</p>
<p>L’hydrocèle demeure fréquente à Léogâne, malgré l’éradication efficace de la filariose, grâce à un traitement médicamenteux de masse par le biais de sel pour la cuisson additionné de diéthylcarbamazine. La persistance de l’ouverture du processus vaginal est une cause plus probable de filariose persistante. Il y a probablement peu de différences entre les cas d’hydrocèle recensés dans les pays industrialisés et les hydrocèles tropicales, à part la négligence. La prévalence de l’hydrocèle ne permet pas d’évaluer l’efficacité des programmes d’éradication parasitaire.</p>

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</description>

<author>Vivian C. McAlister et al.</author>


<category>General Surgery</category>

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<item>
<title>Supporting rebuilding efforts in Afghanistan</title>
<link>http://works.bepress.com/vivianmcalister/171</link>
<guid isPermaLink="true">http://works.bepress.com/vivianmcalister/171</guid>
<pubDate>Wed, 10 Apr 2013 20:20:46 PDT</pubDate>
<description>
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	<p>The Royal College has been quietly assisting in the reconstruction of Afghanistan’s residency education system, devastated by years of war, by supplying members of the NATO Training Mission-Afghanistan (NTM-A) with educational materials and advice to appropriately modernize the country’s training programs.</p>
<p>“These efforts are essential for the training of Afghan physicians in medical and surgical specialties, to ensure a healthy future for the people of Afghanistan,” says Major Vivian McAlister, MD, FRCSC, member of Royal College Council and NTM-A participant.</p>
<p>The capacity-building initiative is supported on the ground by the NTM-A team, which includes numerous Fellows of the Royal College, who advise their Afghan counterparts on ways they can lead advances in the country’s health care system.</p>
<p>As part of these efforts, Dr. Emal Wardak, an orthopedic surgeon from the Wazir Akbar Khan Hospital in Kabul, was presented with a special Royal College speaker certificate during the Orthopaedic Society of Afghanistan 2012 trauma symposium, for his lecture on the evolution of fracture management.</p>
<p>This goodwill gesture was to officially recognize and promote leveraging local knowledge as the rebuilding process progresses.</p>
<p>“In any international endeavor, it is important to recognize that one-size does not fit all and that collaboration is key. I am proud to say that we have been collaborating in every sense with our colleagues in Kabul to map out a resident training system that is appropriate to their needs and that makes use of their expertise,” adds Dr. McAlister.</p>

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</description>

<author>Dialogue</author>


<category>News Stories</category>

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<item>
<title>Medical Scientific Conference Kabul Afghanistan</title>
<link>http://works.bepress.com/vivianmcalister/170</link>
<guid isPermaLink="true">http://works.bepress.com/vivianmcalister/170</guid>
<pubDate>Wed, 10 Apr 2013 20:05:39 PDT</pubDate>
<description>
	<![CDATA[
	<p>As the medical system is being rebuilt in Afghanistan, many programs that are familiar in Canada, are being introduced to a new generation of Afghan physicians. One such program is the medical conference to provide continuing medical education, known as CME.</p>
<p>A two-day medical scientific conference was held by the Armed Forces Academy of Medical Sciences (AFAMS) on 30 – 31 December 2012 in Kabul. With almost 300 attendees, the theme of the conference was efficient delivery of healthcare in Afghanistan.</p>
<p>The conference was planned and run by an Afghan faculty, while members of the Canadian Forces provided advice. All of the presentations were made by Afghan physicians with the exception of one talk given by Major Dennis Marion of the Canadian Forces Health Services. Major Marion, a specialist in Internal Medicine, is currently posted to Edmonton, Alberta.</p>
<p>Major Vivian McAlister, a member of Graduate Medical Education (GME) advisory team who is also a councilor of the Royal College of Physicians and Surgeons of Canada, spoke at the end of the conference to congratulate AFAMS on the high standard of the meeting. Dr McAlister reminded specialists attending the meeting to apply for CME credits to their colleges. He then presented the Royal College speaker certificate to Dr Zabiullah Azizi of Kabul for his presentation on sepsis.</p>
<p>Major Marion spoke on the topic of applying evidence-based medicine techniques to clinical examination. While the principles of rational clinical examination were new to many in the audience, the presentation was welcomed as the way of the future for Afghan medicine.</p>
<p>The Canadian contribution to the NATO Training Mission – Afghanistan has been advising the Afghan National Army during the current phase of its reconstruction. The GME Advisory Team has assisted Afghan medical faculty during the process of developing curricula for training specialist physicians and surgeons in Afghanistan.</p>
<p>The success of medical conferences such as this one held in AFAMS, bodes well for the future of academic medicine in Afghanistan. The contribution of Canada to this process was recognized by Surgeon General Mohammed Musa Wardak during his closing remarks to the conference.</p>

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</description>

<author>CJOC</author>


<category>News Stories</category>

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<title>Military surgeon selected as co-editor of the Canadian Journal of Surgery</title>
<link>http://works.bepress.com/vivianmcalister/169</link>
<guid isPermaLink="true">http://works.bepress.com/vivianmcalister/169</guid>
<pubDate>Wed, 10 Apr 2013 19:50:31 PDT</pubDate>
<description>
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	<p>OTTAWA – The Canadian Journal of Surgery has appointed Major Vivian McAlister, a Canadian Armed Forces (CAF) surgeon, as co-editor, highlighting the high esteem in which CAF doctors are held in the medical community.</p>
<p>When not engaged in military duties, Major McAlister works at Western University in London, Ontario as a Professor of Surgery.  He is also a member of the Council of the Royal College of Physicians and Surgeons of Canada.</p>
<p>"Major McAlister’s appointment as co-editor of the Canadian Journal of Surgery illustrates the very high quality of health professionals within the Canadian Armed Forces," said the Honourable Peter MacKay, Minister of National Defence."The health of Canadian Armed Forces personnel is a top priority for this government and medical officers such as Major McAlister represent the finest doctors in our country and abroad. I congratulate him on behalf of the Government of Canada."</p>
<p>The mission of the Canadian Journal of Surgery, a publication of the Canadian Medical Association, is to contribute to the effective continuing medical education of Canadian surgical specialists, using innovative techniques when feasible, and to provide surgeons with an effective vehicle for the dissemination of observations in the areas of clinical and basic science research.</p>
<p>"As a professor of surgery who has completed six tours in combat, mentorship, and humanitarian assistance operations in Afghanistan and Haiti, Major McAlister brings a superb international reputation and an extraordinary wealth of experience to the Canadian Journal of Surgery," said Brigadier-General Jean-Robert Bernier, the Surgeon General. "His contributions to the journal’s educational mission, his work at Western University, and his service on the Royal College’s council all exemplify the close collaboration and mutual support between the civilian and military medical communities.  This close relationship has existed since before Confederation and benefits all Canadians."</p>
<p>Contact:  Joanna.Labonte@forces.gc.ca</p>
<p>Notes to editor / news director: For more information on Canadian Forces Health Services please visit: http://www.forces.gc.ca/health-sante/default-eng.asp.</p>

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</description>

<author>National Defence and the Canadian Forces</author>


<category>News Stories</category>

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<item>
<title>Evaluation of the updated definition of early allograft dysfunction in donation after brain death and donation after cardiac death liver allografts.</title>
<link>http://works.bepress.com/vivianmcalister/168</link>
<guid isPermaLink="true">http://works.bepress.com/vivianmcalister/168</guid>
<pubDate>Tue, 02 Apr 2013 07:14:15 PDT</pubDate>
<description>
	<![CDATA[
	<p>BACKGROUND:  An updated definition of early allograft dysfunction (EAD) was recently validated in a multicenter study of 300 deceased donor liver transplant recipients. This analysis did not differentiate between donation after brain death (DBD) and donation after cardiac death (DCD) allograft recipients. METHODS:  We reviewed our prospectively entered database for all DBD (n=377) and DCD (n=38) liver transplantations between January 1, 2006 and October 30, 2011. The incidence of EAD as well as its ability to predict graft failure and survival was compared between DBD and DCD groups. RESULTS:  EAD was a valid predictor of both graft and patient survival at six months in DBD allograft recipients, but in DCD allograft recipients there was no significant difference in the rate of graft failure in those with EAD (11.5%) compared with those without EAD (16.7%) (P=0.664) or in the rate of death in recipients with EAD (3.8%) compared with those without EAD (8.3%) (P=0.565). The graft failure rate in the first 6 months in those with international normalized ratio ≥1.6 on day 7 who received a DCD allograft was 37.5% compared with 6.7% for those with international normalized ratio <1.6 on day 7 (P=0.022). CONCLUSIONS:  The recently validated definition of EAD is a valid predictor of patient and graft survival in recipients of DBD allografts. On initial assessment, it does not appear to be a useful predictor of patient and graft survival in recipients of DCD allografts, however a study with a larger sample size of DCD allografts is needed to confirm these findings. The high ALT/AST levels in most recipients of DCD livers as well as the predisposition to biliary complications and early cholestasis make these parameters as poor predictors of graft failure. An alternative definition of EAD that gives greater weight to the INR on day 7 may be more relevant in this population.</p>

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</description>

<author>K Croome et al.</author>


<category>Transplantation</category>

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<item>
<title>A novel in vivo siRNA delivery system specifically targeting liver cells for protection of ConA-induced fulminant hepatitis.</title>
<link>http://works.bepress.com/vivianmcalister/167</link>
<guid isPermaLink="true">http://works.bepress.com/vivianmcalister/167</guid>
<pubDate>Tue, 02 Apr 2013 07:04:12 PDT</pubDate>
<description>
	<![CDATA[
	<p>BACKGROUND:  Fulminant hepatitis progresses to acute liver failure (ALF) when the extent of hepatocyte death exceeds the liver's regenerative capacity. Although small interfering RNA (siRNA) appears promising in animal models of hepatitis, the approach is limited by drawbacks associated with systemic administration of siRNA. The aim of this study is to develop a hepatocyte-specific delivery system of siRNA for treatment of fulminant hepatitis. METHODOLOGY/PRINCIPAL FINDINGS:  Galactose-conjugated liposome nano-particles (Gal-LipoNP) bearing siRNA was prepared, and the particle size and zeta potential of Gal-LipoNP/siRNA complexes were measured. The distribution, cytotoxicity and gene silence efficiency were studied in vivo in a concanavalin A (ConA)-induced hepatitis model. C57BL/6 mice were treated with Gal-LipoNP Fas siRNA by i.v. injection 72 h before ConA challenge, and hepatocyte injury was evaluated using serum alanine transferase (ALT) and aspartate transaminase (AST) levels, as well as liver histopathology and TUNEL-positive hepatocytes. The galactose-ligated liposomes were capable of encapsulating >96% siRNA and exhibited a higher stability than naked siRNA in plasma. Hepatocyte-specific targeting was confirmed by in vivo delivery experiment, in which the majority of Gal-LipoNP-siRNA evaded nuclease digestion and accumulated in the liver as soon as 6 h after administration. In vivo gene silencing was significant in the liver after treatment of Gal-Lipo-siRNA. In the ConA-induced hepatitis model, serum levels of ALT and AST were significantly reduced in mice treated with Gal-lipoNP-siRNA as compared with control mice. Additionally, tissue histopathology and apoptosis showed an overall reduction of injury in the Gal-LipoNP siRNA-treated mice. CONCLUSIONS/SIGNIFICANCE:  This study is the first to our knowledge to demonstrate reduction of hepatic injury by liver-specific induction of RNA interference using Gal-LipoNP Fas siRNA, highlighting a novel RNAi-based therapeutic potential in many liver diseases.</p>

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</description>

<author>N Jiang et al.</author>


<category>General Surgery</category>

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<item>
<title>Endoscopic management of biliary complications following liver transplantation after donation from cardiac death donors.</title>
<link>http://works.bepress.com/vivianmcalister/166</link>
<guid isPermaLink="true">http://works.bepress.com/vivianmcalister/166</guid>
<pubDate>Tue, 02 Apr 2013 06:57:09 PDT</pubDate>
<description>
	<![CDATA[
	<p>BACKGROUND:  Previous studies have shown a higher incidence of biliary complications following donation after cardiac death (DCD) liver transplantation compared with donation after brain death (DBD) liver transplantation. The endoscopic management of ischemic type biliary strictures in patients who have undergone DCD liver transplants needs to be characterized further. METHODS:  A retrospective institutional review of all patients who underwent DCD liver transplant from January 2006 to September 2011 was performed. These patients were compared with all patients who underwent DBD liver transplantation in the same time period. A descriptive analysis of all DCD patients who developed biliary complications and their subsequent endoscopic management was also performed. RESULTS:  Of the 36 patients who received DCD liver transplants, 25% developed biliary complications compared with 13% of patients who received DBD liver transplants (P=0.062). All DCD allograft recipients who developed biliary complications became symptomatic within three months of transplantation. Ischemic type biliary strictures in DCD allograft recipients included disseminated biliary strictures in two patients, biliary strictures of the hepatic duct bifurcation in three patients and biliary strictures of the donor common hepatic duct in three patients. CONCLUSIONS:  There was a trend toward increasing incidence of total biliary complications in recipients of DCD liver allografts compared with those receiving DBD livers, and the rate of diffuse ischemic cholangiopathy was significantly higher. Focal ischemic type biliary strictures can be treated effectively in DCD liver transplant recipients with favourable results. Diffuse ischemic type biliary strictures in DCD liver transplant recipients ultimately requires retransplantation.</p>

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</description>

<author>Kris Croome et al.</author>


<category>General Surgery</category>

<category>General Medicine</category>

<category>Transplantation</category>

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<title>La lente émergence d&apos;un nouveau journalisme médical</title>
<link>http://works.bepress.com/vivianmcalister/165</link>
<guid isPermaLink="true">http://works.bepress.com/vivianmcalister/165</guid>
<pubDate>Tue, 02 Apr 2013 06:48:19 PDT</pubDate>
<description>
	<![CDATA[
	<p>Un demi-siècle s’est écoulé depuis les réflexions de Sir Theodore Fox au sujet de ses 40 années au poste de rédacteur en chef de The Lancet. Il intitulait alors sa série de conférences d’adieu « Crise dans les communications : les fonctions et l’avenir des journaux médicaux » [traduction]1. Malgré la forte croissance du nombre de journaux avant les années 1960, la quantité de soumissions reçues avait augmenté au point où Sir Fox regrettait surtout de devoir en refuser une proportion croissante. À la fin du 19e siècle, le chef du service de santé des États- Unis avait pu cataloguer la somme totale des connaissances médicales de l’époque en un volume équivalant à 1 seul mois de l’Index Medicus, catalogue qui en fut le successeur et qui était en usage lorsque Sir Fox prit sa retraite. Il sonnait alors une alarme que l’on a entendue résonner souvent depuis : comment un chercheur, et encore plus un médecin praticien, pouvait-il se faire une idée de la somme des nouvelles connaissances qui ne cessaient d’être produites ? Si le rythme de parution des publications se maintenait, bientôt il n’y aurait plus assez de papier pour les imprimer, plus assez de temps pour les lire et aucun système de bibliothèque capable de mettre de l’ordre dans ce Babel. Sir Fox estimait que 145 000 articles avaient été indexés en 19641. L’an dernier, PubMed en a indexé 1 045 564. Pour Sir Fox, l’informatisation était la voie de l’avenir. Et maintenant, 50 ans plus tard, nous commençons à peine à accueillir cet avenir. Il faisait une distinction entre les fonctions d’« enregistrement » et de « journalisme » des publications médicales. Si la première servait à archiver des faits pour référence future, la seconde pouvait avoir davantage d’impact, parce qu’elle forgeait les connaissances et les opinions. Tout le monde comprend aujourd’hui les capacités illimitées de l’informatisation moderne pour stocker, repérer et extraire du matériel d’archive, mais nous commençons à peine à reconnaître sa capacité à structurer la connaissance. Le Journal canadien de chirurgie (JCC) est le seul journal de chirurgie publié par des moyens conventionnels qui dépose dès leur parution ses articles dans PubMed Central, permettant ainsi un accès ouvert. Depuis que le Journal a adopté cette pratique, son taux global de citation a quadruplé, pour passer de 145 en l’an 2000 à 503 en 2011. Notre taux d’autocitation demeure à moins de 1 %. L’avenir de l’édition médicale réside clairement dans l’accès ouvert. Pour le JCC, la plus grande difficulté récente, qui a menacé la survie du Journal, a été celle du coût croissant de production et de livraison. On jugeait que l’exemplaire imprimé était essentiel si le Journal voulait demeurer pertinent pour les Canadiens. L’imprimé favorise les articles qui façonnent l’opinion, particulièrement dans un journal tel que le JCC, un des rares journaux de chirurgie qui ne soit pas restreint par la spécialisation. Fort heureusement, 2 développements dans le monde numérique sont venu amoindrir la perte de l’exemplaire imprimé de routine. Le format du flip-book numérique reproduit fidèlement le journal et, pour ceux qui préfèrent toujours le papier, l’impression « sur demande » rend possible la production et l’envoi postal d’un seul exemplaire papier. L’information s’échange désormais dans le grand nuage électronique, où elle est modelée et façonnée par une foule d’utilisateurs de toutes sortes. L’information médicale fait partie de ce nuage et n’est plus désormais limitée aux bibliothèques médicales ou repérable seulement au moyen de moteurs de recherche dédiés tels que PubMed. Mais il ne suffit pas de donner aux auteurs la grande exposition que permet la publication à accès ouvert : le Journal cherchera aussi à promouvoir leur travail de façon à le faire voir et entendre dans la mêlée. Le JCC accueillera à bras ouverts les possibilités que fournissent les médias sociaux modernes de participer à ce processus. Les livres sont indexés différemment des journaux. Au cours de ses 55 années d’histoire, le JCC a accumulé une masse de documents qui sont disponibles pour collection ou republication sous forme de livre. Le JCC a publié plus de 40 articles sur l’histoire de la chirurgie au Canada2. Ses rapports scientifiques constituent une documentation fondamentale du développement de la chirurgie au Canada. L’article publié dans le dernier numé ro sur les résultats précoces et tardifs de la transplantation cardiaque était le 120e documentant l’histoire de la transplantation au Canada3. La publication électronique permet la réutilisation et la diffusion de ce genre de matériel, gratuitement sur l’Internet ou en mode d’impression sur demande à faible coût. Le défi que posent les coûts d’impression croissants a ouvert la porte d’un nouveau monde d’édition médicale qui permettra au JCC de conserver sa place de journal de chirurgie de référence au Canada.</p>

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<author>Vivian C. McAlister</author>


<category>éditoriaux CJS</category>

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<title>Slow birth of new-wave medical journalism</title>
<link>http://works.bepress.com/vivianmcalister/164</link>
<guid isPermaLink="true">http://works.bepress.com/vivianmcalister/164</guid>
<pubDate>Tue, 02 Apr 2013 06:36:48 PDT</pubDate>
<description>
	<![CDATA[
	<p>Half a century has passed since Sir Theodore Fox reflected upon his recently completed 40-year tenure as editor of The Lancet. He titled his farewell lecture series “Crisis in communication: the functions and future of medical journals.”1 Even though the number of journals had dramatically increased by the 1960s, submissions had proliferated to such an extent that Fox’s principal regret was the increasing fraction he was forced to refuse. In the late 19th century, the surgeon general of the United States was able to catalogue the entire body of medical knowledge up to that time in a volume that would contain only 1 month of Index Medicus, the successor catalogue in use at the time of Fox’s retirement. Fox raised an alarm that has frequently been considered since: how can any scientist, let alone any practising physician, make sense of all the new knowledge continuously being produced? If the rate of publication continued, soon there would not be enough paper upon which to print it, not enough time to read it and no library system capable of bringing order to Babel. Fox estimated that 145 000 articles were indexed in 1964.1 Last year, PubMed indexed 1 045 564 articles.</p>

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</description>

<author>Vivian C. McAlister</author>


<category>General Surgery</category>

<category>CJS editorials</category>

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<title>GLOBALLY POSITIONED</title>
<link>http://works.bepress.com/vivianmcalister/163</link>
<guid isPermaLink="true">http://works.bepress.com/vivianmcalister/163</guid>
<pubDate>Tue, 02 Apr 2013 05:59:16 PDT</pubDate>
<description>
	<![CDATA[
	<p>As part of Schulich Medicine & Dentistry’s recently launched strategic plan, the School’s vision is to be a global leader in optimizing life-long health through innovations in research, education and active engagement with its communities. In its new video ‘Globally Positioned’, the School celebrates this vision by demonstrating the incredible work being done by its faculty, students and alumni to improve the quality of life for millions of people around the world.  The video features seven unique stories profiling work being done that is impacting the quality of care in Afghanistan, Bosnia, Canada, China, El Salvador, Guatemala, Haiti, Herzegovina, India, Israel, Palestine, Rwanda, and Tanzania.</p>

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</description>

<author>TMD Company et al.</author>


<category>Health Policy</category>

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<item>
<title>Renal Perfusion Pump vs. Cold Storage for Donation After Cardiac Death Kidneys: A Systematic Review.</title>
<link>http://works.bepress.com/vivianmcalister/162</link>
<guid isPermaLink="true">http://works.bepress.com/vivianmcalister/162</guid>
<pubDate>Tue, 01 Jan 2013 06:15:16 PST</pubDate>
<description>
	<![CDATA[
	<p>BACKGROUND: Static cold storage is generally used to preserve kidney allografts from deceased donors. Hypothermic machine perfusion may improve outcomes after transplantation but there have been few studies with limited power that have addressed this issue.  OBJECTIVE: To review the evidence for the effectiveness of storing kidneys from deceased donors after cardiac death prior to transplantation, using cold static storage solutions or pulsatile hypothermic machine perfusion.  DATA SOURCES: Electronic databases were searched in September 2011 for systematic reviews and/or meta-analyses, randomized controlled trials and other study designs that compared delayed graft function and graft survival. Sources included Cochrane Library, PUBMed and EMBASE. Studies excluded from review included those that were unable to discriminate between donation after cardiac death (DCD) and a neurologically deceased donor (NDD).  REVIEW METHODS: Our primary outcomes were delayed graft function (DGF) and one year graft survival. Statistical analysis was carried out using the Review Manager software from the Cochrane database.  RESULTS: A total of nine studies qualified for review. We found that pulsatile perfusion pumped kidneys from DCD donors had reduced DGF rates compared to kidneys that were placed in cold storage (p = 0.03; odds ratio 0.64, CI 0.43 - 0.95). Although, there was a trend towards improved 1 year graft survival in the pulsatile perfusion group, statistical significance was not reached (p = 0.17; odds ratio 0.74, CI 0.48 - 1.13).  CONCLUSION: Pulsatile machine perfusion of DCD kidneys appears to reduce delayed graft function rates. There did not appear to be a benefit in regards to one year graft survival. Due to the great heterogeneity among the trials along with several confounding factors the overall impact upon allograft function and survival requires more study.</p>

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</description>

<author>V Bathini et al.</author>


<category>Transplantation</category>

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<item>
<title>London Surgeon Traces Guelph&apos;s Research Role in Coagulation</title>
<link>http://works.bepress.com/vivianmcalister/161</link>
<guid isPermaLink="true">http://works.bepress.com/vivianmcalister/161</guid>
<pubDate>Tue, 01 Jan 2013 06:01:52 PST</pubDate>
<description>
	<![CDATA[
	<p>Modern doctors and their patients whose lives depend on therapies used routinely in cardiovascular and transplant surgery owe a debt to a handful of coagulation pioneers whose discoveries during the 1920s took place not at medical schools but at the forerunners of the University of Guelph.   That's the thesis of a journal review article written by a Canadian transplant surgeon about what he calls a little-known connection between modern clinical medicine and early research in agricultural and veterinary sciences done in Guelph.   �The science of agriculture and the science of humans � they're all related,� says Dr. Vivian McAlister, a surgeon at University Hospital in London and a surgery professor at the University of Western Ontario.   His paper chase, including an examination of documents held in the McLaughlin Library archives, unearthed work done by several researchers � including two major names in the history of the Ontario Agricultural College and the Ontario Veterinary College � decades before U of G itself was established.   McAlister's paper, now before the Canadian Medical Association Journal for review, details how early OAC and OVC studies played a role in the development of anti-clotting agents, specifically vitamin K, heparin and warfarin.   More than that, he found that early Guelph researchers pioneered systematic agricultural studies, including the use of controlled trials, a concept that wouldn't catch on in human medicine until later. �They were ahead of medicine,� he says.   In his paper, called �Control of Coagulation: A Gift of Canadian Agriculture,� McAlister explains that vitamin K was named in 1935 by a Danish researcher who would later share a Nobel Prize. But that work stemmed from research by a trio of OAC graduate students.   William McFarlane had studied dairy science in his native United Kingdom; in Canada, he completed a PhD on poultry in 1932 under the supervision of Prof. William Graham. (McFarlane subsequently left for Edmonton but returned to Guelph as a chemistry professor in Macdonald College.)   Along with students William Graham Jr. and Frederick Richardson, McFarlane published a paper in 1930 about experiments on fat-soluble components of chick feed. Working with chicks on a fat-free diet, they noticed persistent bleeding from wounds where the birds' identification tags had been applied. Having ruled out known vitamins and other dietary components, they were left with the possibility that an unknown component prevented blood clotting.   Interested mostly in comparing various dietary supplements and chick growth, the trio went no further. But in a 1943 Nobel Prize lecture given by Copenhagen researcher Henrik Dam, they were credited with the initial observation that led to the discovery of vitamin K.   Other researchers mistakenly believed that vitamin C was the missing ingredient. Dam found an anti-hemorrhagic factor in other foods and named it vitamin K for �koagulation� in Scandinavian and German spellings.   American researcher Edward Doisey extracted, characterized and synthesized vitamin K from alfalfa. McAlister's paper notes that vitamin K soon became available for treating patients who were bleeding or needed surgery. Dam and Doisey shared the 1943 Nobel Prize in Physiology or Medicine.   But that was only part of the Guelph connection to the coagulation story � and not even the first part. McAlister says neither Dam nor other vitamin researchers knew that vitamin K antagonists had been studied almost a decade earlier, this time at OVC.   Dam had shown how the body uses vitamin K to make prothrombin, a precursor in the chain of biochemical events that leads to fibrin, a vital clotting protein. In his Nobel address, he also mentioned that this chain of events could be disrupted by dicoumarol. This substance interferes with vitamin K metabolism, slowing the production of prothrombin.   The precursor to dicoumarol forms in sweet clover that has been spoilt by mould. But nobody knew that back when Francis Schofield, a 1910 OVC graduate and pathologist at the veterinary college, began looking at a bleeding disorder that caused cattle to hemorrhage to death. In 1922, he traced the problem to mouldy sweet clover. He suggested that an anti-thrombin substance in spoilt silage led to uncontrolled bleeding.   Two decades would pass before scientists figured out how the process worked. It was researchers at the University of Wisconsin who found that mould oxidized coumarin in clover. Yoked to formaldehyde, coumarin formed dicoumarol, a vitamin K antagonist.   Those scientists had uncovered a substance that would become a powerful anticoagulant. A derivative became warfarin, named for the acronym of the Wisconsin Alumni Research Fund. Used originally as a rodent pesticide, warfarin � along with dicoumarol � found use in human medicine, not least after then U.S. president Dwight Eisenhower was treated with it after a heart attack.   McAlister's paper also details how Toronto scientists Charles Best, Gordon Murray and Louis Jaques found a cheap, abundant source of purified heparin that could be used in vascular surgery. McAlister says many liver transplant recipients now receive vitamin K, warfarin or heparin during their care.   He first uncovered the Guelph connections more than five years ago, when he was preparing a talk on coagulation and hemorrhage control, including a new drug made in Denmark. He already knew about Dam's work there on vitamin K, but he was searching for more information to strengthen the link to Copenhagen.   �What I was astonished to see was that Dam credited scientists in Guelph with the preliminary work that allowed him to do his Nobel Prize-winning work.�   Curious, he followed up the reference at the McLaughlin Library archives (his paper credits help from archivist Darlene Wiltsie). He sent his review paper to CMAJ about a year ago.   Speaking about the early Guelph research, he says: �The most important message is that these are not isolated matters of luck. This was a planned approach arising out of a 19-century decision to have an agricultural and a veterinary college in Guelph supported by the Government of Ontario. That link was, I think, essential to its success. It gave scientists credibility in the community.�   That point was underlined when his preliminary research on McFarlane led him to the elder William Graham, for whom the former poultry building on campus is named. Although he had nothing to do with studies of bleeding chicks on fat-free diets, Graham Sr. fostered a climate of inquiry that enabled other researchers, including his son, to thrive, says McAlister.   For McAlister, the U of G connection to the story of coagulation is bittersweet. McFarlane and his collaborators knew that a fat-soluble component of the diet was responsible for clotting failure, but they left that research avenue untrodden.   �If they had pursued it, they would have figured it out. They would have got the Nobel Prize.�   Similarly for Schofield, McAlister says, although for different reasons. Pointing to the range of research papers the OVC scientist wrote on infectious diseases in farm animals, McAlister suggests Schofield might have earned a Nobel, too, if he'd stuck to hemorrhagic factors.   Similar sentiments were expressed in a short biography published last year by Douglas Maplesden. He wrote that Schofield's �early discovery of an anticoagulant active via the oral route was one of the most important discoveries of the veterinary profession in the first half of the 20th century. Oral anticoagulants could thereby be developed to poison rodent pests and as human drugs to prevent thrombosis.�   More lyrically, David Archibald, a U of G grad and composer/playwright, retold Schofield's story in a musical portrait called Schofield: The Sleepless Tiger. One song, called The Ballad of Mouldy Sweet Clover, ends with the discovery of warfarin in Wisconsin as follows: �. . . when my bones are still and spent/They'll say there lies the man who sent/A million bleedin' rodents to their grave.�</p>

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</description>

<author>Andrew Vowles</author>


<category>News Stories</category>

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<item>
<title>Perfusion pump better than cold storage for &apos;DCD&apos; kidneys for transplant</title>
<link>http://works.bepress.com/vivianmcalister/160</link>
<guid isPermaLink="true">http://works.bepress.com/vivianmcalister/160</guid>
<pubDate>Tue, 01 Jan 2013 05:57:58 PST</pubDate>
<description>
	<![CDATA[
	<p>NEW YORK (Reuters Health) - Kidneys procured for transplant after cardiac death (as opposed to after brain death) do better when preserved with a perfusion pump rather than cold fluid, a new review shows.  "Although the use of pulsatile perfusion does come at a cost, it can be beneficial and cost-saving if used in the correct population of donor kidneys," Dr. Alp Sener from Western University, London, Ontario, Canada told Reuters Health.   But, Dr. Sener added, "There still remains a vast list of unknown contributors to final renal allograft function, including identifying the optimal length of time that kidney should be left on pump so as to maximize outcomes, as well as determining optimal perfusion pump settings and temperature."  Dr. Sener and colleagues compared "donation after cardiac death" (DCD) kidneys that were put on pulsatile perfusion with those placed in cold storage in terms of delayed graft failure and one-year graft survival, in a systematic review.  Altogether they looked at nine studies: four randomized controlled trials, one prospective but nonrandomized trial, three retrospective studies, and one cohort study.   The rate of delayed graft function was 36% lower in perfusion-pumped kidneys from DCD donors than in kidneys stored in static cold fluid (p=0.03). This finding held true in subgroup analyses of only randomized trials and only nonrandomized trials.   As reported December 5th online in The Journal of Urology, graft survival at one year tended to favor perfusion pump kidneys, but the overall effect failed to achieve statistical significance, except in the subgroup analysis that included only nonrandomized studies.   "We believe all DCD kidneys should be 'pumped,'" coauthor Dr. Vivian McAlister, currently deployed in Afghanistan, told Reuters Health by email. "Further research is looking at extending conditions under which we can successfully transplant DCD kidneys."  "Obviously it is too costly to just 'pump' every kidney that we transplant (especially in Canada where we have quite tight surgical transplant budgets) so we try to be selective in which kidneys we pump; hence the reason we prefer to pump DCD and ECD (extended-criteria donor) kidneys," coauthor Dr. Thomas McGregor told Reuters Health by email.  Coauthor Dr. Patrick Luke predicts - also by email - that "static cold storage will become an entity of the past."   Dr. Sener explains, "We currently have novel and exciting data from ongoing porcine and discarded human kidney experiments that the supplementation of standard preservation solutions with endogenously produced small molecules, including hydrogen sulfide and carbon monoxide, during the time of pulsatile perfusion has a significant impact on improving early graft function as well as in minimizing the cellular and tissue damage that is associated with transplantation."  "These therapies have the potential to make a significant impact on clinical practice in the near future and may shape the way we view standard organ preservation solutions." Dr. Michael J. Goldstein from the Mount Sinai Medical Center, New York, medical director of the New York Organ Donor Network (New York City's local Organ Procurement Organization, or OPO) agrees with the authors.  "We should always favor machine perfusion (MP) over cold static storage," Dr. Goldstein told Reuters Health by email. "In NY, we pump more kidneys per year than any other location in the world, close to 750 annually. We have learned that MP reduces delayed graft failure and prolongs allograft survival over organs that are not pumped or pumped for little amount of the cold ischemic time." "Improvements in organ preservation allow transplant surgeons to challenge the limits that have been imposed by past experience," Dr. Goldstein added. "In order to provide better access to transplantation and utilize more organs, surgeons must broaden their acceptance standards and use new approaches to improve organ quality and function."   But despite what seems like uniform endorsement of pulsatile perfusion, there is room for disagreement.   In email to Reuters Health, Dr. Dorry Segev from Johns Hopkins Medical Institution, Baltimore, Maryland, said, "The reduction of delayed graft function associated with pulsatile perfusion has not correlated, in most studies, with better allograft function or survival, leaving us to wonder what kind of physiologic changes actually occur with pulsatile perfusion and what the real purpose is for this preservation modality."   Dr. Segev added, "Some centers use pulsatile perfusion to expand acceptance patterns for marginal organs, although some centers accept the same organs without pulsatile perfusion parameters." "Given the current evidence in the field, the choice of storage should remain based on institutional practice and technical experience with the available modalities," Dr. Segev concluded.</p>

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</description>

<author>Will Boggs</author>


<category>News Stories</category>

</item>






<item>
<title>Civilian trauma care - learning from the military experience</title>
<link>http://works.bepress.com/vivianmcalister/159</link>
<guid isPermaLink="true">http://works.bepress.com/vivianmcalister/159</guid>
<pubDate>Sun, 14 Oct 2012 09:14:33 PDT</pubDate>
<description>
	<![CDATA[
	<p>In the 21st century, military and civilian trauma surgeons bring similar solutions to similar problems, learning one from another. The objective of this presentation is to review military trauma care in Afghanistan for aspects that may influence civilian practice at home.</p>
<p>• Comprehensive trauma care system: guidelines,</p>
<p>registry, review</p>
<p>• Protocols for care: damage control; massive</p>
<p>blood transfusion policy; mass casualty care</p>
<p>• Techniques: resuscitative thoracotomy;</p>
<p>decompressive craniectomy; pelvic-gluteal</p>
<p>hemorrhage control</p>
<p>• Rehabilitation: Mild traumatic brain injury</p>
<p>• Delegated medical acts: medics / PAs</p>

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</description>

<author>Vivian C. McAlister</author>


<category>General Surgery</category>

</item>






<item>
<title>Grand Rounds: Psoas abscess with Group B Streptococcus</title>
<link>http://works.bepress.com/vivianmcalister/158</link>
<guid isPermaLink="true">http://works.bepress.com/vivianmcalister/158</guid>
<pubDate>Thu, 13 Sep 2012 11:08:08 PDT</pubDate>
<description>
	<![CDATA[
	<p>Case Report: A 43-year-old woman presented to the emergency room at University Hospital, London Health Sciences Centre with an eight-day history of lower back pain. She had presented one-week prior with similar symptoms and was treated conservatively for sciatica. Since then, her pain had progressively increased</p>

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</description>

<author>Adina Feinberg et al.</author>


<category>General Surgery</category>

</item>






<item>
<title>Changes in tonsillar bacteriology of recurrent acute tonsillitis: 1980 vs. 1989.</title>
<link>http://works.bepress.com/vivianmcalister/157</link>
<guid isPermaLink="true">http://works.bepress.com/vivianmcalister/157</guid>
<pubDate>Fri, 31 Aug 2012 18:44:25 PDT</pubDate>
<description>
	<![CDATA[
	<p>Recurrent acute tonsillitis is a common problem. Despite this, there still remain many controversies regarding aetiology and correct management. The tonsillar microflora of 33 children with recurrent acute tonsillitis studied in 1980 and 58 patients studied in 1989 is presented. A comparison of the microbiology in the two periods studied a decade apart suggests that the pathogenic profile is changing. Haemophilus influenzae increased from 39 to 62% in the deep tonsillar tissue in the decade. There was a concomitant increase in incidence of Staphylococcus aureus from 6 to 40% of cases. In the same interval, mixed microflora increased from 18 to 52%. Anaerobic organisms were isolated in insignificant numbers. Unique to this study, 44% of H. influenzae isolates in 1989 were beta lactamase producers, increasing from only 2% in 1980. All of the S. aureus were beta lactamase producers. In the majority, the throat swabs grew only organisms commensal to the upper respiratory tract however, the deep tonsillar tissue excised at tonsillectomy carried significant growths of pathogenic organisms confirming the inadequacy of the superficial tonsillar swab as an indicator of treatment.</p>

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</description>

<author>C I. Timon et al.</author>


<category>General Medicine</category>

</item>






<item>
<title>Hereditary angioneurotic oedema--the management of the problem in a family</title>
<link>http://works.bepress.com/vivianmcalister/156</link>
<guid isPermaLink="true">http://works.bepress.com/vivianmcalister/156</guid>
<pubDate>Fri, 31 Aug 2012 06:14:11 PDT</pubDate>
<description>
	<![CDATA[
	<p>Diagnosis and treatment of hereditary angioneurotic oedema (HAO) is described in a family. C1 esterase inhibitor (C1 INH) deficiency was confirmed with radial immunodiffusion and functional assays. The effect of treament with combinations of tranexamic acid, danazol and stanozolol on C1 INH levels are reported.</p>

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</description>

<author>Vivian C. McAlister et al.</author>


<category>General Medicine</category>

</item>






<item>
<title>Evaluation of the updated definition of early allograft dysfunction in donation after brain death and donation after cardiac death liver allografts.</title>
<link>http://works.bepress.com/vivianmcalister/155</link>
<guid isPermaLink="true">http://works.bepress.com/vivianmcalister/155</guid>
<pubDate>Sun, 19 Aug 2012 18:42:43 PDT</pubDate>
<description>
	<![CDATA[
	<p>BACKGROUND:</p>
<p>An updated definition of early allograft dysfunction (EAD) was recently validated in a multicenter study of 300 deceased donor liver transplant recipients. This analysis did not differentiate between donation after brain death (DBD) and donation after cardiac death (DCD) allograft recipients.</p>
<p>METHODS:</p>
<p>We reviewed our prospectively entered database for all DBD (n=377) and DCD (n=38) liver transplantations between January 1, 2006 and October 30, 2011. The incidence of EAD as well as its ability to predict graft failure and survival was compared between DBD and DCD groups.</p>
<p>RESULTS:</p>
<p>EAD was a valid predictor of both graft and patient survival at six months in DBD allograft recipients, but in DCD allograft recipients there was no significant difference in the rate of graft failure in those with EAD (11.5%) compared with those without EAD (16.7%) (P=0.664) or in the rate of death in recipients with EAD (3.8%) compared with those without EAD (8.3%) (P=0.565). The graft failure rate in the first 6 months in those with international normalized ratio ≥1.6 on day 7 who received a DCD allograft was 37.5% compared with 6.7% for those with international normalized ratio <1.6 on day 7 (P=0.022).</p>
<p>CONCLUSIONS:</p>
<p>The recently validated definition of EAD is a valid predictor of patient and graft survival in recipients of DBD allografts. On initial assessment, it does not appear to be a useful predictor of patient and graft survival in recipients of DCD allografts, however a study with a larger sample size of DCD allografts is needed to confirm these findings. The high ALT/AST levels in most recipients of DCD livers as well as the predisposition to biliary complications and early cholestasis make these parameters as poor predictors of graft failure. An alternative definition of EAD that gives greater weight to the INR on day 7 may be more relevant in this population.</p>

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</description>

<author>Kris Croome et al.</author>


<category>Transplantation</category>

</item>






<item>
<title>1 Canadian Field Hospital in Haiti: surgical experience in earthquake relief</title>
<link>http://works.bepress.com/vivianmcalister/154</link>
<guid isPermaLink="true">http://works.bepress.com/vivianmcalister/154</guid>
<pubDate>Thu, 02 Aug 2012 19:49:46 PDT</pubDate>
<description>
	<![CDATA[
	<p>The Canadian Forces’ (CF) deployable hospital, 1 Canadian Field Hospital, was deployed to Haiti after an earthquake that caused massive devastation. Two surgical teams performed 167 operations over a 39-day period starting 17 days after the index event. Most operations were unrelated to the earthquake. Replacing or supplementing the destroyed local surgical capacity for a brief period after a disaster can be a valuable contribution to relief efforts. For future humanitarian operations/disaster response missions, the CF will study the feasibility of accelerating the deployment of surgical capabilities. L’hôpital déployable des Forces canadiennes, le 1er Hôpital de campagne du Canada, a été envoyé à Haïti après un tremblement de terre qui a causé une dévastation massive. Deux équipes chirurgicales ont effectué 167 opérations au cours d’une période de 39 jours ayant débuté 17 jours après l’événement indice. La plupart des interventions chirurgicales n’étaient pas reliées au tremblement de terre. Le remplacement ou la supplémentation pendant une courte période de la capacité chirurgicale locale détruite à la suite d’une catastrophe peut être une contribution précieuse aux efforts de secours. En vue de futures missions de chirurgie humanitaire et réponse aux catastrophes, les Forces canadiennes étudieront la possibilité d’accélérer le déploiement des capacités chirurgicales.</p>

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</description>

<author>Max Talbot et al.</author>


<category>Combat Surgery</category>

</item>






<item>
<title>Mass Casualty Training Exercise at The Canadian Surgery Forum</title>
<link>http://works.bepress.com/vivianmcalister/153</link>
<guid isPermaLink="true">http://works.bepress.com/vivianmcalister/153</guid>
<pubDate>Tue, 24 Jul 2012 09:59:14 PDT</pubDate>
<description>
	<![CDATA[
	<p>On September 18, 2011 second year Schulich School of Medicine & Dentistry students helped run the first mass casualty training exercise, directed by Dr. Vivian McAlister, Division of General Surgery, at the Canadian Surgery Forum held this year at the London Convention Centre.</p>

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</description>

<author>Western Surgery</author>


<category>Health Policy</category>

</item>





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