Amputee rehabilitation may be limited by complexity of injury (e.g. bilateral arm amputation), associated injury (e.g. colostomy) or by the level of amputation (e.g. high above knee). Our objective is to assess the potential for composite tissue allotransplantation (CTA) to overcome these barriers. Medical literature was searched and programs were surveyed regarding the current status of CTA. Results CTA remains an experimental reconstructive option that involves a large collaborative (physiatry, orthopaedic, plastic and transplant surgeons). Limb transplantation has evolved out of limb reimplantation surgery and organ transplantation. Approximately 10 programs world wide, with almost a decade of experience, report 90% success with good function. Most experience in forearm transplantation (50 grafts in 36 patients). Research in London ON, where a civilian CTA program is being developed, has demonstrated the protective effect immunologically of vascularized bone marrow so that the immunosuppressive requirements are equivalent or less than those for organ transplantation. A review of Canadian casualties suggests that relatively few will require forearm transplantation and more would benefit from above-knee leg replacement. Knee transplantation, permitting conversion to a below knee prosthesis, has been as successful as forearm transplantation. Conclusions CTA may offer options for treatment of carefully selected veterans who are motivated to take part in an experimental reconstructive program. Lay Summary: Carefully selected combat casualties with difficult amputations may be good candidates for a limb transplantation program being developed in London ON. Worldwide experience suggests forearm transplantation is very successful with relatively low immunosuppressive drug requirements. Combat casualties will require leg as well as hand transplantation.