Charge dependence of ligand release and monolayer stability of gold nanoparticles by biogenic thiols
DOI: 10.1021/bc8000694 Copyright © 2008 American Chemical Society
The effect of surface charge on the stability of gold nanoparticles (AuNPs) to the biogenic thiols glutathione (GSH), dihydrolipoic acid (DHLA), and cysteine was quantified. It was observed that the rate of release of fluorescein-tagged ligand was determined by the surface charge of the AuNPs, with cationic particles much more labile than anionic analogues. This ability to tune stability is significant for the design of both delivery vehicles and intracellular probes.
A Chompoosor, G Han, and VM Rotello. "Charge dependence of ligand release and monolayer stability of gold nanoparticles by biogenic thiols" Bioconjugate Chemistry 19.7 (2008): 1342-1345.
Available at: http://works.bepress.com/vincent_rotello/94