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Selected Works of Vincent Rotello
Article
Photoregulated Release of Caged Anticancer Drugs from Gold Nanoparticles
Journal of the American Chemical Society (2009)
  • SS Agasti
  • A Chompoosor
  • CC You
  • P Ghosh
  • CK Kim
  • VM Rotello
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Abstract

An anticancer drug (5-fluorouracil) was conjugated to the surface of gold nanoparticles through a photocleavable o-nitrobenzyl linkage. In this system, the particle serves as both cage and carrier for the therapeutic, providing a nontoxic conjugate that effectively releases the payload upon long wavelength UV irradiation.

Disciplines
Publication Date
April 7, 2009
Publisher Statement
DOI: 10.1021/ja900591t
Citation Information
SS Agasti, A Chompoosor, CC You, P Ghosh, et al.. "Photoregulated Release of Caged Anticancer Drugs from Gold Nanoparticles" Journal of the American Chemical Society Vol. 131 Iss. 16 (2009)
Available at: http://works.bepress.com/vincent_rotello/52/