"The potential of achiral sponge-derived and synthetic bromoindoles as selective cytotoxins against PANC-1 tumor cells." by Nicholas Lorig-Roach

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The potential of achiral sponge-derived and synthetic bromoindoles as selective cytotoxins against PANC-1 tumor cells.

Natural Sciences and Mathematics | Faculty Scholarship

Nicholas Lorig-Roach, University of California, Santa Cruz, California, USA
Frances Hamkins-Indik, University of California, Santa Cruz, California, USA
Tyler A. Johnson, University of California, Santa Cruz, California, USA
Karen Tenney, University of California, Santa Cruz, California, USA
Frederick A. Valeriote, Henry Ford Hospital, Detroit, Michigan, USA
Phillip Crews, University of California, Santa Cruz

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Department

Natural Sciences and Mathematics

Document Type

Article

Source

Tetrahedron

Publication Date

1-11-2018

Disciplines

Abstract

Our quest to isolate and characterize natural products with in vitro solid tumor selectivity is driven by access to repositories of Indo-Pacific sponge extracts. In this project an extract of a species of Haplosclerida sponge obtained from the US NCI Natural Products Repository displayed, by in vitro disk diffusion assay (DDA) and IC

PubMed ID

29576661

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Citation Information

Nicholas Lorig-Roach, Frances Hamkins-Indik, Tyler A. Johnson, Karen Tenney, et al.. "The potential of achiral sponge-derived and synthetic bromoindoles as selective cytotoxins against PANC-1 tumor cells." Vol. 74 Iss. 2 (2018) p. 217 - 223 ISSN: 0040-4020
Available at: http://works.bepress.com/tyler-a-johnson/14/