SelectedWorks - Trevor J. Lujan

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Selected Works of Trevor J. Lujan

Associate Professor, Department of Mechanical & Biomedical Engineering

Dr. Trevor J. Lujan joined the faculty of the Department of Mechanical and Biomedical Engineering at Boise State University in 2012 (Ph.D. from University of Utah, B.S. from University of Wisconsin - Madison). His research is focused on musculoskeletal biomechanics and mechanobiology, with an overarching goal to investigate the effect of mechanical forces on connective tissue injury, remodeling, and repair, and to then translate this research into innovative medical solutions that are effective, practical, and affordable. Dr. Lujan's work has been supported by grants from the National Institutes of Health, the National Science Foundation, and the state of Idaho.

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About Trevor J. Lujan

Dr. Trevor J. Lujan joined the faculty of the Department of Mechanical and Biomedical Engineering at Boise State University in 2012 (Ph.D. from University of Utah, B.S. from University of Wisconsin - Madison). His research is focused on musculoskeletal biomechanics and mechanobiology, with an overarching goal to investigate the effect of mechanical forces on connective tissue injury, remodeling, and repair, and to then translate this research into innovative medical solutions that are effective, practical, and affordable. Dr. Lujan's work has been supported by grants from the National Institutes of Health, the National Science Foundation, and the state of Idaho.

Peer-Reviewed Journal Articles (34)

Finite Element Modeling of Meniscal Tears Using Continuum Damage Mechanics and Digital Image Correlation (Derek Q. Nesbitt, Dylan E. Burruel, Bradley S. Henderson, et al.) Scientific Reports (2023)

Meniscal tears are a common, painful, and debilitating knee injury with limited treatment options. Computational models that predict meniscal tears may help advance injury prevention and repair, but first these models must be validated using ...

Dots-on-Plots: A Web Application to Analyze Stress–Strain Curves From Tensile Tests of Soft Tissue (Derek Q. Nesbitt, Miranda L. Nelson, Kyle S. Shannon, et al.) Journal of Biomechanical Engineering (2023)

The calculation of tensile mechanical properties from stress–strain curves is a fundamental step in characterizing material behavior, yet no standardized method exists to perform these calculations for soft tissue. To address this deficiency, we developed ...

In vitro Method to Quantify and Visualize Mechanical Wear in Human Meniscus Subjected to Joint Loading (Kate J. Benfield, Zachary A. Pinkley, Dylan E. Burruel, et al.) Journal of the Mechanical Behavior of Biomedical Materials (2022)

The mechanical wear and tear of soft connective tissue from repetitive joint loading is a primary factor in degenerative joint disease, and therefore methods are needed to accurately characterize wear in joint structures. Here, we ...

Tensile Fatigue Strength and Endurance Limit of Human Meniscus (Bradley S. Henderson, Katelyn F. Cudworth, Madison E. Wale, et al.) Journal of the Mechanical Behavior of Biomedical Materials (2022)

The knee menisci are prone to mechanical fatigue injury from the cyclic tensile stresses that are generated during daily joint loading. Here we characterize the tensile fatigue behavior of human medial meniscus and investigate the ...

Effect of Age on the Failure Properties of Human Meniscus: High-Speed Strain Mapping of Tissue Tears (Derek Q. Nesbitt, Danielle N. Siegel, Sean J. Nelson, et al.) Journal of Biomechanics (2021)

The knee meniscus is a soft fibrous tissue with a high incidence of injury in older populations. The objective of this study was to determine the effect of age on the failure behavior of human ...

Applying ASTM Standards to Tensile Tests of Musculoskeletal Soft Tissue: Methods to Reduce Grip Failures and Promote Reproducibility (Madison E. Wale, Derek Q. Nesbitt, Bradley S. Henderson, et al.) Journal of Biomechanical Engineering (2021)

Tensile testing is an essential experiment to assess the mechanical integrity of musculoskeletal soft tissues, yet standard test methods have not been developed to ensure the quality and reproducibility of these experiments. The ASTM International ...

Print-A-Punch: A 3D Printed Device to Cut Dumbbell-Shaped Specimens from Soft Tissue for Tensile Testing (Sean J. Nelson, Jaremy J. Creechley, Madison E. Wale, et al.) Journal of Biomechanics (2020)

The failure behavior and mechanical properties of soft tissue can be characterized by conducting uniaxial tensile tests on small sectioned specimens, called test coupons. An ideal coupon geometry for tensile testing is a dumbbell shape ...

Development of Photoactive g-C3N4/Poly(vinyl Alcohol) Composite Hydrogel Films with Antimicrobial and Antibiofilm Activity (Bradley S. Henderson, Tyler R. Smith, Katelyn F. Cudworth, et al.) ACS Applied Bio Materials (2020)

Free-standing, composite hydrogels containing the visible-light responsive metal-free semiconductor graphitic carbon nitride (g-C3N4) as an integral component have been fabricated by direct casting techniques. At 0.67% g-C3N4 loading, intermolecular interactions between the semiconductor particles and ...

Prechondrogenic ATDC5 Cell Attachment and Differentiation on Graphene Foam; Modulation by Surface Functionalization with Fibronectin (Stephanie M. Frahs, Jonathon C. Reeck, Katie M. Yocham, et al.) ACS Applied Materials & Interfaces (2019)

Graphene foam holds promise for tissue engineering applications. In this study, graphene foam was used as a three-dimension scaffold to evaluate cell attachment, cell morphology, and molecular markers of early differentiation. The aim of this ...

A Hand-Held Device to Apply Instrument-Assisted Soft Tissue Mobilization at Targeted Compression Forces and Stroke Frequencies (John B. Everingham, Peter T. Martin and Trevor J. Lujan) Journal of Medical Devices (2019)

Instrument-assisted soft tissue mobilization (IASTM) is a manual therapy technique that is commonly used to treat dysfunctions in ligaments and other musculoskeletal tissues. The objective of this study was to develop a simple hand-held device ...

Extracellular Matrix Expression and Production in Fibroblast-Collagen Gels: Towards an In Vitro Model for Ligament Wound Healing (Stephanie Frahs, Julia Thom Oxford, Erika E. Neumann, et al.) Annals of Biomedical Engineering (2018)

—Ligament wound healing involves the proliferation of a dense and disorganized fibrous matrix that slowly remodels into scar tissue at the injury site. This remodeling process does not fully restore the highly aligned collagen network ...

Mechanical Properties of Graphene Foam and Graphene Foam—Tissue Composites (Katie M. Yocham, Crystal Scott, Kiyo Fujimoto, et al.) Advanced Engineering Materials (2018)

Graphene foam (GF), a 3‐dimensional derivative of graphene, has received much attention recently for applications in tissue engineering due to its unique mechanical, electrical, and thermal properties. Although GF is an appealing material for cartilage ...

Modeling the Effect of Collagen Fibril Alignment on Ligament Mechanical Behavior (Christina J. Stender, Rust Evan, Peter T. Martin, et al.) Biomechanics and Modeling in Mechanobiology (2018)

Ligament mechanical behavior is primarily regulated by fibrous networks of type I collagen. Although these fibrous networks are typically highly aligned, healthy and injured ligament can also exhibit disorganized collagen architecture. The objective of this ...

Wear Testing of a Canine Hip Resurfacing Implant That Uses Highly Cross‐Linked Polyethylene (Kevin J. Warburton, John B. Everingham, Jillian L. Helms, et al.) Journal of Orthopaedic Research (2018)

Hip resurfacing offers advantages for young, active patients afflicted with hip osteoarthritis and may also be a beneficial treatment for adult canines. Conventional hip resurfacing uses metal‐on‐metal bearings to preserve bone stock, but it may ...

Quantifying Wear Depth in Hip Prostheses Using a 3D Optical Scanner (Katherine A. Hollar, Daniel S. Ferguson, John B. Everingham, et al.) Wear (2018)

The visualization of wear depth in hip prostheses can assist the evaluation of new bearing materials and implant designs. The goal of this study was to develop an accurate, fast, and economical methodology to generate ...

Fatigue Life of Bovine Meniscus Under Longitudinal and Transverse Tensile Loading (Jaremy J. Creechley, Madison E. Krentz and Trevor J. Lujan) Journal of the Mechanical Behavior of Biomedical Materials (2017)

The knee meniscus is composed of a fibrous extracellular matrix that is subjected to large and repeated loads. Consequently, the meniscus is frequently torn, and a potential mechanism for failure is fatigue. The objective of ...

A Validated Software Application to Measure Fiber Organization in Soft Tissue (Erica E. Morrill, Azamat N. Tulepbergenov, Christina J. Stender, et al.) Biomechanics and Modeling in Mechanobiology (2016)

The mechanical behavior of soft connective tissue is governed by a dense network of fibrillar proteins in the extracellular matrix. Characterization of this fibrous network requires the accurate extraction of descriptive structural parameters from imaging ...

Automated Measurement of Fracture Callus in Radiographs Using Portable Software (Stephen M. Porter, Hannah L. Dailey, Katharine A. Hollar, et al.) Journal of Orthopaedic Research (2016)

The development of software applications that assist the radiographic evaluation of fracture healing could advance clinical diagnosis and expedite the identification of effective treatment strategies. A radiographic feature regularly used as an outcome measure for ...

Motion Predicts Clinical Callus Formation: Construct-Specific Finite Element Analysis of Supracondylar Femoral Fractures (Jacob Elkins, J. Lawrence Marsh, Trevor Lujan, et al.) The Journal of Bone and Joint Surgery (2016)

Background: Mechanotransduction is theorized to influence fracture-healing, but optimal fracture-site motion is poorly defined. We hypothesized that three-dimensional (3-D) fracture-site motion as estimated by finite element (FE) analysis would influence callus formation for a clinical ...

Aryl Hydrocarbon Receptor Activation by TCDD Modulates Expression of Extracellular Matrix Remodeling Genes During Experimental Liver Fibrosis (Cheri L. Lamb, Giovan Cholico, Daniel E. Perkins, et al.) BioMed Research International (2016)

The aryl hydrocarbon receptor (AhR) is a soluble, ligand-activated transcription factor that mediates the toxicity of 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD). Increasing evidence implicates the AhR in regulating extracellular matrix (ECM) homeostasis. We recently reported that TCDD ...

Imaging Techniques for the Assessment of Fracture Repair (P. Augat, E. F. Morgan, T. J. Lujan, et al.) Injury (2014)

Imaging of a healing fracture provides a non-invasive and often instructive reproduction of the fracture repair progress and the healing status of bone. However, the interpretation of this reproduction is often qualitative and provides only ...

Visible Light Photoinitiation of Mesenchymal Stem Cell-Laden Bioresponsive Hydrogels (C. S. Bahney, T. J. Lujan, C. W. Hsu, et al.) European Cells and Materials (2011)

Biological activity can be added to synthetic scaffolds by incorporating functional peptide sequences that provide enzyme-mediated degradation sites, facilitate cellular adhesion or stimulate signaling pathways. Poly(ethylene glycol) diacrylate is a popular synthetic base for tissue ...

Healing Complications are Common After Locked Plating for Distal Femur Fractures (Christopher Henderson, Trevor J. Lujan, Lori L. Kuhl, et al.) Clinical Orthopaedics and Related Research (2011)

Background Several mechanical studies suggest locking plate constructs may inhibit callus necessary for healing of distal femur fractures. However, the rate of nonunion and factors associated with nonunion are not well established.Questions/purposes We (1) determined ...

A Novel Bioreactor for the Dynamic Stimulation and Mechanical Evaluation of Multiple Tissue-Engineered Constructs (Trevor J. Lujan, Kyle M. Wirtz, Chelsea S. Bahney, et al.) Tissue Engineering Part C: Methods (2011)

Systematic advancements in the field of musculoskeletal tissue engineering require clear communication about the mechanical environments that promote functional tissue growth. To support the rapid discovery of effective mechanostimulation protocols, this study developed and validated ...

Effects of Construct Stiffness on Healing of Fractures Stabilized with Locking Plates (Michael Bottlang, Josef Doornink, Trevor J. Lujan, et al.) The Journal of Bone & Joint Surgery (2010)

The benefits of locked-plate fixation, which include improved fixation strength in osteoporotic bone and the ability to provide a more biologically friendly fixation construct, have led to the rapid adoption of this technology. Biological fixation ...