Articles
Fast Microtubule Dynamics in Meiotic Spindles Measured by Single Molecule Imaging: Evidence That the Spindle Environment Does Not Stabilize Microtubules (with D. J. Needleman, A. Groen, R. Ohi, L. Mirny, and T. Mitchison), Molecular Biology of the Cell (2010)
Metaphase spindles are steady-state ensembles of microtubules that turn over rapidly and slide poleward in...
Welcome to a new kind of tension: translating kinetochore mechanics into a wait-anaphase signal (with E. D. Salmon), Journal of Cell Science (2010)
Recent high-resolution studies of kinetochore structure have transformed the way researchers think about this crucial...
Intrakinetochore stretch is associated with changes in kinetochore phosphorylation and spindle assembly checkpoint activity (with E. D. Salmon), Journal of Cell Biology (2009)
Cells have evolved a signaling pathway called the spindle assembly checkpoint (SAC) to increase the...
Functional Overlap of Microtubule Assembly Factors in Chromatin-Promoted Spindle Assembly (with A. C. Groen, J. C. Gatlin, and E. D. Salmon), Molecular Biology of the Cell (2009)
Distinct pathways from centrosomes and chromatin are thought to contribute in parallel to microtubule nucleation...
Spindle Fusion Requires Dynein-Mediated Sliding of Oppositely Oriented Microtubules (with J. C. Gatlin, A. Maltov, A. C. Groen, D. J. Needleman, G. Danuser, T. J. Mitchison, and E. D. Salmon), Current Biology (2009)
Background Bipolar spindle assembly is critical for achieving accurate segregation of chromosomes. In the absence...
Micromanipulation studies of chromatin fibers in Xenopus egg extracts reveal ATP-dependent nucleosome assembly dynamics (with J. Yan, D. Skoko, R. Heald, and J. F. Marko), Molecular Biology of the Cell (2007)
We have studied assembly of chromatin using Xenopus egg extracts and single DNA molecules held...
Xenopus tropicalis egg extracts provide insight into scaling of the mitotic spindle (with M. D. Blower, K. S. Brown, T. C. Grammer, R. M. Harland, and R. Heald), Journal of Cell Biology (2007)
The African clawed frog Xenopus laevis has been instrumental to investigations of both development and...
Histone H1 is essential for mitotic chromosome architecture and segregation in Xenopus laevis egg extracts (with J. Yan, D. Skoko, R. Heald, and J. F. Marco), Journal of Cell Biology (2005)
During cell division, condensation and resolution of chromosome arms and the assembly of a functional...
The condensin complex is required for proper spindle assembly and chromosome segregation in Xenopus egg extracts (with S. M. Wignall, R. Deehan, and R. Heald), Journal of Cell Biology (2003)
Chromosome condensation is required for the physical resolution and segregation of sister chromatids during cell...