The main goal of the research in my laboratory is to understand how the immune system recognizes and eliminates infections. We are exploring the influence of glycomics on immunity. Glycomics is an emerging science and is the study of the structure and function of expressed carbohydrates or glycans. The studies in our laboratory will help us understand the basic mechanisms of immune recognition and lymphocyte differentiation that result in pathogen clearance and immunological memory. These studies may yield important parameters critical to the regulation of the immune response that may have potential for therapeutic purposes relevant to vaccination, autoimmunity, and infectious disease.
Articles
Memory T Cells Are Enriched in Lymph Nodes of Selectin-Ligand–Deficient Mice (with J. R. Harp and M. A. Gilchrist), Journal of Immunology (2010)
Fucosyltransferase-IV and -VII double knockout (FtDKO) mice reveal profound impairment in T cell trafficking to...
Both Systemic and Mucosal LCMV Immunization Generate Robust Viral-Specific IgG in Mucosal Secretions, But Elicit Poor LCMV-Specific IgA (with Bheemreddy Rajini, Junwei Zeng, Pratima Krishna Suvas, and Heather M. Dech), Viral Immunology (2010)
Immunoglobulins in secretions play a critical role in protection at mucosal surfaces. We examined the...
Naı¨ve T Cells Re-Distribute to the Lungs of Selectin Ligand Deficient Mice (with John R. Harp), PLoS One (2010)
BACKGROUND: Selectin mediated tethering represents one of the earliest steps in T cell extravasation into...
The generation of influenza-specific humoral responses is impaired in ST6Gal I-deficient mice. (with J Zeng, H. M. Joo, B. Rajini, J. P. Wrammert, and M. Y. Sangster), Journal of Immunology (2009)
Posttranslational modification of proteins, such as glycosylation, can impact cell signaling and function. ST6Gal I,...
Role of chromodomain helicase DNA-binding protein 2 in DNA damage response signaling and tumorigenesis. (with P. Nagarajan, S. Rajagopalan, S. Kania, R. Donnell, and S. Venkatachalam), Oncogene (2009)
The chromodomain helicase DNA-binding proteins (CHDs) are known to affect transcription through their ability to...