General Information: The Biological-Activity Testing and Modeling Laboratory is housed in
the York Veterinary Teaching Hospital at The University of Tennessee Institute of
Agriculture. The laboratory is coordinated by Prof. T. W. Schultz and includes
post-doctoral trainees, technicians, graduate students, and collaborating scientists. The
mission of the laboratory includes the: 1) development, validation, and use of rapid and
inexpensive assays for the evaluation of organic toxicants; 2) development, validation,
and use of structure-activity models for predicting chemical reactivity and toxic
potencies, and 3) advancement of the basic understanding of chemical-biological
interactions. The laboratory has academic ties to the Department of Comparative Medicine
in the College of Veterinary Medicine and the Department of Ecology and Evolutionary
Biology in the College of Arts and Sciences. The laboratory has research ties to the
Center for Environmental Biotechnology. In addition, the laboratory has cooperative
arrangements with several foreign research groups. 



A feasibility study: Can information collected to classify for mutagenicity be informative in predicting carcinogenicity? (with Petko I. Petkov, Grace Patlewicz, Masamitsu Honma, Milen Todorov, Stefan Kotov, Sabcho D. Dimitrov, E Maria Donner, and Ovanes G. Mekenyan), Regulatory Toxicology and Pharmacology (2015)

Carcinogenicity is a complex endpoint of high concern yet the rodent bioassay still used is...



Mixture Toxicity of S(N)2-Reactive Soft Electrophiles: 1. Evaluation of Mixtures Containing alpha-Halogenated Acetonitriles (with D A. Dawson, J Jeyaratnam, T Mooneyham, and G Pöch), Archives of environmental contamination and toxicology (2010)

The concept of multiple modes of toxic action denotes that an individual chemical can induce...



Experimental reactivity parameters for toxicity modeling: application to the acute aquatic toxicity of SN2 electrophiles to Tetrahymena pyriformis (with D W. Roberts, E M. Wolf, and A O. Aptula), Chemical research in toxicology (2010)

A diverse set of 60 haloaliphatic compounds were evaluated for reactivity with cysteine thiol groups...



Read-across to rank skin sensitization potential: subcategories for the Michael acceptor domain (with K Rogers and A O. Aptula), Contact dermatitis (2009)

BACKGROUND: Eliminating animal testing for skin sensitization is a significant challenge in consumer safety risk...



Screening of potentially hormonally active chemicals using bioluminescent yeast bioreporters (with J Sanseverino, M E. Eldridge, A C. Layton, J P. Easter, J W. Yarbrough, and G S. Sayler), Toxicological sciences : an official journal of the Society of Toxicology (2009)

Saccharomyces cerevisiae bioluminescent bioreporter assays were developed previously to assess a chemical's estrogenic or androgenic...