Quality of life, physical and mental health, and lifestyle behaviors were assessed in 500 graduate and undergraduate students at a Historically Black University. 82% of the sample rated their quality of life positively. 11.3% of the sample reported mild depression, while 4.9% and 1.1% of the sample reported moderate and severe depression respectively. 8.4% of the sample reported suicidal ideation within the past two weeks. Family, financial and academic stressors were found to be significant predictors of depressive symptoms. Implications for mental health care are discussed.