We examined 393 African American married couples assigned to (a) a culturally sensitive version of a widely disseminated relationship enhancement program (CS-PREP) (b) a similar version of the same program that also included a focus on prayer (PFP condition), or (c) an information-only control condition in which couples received a self-help version of the same program. Husbands averaged 40.5 years of age and wives averaged 38.9 years. We found a significant interaction between intervention and time of assessment, reflecting group differences in linear trends for the three conditions, with the two intervention conditions performing better than the control condition, and PFP producing superior outcomes to CS-PREP only for wives at post and marginally better results at 12-month follow-up. Results support continued exploration of the adjunctive use of prayer in the context of relationship enhancement programs where appropriate to make them more culturally sensitive.