![](https://d3ilqtpdwi981i.cloudfront.net/O3qLoPQzTOXF7SO4MWUd9eZvnQc=/425x550/smart/https://bepress-attached-resources.s3.amazonaws.com/uploads/65/d6/3f/65d63f46-02ac-4d9a-857c-ec5aaf2770f0/thumbnail_ec098faa-9b52-40b1-8382-b037309adf25.jpg)
- pluronic,
- lecithin,
- organogel,
- PLO,
- topical administration,
- dementia
OBJECTIVE: Treatment of mood and behavioral symptoms in geriatric patients with advanced dementia may be impeded by poor compliance with oral medications. Pluronic lecithin organogel (PLO) is a compounding substrate that can be used for the topical administration of psychotropic medications.
METHODS: Charts of patients treated with psychotropic medications compounded with PLO cream were reviewed for treatment outcomes. All patients were treated by a nursing home outreach service.
RESULTS: Records from twenty-four patients, mean age 86.8 + 5.9, were reviewed. Common psychiatric symptoms included agitation, aggressive behavior, and depression. Medications most commonly administered as a PLO cream included quetiapine and venlafaxine. All patients had mild to marked improvement in psychiatric symptoms.
CONCLUSIONS: Pluronic lecithin organogel (PLO) may be an effective option for the topical administration of psychiatric medications in geriatric patients with dementia who are not compliant with oral medications.
Available at: http://works.bepress.com/suzanne_holroyd/1/