ABSTRACT PURPOSE We wanted to describe the vocabulary and narrative context of pri- mary care physicians’ inquiries about suicide. METHODS One hundred fifty-two primary care physicians (53% to 61% of those approached) were randomly recruited from 4 sites in Northern California and Rochester, New York, to participate in a study assessing the effect of a patient’s request for antidepressant medication on a physician’s prescribing behavior. Standardized patients portraying 2 conditions (carpal tunnel syndrome and major depression, or back pain and adjustment disorder with depressed mood) and 3 antidepressant request types (brand-specific, general, or none) made 298 unan- nounced visits to these physicians between May 2003 and May 2004. Standard- ized patients were instructed to deny suicidality if the physician asked. We identi- fied the subset of transcripts that contained a distinct suicide inquiry (n=91) for inductive analysis and review. Our qualitative analysis focused on elucidating the narrative context in which inquiries are made, how physicians construct their inquiries, and how they respond to a patient’s denial of suicidality. RESULTS Most suicide inquiries used clear terminology related to self-harm, sui- cide, or killing oneself. Three types of inquiry were identified: (1) straightforward (eg, “Are you feeling like hurting yourself?”); (2) supportive framing (eg, “Some- times depression gets so bad that people feel that life is no longer worth living. Have you felt this way?”); and (3) no problem preferred (eg, “You’re not feeling suicidal, are you?”). Four inquiries were glaringly awkward, potentially inhibiting a patient’s disclosure. Most (79%) suicide inquiries were preceded by statements focusing on psychosocial concerns, and most (86%) physician responses to a standardized patient’s denial of ideation were followed up with relevant state- ments (eg, “I hope you would tell me if you did.”). CONCLUSION Although most suicide inquiries by primary care physicians are sensitive, clear, and supportive, some language is used that may inhibit suicide disclosure. Some physician responses may unintentionally reinforce patients for remaining silent about their risk. This study will inform future research in the development of quality improvement interventions to support primary care phy- sicians in making clear, appropriate, and sensitive inquires about suicide.