Identification of two gene variants associated with risk of advanced fibrosis in patients with chronic hepatitis C
BACKGROUND & AIMS: Previously identified clinical risk factors such as sex, alcohol consumption, and age at infection do not accurately predict which patients with chronic hepatitis C (CHC) will develop advanced fibrosis (bridging fibrosis and cirrhosis). The aim of this study was to identify genetic polymorphisms that can predict the risk of advanced fibrosis in patients with CHC. METHODS: A total of 916 subjects with CHC was enrolled from 2 centers. A gene-centric disease association study of 24,832 putative functional, single nucleotide polymorphisms (SNPs) was performed. Of the 1609 SNPs that were significantly associated (P
Hongin Huang, M L. Shiffman, R C. Cheung, T J. Layden, S Friedman, O T. Abar, L Yee, Anand Chokkalingam, Steven J. Schrodi, Jason Chan, Joseph J. Catanese, Diane U. Leong, David Ross, Xiaolan Hu, A Monto, Linda B. McAllister, Sam Broder, Tom White, John J. Sninsky, and T L. Wright. "Identification of two gene variants associated with risk of advanced fibrosis in patients with chronic hepatitis C" Gastroenterology 130.6 (2006): 1679-1687.
Available at: http://works.bepress.com/steve_schrodi/10