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Article
Multi-Modal Exercise Training and Protein-Pacing Enhances Physical Performance Adaptations Independent of Growth Hormone and BDNF but May Be Dependent on IGF-1 in Exercise-Trained Men
Health and Human Physiological Sciences
  • Stephen J. Ives, Skidmore College
  • Chelsea Norton, Skidmore College
  • Vincent Miller, Skidmore College
  • Olivia Minicucci, Skidmore College
  • Jake Robinson, Skidmore College
  • Gabe O'Brien, Skidmore College
  • Daniela Escudero, Skidmore College
  • Maia Paul, Skidmore College
  • Caitlin Sheridan, Skidmore College
  • Kathryn Curran, Skidmore College
  • Kayla Rose, Skidmore College
  • Nathaniel Robinson, Skidmore College
  • Feng He, Skidmore College
  • Paul J. Arciero, Skidmore College
Document Type
Article
Publication Date
1-1-2016
Keywords
  • Brain-derived neurotrophic factor,
  • endurance,
  • growth hormone,
  • healthspan,
  • high intensity interval training,
  • performance,
  • protein-pacing,
  • resistance training,
  • stretching
Abstract

OBJECTIVE: Protein-pacing (P; 5-6meals/day @ 2.0g/kgBW/day) and multi-mode exercise (RISE; resistance, interval, stretching, endurance) training (PRISE) improves muscular endurance, strength, power and arterial health in exercise-trained women. The current study extends these findings by examining PRISE on fitness, growth hormone (GH), insulin-like growth factor-1 (IGF-1), and brain-derived neurotrophic factor (BDNF) response, cardiometabolic health, and body composition in exercise-trained men.

DESIGN: Twenty active males (>4daysexercise/week) completed either: PRISE (n=11) or RISE (5-6meals/day @ 1.0g/kgBW/day; n=9) for 12weeks. Muscular strength (1-repetition maximum bench and leg press, 1-RM BP, and 1-RM LP), endurance (sit-ups, SU; push-ups, PU), power (squat jump, SJ, and bench throw, BT), flexibility (sit-and-reach, SR), aerobic performance (5km cycling time-trial, TT), GH, IGF-1, BDNF, augmentation index, (AIx), and body composition, were assessed at weeks 0 (pre) and 13 (post).

RESULTS:At baseline, no differences existed between groups except for GH (RISE, 230±13 vs. PRISE, 382±59pg/ml, p

CONCLUSIONS: Exercise-trained men consuming a P diet combined with multi-component exercise training (PRISE) enhance muscular power, strength, aerobic performance, and flexibility which are not likely related to GH or BDNF but possibly to IGF-1 response.

Published In
Growth Hormone & IGF Research
Pages
60-70
DOI
10.1016/j.ghir.2016.10.002
Citation Information
Ives SJ, Norton C, Miller V, Minicucci O, Robinson J, O'Brien G, Escudero D, Paul M, Sheridan C, Curran K, et al. Multi-modal exercise training and protein-pacing enhances physical performance adaptations independent of growth hormone and BDNF but may be dependent on IGF-1 in exercise-trained men. Growth Horm IGF Res. 2016 Oct 15. pii: S1096-6374(16)30060-0. doi: 10.1016/j.ghir.2016.10.002. [Epub ahead of print] PubMed PMID: 27789212.