*Activin Receptors, Type I

Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter (with J. Hanai, L. F. Chen, T. Kanno, N. Ohtani-Fujita, W. Y. Kim, W. H. Guo, T. Imamura, Y. Ishidou, M. Fukuchi, M. J. Shi, M. Kawabata, K. Miyazono, and Y. Ito), The Journal of biological chemistry (1999)

Smads are signal transducers for members of the transforming growth factor-beta (TGF-beta) superfamily. Upon ligand...

 

*Adenosine Triphosphatases

Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes (with Carol E. Schrader, W. Edelmann, and R. Kucherlapati), The Journal of experimental medicine (1999)

Mice deficient in various mismatch repair (MMR) enzymes were examined to determine whether this repair...

 

*B-Lymphocytes

Surface immunoglobulin light chain expression in pre-B cell leukemias (with B. Koziner, A. Al-Katib, D. Gebhard, A. Mittelman, M. Andreeff, and B. D. Clarkson), Annals of the New York Academy of Sciences (1986)

Cytofluorographic analysis of surface immunoglobulin (sIg) light chain clonal excess (CE), defined as (%kappa+ -...

 
Rearrangements and deletions of immunoglobulin heavy chain genes in the double-producing B cell lymphoma I.29 (with K. B. Marcu, S. Sirlin, B. Alhadeff, and U. Hammerling), Molecular and cellular biology (1982)

The B cell lymphoma I.29 consists of a mixture of cells expressing membrane-bound immunoglobulin M...

 

*Base Pair Mismatch

Mismatch repair converts AID-instigated nicks to double-strand breaks for antibody class-switch recombination (with Carol E. Schrader), Trends in genetics : TIG (2005)

Mismatch repair (MMR) proteins are important for antibody class-switch recombination (CSR), but their roles are...

 
Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions (with Carol E. Schrader and Joycelyn Vardo), The Journal of experimental medicine (2002)

B cells from mice deficient in mismatch repair (MMR) proteins show decreased ability to undergo...

 

*Binding Sites, Antibody

The ubiquitously expressed DNA-binding protein late SV40 factor binds Ig switch regions and represses class switching to IgA (with Elise E. Drouin, Carol E. Schrader, and Ulla Hansen), Journal of immunology (Baltimore, Md. : 1950) (2002)

Ig heavy chain class switch recombination (CSR) determines the expression of Ig isotypes. The molecular...

 
Synthesis and isolation of DNA complementary to nucleotide sequences encoding the variable region of immunoglobulin kappa chain (with J. M. Bishop), Biochemistry (1977)

No abstract provided.

 

*Cell Cycle

Cell cycle regulation of immunoglobulin class switch recombination and germ-line transcription: potential role of Ets family members (with M. Lundgren, L. Strom, L. O. Bergquist, S. Skog, T. Heiden, and E. Severinson), European journal of immunology (1995)

Previous studies have indicated that transcription of germ-line (GL) CH genes is necessary to obtain...

 

*DNA

Synthesis and isolation of DNA complementary to nucleotide sequences encoding the variable region of immunoglobulin kappa chain (with J. M. Bishop), Biochemistry (1977)

No abstract provided.

 
Synthesis of a deoxyribonucleic acid sequence complementary to ovalbumin messenger ribonucleic acid and quantification of ovalbumin genes (with D. Sullivan, R. Palacios, J. M. Taylor, A. J. Faras, M. L. Kiely, N. M. Summers, J. M. Bishop, and R. T. Schimke), The Journal of biological chemistry (1973)

No abstract provided.

 

*DNA Glycosylases

Immunoglobulin genes: generating diversity with AID and UNG (with Ursula Storb), Current biology : CB (2002)

Somatic hypermutation and switch recombination of immunoglobulin genes require the activity of the activation-induced deaminase,...

 

*DNA Repair

Mismatch repair converts AID-instigated nicks to double-strand breaks for antibody class-switch recombination (with Carol E. Schrader), Trends in genetics : TIG (2005)

Mismatch repair (MMR) proteins are important for antibody class-switch recombination (CSR), but their roles are...

 

*DNA Repair Enzymes

Mlh1 can function in antibody class switch recombination independently of Msh2 (with Carol E. Schrader and Joycelyn Vardo), The Journal of experimental medicine (2003)

Mismatch repair proteins participate in antibody class switch recombination, although their roles are unknown. Previous...

 
Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions (with Carol E. Schrader and Joycelyn Vardo), The Journal of experimental medicine (2002)

B cells from mice deficient in mismatch repair (MMR) proteins show decreased ability to undergo...

 
Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes (with Carol E. Schrader, W. Edelmann, and R. Kucherlapati), The Journal of experimental medicine (1999)

Mice deficient in various mismatch repair (MMR) enzymes were examined to determine whether this repair...

 

*DNA Replication

Mutations, duplication, and deletion of recombined switch regions suggest a role for DNA replication in the immunoglobulin heavy-chain switch (with W. Dunnick and M. Wilson), Molecular and cellular biology (1989)

The heavy-chain switch from immunoglobulin M (IgM) expression to IgA expression is mediated by a...

 

*DNA-Binding Proteins

Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination (with Carol E. Schrader, Sean P. Bradley, Joycelyn Vardo, Sofia N. Mochegova, and Erin Flanagan), The EMBO journal (2003)

Nucleotide substitutions are found in recombined Ig switch (S) regions and also in unrecombined (germline,...

 
The Smu tandem repeat region is critical for Ig isotype switching in the absence of Msh2 (with Irene M. Min, Carol E. Schrader, Joycelyn Vardo, Thomas M. Luby, Nicole D'Avirro, and Erik Selsing), Immunity (2003)

Deficiencies of the Msh2 protein or the Smu tandem repeat (SmuTR) sequences each reduce isotype...

 
Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes (with Carol E. Schrader, W. Edelmann, and R. Kucherlapati), The Journal of experimental medicine (1999)

Mice deficient in various mismatch repair (MMR) enzymes were examined to determine whether this repair...

 

*Evolution, Molecular

Evolution of isotype switching (with Chris T. Amemiya), Seminars in immunology (2004)

This review discusses evolution of the process of Ig heavy chain class switching, relating it...

 

*Gene Conversion

Does activation-induced deaminase initiate antibody diversification by DNA deamination (with Sean P. Bradley), Trends in genetics : TIG (2002)

Activation-induced deaminase (AID) is expressed only in germinal center B cells. There, it is required...

 

*Gene Expression Regulation

Activation of NF-kappaB/Rel by CD40 engagement induces the mouse germ line immunoglobulin Cgamma1 promoter (with S. C. Lin), Molecular and cellular biology (1996)

Interaction between CD40 on B cells and CD40 ligand (CD40L) on T cells has been...

 
Regulation of transcription of immunoglobulin germ-line gamma 1 RNA: analysis of the promoter/enhancer (with M. Z. Xu), The EMBO journal (1992)

Antibody class switching is achieved by recombinations between switch (S) regions which consist of tandemly...

 
Rearrangements and deletions of immunoglobulin heavy chain genes in the double-producing B cell lymphoma I.29 (with K. B. Marcu, S. Sirlin, B. Alhadeff, and U. Hammerling), Molecular and cellular biology (1982)

The B cell lymphoma I.29 consists of a mixture of cells expressing membrane-bound immunoglobulin M...

 

*Gene Rearrangement

Evolution of isotype switching (with Chris T. Amemiya), Seminars in immunology (2004)

This review discusses evolution of the process of Ig heavy chain class switching, relating it...

 

*Gene Rearrangement, B-Lymphocyte

Cell cycle regulation of immunoglobulin class switch recombination and germ-line transcription: potential role of Ets family members (with M. Lundgren, L. Strom, L. O. Bergquist, S. Skog, T. Heiden, and E. Severinson), European journal of immunology (1995)

Previous studies have indicated that transcription of germ-line (GL) CH genes is necessary to obtain...

 

*Gene Rearrangement, B-Lymphocyte, Heavy Chain

Copy choice mechanism of immunoglobulin heavy-chain switch recombination (with W. Dunnick), Molecular and cellular biology (1990)

The immunoglobulin heavy-chain switch is mediated by a recombination event between DNA switch regions associated...

 
Reticulum cell sarcomas of SJL mice have rearranged immunoglobulin heavy and light chain genes (with J. L. Lasky, N. M. Ponzio, M. P. Scheid, and G. J. Thorbecke), European journal of immunology (1989)

The immunoglobulin (Ig) heavy (H) and light (L) chain gene rearrangements of the high incidence...

 

*Gene Rearrangement, B-Lymphocyte, Light Chain

Reticulum cell sarcomas of SJL mice have rearranged immunoglobulin heavy and light chain genes (with J. L. Lasky, N. M. Ponzio, M. P. Scheid, and G. J. Thorbecke), European journal of immunology (1989)

The immunoglobulin (Ig) heavy (H) and light (L) chain gene rearrangements of the high incidence...

 

*Genes

Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching (with S. Sirlin), The EMBO journal (1986)

IgM+ cells cultured from the I.29 B cell lymphoma can be induced with lipopolysaccharide (LPS)...

 
Isolation of messenger RNA for an immunoglobulin kappa chain and enumeration of the genes for the constatn region of kappa chain in the mouse (with R. C. Huang, E. Stavnezer, and J. M. Bishop), Journal of molecular biology (1974)

No abstract provided.

 
Synthesis of a deoxyribonucleic acid sequence complementary to ovalbumin messenger ribonucleic acid and quantification of ovalbumin genes (with D. Sullivan, R. Palacios, J. M. Taylor, A. J. Faras, M. L. Kiely, N. M. Summers, J. M. Bishop, and R. T. Schimke), The Journal of biological chemistry (1973)

No abstract provided.

 

*Genes, Immunoglobulin

Immunoglobulin genes: generating diversity with AID and UNG (with Ursula Storb), Current biology : CB (2002)

Somatic hypermutation and switch recombination of immunoglobulin genes require the activity of the activation-induced deaminase,...

 
Does activation-induced deaminase initiate antibody diversification by DNA deamination (with Sean P. Bradley), Trends in genetics : TIG (2002)

Activation-induced deaminase (AID) is expressed only in germinal center B cells. There, it is required...

 
CBF alpha3 (AML2) is induced by TGF-beta1 to bind and activate the mouse germline Ig alpha promoter (with M. J. Shi), Journal of immunology (Baltimore, Md. : 1950) (1998)

TGF-beta1 directs class switching to IgA by splenic B cells and by the surface IgM+...

 
CD40 cross-linking induces Ig epsilon germline transcripts in B cells via activation of NF-kappaB: synergy with IL-4 induction (with L. A. Iciek and S. A. Delphin), Journal of immunology (Baltimore, Md. : 1950) (1997)

Transcription of unrearranged (germline) Ig heavy chain C region (C(H)) genes is required before Ab...

 
Activation of NF-kappaB/Rel by CD40 engagement induces the mouse germ line immunoglobulin Cgamma1 promoter (with S. C. Lin), Molecular and cellular biology (1996)

Interaction between CD40 on B cells and CD40 ligand (CD40L) on T cells has been...

 
Regulation of antibody class switching to IgE: characterization of an IL-4-responsive region in the immunoglobulin heavy-chain germline epsilon promoter (with S. Delphin), Annals of the New York Academy of Sciences (1995)

A large body of data indicate that antibody class switching is directed by cytokines by...

 
Cell cycle regulation of immunoglobulin class switch recombination and germ-line transcription: potential role of Ets family members (with M. Lundgren, L. Strom, L. O. Bergquist, S. Skog, T. Heiden, and E. Severinson), European journal of immunology (1995)

Previous studies have indicated that transcription of germ-line (GL) CH genes is necessary to obtain...

 
Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50 (with S. Delphin), The Journal of experimental medicine (1995)

A large body of data indicate that antibody class switching is directed by cytokines by...

 
Activation of the Ig germ-line gamma 1 promoter. Involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site (with M. Lundgren, C. Larsson, A. Femino, M. Xu, and E. Severinson), Journal of immunology (Baltimore, Md. : 1950) (1994)

Ig isotype switching in B lymphocytes is preceded by transcription of the corresponding unrearranged, or...

 
Regulation of transcription of the germline immunoglobulin alpha constant region gene (with Y. C. Lin and P. Shockett), Current topics in microbiology and immunology (1992)

No abstract provided.

 
Effect of cytokines on switching to IgA and alpha germline transcripts in the B lymphoma I.29 mu. Transforming growth factor-beta activates transcription of the unrearranged C alpha gene (with P. Shockett), Journal of immunology (Baltimore, Md. : 1950) (1991)

H chain isotype switch recombination is preceded by the appearance of RNA initiating 5' of...

 
Copy choice mechanism of immunoglobulin heavy-chain switch recombination (with W. Dunnick), Molecular and cellular biology (1990)

The immunoglobulin heavy-chain switch is mediated by a recombination event between DNA switch regions associated...

 
Structure of germ line immunoglobulin alpha heavy-chain RNA and its location on polysomes (with G. Radcliffe, Y. C. Lin, M. Julius, and K. B. Marcu), Molecular and cellular biology (1990)

We describe the structure of the major germ line RNA transcribed from unrearranged immunoglobulin alpha...

 
Structure of germline immunoglobulin heavy-chain gamma 1 transcripts in interleukin 4 treated mouse spleen cells (with M. Xu), Developmental immunology (1990)

Antibody class switching is mediated by a DNA recombination event that replaces the C mu...

 
A B-cell-specific nuclear protein that binds to DNA sites 5' to immunoglobulin S alpha tandem repeats is regulated during differentiation (with S. H. Waters and K. U. Saikh), Molecular and cellular biology (1989)

Immunoglobulin heavy-chain switching is effected by recombination events between sites associated with tandemly repeated switch...

 
Mutations, duplication, and deletion of recombined switch regions suggest a role for DNA replication in the immunoglobulin heavy-chain switch (with W. Dunnick and M. Wilson), Molecular and cellular biology (1989)

The heavy-chain switch from immunoglobulin M (IgM) expression to IgA expression is mediated by a...

 
The J kappa proximal region of the human K locus contains three uncommon V kappa genes which are arranged in opposite transcriptional polarities (with W. Lorenz, K. F. Schable, R. Thiebe, and H. G. Zachau), Molecular immunology (1988)

The structure of one of the V kappa gene-containing regions of the locus coding for...

 

*Genes, Regulator

Copy choice mechanism of immunoglobulin heavy-chain switch recombination (with W. Dunnick), Molecular and cellular biology (1990)

The immunoglobulin heavy-chain switch is mediated by a recombination event between DNA switch regions associated...

 
Specificity of immunoglobulin heavy chain switching by cultured I.29 B lymphoma cells (with G. Radcliffe and E. Severinson), Monographs in allergy (1988)

No abstract provided.

 

*Genes, Switch

Cell cycle regulation of immunoglobulin class switch recombination and germ-line transcription: potential role of Ets family members (with M. Lundgren, L. Strom, L. O. Bergquist, S. Skog, T. Heiden, and E. Severinson), European journal of immunology (1995)

Previous studies have indicated that transcription of germ-line (GL) CH genes is necessary to obtain...

 
Copy choice mechanism of immunoglobulin heavy-chain switch recombination (with W. Dunnick), Molecular and cellular biology (1990)

The immunoglobulin heavy-chain switch is mediated by a recombination event between DNA switch regions associated...

 
Specificity of immunoglobulin heavy chain switching by cultured I.29 B lymphoma cells (with G. Radcliffe and E. Severinson), Monographs in allergy (1988)

No abstract provided.

 

*Histocytochemistry

Synthesis of a mouse immunoglobulin light chain in a rabbit reticulocyte cell-free system (with R. C. Huang), Nature: New biology (1971)

No abstract provided.

 

*Immunoglobulin alpha-Chains

Membrane-bound and secreted IgA contain structurally different alpha-chains (with R. Sitia, H. Kikutani, A. Rubartelli, Y. Bushkin, and U. Hammerling), Journal of immunology (Baltimore, Md. : 1950) (1982)

Three different forms of alpha-chains are synthesized by BF0.3 and 615.2, two cloned cell lines...

 

*Immunoglobulin Class Switching

Antibody class switching differs among SJL, C57BL/6 and 129 mice (with Denise A. Kaminski), International immunology (2007)

Inbred mouse strains used for gene manipulation studies vary in many respects, including immune system...

 
Enhanced IgA class switching in marginal zone and B1 B cells relative to follicular/B2 B cells (with Denise A. Kaminski), Journal of immunology (Baltimore, Md. : 1950) (2006)

Mouse splenic marginal zone (MZ) B cells and B1 B cells enriched in the peritoneal...

 
The histone methyltransferase Suv39h1 increases class switch recombination specifically to IgA (with Sean P. Bradley, Denise A. Kaminski, Antoine H. F. M. Peters, and Thomas Jenuwein), Journal of immunology (Baltimore, Md. : 1950) (2006)

Ab class (isotype) switching allows the humoral immune system to adaptively respond to different infectious...

 
Mismatch repair converts AID-instigated nicks to double-strand breaks for antibody class-switch recombination (with Carol E. Schrader), Trends in genetics : TIG (2005)

Mismatch repair (MMR) proteins are important for antibody class-switch recombination (CSR), but their roles are...

 
Evolution of isotype switching (with Chris T. Amemiya), Seminars in immunology (2004)

This review discusses evolution of the process of Ig heavy chain class switching, relating it...

 
Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions (with Carol E. Schrader, Joycelyn Vardo, Erin K. Linehan, Michael Z. Twarog, Laura J. Niedernhofer, and Jan H. J. Hoeijmakers), The Journal of experimental medicine (2004)

The structure-specific endonuclease ERCC1-XPF is an essential component of the nucleotide excision DNA repair pathway....

 
The ubiquitously expressed DNA-binding protein late SV40 factor binds Ig switch regions and represses class switching to IgA (with Elise E. Drouin, Carol E. Schrader, and Ulla Hansen), Journal of immunology (Baltimore, Md. : 1950) (2002)

Ig heavy chain class switch recombination (CSR) determines the expression of Ig isotypes. The molecular...

 
Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions (with Carol E. Schrader and Joycelyn Vardo), The Journal of experimental medicine (2002)

B cells from mice deficient in mismatch repair (MMR) proteins show decreased ability to undergo...

 
Immunology. A touch of antibody class, Science (New York, N.Y.) (2000)

When B cells, the antibody producing cells of the body, encounter antigen they switch from...

 
Ialpha exon-replacement mice synthesize a spliced HPRT-C(alpha) transcript which may explain their ability to switch to IgA. Inhibition of switching to IgG in these mice (with G. Qiu and G. R. Harriman), International immunology (1999)

Antibody class switching is regulated by transcription of unrearranged C(H) genes to produce germline (GL)...

 
Activation of NF-kappaB/Rel by CD40 engagement induces the mouse germ line immunoglobulin Cgamma1 promoter (with S. C. Lin), Molecular and cellular biology (1996)

Interaction between CD40 on B cells and CD40 ligand (CD40L) on T cells has been...

 
Immunoglobulin class switching, Current opinion in immunology (1996)

Antibody class switching is induced by B-cell activators in the presence of cytokines. The identity...

 
Regulation of antibody class switching to IgE: characterization of an IL-4-responsive region in the immunoglobulin heavy-chain germline epsilon promoter (with S. Delphin), Annals of the New York Academy of Sciences (1995)

A large body of data indicate that antibody class switching is directed by cytokines by...

 

*Immunoglobulin Fragments

Isolation of messenger RNA for an immunoglobulin kappa chain and enumeration of the genes for the constatn region of kappa chain in the mouse (with R. C. Huang, E. Stavnezer, and J. M. Bishop), Journal of molecular biology (1974)

No abstract provided.

 
Letter: Translation of messenger RNA for mouse immunoglobulin light chains in living frog oocytes (with M. Smith, R. C. Huang, J. B. Gurdon, and C. D. Lane), Journal of molecular biology (1973)

No abstract provided.

 

*Immunoglobulin Heavy Chains

Membrane-bound and secreted IgA contain structurally different alpha-chains (with R. Sitia, H. Kikutani, A. Rubartelli, Y. Bushkin, and U. Hammerling), Journal of immunology (Baltimore, Md. : 1950) (1982)

Three different forms of alpha-chains are synthesized by BF0.3 and 615.2, two cloned cell lines...

 

*Immunoglobulin kappa-Chains

Isolation of messenger RNA for an immunoglobulin kappa chain and enumeration of the genes for the constatn region of kappa chain in the mouse (with R. C. Huang, E. Stavnezer, and J. M. Bishop), Journal of molecular biology (1974)

No abstract provided.

 

*Immunoglobulin Switch Region

Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination (with Carol E. Schrader, Sean P. Bradley, Joycelyn Vardo, Sofia N. Mochegova, and Erin Flanagan), The EMBO journal (2003)

Nucleotide substitutions are found in recombined Ig switch (S) regions and also in unrecombined (germline,...

 
The ubiquitously expressed DNA-binding protein late SV40 factor binds Ig switch regions and represses class switching to IgA (with Elise E. Drouin, Carol E. Schrader, and Ulla Hansen), Journal of immunology (Baltimore, Md. : 1950) (2002)

Ig heavy chain class switch recombination (CSR) determines the expression of Ig isotypes. The molecular...

 
The mu switch region tandem repeats are important, but not required, for antibody class switch recombination (with Thomas M. Luby, Carol E. Schrader, and Erik Selsing), The Journal of experimental medicine (2001)

Class switch DNA recombinations change the constant (C) region of the antibody heavy (H) chain...

 
Immunology. A touch of antibody class, Science (New York, N.Y.) (2000)

When B cells, the antibody producing cells of the body, encounter antigen they switch from...

 
Evidence for class-specific factors in immunoglobulin isotype switching (with A. Shanmugam, M. J. Shi, L. Yauch, and A. L. Kenter), The Journal of experimental medicine (2000)

Immunoglobulin class switch recombination (SR) occurs by a B cell-specific, intrachromosomal deletional process between switch...

 
Regulation of switch recombination to the murine gamma 1 gene (with W. Dunnick, L. Elenich, J. Berry, D. Albrecht, and J. L. Claflin), Current topics in microbiology and immunology (1992)

No abstract provided.

 
Regulation of the antibody class switch to IgA (with Y. C. Lin and P. Shockett), Immunologic research (1991)

No abstract provided.

 
Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes (with G. Radcliffe, Y. C. Lin, J. Nietupski, L. Berggren, R. Sitia, and E. Severinson), Proceedings of the National Academy of Sciences of the United States of America (1988)

Immunoglobulin heavy-chain switching is effected by a DNA recombination event that replaces the C mu...

 

*Immunoglobulin Variable Region

Synthesis and isolation of DNA complementary to nucleotide sequences encoding the variable region of immunoglobulin kappa chain (with J. M. Bishop), Biochemistry (1977)

No abstract provided.

 

*Lymphocyte Activation

The regulation of membrane-bound and secreted alpha-chain biosynthesis during the differentiation of the B cell lymphoma I.29 (with R. Sitia, A. Rubartelli, H. Kikutani, and U. Hammerling), Journal of immunology (Baltimore, Md. : 1950) (1985)

The regulation of the synthesis of membrane-bound and secreted IgA was investigated in the murine...

 

*Lymphocyte Cooperation

Cognate T cell help for CD40-deficient B cells induces c-myc RNA expression, but DNA synthesis requires an additional signal through surface Ig (with Carol E. Schrader, H. Kikutani, and D. C. Parker), Journal of immunology (Baltimore, Md. : 1950) (1997)

To investigate the role of CD40 ligand in the delivery of help to B cells,...

 
Activation of NF-kappaB/Rel by CD40 engagement induces the mouse germ line immunoglobulin Cgamma1 promoter (with S. C. Lin), Molecular and cellular biology (1996)

Interaction between CD40 on B cells and CD40 ligand (CD40L) on T cells has been...

 

*Models, Genetic

Shifts in targeting of class switch recombination sites in mice that lack mu switch region tandem repeats or Msh2 (with Irene M. Min, Lisa R. Rothlein, Carol E. Schrader, and Erik Selsing), The Journal of experimental medicine (2005)

The mechanisms that target class switch recombination (CSR) to antibody gene switch (S) regions are...

 

*Mutation

Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination (with Carol E. Schrader, Sean P. Bradley, Joycelyn Vardo, Sofia N. Mochegova, and Erin Flanagan), The EMBO journal (2003)

Nucleotide substitutions are found in recombined Ig switch (S) regions and also in unrecombined (germline,...

 

*Neoplasm Proteins

CBF alpha3 (AML2) is induced by TGF-beta1 to bind and activate the mouse germline Ig alpha promoter (with M. J. Shi), Journal of immunology (Baltimore, Md. : 1950) (1998)

TGF-beta1 directs class switching to IgA by splenic B cells and by the surface IgM+...

 

*Nucleic Acid Conformation

Triple helix stabilization, Nature (1991)

No abstract provided.

 

*Nucleic Acid Hybridization

Immunology. A touch of antibody class, Science (New York, N.Y.) (2000)

When B cells, the antibody producing cells of the body, encounter antigen they switch from...

 

*Promoter Regions (Genetics)

CBF alpha3 (AML2) is induced by TGF-beta1 to bind and activate the mouse germline Ig alpha promoter (with M. J. Shi), Journal of immunology (Baltimore, Md. : 1950) (1998)

TGF-beta1 directs class switching to IgA by splenic B cells and by the surface IgM+...

 
CD40 cross-linking induces Ig epsilon germline transcripts in B cells via activation of NF-kappaB: synergy with IL-4 induction (with L. A. Iciek and S. A. Delphin), Journal of immunology (Baltimore, Md. : 1950) (1997)

Transcription of unrearranged (germline) Ig heavy chain C region (C(H)) genes is required before Ab...

 
Activation of NF-kappaB/Rel by CD40 engagement induces the mouse germ line immunoglobulin Cgamma1 promoter (with S. C. Lin), Molecular and cellular biology (1996)

Interaction between CD40 on B cells and CD40 ligand (CD40L) on T cells has been...

 
Regulation of antibody class switching to IgE: characterization of an IL-4-responsive region in the immunoglobulin heavy-chain germline epsilon promoter (with S. Delphin), Annals of the New York Academy of Sciences (1995)

A large body of data indicate that antibody class switching is directed by cytokines by...

 
Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50 (with S. Delphin), The Journal of experimental medicine (1995)

A large body of data indicate that antibody class switching is directed by cytokines by...

 
Activation of the Ig germ-line gamma 1 promoter. Involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site (with M. Lundgren, C. Larsson, A. Femino, M. Xu, and E. Severinson), Journal of immunology (Baltimore, Md. : 1950) (1994)

Ig isotype switching in B lymphocytes is preceded by transcription of the corresponding unrearranged, or...

 

*Protein Biosynthesis

Letter: Translation of messenger RNA for mouse immunoglobulin light chains in living frog oocytes (with M. Smith, R. C. Huang, J. B. Gurdon, and C. D. Lane), Journal of molecular biology (1973)

No abstract provided.

 

*Recombination, Genetic

DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination (with Xiaoming Wu), The Journal of experimental medicine (2007)

Immunoglobulin (Ig) class switch recombination (CSR) is initiated by activation-induced cytidine deaminase (AID), which converts...

 
The histone methyltransferase Suv39h1 increases class switch recombination specifically to IgA (with Sean P. Bradley, Denise A. Kaminski, Antoine H. F. M. Peters, and Thomas Jenuwein), Journal of immunology (Baltimore, Md. : 1950) (2006)

Ab class (isotype) switching allows the humoral immune system to adaptively respond to different infectious...

 
Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions (with Carol E. Schrader, Joycelyn Vardo, Erin K. Linehan, Michael Z. Twarog, Laura J. Niedernhofer, and Jan H. J. Hoeijmakers), The Journal of experimental medicine (2004)

The structure-specific endonuclease ERCC1-XPF is an essential component of the nucleotide excision DNA repair pathway....

 
Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination (with Carol E. Schrader, Sean P. Bradley, Joycelyn Vardo, Sofia N. Mochegova, and Erin Flanagan), The EMBO journal (2003)

Nucleotide substitutions are found in recombined Ig switch (S) regions and also in unrecombined (germline,...

 
Mlh1 can function in antibody class switch recombination independently of Msh2 (with Carol E. Schrader and Joycelyn Vardo), The Journal of experimental medicine (2003)

Mismatch repair proteins participate in antibody class switch recombination, although their roles are unknown. Previous...

 
Copy choice mechanism of immunoglobulin heavy-chain switch recombination (with W. Dunnick), Molecular and cellular biology (1990)

The immunoglobulin heavy-chain switch is mediated by a recombination event between DNA switch regions associated...

 

PDF

Aberrant recombination events in B cell lines derived from a kappa-deficient human (with O. Kekish, D. Batter, J. Grenier, I. Balazs, E. Henderson, and B. J. Zegers), Nucleic acids research (1985)

We have analyzed the structure of Ig kappa chain genes in B cell lines derived...

 

*Reticulocytes

Synthesis of a mouse immunoglobulin light chain in a rabbit reticulocyte cell-free system (with R. C. Huang), Nature: New biology (1971)

No abstract provided.

 

*RNA Splicing

Ialpha exon-replacement mice synthesize a spliced HPRT-C(alpha) transcript which may explain their ability to switch to IgA. Inhibition of switching to IgG in these mice (with G. Qiu and G. R. Harriman), International immunology (1999)

Antibody class switching is regulated by transcription of unrearranged C(H) genes to produce germline (GL)...

 

*RNA, Messenger

Synthesis and isolation of DNA complementary to nucleotide sequences encoding the variable region of immunoglobulin kappa chain (with J. M. Bishop), Biochemistry (1977)

No abstract provided.

 
Synthesis of a deoxyribonucleic acid sequence complementary to ovalbumin messenger ribonucleic acid and quantification of ovalbumin genes (with D. Sullivan, R. Palacios, J. M. Taylor, A. J. Faras, M. L. Kiely, N. M. Summers, J. M. Bishop, and R. T. Schimke), The Journal of biological chemistry (1973)

No abstract provided.

 
Letter: Translation of messenger RNA for mouse immunoglobulin light chains in living frog oocytes (with M. Smith, R. C. Huang, J. B. Gurdon, and C. D. Lane), Journal of molecular biology (1973)

No abstract provided.

 

*Tandem Repeat Sequences

The Smu tandem repeat region is critical for Ig isotype switching in the absence of Msh2 (with Irene M. Min, Carol E. Schrader, Joycelyn Vardo, Thomas M. Luby, Nicole D'Avirro, and Erik Selsing), Immunity (2003)

Deficiencies of the Msh2 protein or the Smu tandem repeat (SmuTR) sequences each reduce isotype...

 
The mu switch region tandem repeats are important, but not required, for antibody class switch recombination (with Thomas M. Luby, Carol E. Schrader, and Erik Selsing), The Journal of experimental medicine (2001)

Class switch DNA recombinations change the constant (C) region of the antibody heavy (H) chain...

 

*Trans-Activation (Genetics)

Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter (with J. Hanai, L. F. Chen, T. Kanno, N. Ohtani-Fujita, W. Y. Kim, W. H. Guo, T. Imamura, Y. Ishidou, M. Fukuchi, M. J. Shi, M. Kawabata, K. Miyazono, and Y. Ito), The Journal of biological chemistry (1999)

Smads are signal transducers for members of the transforming growth factor-beta (TGF-beta) superfamily. Upon ligand...

 

*Transcription Factors

Overexpression of BSAP/Pax-5 inhibits switching to IgA and enhances switching to IgE in the I.29 mu B cell line (with G. Qiu), Journal of immunology (Baltimore, Md. : 1950) (1998)

B cell-specific activator protein (BSAP)/Pax-5 is a paired domain DNA-binding protein expressed in the developing...

 
Cell cycle regulation of immunoglobulin class switch recombination and germ-line transcription: potential role of Ets family members (with M. Lundgren, L. Strom, L. O. Bergquist, S. Skog, T. Heiden, and E. Severinson), European journal of immunology (1995)

Previous studies have indicated that transcription of germ-line (GL) CH genes is necessary to obtain...

 

*Transcription, Genetic

Analysis of transforming growth factor-beta1-induced Ig germ-line gamma2b transcription and its implication for IgA isotype switching (with Seok-Rae Park, Goo-Young Seo, Ae-Jin Choi, and Pyeung-Hyeun Kim), European journal of immunology (2005)

Transforming growth factor (TGF)-beta1 directs class switch recombination (CSR) to IgG2b as well as to...

 
Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription (with Ching-Hung Shen), Molecular and cellular biology (1998)

Signal transducer and activator of transcription 6 (Stat6) and NF-kappaB are widely distributed transcription factors...

 
Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes (with G. Radcliffe, Y. C. Lin, J. Nietupski, L. Berggren, R. Sitia, and E. Severinson), Proceedings of the National Academy of Sciences of the United States of America (1988)

Immunoglobulin heavy-chain switching is effected by a DNA recombination event that replaces the C mu...

 

Acetylation

Stimuli that enhance IgA class switching increase histone 3 acetylation at S alpha, but poorly stimulate sequential switching from IgG2b (with Denise A. Kaminski), European journal of immunology (2006)

Germ-line (GL) alpha transcription can be induced in mouse splenic B cells by LPS and...

 
Antibody class switching: uncoupling S region accessibility from transcription (with Denise A. Kaminski), Trends in genetics : TIG (2004)

Immunogloblin class switch recombination (CSR) is a regulated process that changes antibody effector functions. Recently,...

 

Activating Transcription Factor 2

Differential regulation of mouse germline Ig gamma 1 and epsilon promoters by IL-4 and CD40 (with C. S. Mao), Journal of immunology (Baltimore, Md. : 1950) (2001)

Before Ig class switching, RNA transcription through the specific S regions undergoing recombination is induced...

 

Activating Transcription Factors

Differential regulation of mouse germline Ig gamma 1 and epsilon promoters by IL-4 and CD40 (with C. S. Mao), Journal of immunology (Baltimore, Md. : 1950) (2001)

Before Ig class switching, RNA transcription through the specific S regions undergoing recombination is induced...

 
Regulation of transcription of the germ-line Ig alpha constant region gene by an ATF element and by novel transforming growth factor-beta 1-responsive elements (with Y. C. Lin), Journal of immunology (Baltimore, Md. : 1950) (1992)

Inasmuch as transcription of unrearranged, or germ-line, Ig CH genes appears to direct switch recombination,...

 

Adenosine Triphosphatases

Mlh1 can function in antibody class switch recombination independently of Msh2 (with Carol E. Schrader and Joycelyn Vardo), The Journal of experimental medicine (2003)

Mismatch repair proteins participate in antibody class switch recombination, although their roles are unknown. Previous...

 
Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions (with Carol E. Schrader and Joycelyn Vardo), The Journal of experimental medicine (2002)

B cells from mice deficient in mismatch repair (MMR) proteins show decreased ability to undergo...

 

Adjuvants, Immunologic

Activation of the mouse Ig germline epsilon promoter by IL-4 is dependent on AP-1 transcription factors (with Ching-Hung Shen), Journal of immunology (Baltimore, Md. : 1950) (2000)

Induction of germline (GL) epsilon transcripts, an essential step preceding Ig isotype switching to IgE,...

 
Overexpression of BSAP/Pax-5 inhibits switching to IgA and enhances switching to IgE in the I.29 mu B cell line (with G. Qiu), Journal of immunology (Baltimore, Md. : 1950) (1998)

B cell-specific activator protein (BSAP)/Pax-5 is a paired domain DNA-binding protein expressed in the developing...

 

Amino Acid Sequence

Mouse CD6: sequence of cDNA and expression of mRNA (with A. Pal, P. L. Romain, N. G. Singer, and D. Fox), Immunology letters (1996)

No abstract provided.

 
Structure of germline immunoglobulin heavy-chain gamma 1 transcripts in interleukin 4 treated mouse spleen cells (with M. Xu), Developmental immunology (1990)

Antibody class switching is mediated by a DNA recombination event that replaces the C mu...

 
Mouse antibody response to group A streptococcal carbohydrate (with C. D. Jarvis and L. E. Cannon), Journal of immunology (Baltimore, Md. : 1950) (1989)

In an attempt to more fully understand the generation of antibody diversity to carbohydrate (CHO)...

 
I.29 lymphoma cells express a nonmutated VH gene before and after H chain switch (with D. Klein, J. Nietupski, and S. Sirlin), Journal of immunology (Baltimore, Md. : 1950) (1988)

The I.29 B cell lymphoma consists of IgM+ and IgA+ cells which express the same...

 
Synthesis of a mouse immunoglobulin light chain in a rabbit reticulocyte cell-free system (with R. C. Huang), Nature: New biology (1971)

No abstract provided.

 

Amino Acid Substitution

The ubiquitously expressed DNA-binding protein late SV40 factor binds Ig switch regions and represses class switching to IgA (with Elise E. Drouin, Carol E. Schrader, and Ulla Hansen), Journal of immunology (Baltimore, Md. : 1950) (2002)

Ig heavy chain class switch recombination (CSR) determines the expression of Ig isotypes. The molecular...

 

Animals

DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination (with Xiaoming Wu), The Journal of experimental medicine (2007)

Immunoglobulin (Ig) class switch recombination (CSR) is initiated by activation-induced cytidine deaminase (AID), which converts...

 
Antibody class switching differs among SJL, C57BL/6 and 129 mice (with Denise A. Kaminski), International immunology (2007)

Inbred mouse strains used for gene manipulation studies vary in many respects, including immune system...

 
Stimuli that enhance IgA class switching increase histone 3 acetylation at S alpha, but poorly stimulate sequential switching from IgG2b (with Denise A. Kaminski), European journal of immunology (2006)

Germ-line (GL) alpha transcription can be induced in mouse splenic B cells by LPS and...

 
Enhanced IgA class switching in marginal zone and B1 B cells relative to follicular/B2 B cells (with Denise A. Kaminski), Journal of immunology (Baltimore, Md. : 1950) (2006)

Mouse splenic marginal zone (MZ) B cells and B1 B cells enriched in the peritoneal...

 
The histone methyltransferase Suv39h1 increases class switch recombination specifically to IgA (with Sean P. Bradley, Denise A. Kaminski, Antoine H. F. M. Peters, and Thomas Jenuwein), Journal of immunology (Baltimore, Md. : 1950) (2006)

Ab class (isotype) switching allows the humoral immune system to adaptively respond to different infectious...

 
Mismatch repair converts AID-instigated nicks to double-strand breaks for antibody class-switch recombination (with Carol E. Schrader), Trends in genetics : TIG (2005)

Mismatch repair (MMR) proteins are important for antibody class-switch recombination (CSR), but their roles are...

 
Inducible DNA breaks in Ig S regions are dependent on AID and UNG (with Carol E. Schrader, Erin K. Linehan, Sofia N. Mochegova, and Robert T. Woodland), The Journal of experimental medicine (2005)

Class switch recombination (CSR) occurs by an intrachromosomal deletion whereby the IgM constant region gene...

 
Shifts in targeting of class switch recombination sites in mice that lack mu switch region tandem repeats or Msh2 (with Irene M. Min, Lisa R. Rothlein, Carol E. Schrader, and Erik Selsing), The Journal of experimental medicine (2005)

The mechanisms that target class switch recombination (CSR) to antibody gene switch (S) regions are...

 
Analysis of transforming growth factor-beta1-induced Ig germ-line gamma2b transcription and its implication for IgA isotype switching (with Seok-Rae Park, Goo-Young Seo, Ae-Jin Choi, and Pyeung-Hyeun Kim), European journal of immunology (2005)

Transforming growth factor (TGF)-beta1 directs class switch recombination (CSR) to IgG2b as well as to...

 
Evolution of isotype switching (with Chris T. Amemiya), Seminars in immunology (2004)

This review discusses evolution of the process of Ig heavy chain class switching, relating it...

 
Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions (with Carol E. Schrader, Joycelyn Vardo, Erin K. Linehan, Michael Z. Twarog, Laura J. Niedernhofer, and Jan H. J. Hoeijmakers), The Journal of experimental medicine (2004)

The structure-specific endonuclease ERCC1-XPF is an essential component of the nucleotide excision DNA repair pathway....

 
Antibody class switching: uncoupling S region accessibility from transcription (with Denise A. Kaminski), Trends in genetics : TIG (2004)

Immunogloblin class switch recombination (CSR) is a regulated process that changes antibody effector functions. Recently,...

 
Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination (with Carol E. Schrader, Sean P. Bradley, Joycelyn Vardo, Sofia N. Mochegova, and Erin Flanagan), The EMBO journal (2003)

Nucleotide substitutions are found in recombined Ig switch (S) regions and also in unrecombined (germline,...

 
The Smu tandem repeat region is critical for Ig isotype switching in the absence of Msh2 (with Irene M. Min, Carol E. Schrader, Joycelyn Vardo, Thomas M. Luby, Nicole D'Avirro, and Erik Selsing), Immunity (2003)

Deficiencies of the Msh2 protein or the Smu tandem repeat (SmuTR) sequences each reduce isotype...

 
Mlh1 can function in antibody class switch recombination independently of Msh2 (with Carol E. Schrader and Joycelyn Vardo), The Journal of experimental medicine (2003)

Mismatch repair proteins participate in antibody class switch recombination, although their roles are unknown. Previous...

 
Immunoglobulin genes: generating diversity with AID and UNG (with Ursula Storb), Current biology : CB (2002)

Somatic hypermutation and switch recombination of immunoglobulin genes require the activity of the activation-induced deaminase,...

 
The ubiquitously expressed DNA-binding protein late SV40 factor binds Ig switch regions and represses class switching to IgA (with Elise E. Drouin, Carol E. Schrader, and Ulla Hansen), Journal of immunology (Baltimore, Md. : 1950) (2002)

Ig heavy chain class switch recombination (CSR) determines the expression of Ig isotypes. The molecular...

 
Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions (with Carol E. Schrader and Joycelyn Vardo), The Journal of experimental medicine (2002)

B cells from mice deficient in mismatch repair (MMR) proteins show decreased ability to undergo...

 
Differential regulation of mouse germline Ig gamma 1 and epsilon promoters by IL-4 and CD40 (with C. S. Mao), Journal of immunology (Baltimore, Md. : 1950) (2001)

Before Ig class switching, RNA transcription through the specific S regions undergoing recombination is induced...

 
Roles of Ets proteins, NF-kappa B and nocodazole in regulating induction of transcription of mouse germline Ig alpha RNA by transforming growth factor-beta 1 (with M. J. Shi, S. R. Park, and P. H. Kim), International immunology (2001)

Antibody class switch recombination (CSR) occurs after antigen activation of B cells. CSR is directed...

 
The mu switch region tandem repeats are important, but not required, for antibody class switch recombination (with Thomas M. Luby, Carol E. Schrader, and Erik Selsing), The Journal of experimental medicine (2001)

Class switch DNA recombinations change the constant (C) region of the antibody heavy (H) chain...

 
Activation of the mouse Ig germline epsilon promoter by IL-4 is dependent on AP-1 transcription factors (with Ching-Hung Shen), Journal of immunology (Baltimore, Md. : 1950) (2000)

Induction of germline (GL) epsilon transcripts, an essential step preceding Ig isotype switching to IgE,...

 
Immunology. A touch of antibody class, Science (New York, N.Y.) (2000)

When B cells, the antibody producing cells of the body, encounter antigen they switch from...

 
Evidence for class-specific factors in immunoglobulin isotype switching (with A. Shanmugam, M. J. Shi, L. Yauch, and A. L. Kenter), The Journal of experimental medicine (2000)

Immunoglobulin class switch recombination (SR) occurs by a B cell-specific, intrachromosomal deletional process between switch...

 
Molecular processes that regulate class switching, Current topics in microbiology and immunology (1999)

No abstract provided.

 
Switch recombination in a transfected plasmid occurs preferentially in a B cell line that undergoes switch recombination of its chromosomal Ig heavy chain genes (with Sean P. Bradley, Norman Rousseau, Todd Pearson, Ananth Shanmugam, Debra J. Waite, Paul R. Rogers, and Amy L. Kenter), Journal of immunology (Baltimore, Md. : 1950) (1999)

Ab class switching is induced upon B cell activation in vivo by immunization or infection...

 
Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes (with Carol E. Schrader, W. Edelmann, and R. Kucherlapati), The Journal of experimental medicine (1999)

Mice deficient in various mismatch repair (MMR) enzymes were examined to determine whether this repair...

 
Ialpha exon-replacement mice synthesize a spliced HPRT-C(alpha) transcript which may explain their ability to switch to IgA. Inhibition of switching to IgG in these mice (with G. Qiu and G. R. Harriman), International immunology (1999)

Antibody class switching is regulated by transcription of unrearranged C(H) genes to produce germline (GL)...

 
CBF alpha3 (AML2) is induced by TGF-beta1 to bind and activate the mouse germline Ig alpha promoter (with M. J. Shi), Journal of immunology (Baltimore, Md. : 1950) (1998)

TGF-beta1 directs class switching to IgA by splenic B cells and by the surface IgM+...

 
Overexpression of BSAP/Pax-5 inhibits switching to IgA and enhances switching to IgE in the I.29 mu B cell line (with G. Qiu), Journal of immunology (Baltimore, Md. : 1950) (1998)

B cell-specific activator protein (BSAP)/Pax-5 is a paired domain DNA-binding protein expressed in the developing...

 
The ability of CD40L, but not lipopolysaccharide, to initiate immunoglobulin switching to immunoglobulin G1 is explained by differential induction of NF-kappaB/Rel proteins (with S. C. Lin and H. H. Wortis), Molecular and cellular biology (1998)

Antibodies of the immunoglobulin G1 class are induced in mice by T-cell-dependent antigens but not...

 
CD40 cross-linking induces Ig epsilon germline transcripts in B cells via activation of NF-kappaB: synergy with IL-4 induction (with L. A. Iciek and S. A. Delphin), Journal of immunology (Baltimore, Md. : 1950) (1997)

Transcription of unrearranged (germline) Ig heavy chain C region (C(H)) genes is required before Ab...

 
Cognate T cell help for CD40-deficient B cells induces c-myc RNA expression, but DNA synthesis requires an additional signal through surface Ig (with Carol E. Schrader, H. Kikutani, and D. C. Parker), Journal of immunology (Baltimore, Md. : 1950) (1997)

To investigate the role of CD40 ligand in the delivery of help to B cells,...

 
Activation of NF-kappaB/Rel by CD40 engagement induces the mouse germ line immunoglobulin Cgamma1 promoter (with S. C. Lin), Molecular and cellular biology (1996)

Interaction between CD40 on B cells and CD40 ligand (CD40L) on T cells has been...

 
Immunoglobulin class switching, Current opinion in immunology (1996)

Antibody class switching is induced by B-cell activators in the presence of cytokines. The identity...

 
Antibody class switching, Advances in immunology (1996)

No abstract provided.

 
Mouse CD6: sequence of cDNA and expression of mRNA (with A. Pal, P. L. Romain, N. G. Singer, and D. Fox), Immunology letters (1996)

No abstract provided.

 
Regulation of antibody class switching to IgE: characterization of an IL-4-responsive region in the immunoglobulin heavy-chain germline epsilon promoter (with S. Delphin), Annals of the New York Academy of Sciences (1995)

A large body of data indicate that antibody class switching is directed by cytokines by...

 
Regulation of antibody production and class switching by TGF-beta, Journal of immunology (Baltimore, Md. : 1950) (1995)

No abstract provided.

 
Cell cycle regulation of immunoglobulin class switch recombination and germ-line transcription: potential role of Ets family members (with M. Lundgren, L. Strom, L. O. Bergquist, S. Skog, T. Heiden, and E. Severinson), European journal of immunology (1995)

Previous studies have indicated that transcription of germ-line (GL) CH genes is necessary to obtain...

 
Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50 (with S. Delphin), The Journal of experimental medicine (1995)

A large body of data indicate that antibody class switching is directed by cytokines by...

 
Activation of the Ig germ-line gamma 1 promoter. Involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site (with M. Lundgren, C. Larsson, A. Femino, M. Xu, and E. Severinson), Journal of immunology (Baltimore, Md. : 1950) (1994)

Ig isotype switching in B lymphocytes is preceded by transcription of the corresponding unrearranged, or...

 
Inhibitors of poly(ADP-ribose) polymerase increase antibody class switching (with P. Shockett), Journal of immunology (Baltimore, Md. : 1950) (1993)

Previous studies suggest that heavy chain isotype switch (S) recombination is directed by cytokine-induced transcription...

 
Regulation of transcription of the germ-line Ig alpha constant region gene by an ATF element and by novel transforming growth factor-beta 1-responsive elements (with Y. C. Lin), Journal of immunology (Baltimore, Md. : 1950) (1992)

Inasmuch as transcription of unrearranged, or germ-line, Ig CH genes appears to direct switch recombination,...

 
Regulation of switch recombination to the murine gamma 1 gene (with W. Dunnick, L. Elenich, J. Berry, D. Albrecht, and J. L. Claflin), Current topics in microbiology and immunology (1992)

No abstract provided.

 
Regulation of transcription of immunoglobulin germ-line gamma 1 RNA: analysis of the promoter/enhancer (with M. Z. Xu), The EMBO journal (1992)

Antibody class switching is achieved by recombinations between switch (S) regions which consist of tandemly...

 
Regulation of transcription of the germline immunoglobulin alpha constant region gene (with Y. C. Lin and P. Shockett), Current topics in microbiology and immunology (1992)

No abstract provided.

 
Effect of cytokines on switching to IgA and alpha germline transcripts in the B lymphoma I.29 mu. Transforming growth factor-beta activates transcription of the unrearranged C alpha gene (with P. Shockett), Journal of immunology (Baltimore, Md. : 1950) (1991)

H chain isotype switch recombination is preceded by the appearance of RNA initiating 5' of...

 
Induction of germ-line immunoglobulin heavy chain transcripts by mitogens and interleukins prior to switch recombination (with E. Severinson and C. Fernandez), European journal of immunology (1990)

It has recently been postulated that immunoglobulin class switching is preceded by transcription from unrearranged...

 
Copy choice mechanism of immunoglobulin heavy-chain switch recombination (with W. Dunnick), Molecular and cellular biology (1990)

The immunoglobulin heavy-chain switch is mediated by a recombination event between DNA switch regions associated...

 
Structure of germ line immunoglobulin alpha heavy-chain RNA and its location on polysomes (with G. Radcliffe, Y. C. Lin, M. Julius, and K. B. Marcu), Molecular and cellular biology (1990)

We describe the structure of the major germ line RNA transcribed from unrearranged immunoglobulin alpha...

 
Structure of germline immunoglobulin heavy-chain gamma 1 transcripts in interleukin 4 treated mouse spleen cells (with M. Xu), Developmental immunology (1990)

Antibody class switching is mediated by a DNA recombination event that replaces the C mu...

 
Mouse antibody response to group A streptococcal carbohydrate (with C. D. Jarvis and L. E. Cannon), Journal of immunology (Baltimore, Md. : 1950) (1989)

In an attempt to more fully understand the generation of antibody diversity to carbohydrate (CHO)...

 
A B-cell-specific nuclear protein that binds to DNA sites 5' to immunoglobulin S alpha tandem repeats is regulated during differentiation (with S. H. Waters and K. U. Saikh), Molecular and cellular biology (1989)

Immunoglobulin heavy-chain switching is effected by recombination events between sites associated with tandemly repeated switch...

 
Reticulum cell sarcomas of SJL mice have rearranged immunoglobulin heavy and light chain genes (with J. L. Lasky, N. M. Ponzio, M. P. Scheid, and G. J. Thorbecke), European journal of immunology (1989)

The immunoglobulin (Ig) heavy (H) and light (L) chain gene rearrangements of the high incidence...

 
Mutations, duplication, and deletion of recombined switch regions suggest a role for DNA replication in the immunoglobulin heavy-chain switch (with W. Dunnick and M. Wilson), Molecular and cellular biology (1989)

The heavy-chain switch from immunoglobulin M (IgM) expression to IgA expression is mediated by a...

 
Interleukins 4 and 5: mechanisms of action (with E. Severinson, H. B. Moon, S. Bergstedt-Lindqvist, U. Persson, and C. Heusser), Advances in experimental medicine and biology (1989)

No abstract provided.

 
I.29 lymphoma cells express a nonmutated VH gene before and after H chain switch (with D. Klein, J. Nietupski, and S. Sirlin), Journal of immunology (Baltimore, Md. : 1950) (1988)

The I.29 B cell lymphoma consists of IgM+ and IgA+ cells which express the same...

 
Specificity of immunoglobulin heavy chain switching by cultured I.29 B lymphoma cells (with G. Radcliffe and E. Severinson), Monographs in allergy (1988)

No abstract provided.

 
Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching (with S. Sirlin), The EMBO journal (1986)

IgM+ cells cultured from the I.29 B cell lymphoma can be induced with lipopolysaccharide (LPS)...

 
Molecular defects in a human immunoglobulin kappa chain deficiency (with O. Kekish and B. J. Zegers), Science (New York, N.Y.) (1985)

The molecular basis of a human immunoglobulin deficiency characterized by the complete absence of kappa...

 
The regulation of membrane-bound and secreted alpha-chain biosynthesis during the differentiation of the B cell lymphoma I.29 (with R. Sitia, A. Rubartelli, H. Kikutani, and U. Hammerling), Journal of immunology (Baltimore, Md. : 1950) (1985)

The regulation of the synthesis of membrane-bound and secreted IgA was investigated in the murine...

 

File

Induction of immunoglobulin isotype switching in cultured I.29 B lymphoma cells. Characterization of the accompanying rearrangements of heavy chain genes (with S. Sirlin and J. Abbott), The Journal of experimental medicine (1985)

The murine B cell lymphoma I.29 contains cells expressing surface IgM or IgA with identical...

 
Immunoglobulin heavy chain switching in cultured I.29 murine B lymphoma cells: commitment to an IgA or IgE switch (with J. Abbott and S. Sirlin), Current topics in microbiology and immunology (1984)

No abstract provided.

 
Molecular genetics of immunoglobulin heavy chain switching, Survey of immunologic research (1983)

No abstract provided.

 
Rearrangements and deletions of immunoglobulin heavy chain genes in the double-producing B cell lymphoma I.29 (with K. B. Marcu, S. Sirlin, B. Alhadeff, and U. Hammerling), Molecular and cellular biology (1982)

The B cell lymphoma I.29 consists of a mixture of cells expressing membrane-bound immunoglobulin M...

 
Genetic structure and origin of t haplotypes of mice, analyzed with H-2 cDNA probes (with H. S. Shin, K. Artzt, and D. Bennett), Cell (1982)

We investigated the genetic organization and evolutionary origin of t chromosomes of mice by examining...

 
Membrane-bound and secreted IgA contain structurally different alpha-chains (with R. Sitia, H. Kikutani, A. Rubartelli, Y. Bushkin, and U. Hammerling), Journal of immunology (Baltimore, Md. : 1950) (1982)

Three different forms of alpha-chains are synthesized by BF0.3 and 615.2, two cloned cell lines...

 
Synthesis and processing of the alpha heavy chains of secreted and membrane-bound IgA (with H. Kikutani, R. Sitia, and R. A. Good), Proceedings of the National Academy of Sciences of the United States of America (1981)

We have compared the synthesis and processing of immunoglobulin alpha chains in two murine cell...

 
Expression of an antigen receptor on T cells does not require recombination at the immunoglobulin JH-C mu locus (with Y. Cayre, M. A. Palladino, and K. B. Marcu), Proceedings of the National Academy of Sciences of the United States of America (1981)

Considerable evidence has accumulated suggesting that the antigen receptor(s) on T cells is coded for...

 
Detection and characterization of RNA tumor virus-specific DNA in cells (with H. E. Varmus, E. Medeiros, and J. M. Bishop), Bibliotheca haematologica (1975)

RNA tumor virus-specific DNA in cells can be detected by its capacity to 1) alter...

 
Isolation of messenger RNA for an immunoglobulin kappa chain and enumeration of the genes for the constatn region of kappa chain in the mouse (with R. C. Huang, E. Stavnezer, and J. M. Bishop), Journal of molecular biology (1974)

No abstract provided.

 
Synthesis of a deoxyribonucleic acid sequence complementary to ovalbumin messenger ribonucleic acid and quantification of ovalbumin genes (with D. Sullivan, R. Palacios, J. M. Taylor, A. J. Faras, M. L. Kiely, N. M. Summers, J. M. Bishop, and R. T. Schimke), The Journal of biological chemistry (1973)

No abstract provided.

 
Letter: Translation of messenger RNA for mouse immunoglobulin light chains in living frog oocytes (with M. Smith, R. C. Huang, J. B. Gurdon, and C. D. Lane), Journal of molecular biology (1973)

No abstract provided.

 
Synthesis of a mouse immunoglobulin light chain in a rabbit reticulocyte cell-free system (with R. C. Huang), Nature: New biology (1971)

No abstract provided.

 

Antibodies, Anti-Idiotypic

Stimuli that enhance IgA class switching increase histone 3 acetylation at S alpha, but poorly stimulate sequential switching from IgG2b (with Denise A. Kaminski), European journal of immunology (2006)

Germ-line (GL) alpha transcription can be induced in mouse splenic B cells by LPS and...

 
Regulation of transcription of immunoglobulin germ-line gamma 1 RNA: analysis of the promoter/enhancer (with M. Z. Xu), The EMBO journal (1992)

Antibody class switching is achieved by recombinations between switch (S) regions which consist of tandemly...

 

File

Induction of immunoglobulin isotype switching in cultured I.29 B lymphoma cells. Characterization of the accompanying rearrangements of heavy chain genes (with S. Sirlin and J. Abbott), The Journal of experimental medicine (1985)

The murine B cell lymphoma I.29 contains cells expressing surface IgM or IgA with identical...

 

Antibodies, Bacterial

Mouse antibody response to group A streptococcal carbohydrate (with C. D. Jarvis and L. E. Cannon), Journal of immunology (Baltimore, Md. : 1950) (1989)

In an attempt to more fully understand the generation of antibody diversity to carbohydrate (CHO)...

 

Antibodies, Monoclonal

File

Induction of immunoglobulin isotype switching in cultured I.29 B lymphoma cells. Characterization of the accompanying rearrangements of heavy chain genes (with S. Sirlin and J. Abbott), The Journal of experimental medicine (1985)

The murine B cell lymphoma I.29 contains cells expressing surface IgM or IgA with identical...

 

Antibodies, Neoplasm

Expression of immunoglobulin lambda light chain by the promyelocytic cell line HL-60 (with A. Al-Katib and B. Koziner), Journal of immunology (Baltimore, Md. : 1950) (1986)

The HL-60 cell line, established from a patient with acute promyelocytic leukemia, can be induced...

 

Antibody Diversity

Shifts in targeting of class switch recombination sites in mice that lack mu switch region tandem repeats or Msh2 (with Irene M. Min, Lisa R. Rothlein, Carol E. Schrader, and Erik Selsing), The Journal of experimental medicine (2005)

The mechanisms that target class switch recombination (CSR) to antibody gene switch (S) regions are...

 
Does activation-induced deaminase initiate antibody diversification by DNA deamination (with Sean P. Bradley), Trends in genetics : TIG (2002)

Activation-induced deaminase (AID) is expressed only in germinal center B cells. There, it is required...

 
Regulation of the antibody class switch to IgA (with Y. C. Lin and P. Shockett), Immunologic research (1991)

No abstract provided.

 
Structure of germline immunoglobulin heavy-chain gamma 1 transcripts in interleukin 4 treated mouse spleen cells (with M. Xu), Developmental immunology (1990)

Antibody class switching is mediated by a DNA recombination event that replaces the C mu...

 

Antibody Formation

Regulation of antibody production and class switching by TGF-beta, Journal of immunology (Baltimore, Md. : 1950) (1995)

No abstract provided.

 

Antibody Specificity

Antibody class switching, Advances in immunology (1996)

No abstract provided.

 
Isolation of messenger RNA for an immunoglobulin kappa chain and enumeration of the genes for the constatn region of kappa chain in the mouse (with R. C. Huang, E. Stavnezer, and J. M. Bishop), Journal of molecular biology (1974)

No abstract provided.

 

Antibody-Producing Cells

Membrane-bound and secreted IgA contain structurally different alpha-chains (with R. Sitia, H. Kikutani, A. Rubartelli, Y. Bushkin, and U. Hammerling), Journal of immunology (Baltimore, Md. : 1950) (1982)

Three different forms of alpha-chains are synthesized by BF0.3 and 615.2, two cloned cell lines...

 

Antigen-Presenting Cells

Cognate T cell help for CD40-deficient B cells induces c-myc RNA expression, but DNA synthesis requires an additional signal through surface Ig (with Carol E. Schrader, H. Kikutani, and D. C. Parker), Journal of immunology (Baltimore, Md. : 1950) (1997)

To investigate the role of CD40 ligand in the delivery of help to B cells,...

 

Antigens

Molecular processes that regulate class switching, Current topics in microbiology and immunology (1999)

No abstract provided.

 
Antibody class switching, Advances in immunology (1996)

No abstract provided.

 

Antigens, CD

Antibody class switching differs among SJL, C57BL/6 and 129 mice (with Denise A. Kaminski), International immunology (2007)

Inbred mouse strains used for gene manipulation studies vary in many respects, including immune system...

 
Mouse CD6: sequence of cDNA and expression of mRNA (with A. Pal, P. L. Romain, N. G. Singer, and D. Fox), Immunology letters (1996)

No abstract provided.

 

Antigens, CD40

Differential regulation of mouse germline Ig gamma 1 and epsilon promoters by IL-4 and CD40 (with C. S. Mao), Journal of immunology (Baltimore, Md. : 1950) (2001)

Before Ig class switching, RNA transcription through the specific S regions undergoing recombination is induced...

 
Regulation of the promoter for human immunoglobulin gamma3 germ-line transcription and its interaction with the 3'alpha enhancer (with Q. Pan, C. Petit-Frere, and L. Hammarstrom), European journal of immunology (2000)

The mechanism underlying the differential regulation of switching to human IgG subclasses is still largely...

 
The ability of CD40L, but not lipopolysaccharide, to initiate immunoglobulin switching to immunoglobulin G1 is explained by differential induction of NF-kappaB/Rel proteins (with S. C. Lin and H. H. Wortis), Molecular and cellular biology (1998)

Antibodies of the immunoglobulin G1 class are induced in mice by T-cell-dependent antigens but not...

 
CD40 cross-linking induces Ig epsilon germline transcripts in B cells via activation of NF-kappaB: synergy with IL-4 induction (with L. A. Iciek and S. A. Delphin), Journal of immunology (Baltimore, Md. : 1950) (1997)

Transcription of unrearranged (germline) Ig heavy chain C region (C(H)) genes is required before Ab...

 
Cognate T cell help for CD40-deficient B cells induces c-myc RNA expression, but DNA synthesis requires an additional signal through surface Ig (with Carol E. Schrader, H. Kikutani, and D. C. Parker), Journal of immunology (Baltimore, Md. : 1950) (1997)

To investigate the role of CD40 ligand in the delivery of help to B cells,...

 
Activation of NF-kappaB/Rel by CD40 engagement induces the mouse germ line immunoglobulin Cgamma1 promoter (with S. C. Lin), Molecular and cellular biology (1996)

Interaction between CD40 on B cells and CD40 ligand (CD40L) on T cells has been...

 

Antigens, Differentiation, T-Lymphocyte

Mouse CD6: sequence of cDNA and expression of mRNA (with A. Pal, P. L. Romain, N. G. Singer, and D. Fox), Immunology letters (1996)

No abstract provided.

 

Antigens, Neoplasm

Surface immunoglobulin light chain expression in pre-B cell leukemias (with B. Koziner, A. Al-Katib, D. Gebhard, A. Mittelman, M. Andreeff, and B. D. Clarkson), Annals of the New York Academy of Sciences (1986)

Cytofluorographic analysis of surface immunoglobulin (sIg) light chain clonal excess (CE), defined as (%kappa+ -...

 

Antineoplastic Agents

Roles of Ets proteins, NF-kappa B and nocodazole in regulating induction of transcription of mouse germline Ig alpha RNA by transforming growth factor-beta 1 (with M. J. Shi, S. R. Park, and P. H. Kim), International immunology (2001)

Antibody class switch recombination (CSR) occurs after antigen activation of B cells. CSR is directed...

 

Anura

Letter: Translation of messenger RNA for mouse immunoglobulin light chains in living frog oocytes (with M. Smith, R. C. Huang, J. B. Gurdon, and C. D. Lane), Journal of molecular biology (1973)

No abstract provided.

 

Avian Sarcoma Viruses

Detection and characterization of RNA tumor virus-specific DNA in cells (with H. E. Varmus, E. Medeiros, and J. M. Bishop), Bibliotheca haematologica (1975)

RNA tumor virus-specific DNA in cells can be detected by its capacity to 1) alter...

 

B-Cell Activating Factor

Antibody class switching differs among SJL, C57BL/6 and 129 mice (with Denise A. Kaminski), International immunology (2007)

Inbred mouse strains used for gene manipulation studies vary in many respects, including immune system...

 
Stimuli that enhance IgA class switching increase histone 3 acetylation at S alpha, but poorly stimulate sequential switching from IgG2b (with Denise A. Kaminski), European journal of immunology (2006)

Germ-line (GL) alpha transcription can be induced in mouse splenic B cells by LPS and...

 

B-Cell-Specific Activator Protein

The histone methyltransferase Suv39h1 increases class switch recombination specifically to IgA (with Sean P. Bradley, Denise A. Kaminski, Antoine H. F. M. Peters, and Thomas Jenuwein), Journal of immunology (Baltimore, Md. : 1950) (2006)

Ab class (isotype) switching allows the humoral immune system to adaptively respond to different infectious...

 
Overexpression of BSAP/Pax-5 inhibits switching to IgA and enhances switching to IgE in the I.29 mu B cell line (with G. Qiu), Journal of immunology (Baltimore, Md. : 1950) (1998)

B cell-specific activator protein (BSAP)/Pax-5 is a paired domain DNA-binding protein expressed in the developing...

 

B-Lymphocyte Subsets

Antibody class switching differs among SJL, C57BL/6 and 129 mice (with Denise A. Kaminski), International immunology (2007)

Inbred mouse strains used for gene manipulation studies vary in many respects, including immune system...

 
Enhanced IgA class switching in marginal zone and B1 B cells relative to follicular/B2 B cells (with Denise A. Kaminski), Journal of immunology (Baltimore, Md. : 1950) (2006)

Mouse splenic marginal zone (MZ) B cells and B1 B cells enriched in the peritoneal...

 

B-Lymphocytes

Antibody class switching differs among SJL, C57BL/6 and 129 mice (with Denise A. Kaminski), International immunology (2007)

Inbred mouse strains used for gene manipulation studies vary in many respects, including immune system...

 
Stimuli that enhance IgA class switching increase histone 3 acetylation at S alpha, but poorly stimulate sequential switching from IgG2b (with Denise A. Kaminski), European journal of immunology (2006)

Germ-line (GL) alpha transcription can be induced in mouse splenic B cells by LPS and...

 
The histone methyltransferase Suv39h1 increases class switch recombination specifically to IgA (with Sean P. Bradley, Denise A. Kaminski, Antoine H. F. M. Peters, and Thomas Jenuwein), Journal of immunology (Baltimore, Md. : 1950) (2006)

Ab class (isotype) switching allows the humoral immune system to adaptively respond to different infectious...

 
Mismatch repair converts AID-instigated nicks to double-strand breaks for antibody class-switch recombination (with Carol E. Schrader), Trends in genetics : TIG (2005)

Mismatch repair (MMR) proteins are important for antibody class-switch recombination (CSR), but their roles are...

 
Inducible DNA breaks in Ig S regions are dependent on AID and UNG (with Carol E. Schrader, Erin K. Linehan, Sofia N. Mochegova, and Robert T. Woodland), The Journal of experimental medicine (2005)

Class switch recombination (CSR) occurs by an intrachromosomal deletion whereby the IgM constant region gene...

 
Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination (with Carol E. Schrader, Sean P. Bradley, Joycelyn Vardo, Sofia N. Mochegova, and Erin Flanagan), The EMBO journal (2003)

Nucleotide substitutions are found in recombined Ig switch (S) regions and also in unrecombined (germline,...

 
Does activation-induced deaminase initiate antibody diversification by DNA deamination (with Sean P. Bradley), Trends in genetics : TIG (2002)

Activation-induced deaminase (AID) is expressed only in germinal center B cells. There, it is required...

 
Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions (with Carol E. Schrader and Joycelyn Vardo), The Journal of experimental medicine (2002)

B cells from mice deficient in mismatch repair (MMR) proteins show decreased ability to undergo...

 
Differential regulation of mouse germline Ig gamma 1 and epsilon promoters by IL-4 and CD40 (with C. S. Mao), Journal of immunology (Baltimore, Md. : 1950) (2001)

Before Ig class switching, RNA transcription through the specific S regions undergoing recombination is induced...

 
Roles of Ets proteins, NF-kappa B and nocodazole in regulating induction of transcription of mouse germline Ig alpha RNA by transforming growth factor-beta 1 (with M. J. Shi, S. R. Park, and P. H. Kim), International immunology (2001)

Antibody class switch recombination (CSR) occurs after antigen activation of B cells. CSR is directed...

 
The mu switch region tandem repeats are important, but not required, for antibody class switch recombination (with Thomas M. Luby, Carol E. Schrader, and Erik Selsing), The Journal of experimental medicine (2001)

Class switch DNA recombinations change the constant (C) region of the antibody heavy (H) chain...

 
Activation of the mouse Ig germline epsilon promoter by IL-4 is dependent on AP-1 transcription factors (with Ching-Hung Shen), Journal of immunology (Baltimore, Md. : 1950) (2000)

Induction of germline (GL) epsilon transcripts, an essential step preceding Ig isotype switching to IgE,...

 
Immunology. A touch of antibody class, Science (New York, N.Y.) (2000)

When B cells, the antibody producing cells of the body, encounter antigen they switch from...

 
Evidence for class-specific factors in immunoglobulin isotype switching (with A. Shanmugam, M. J. Shi, L. Yauch, and A. L. Kenter), The Journal of experimental medicine (2000)

Immunoglobulin class switch recombination (SR) occurs by a B cell-specific, intrachromosomal deletional process between switch...

 
Regulation of the promoter for human immunoglobulin gamma3 germ-line transcription and its interaction with the 3'alpha enhancer (with Q. Pan, C. Petit-Frere, and L. Hammarstrom), European journal of immunology (2000)

The mechanism underlying the differential regulation of switching to human IgG subclasses is still largely...

 
Molecular processes that regulate class switching, Current topics in microbiology and immunology (1999)

No abstract provided.

 
Switch recombination in a transfected plasmid occurs preferentially in a B cell line that undergoes switch recombination of its chromosomal Ig heavy chain genes (with Sean P. Bradley, Norman Rousseau, Todd Pearson, Ananth Shanmugam, Debra J. Waite, Paul R. Rogers, and Amy L. Kenter), Journal of immunology (Baltimore, Md. : 1950) (1999)

Ab class switching is induced upon B cell activation in vivo by immunization or infection...

 
Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes (with Carol E. Schrader, W. Edelmann, and R. Kucherlapati), The Journal of experimental medicine (1999)

Mice deficient in various mismatch repair (MMR) enzymes were examined to determine whether this repair...

 
CBF alpha3 (AML2) is induced by TGF-beta1 to bind and activate the mouse germline Ig alpha promoter (with M. J. Shi), Journal of immunology (Baltimore, Md. : 1950) (1998)

TGF-beta1 directs class switching to IgA by splenic B cells and by the surface IgM+...

 
Overexpression of BSAP/Pax-5 inhibits switching to IgA and enhances switching to IgE in the I.29 mu B cell line (with G. Qiu), Journal of immunology (Baltimore, Md. : 1950) (1998)

B cell-specific activator protein (BSAP)/Pax-5 is a paired domain DNA-binding protein expressed in the developing...

 
The ability of CD40L, but not lipopolysaccharide, to initiate immunoglobulin switching to immunoglobulin G1 is explained by differential induction of NF-kappaB/Rel proteins (with S. C. Lin and H. H. Wortis), Molecular and cellular biology (1998)

Antibodies of the immunoglobulin G1 class are induced in mice by T-cell-dependent antigens but not...

 
CD40 cross-linking induces Ig epsilon germline transcripts in B cells via activation of NF-kappaB: synergy with IL-4 induction (with L. A. Iciek and S. A. Delphin), Journal of immunology (Baltimore, Md. : 1950) (1997)

Transcription of unrearranged (germline) Ig heavy chain C region (C(H)) genes is required before Ab...

 
Cognate T cell help for CD40-deficient B cells induces c-myc RNA expression, but DNA synthesis requires an additional signal through surface Ig (with Carol E. Schrader, H. Kikutani, and D. C. Parker), Journal of immunology (Baltimore, Md. : 1950) (1997)

To investigate the role of CD40 ligand in the delivery of help to B cells,...

 
Antibody class switching, Advances in immunology (1996)

No abstract provided.

 
Activation of the Ig germ-line gamma 1 promoter. Involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site (with M. Lundgren, C. Larsson, A. Femino, M. Xu, and E. Severinson), Journal of immunology (Baltimore, Md. : 1950) (1994)

Ig isotype switching in B lymphocytes is preceded by transcription of the corresponding unrearranged, or...

 
Inhibitors of poly(ADP-ribose) polymerase increase antibody class switching (with P. Shockett), Journal of immunology (Baltimore, Md. : 1950) (1993)

Previous studies suggest that heavy chain isotype switch (S) recombination is directed by cytokine-induced transcription...

 
Regulation of switch recombination to the murine gamma 1 gene (with W. Dunnick, L. Elenich, J. Berry, D. Albrecht, and J. L. Claflin), Current topics in microbiology and immunology (1992)

No abstract provided.

 
A B-cell-specific nuclear protein that binds to DNA sites 5' to immunoglobulin S alpha tandem repeats is regulated during differentiation (with S. H. Waters and K. U. Saikh), Molecular and cellular biology (1989)

Immunoglobulin heavy-chain switching is effected by recombination events between sites associated with tandemly repeated switch...

 
Interleukins 4 and 5: mechanisms of action (with E. Severinson, H. B. Moon, S. Bergstedt-Lindqvist, U. Persson, and C. Heusser), Advances in experimental medicine and biology (1989)

No abstract provided.

 
Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes (with G. Radcliffe, Y. C. Lin, J. Nietupski, L. Berggren, R. Sitia, and E. Severinson), Proceedings of the National Academy of Sciences of the United States of America (1988)

Immunoglobulin heavy-chain switching is effected by a DNA recombination event that replaces the C mu...

 
I.29 lymphoma cells express a nonmutated VH gene before and after H chain switch (with D. Klein, J. Nietupski, and S. Sirlin), Journal of immunology (Baltimore, Md. : 1950) (1988)

The I.29 B cell lymphoma consists of IgM+ and IgA+ cells which express the same...

 
Specificity of immunoglobulin heavy chain switching by cultured I.29 B lymphoma cells (with G. Radcliffe and E. Severinson), Monographs in allergy (1988)

No abstract provided.

 
Expression of immunoglobulin lambda light chain by the promyelocytic cell line HL-60 (with A. Al-Katib and B. Koziner), Journal of immunology (Baltimore, Md. : 1950) (1986)

The HL-60 cell line, established from a patient with acute promyelocytic leukemia, can be induced...

 

PDF

Presence of a polyadenylated RNA fragment encoding the membrane domain for immunoglobulin alpha chain indicates that mRNAs for both secreted and membrane-bound alpha chains can be produced from the same RNA transcript, Nucleic acids research (1986)

RNA blotting was employed to examine polyadenylated immunoglobulin alpha chain RNAs in a B lymphoma...

 
Surface immunoglobulin light-chain expression by the "common" all cell line REH (with B. Koziner and A. Al-Katib), Clinical immunology and immunopathology (1985)

To provide further support of the B-cell lineage of "common" acute lymphoblastic leukemia (ALL), we...

 
The regulation of membrane-bound and secreted alpha-chain biosynthesis during the differentiation of the B cell lymphoma I.29 (with R. Sitia, A. Rubartelli, H. Kikutani, and U. Hammerling), Journal of immunology (Baltimore, Md. : 1950) (1985)

The regulation of the synthesis of membrane-bound and secreted IgA was investigated in the murine...

 

PDF

Aberrant recombination events in B cell lines derived from a kappa-deficient human (with O. Kekish, D. Batter, J. Grenier, I. Balazs, E. Henderson, and B. J. Zegers), Nucleic acids research (1985)

We have analyzed the structure of Ig kappa chain genes in B cell lines derived...

 

File

Induction of immunoglobulin isotype switching in cultured I.29 B lymphoma cells. Characterization of the accompanying rearrangements of heavy chain genes (with S. Sirlin and J. Abbott), The Journal of experimental medicine (1985)

The murine B cell lymphoma I.29 contains cells expressing surface IgM or IgA with identical...

 
Immunoglobulin heavy chain switching in cultured I.29 murine B lymphoma cells: commitment to an IgA or IgE switch (with J. Abbott and S. Sirlin), Current topics in microbiology and immunology (1984)

No abstract provided.

 
Molecular genetics of immunoglobulin heavy chain switching, Survey of immunologic research (1983)

No abstract provided.

 
Membrane-bound and secreted IgA contain structurally different alpha-chains (with R. Sitia, H. Kikutani, A. Rubartelli, Y. Bushkin, and U. Hammerling), Journal of immunology (Baltimore, Md. : 1950) (1982)

Three different forms of alpha-chains are synthesized by BF0.3 and 615.2, two cloned cell lines...

 
Synthesis and processing of the alpha heavy chains of secreted and membrane-bound IgA (with H. Kikutani, R. Sitia, and R. A. Good), Proceedings of the National Academy of Sciences of the United States of America (1981)

We have compared the synthesis and processing of immunoglobulin alpha chains in two murine cell...

 

B-Lymphocytes/enzymology/*immunology

DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination (with Xiaoming Wu), The Journal of experimental medicine (2007)

Immunoglobulin (Ig) class switch recombination (CSR) is initiated by activation-induced cytidine deaminase (AID), which converts...

 

Base Composition

Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination (with Carol E. Schrader, Sean P. Bradley, Joycelyn Vardo, Sofia N. Mochegova, and Erin Flanagan), The EMBO journal (2003)

Nucleotide substitutions are found in recombined Ig switch (S) regions and also in unrecombined (germline,...

 

Base Pair Mismatch

Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions (with Carol E. Schrader, Joycelyn Vardo, Erin K. Linehan, Michael Z. Twarog, Laura J. Niedernhofer, and Jan H. J. Hoeijmakers), The Journal of experimental medicine (2004)

The structure-specific endonuclease ERCC1-XPF is an essential component of the nucleotide excision DNA repair pathway....

 
Mlh1 can function in antibody class switch recombination independently of Msh2 (with Carol E. Schrader and Joycelyn Vardo), The Journal of experimental medicine (2003)

Mismatch repair proteins participate in antibody class switch recombination, although their roles are unknown. Previous...

 
Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes (with Carol E. Schrader, W. Edelmann, and R. Kucherlapati), The Journal of experimental medicine (1999)

Mice deficient in various mismatch repair (MMR) enzymes were examined to determine whether this repair...

 

Base Sequence

Analysis of transforming growth factor-beta1-induced Ig germ-line gamma2b transcription and its implication for IgA isotype switching (with Seok-Rae Park, Goo-Young Seo, Ae-Jin Choi, and Pyeung-Hyeun Kim), European journal of immunology (2005)

Transforming growth factor (TGF)-beta1 directs class switch recombination (CSR) to IgG2b as well as to...

 
Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination (with Carol E. Schrader, Sean P. Bradley, Joycelyn Vardo, Sofia N. Mochegova, and Erin Flanagan), The EMBO journal (2003)

Nucleotide substitutions are found in recombined Ig switch (S) regions and also in unrecombined (germline,...

 
Mlh1 can function in antibody class switch recombination independently of Msh2 (with Carol E. Schrader and Joycelyn Vardo), The Journal of experimental medicine (2003)

Mismatch repair proteins participate in antibody class switch recombination, although their roles are unknown. Previous...

 
The ubiquitously expressed DNA-binding protein late SV40 factor binds Ig switch regions and represses class switching to IgA (with Elise E. Drouin, Carol E. Schrader, and Ulla Hansen), Journal of immunology (Baltimore, Md. : 1950) (2002)

Ig heavy chain class switch recombination (CSR) determines the expression of Ig isotypes. The molecular...

 
Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions (with Carol E. Schrader and Joycelyn Vardo), The Journal of experimental medicine (2002)

B cells from mice deficient in mismatch repair (MMR) proteins show decreased ability to undergo...

 
Differential regulation of mouse germline Ig gamma 1 and epsilon promoters by IL-4 and CD40 (with C. S. Mao), Journal of immunology (Baltimore, Md. : 1950) (2001)

Before Ig class switching, RNA transcription through the specific S regions undergoing recombination is induced...

 
Roles of Ets proteins, NF-kappa B and nocodazole in regulating induction of transcription of mouse germline Ig alpha RNA by transforming growth factor-beta 1 (with M. J. Shi, S. R. Park, and P. H. Kim), International immunology (2001)

Antibody class switch recombination (CSR) occurs after antigen activation of B cells. CSR is directed...

 
The mu switch region tandem repeats are important, but not required, for antibody class switch recombination (with Thomas M. Luby, Carol E. Schrader, and Erik Selsing), The Journal of experimental medicine (2001)

Class switch DNA recombinations change the constant (C) region of the antibody heavy (H) chain...

 
Activation of the mouse Ig germline epsilon promoter by IL-4 is dependent on AP-1 transcription factors (with Ching-Hung Shen), Journal of immunology (Baltimore, Md. : 1950) (2000)

Induction of germline (GL) epsilon transcripts, an essential step preceding Ig isotype switching to IgE,...

 
Evidence for class-specific factors in immunoglobulin isotype switching (with A. Shanmugam, M. J. Shi, L. Yauch, and A. L. Kenter), The Journal of experimental medicine (2000)

Immunoglobulin class switch recombination (SR) occurs by a B cell-specific, intrachromosomal deletional process between switch...

 
Regulation of the promoter for human immunoglobulin gamma3 germ-line transcription and its interaction with the 3'alpha enhancer (with Q. Pan, C. Petit-Frere, and L. Hammarstrom), European journal of immunology (2000)

The mechanism underlying the differential regulation of switching to human IgG subclasses is still largely...

 
Switch recombination in a transfected plasmid occurs preferentially in a B cell line that undergoes switch recombination of its chromosomal Ig heavy chain genes (with Sean P. Bradley, Norman Rousseau, Todd Pearson, Ananth Shanmugam, Debra J. Waite, Paul R. Rogers, and Amy L. Kenter), Journal of immunology (Baltimore, Md. : 1950) (1999)

Ab class switching is induced upon B cell activation in vivo by immunization or infection...

 
Overexpression of BSAP/Pax-5 inhibits switching to IgA and enhances switching to IgE in the I.29 mu B cell line (with G. Qiu), Journal of immunology (Baltimore, Md. : 1950) (1998)

B cell-specific activator protein (BSAP)/Pax-5 is a paired domain DNA-binding protein expressed in the developing...

 
CD40 cross-linking induces Ig epsilon germline transcripts in B cells via activation of NF-kappaB: synergy with IL-4 induction (with L. A. Iciek and S. A. Delphin), Journal of immunology (Baltimore, Md. : 1950) (1997)

Transcription of unrearranged (germline) Ig heavy chain C region (C(H)) genes is required before Ab...

 
Activation of NF-kappaB/Rel by CD40 engagement induces the mouse germ line immunoglobulin Cgamma1 promoter (with S. C. Lin), Molecular and cellular biology (1996)

Interaction between CD40 on B cells and CD40 ligand (CD40L) on T cells has been...

 
Antibody class switching, Advances in immunology (1996)

No abstract provided.

 
Mouse CD6: sequence of cDNA and expression of mRNA (with A. Pal, P. L. Romain, N. G. Singer, and D. Fox), Immunology letters (1996)

No abstract provided.

 
Regulation of antibody class switching to IgE: characterization of an IL-4-responsive region in the immunoglobulin heavy-chain germline epsilon promoter (with S. Delphin), Annals of the New York Academy of Sciences (1995)

A large body of data indicate that antibody class switching is directed by cytokines by...

 
Cell cycle regulation of immunoglobulin class switch recombination and germ-line transcription: potential role of Ets family members (with M. Lundgren, L. Strom, L. O. Bergquist, S. Skog, T. Heiden, and E. Severinson), European journal of immunology (1995)

Previous studies have indicated that transcription of germ-line (GL) CH genes is necessary to obtain...

 
Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50 (with S. Delphin), The Journal of experimental medicine (1995)

A large body of data indicate that antibody class switching is directed by cytokines by...

 
Activation of the Ig germ-line gamma 1 promoter. Involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site (with M. Lundgren, C. Larsson, A. Femino, M. Xu, and E. Severinson), Journal of immunology (Baltimore, Md. : 1950) (1994)

Ig isotype switching in B lymphocytes is preceded by transcription of the corresponding unrearranged, or...

 
Regulation of transcription of the germ-line Ig alpha constant region gene by an ATF element and by novel transforming growth factor-beta 1-responsive elements (with Y. C. Lin), Journal of immunology (Baltimore, Md. : 1950) (1992)

Inasmuch as transcription of unrearranged, or germ-line, Ig CH genes appears to direct switch recombination,...

 
Regulation of transcription of immunoglobulin germ-line gamma 1 RNA: analysis of the promoter/enhancer (with M. Z. Xu), The EMBO journal (1992)

Antibody class switching is achieved by recombinations between switch (S) regions which consist of tandemly...

 
Regulation of transcription of the germline immunoglobulin alpha constant region gene (with Y. C. Lin and P. Shockett), Current topics in microbiology and immunology (1992)

No abstract provided.

 
Triple helix stabilization, Nature (1991)

No abstract provided.

 
Copy choice mechanism of immunoglobulin heavy-chain switch recombination (with W. Dunnick), Molecular and cellular biology (1990)

The immunoglobulin heavy-chain switch is mediated by a recombination event between DNA switch regions associated...

 
Structure of germ line immunoglobulin alpha heavy-chain RNA and its location on polysomes (with G. Radcliffe, Y. C. Lin, M. Julius, and K. B. Marcu), Molecular and cellular biology (1990)

We describe the structure of the major germ line RNA transcribed from unrearranged immunoglobulin alpha...

 
Structure of germline immunoglobulin heavy-chain gamma 1 transcripts in interleukin 4 treated mouse spleen cells (with M. Xu), Developmental immunology (1990)

Antibody class switching is mediated by a DNA recombination event that replaces the C mu...

 
Mouse antibody response to group A streptococcal carbohydrate (with C. D. Jarvis and L. E. Cannon), Journal of immunology (Baltimore, Md. : 1950) (1989)

In an attempt to more fully understand the generation of antibody diversity to carbohydrate (CHO)...

 
A B-cell-specific nuclear protein that binds to DNA sites 5' to immunoglobulin S alpha tandem repeats is regulated during differentiation (with S. H. Waters and K. U. Saikh), Molecular and cellular biology (1989)

Immunoglobulin heavy-chain switching is effected by recombination events between sites associated with tandemly repeated switch...

 
Mutations, duplication, and deletion of recombined switch regions suggest a role for DNA replication in the immunoglobulin heavy-chain switch (with W. Dunnick and M. Wilson), Molecular and cellular biology (1989)

The heavy-chain switch from immunoglobulin M (IgM) expression to IgA expression is mediated by a...

 
The J kappa proximal region of the human K locus contains three uncommon V kappa genes which are arranged in opposite transcriptional polarities (with W. Lorenz, K. F. Schable, R. Thiebe, and H. G. Zachau), Molecular immunology (1988)

The structure of one of the V kappa gene-containing regions of the locus coding for...

 
I.29 lymphoma cells express a nonmutated VH gene before and after H chain switch (with D. Klein, J. Nietupski, and S. Sirlin), Journal of immunology (Baltimore, Md. : 1950) (1988)

The I.29 B cell lymphoma consists of IgM+ and IgA+ cells which express the same...

 

PDF

Presence of a polyadenylated RNA fragment encoding the membrane domain for immunoglobulin alpha chain indicates that mRNAs for both secreted and membrane-bound alpha chains can be produced from the same RNA transcript, Nucleic acids research (1986)

RNA blotting was employed to examine polyadenylated immunoglobulin alpha chain RNAs in a B lymphoma...

 
Molecular defects in a human immunoglobulin kappa chain deficiency (with O. Kekish and B. J. Zegers), Science (New York, N.Y.) (1985)

The molecular basis of a human immunoglobulin deficiency characterized by the complete absence of kappa...

 

PDF

Aberrant recombination events in B cell lines derived from a kappa-deficient human (with O. Kekish, D. Batter, J. Grenier, I. Balazs, E. Henderson, and B. J. Zegers), Nucleic acids research (1985)

We have analyzed the structure of Ig kappa chain genes in B cell lines derived...

 
Rearrangements and deletions of immunoglobulin heavy chain genes in the double-producing B cell lymphoma I.29 (with K. B. Marcu, S. Sirlin, B. Alhadeff, and U. Hammerling), Molecular and cellular biology (1982)

The B cell lymphoma I.29 consists of a mixture of cells expressing membrane-bound immunoglobulin M...

 
Isolation of messenger RNA for an immunoglobulin kappa chain and enumeration of the genes for the constatn region of kappa chain in the mouse (with R. C. Huang, E. Stavnezer, and J. M. Bishop), Journal of molecular biology (1974)

No abstract provided.

 
Synthesis of a deoxyribonucleic acid sequence complementary to ovalbumin messenger ribonucleic acid and quantification of ovalbumin genes (with D. Sullivan, R. Palacios, J. M. Taylor, A. J. Faras, M. L. Kiely, N. M. Summers, J. M. Bishop, and R. T. Schimke), The Journal of biological chemistry (1973)

No abstract provided.

 

Basic-Leucine Zipper Transcription Factors

Differential regulation of mouse germline Ig gamma 1 and epsilon promoters by IL-4 and CD40 (with C. S. Mao), Journal of immunology (Baltimore, Md. : 1950) (2001)

Before Ig class switching, RNA transcription through the specific S regions undergoing recombination is induced...

 

Binding Sites

The histone methyltransferase Suv39h1 increases class switch recombination specifically to IgA (with Sean P. Bradley, Denise A. Kaminski, Antoine H. F. M. Peters, and Thomas Jenuwein), Journal of immunology (Baltimore, Md. : 1950) (2006)

Ab class (isotype) switching allows the humoral immune system to adaptively respond to different infectious...

 
Differential regulation of mouse germline Ig gamma 1 and epsilon promoters by IL-4 and CD40 (with C. S. Mao), Journal of immunology (Baltimore, Md. : 1950) (2001)

Before Ig class switching, RNA transcription through the specific S regions undergoing recombination is induced...

 
Roles of Ets proteins, NF-kappa B and nocodazole in regulating induction of transcription of mouse germline Ig alpha RNA by transforming growth factor-beta 1 (with M. J. Shi, S. R. Park, and P. H. Kim), International immunology (2001)

Antibody class switch recombination (CSR) occurs after antigen activation of B cells. CSR is directed...

 
Overexpression of BSAP/Pax-5 inhibits switching to IgA and enhances switching to IgE in the I.29 mu B cell line (with G. Qiu), Journal of immunology (Baltimore, Md. : 1950) (1998)

B cell-specific activator protein (BSAP)/Pax-5 is a paired domain DNA-binding protein expressed in the developing...

 
Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription (with Ching-Hung Shen), Molecular and cellular biology (1998)

Signal transducer and activator of transcription 6 (Stat6) and NF-kappaB are widely distributed transcription factors...

 
CD40 cross-linking induces Ig epsilon germline transcripts in B cells via activation of NF-kappaB: synergy with IL-4 induction (with L. A. Iciek and S. A. Delphin), Journal of immunology (Baltimore, Md. : 1950) (1997)

Transcription of unrearranged (germline) Ig heavy chain C region (C(H)) genes is required before Ab...

 
Activation of NF-kappaB/Rel by CD40 engagement induces the mouse germ line immunoglobulin Cgamma1 promoter (with S. C. Lin), Molecular and cellular biology (1996)

Interaction between CD40 on B cells and CD40 ligand (CD40L) on T cells has been...

 
Regulation of antibody class switching to IgE: characterization of an IL-4-responsive region in the immunoglobulin heavy-chain germline epsilon promoter (with S. Delphin), Annals of the New York Academy of Sciences (1995)

A large body of data indicate that antibody class switching is directed by cytokines by...

 
Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50 (with S. Delphin), The Journal of experimental medicine (1995)

A large body of data indicate that antibody class switching is directed by cytokines by...

 
Activation of the Ig germ-line gamma 1 promoter. Involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site (with M. Lundgren, C. Larsson, A. Femino, M. Xu, and E. Severinson), Journal of immunology (Baltimore, Md. : 1950) (1994)

Ig isotype switching in B lymphocytes is preceded by transcription of the corresponding unrearranged, or...

 

Blood Proteins

Differential regulation of mouse germline Ig gamma 1 and epsilon promoters by IL-4 and CD40 (with C. S. Mao), Journal of immunology (Baltimore, Md. : 1950) (2001)

Before Ig class switching, RNA transcription through the specific S regions undergoing recombination is induced...

 
Regulation of transcription of the germ-line Ig alpha constant region gene by an ATF element and by novel transforming growth factor-beta 1-responsive elements (with Y. C. Lin), Journal of immunology (Baltimore, Md. : 1950) (1992)

Inasmuch as transcription of unrearranged, or germ-line, Ig CH genes appears to direct switch recombination,...

 

Blotting, Southern

Switch recombination in a transfected plasmid occurs preferentially in a B cell line that undergoes switch recombination of its chromosomal Ig heavy chain genes (with Sean P. Bradley, Norman Rousseau, Todd Pearson, Ananth Shanmugam, Debra J. Waite, Paul R. Rogers, and Amy L. Kenter), Journal of immunology (Baltimore, Md. : 1950) (1999)

Ab class switching is induced upon B cell activation in vivo by immunization or infection...

 
Reticulum cell sarcomas of SJL mice have rearranged immunoglobulin heavy and light chain genes (with J. L. Lasky, N. M. Ponzio, M. P. Scheid, and G. J. Thorbecke), European journal of immunology (1989)

The immunoglobulin (Ig) heavy (H) and light (L) chain gene rearrangements of the high incidence...

 

Bone Morphogenetic Proteins

Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter (with J. Hanai, L. F. Chen, T. Kanno, N. Ohtani-Fujita, W. Y. Kim, W. H. Guo, T. Imamura, Y. Ishidou, M. Fukuchi, M. J. Shi, M. Kawabata, K. Miyazono, and Y. Ito), The Journal of biological chemistry (1999)

Smads are signal transducers for members of the transforming growth factor-beta (TGF-beta) superfamily. Upon ligand...

 

Carbon Isotopes

Letter: Translation of messenger RNA for mouse immunoglobulin light chains in living frog oocytes (with M. Smith, R. C. Huang, J. B. Gurdon, and C. D. Lane), Journal of molecular biology (1973)

No abstract provided.

 

Carbon Radioisotopes

Isolation of messenger RNA for an immunoglobulin kappa chain and enumeration of the genes for the constatn region of kappa chain in the mouse (with R. C. Huang, E. Stavnezer, and J. M. Bishop), Journal of molecular biology (1974)

No abstract provided.

 

Carrier Proteins

Mlh1 can function in antibody class switch recombination independently of Msh2 (with Carol E. Schrader and Joycelyn Vardo), The Journal of experimental medicine (2003)

Mismatch repair proteins participate in antibody class switch recombination, although their roles are unknown. Previous...

 
Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions (with Carol E. Schrader and Joycelyn Vardo), The Journal of experimental medicine (2002)

B cells from mice deficient in mismatch repair (MMR) proteins show decreased ability to undergo...

 
Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes (with Carol E. Schrader, W. Edelmann, and R. Kucherlapati), The Journal of experimental medicine (1999)

Mice deficient in various mismatch repair (MMR) enzymes were examined to determine whether this repair...

 

CCAAT-Enhancer-Binding Proteins

Differential regulation of mouse germline Ig gamma 1 and epsilon promoters by IL-4 and CD40 (with C. S. Mao), Journal of immunology (Baltimore, Md. : 1950) (2001)

Before Ig class switching, RNA transcription through the specific S regions undergoing recombination is induced...

 
Activation of the mouse Ig germline epsilon promoter by IL-4 is dependent on AP-1 transcription factors (with Ching-Hung Shen), Journal of immunology (Baltimore, Md. : 1950) (2000)

Induction of germline (GL) epsilon transcripts, an essential step preceding Ig isotype switching to IgE,...

 
Regulation of the promoter for human immunoglobulin gamma3 germ-line transcription and its interaction with the 3'alpha enhancer (with Q. Pan, C. Petit-Frere, and L. Hammarstrom), European journal of immunology (2000)

The mechanism underlying the differential regulation of switching to human IgG subclasses is still largely...

 
Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50 (with S. Delphin), The Journal of experimental medicine (1995)

A large body of data indicate that antibody class switching is directed by cytokines by...

 
Activation of the Ig germ-line gamma 1 promoter. Involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site (with M. Lundgren, C. Larsson, A. Femino, M. Xu, and E. Severinson), Journal of immunology (Baltimore, Md. : 1950) (1994)

Ig isotype switching in B lymphocytes is preceded by transcription of the corresponding unrearranged, or...

 

CD40 Ligand

Activation of the mouse Ig germline epsilon promoter by IL-4 is dependent on AP-1 transcription factors (with Ching-Hung Shen), Journal of immunology (Baltimore, Md. : 1950) (2000)

Induction of germline (GL) epsilon transcripts, an essential step preceding Ig isotype switching to IgE,...

 
The ability of CD40L, but not lipopolysaccharide, to initiate immunoglobulin switching to immunoglobulin G1 is explained by differential induction of NF-kappaB/Rel proteins (with S. C. Lin and H. H. Wortis), Molecular and cellular biology (1998)

Antibodies of the immunoglobulin G1 class are induced in mice by T-cell-dependent antigens but not...

 
CD40 cross-linking induces Ig epsilon germline transcripts in B cells via activation of NF-kappaB: synergy with IL-4 induction (with L. A. Iciek and S. A. Delphin), Journal of immunology (Baltimore, Md. : 1950) (1997)

Transcription of unrearranged (germline) Ig heavy chain C region (C(H)) genes is required before Ab...

 
Activation of NF-kappaB/Rel by CD40 engagement induces the mouse germ line immunoglobulin Cgamma1 promoter (with S. C. Lin), Molecular and cellular biology (1996)

Interaction between CD40 on B cells and CD40 ligand (CD40L) on T cells has been...

 

Cell Cycle

Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes (with Carol E. Schrader, W. Edelmann, and R. Kucherlapati), The Journal of experimental medicine (1999)

Mice deficient in various mismatch repair (MMR) enzymes were examined to determine whether this repair...

 

Cell Differentiation

Antibody class switching, Advances in immunology (1996)

No abstract provided.

 
Expression of immunoglobulin lambda light chain by the promyelocytic cell line HL-60 (with A. Al-Katib and B. Koziner), Journal of immunology (Baltimore, Md. : 1950) (1986)

The HL-60 cell line, established from a patient with acute promyelocytic leukemia, can be induced...

 
Surface immunoglobulin light-chain expression by the "common" all cell line REH (with B. Koziner and A. Al-Katib), Clinical immunology and immunopathology (1985)

To provide further support of the B-cell lineage of "common" acute lymphoblastic leukemia (ALL), we...

 
Molecular genetics of immunoglobulin heavy chain switching, Survey of immunologic research (1983)

No abstract provided.

 

Cell Division

Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes (with Carol E. Schrader, W. Edelmann, and R. Kucherlapati), The Journal of experimental medicine (1999)

Mice deficient in various mismatch repair (MMR) enzymes were examined to determine whether this repair...

 

Cell Line

The ubiquitously expressed DNA-binding protein late SV40 factor binds Ig switch regions and represses class switching to IgA (with Elise E. Drouin, Carol E. Schrader, and Ulla Hansen), Journal of immunology (Baltimore, Md. : 1950) (2002)

Ig heavy chain class switch recombination (CSR) determines the expression of Ig isotypes. The molecular...

 
Differential regulation of mouse germline Ig gamma 1 and epsilon promoters by IL-4 and CD40 (with C. S. Mao), Journal of immunology (Baltimore, Md. : 1950) (2001)

Before Ig class switching, RNA transcription through the specific S regions undergoing recombination is induced...

 
Activation of the mouse Ig germline epsilon promoter by IL-4 is dependent on AP-1 transcription factors (with Ching-Hung Shen), Journal of immunology (Baltimore, Md. : 1950) (2000)

Induction of germline (GL) epsilon transcripts, an essential step preceding Ig isotype switching to IgE,...

 
Evidence for class-specific factors in immunoglobulin isotype switching (with A. Shanmugam, M. J. Shi, L. Yauch, and A. L. Kenter), The Journal of experimental medicine (2000)

Immunoglobulin class switch recombination (SR) occurs by a B cell-specific, intrachromosomal deletional process between switch...

 
Switch recombination in a transfected plasmid occurs preferentially in a B cell line that undergoes switch recombination of its chromosomal Ig heavy chain genes (with Sean P. Bradley, Norman Rousseau, Todd Pearson, Ananth Shanmugam, Debra J. Waite, Paul R. Rogers, and Amy L. Kenter), Journal of immunology (Baltimore, Md. : 1950) (1999)

Ab class switching is induced upon B cell activation in vivo by immunization or infection...

 
Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription (with Ching-Hung Shen), Molecular and cellular biology (1998)

Signal transducer and activator of transcription 6 (Stat6) and NF-kappaB are widely distributed transcription factors...

 
Activation of the Ig germ-line gamma 1 promoter. Involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site (with M. Lundgren, C. Larsson, A. Femino, M. Xu, and E. Severinson), Journal of immunology (Baltimore, Md. : 1950) (1994)

Ig isotype switching in B lymphocytes is preceded by transcription of the corresponding unrearranged, or...

 
Inhibitors of poly(ADP-ribose) polymerase increase antibody class switching (with P. Shockett), Journal of immunology (Baltimore, Md. : 1950) (1993)

Previous studies suggest that heavy chain isotype switch (S) recombination is directed by cytokine-induced transcription...

 
Regulation of transcription of the germ-line Ig alpha constant region gene by an ATF element and by novel transforming growth factor-beta 1-responsive elements (with Y. C. Lin), Journal of immunology (Baltimore, Md. : 1950) (1992)

Inasmuch as transcription of unrearranged, or germ-line, Ig CH genes appears to direct switch recombination,...

 
Regulation of the antibody class switch to IgA (with Y. C. Lin and P. Shockett), Immunologic research (1991)

No abstract provided.

 
Structure of germ line immunoglobulin alpha heavy-chain RNA and its location on polysomes (with G. Radcliffe, Y. C. Lin, M. Julius, and K. B. Marcu), Molecular and cellular biology (1990)

We describe the structure of the major germ line RNA transcribed from unrearranged immunoglobulin alpha...

 
Mouse antibody response to group A streptococcal carbohydrate (with C. D. Jarvis and L. E. Cannon), Journal of immunology (Baltimore, Md. : 1950) (1989)

In an attempt to more fully understand the generation of antibody diversity to carbohydrate (CHO)...

 
A B-cell-specific nuclear protein that binds to DNA sites 5' to immunoglobulin S alpha tandem repeats is regulated during differentiation (with S. H. Waters and K. U. Saikh), Molecular and cellular biology (1989)

Immunoglobulin heavy-chain switching is effected by recombination events between sites associated with tandemly repeated switch...

 
I.29 lymphoma cells express a nonmutated VH gene before and after H chain switch (with D. Klein, J. Nietupski, and S. Sirlin), Journal of immunology (Baltimore, Md. : 1950) (1988)

The I.29 B cell lymphoma consists of IgM+ and IgA+ cells which express the same...

 
Expression of immunoglobulin lambda light chain by the promyelocytic cell line HL-60 (with A. Al-Katib and B. Koziner), Journal of immunology (Baltimore, Md. : 1950) (1986)

The HL-60 cell line, established from a patient with acute promyelocytic leukemia, can be induced...

 
Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching (with S. Sirlin), The EMBO journal (1986)

IgM+ cells cultured from the I.29 B cell lymphoma can be induced with lipopolysaccharide (LPS)...

 
Surface immunoglobulin light-chain expression by the "common" all cell line REH (with B. Koziner and A. Al-Katib), Clinical immunology and immunopathology (1985)

To provide further support of the B-cell lineage of "common" acute lymphoblastic leukemia (ALL), we...

 
The regulation of membrane-bound and secreted alpha-chain biosynthesis during the differentiation of the B cell lymphoma I.29 (with R. Sitia, A. Rubartelli, H. Kikutani, and U. Hammerling), Journal of immunology (Baltimore, Md. : 1950) (1985)

The regulation of the synthesis of membrane-bound and secreted IgA was investigated in the murine...

 

PDF

Aberrant recombination events in B cell lines derived from a kappa-deficient human (with O. Kekish, D. Batter, J. Grenier, I. Balazs, E. Henderson, and B. J. Zegers), Nucleic acids research (1985)

We have analyzed the structure of Ig kappa chain genes in B cell lines derived...

 

File

Induction of immunoglobulin isotype switching in cultured I.29 B lymphoma cells. Characterization of the accompanying rearrangements of heavy chain genes (with S. Sirlin and J. Abbott), The Journal of experimental medicine (1985)

The murine B cell lymphoma I.29 contains cells expressing surface IgM or IgA with identical...

 
Immunoglobulin heavy chain switching in cultured I.29 murine B lymphoma cells: commitment to an IgA or IgE switch (with J. Abbott and S. Sirlin), Current topics in microbiology and immunology (1984)

No abstract provided.

 
Membrane-bound and secreted IgA contain structurally different alpha-chains (with R. Sitia, H. Kikutani, A. Rubartelli, Y. Bushkin, and U. Hammerling), Journal of immunology (Baltimore, Md. : 1950) (1982)

Three different forms of alpha-chains are synthesized by BF0.3 and 615.2, two cloned cell lines...

 
Synthesis and processing of the alpha heavy chains of secreted and membrane-bound IgA (with H. Kikutani, R. Sitia, and R. A. Good), Proceedings of the National Academy of Sciences of the United States of America (1981)

We have compared the synthesis and processing of immunoglobulin alpha chains in two murine cell...

 
Expression of an antigen receptor on T cells does not require recombination at the immunoglobulin JH-C mu locus (with Y. Cayre, M. A. Palladino, and K. B. Marcu), Proceedings of the National Academy of Sciences of the United States of America (1981)

Considerable evidence has accumulated suggesting that the antigen receptor(s) on T cells is coded for...

 
Synthesis and isolation of DNA complementary to nucleotide sequences encoding the variable region of immunoglobulin kappa chain (with J. M. Bishop), Biochemistry (1977)

No abstract provided.

 
Detection and characterization of RNA tumor virus-specific DNA in cells (with H. E. Varmus, E. Medeiros, and J. M. Bishop), Bibliotheca haematologica (1975)

RNA tumor virus-specific DNA in cells can be detected by its capacity to 1) alter...

 
Isolation of messenger RNA for an immunoglobulin kappa chain and enumeration of the genes for the constatn region of kappa chain in the mouse (with R. C. Huang, E. Stavnezer, and J. M. Bishop), Journal of molecular biology (1974)

No abstract provided.

 
Letter: Translation of messenger RNA for mouse immunoglobulin light chains in living frog oocytes (with M. Smith, R. C. Huang, J. B. Gurdon, and C. D. Lane), Journal of molecular biology (1973)

No abstract provided.

 

Cell Nucleus

Differential regulation of mouse germline Ig gamma 1 and epsilon promoters by IL-4 and CD40 (with C. S. Mao), Journal of immunology (Baltimore, Md. : 1950) (2001)

Before Ig class switching, RNA transcription through the specific S regions undergoing recombination is induced...

 

Cell Proliferation

Antibody class switching differs among SJL, C57BL/6 and 129 mice (with Denise A. Kaminski), International immunology (2007)

Inbred mouse strains used for gene manipulation studies vary in many respects, including immune system...

 

Cell Separation

Surface immunoglobulin light-chain expression by the "common" all cell line REH (with B. Koziner and A. Al-Katib), Clinical immunology and immunopathology (1985)

To provide further support of the B-cell lineage of "common" acute lymphoblastic leukemia (ALL), we...

 

File

Induction of immunoglobulin isotype switching in cultured I.29 B lymphoma cells. Characterization of the accompanying rearrangements of heavy chain genes (with S. Sirlin and J. Abbott), The Journal of experimental medicine (1985)

The murine B cell lymphoma I.29 contains cells expressing surface IgM or IgA with identical...

 

Cell Survival

Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes (with Carol E. Schrader, W. Edelmann, and R. Kucherlapati), The Journal of experimental medicine (1999)

Mice deficient in various mismatch repair (MMR) enzymes were examined to determine whether this repair...

 

Cell Transformation, Neoplastic

The regulation of membrane-bound and secreted alpha-chain biosynthesis during the differentiation of the B cell lymphoma I.29 (with R. Sitia, A. Rubartelli, H. Kikutani, and U. Hammerling), Journal of immunology (Baltimore, Md. : 1950) (1985)

The regulation of the synthesis of membrane-bound and secreted IgA was investigated in the murine...

 

Cell-Free System

Synthesis of a mouse immunoglobulin light chain in a rabbit reticulocyte cell-free system (with R. C. Huang), Nature: New biology (1971)

No abstract provided.

 

Cells, Cultured

Stimuli that enhance IgA class switching increase histone 3 acetylation at S alpha, but poorly stimulate sequential switching from IgG2b (with Denise A. Kaminski), European journal of immunology (2006)

Germ-line (GL) alpha transcription can be induced in mouse splenic B cells by LPS and...

 
Enhanced IgA class switching in marginal zone and B1 B cells relative to follicular/B2 B cells (with Denise A. Kaminski), Journal of immunology (Baltimore, Md. : 1950) (2006)

Mouse splenic marginal zone (MZ) B cells and B1 B cells enriched in the peritoneal...

 
The histone methyltransferase Suv39h1 increases class switch recombination specifically to IgA (with Sean P. Bradley, Denise A. Kaminski, Antoine H. F. M. Peters, and Thomas Jenuwein), Journal of immunology (Baltimore, Md. : 1950) (2006)

Ab class (isotype) switching allows the humoral immune system to adaptively respond to different infectious...

 
Roles of Ets proteins, NF-kappa B and nocodazole in regulating induction of transcription of mouse germline Ig alpha RNA by transforming growth factor-beta 1 (with M. J. Shi, S. R. Park, and P. H. Kim), International immunology (2001)

Antibody class switch recombination (CSR) occurs after antigen activation of B cells. CSR is directed...

 
The mu switch region tandem repeats are important, but not required, for antibody class switch recombination (with Thomas M. Luby, Carol E. Schrader, and Erik Selsing), The Journal of experimental medicine (2001)

Class switch DNA recombinations change the constant (C) region of the antibody heavy (H) chain...

 
Activation of the mouse Ig germline epsilon promoter by IL-4 is dependent on AP-1 transcription factors (with Ching-Hung Shen), Journal of immunology (Baltimore, Md. : 1950) (2000)

Induction of germline (GL) epsilon transcripts, an essential step preceding Ig isotype switching to IgE,...

 
Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes (with Carol E. Schrader, W. Edelmann, and R. Kucherlapati), The Journal of experimental medicine (1999)

Mice deficient in various mismatch repair (MMR) enzymes were examined to determine whether this repair...

 
Effect of cytokines on switching to IgA and alpha germline transcripts in the B lymphoma I.29 mu. Transforming growth factor-beta activates transcription of the unrearranged C alpha gene (with P. Shockett), Journal of immunology (Baltimore, Md. : 1950) (1991)

H chain isotype switch recombination is preceded by the appearance of RNA initiating 5' of...

 
Interleukins 4 and 5: mechanisms of action (with E. Severinson, H. B. Moon, S. Bergstedt-Lindqvist, U. Persson, and C. Heusser), Advances in experimental medicine and biology (1989)

No abstract provided.

 

Centrifugation, Density Gradient

Synthesis of a mouse immunoglobulin light chain in a rabbit reticulocyte cell-free system (with R. C. Huang), Nature: New biology (1971)

No abstract provided.

 

Chemistry

Membrane-bound and secreted IgA contain structurally different alpha-chains (with R. Sitia, H. Kikutani, A. Rubartelli, Y. Bushkin, and U. Hammerling), Journal of immunology (Baltimore, Md. : 1950) (1982)

Three different forms of alpha-chains are synthesized by BF0.3 and 615.2, two cloned cell lines...

 
Synthesis of a deoxyribonucleic acid sequence complementary to ovalbumin messenger ribonucleic acid and quantification of ovalbumin genes (with D. Sullivan, R. Palacios, J. M. Taylor, A. J. Faras, M. L. Kiely, N. M. Summers, J. M. Bishop, and R. T. Schimke), The Journal of biological chemistry (1973)

No abstract provided.

 
Synthesis of a mouse immunoglobulin light chain in a rabbit reticulocyte cell-free system (with R. C. Huang), Nature: New biology (1971)

No abstract provided.

 

Chickens

Synthesis of a deoxyribonucleic acid sequence complementary to ovalbumin messenger ribonucleic acid and quantification of ovalbumin genes (with D. Sullivan, R. Palacios, J. M. Taylor, A. J. Faras, M. L. Kiely, N. M. Summers, J. M. Bishop, and R. T. Schimke), The Journal of biological chemistry (1973)

No abstract provided.

 

Chloramphenicol O-Acetyltransferase

The ability of CD40L, but not lipopolysaccharide, to initiate immunoglobulin switching to immunoglobulin G1 is explained by differential induction of NF-kappaB/Rel proteins (with S. C. Lin and H. H. Wortis), Molecular and cellular biology (1998)

Antibodies of the immunoglobulin G1 class are induced in mice by T-cell-dependent antigens but not...

 

Chromatin

The ubiquitously expressed DNA-binding protein late SV40 factor binds Ig switch regions and represses class switching to IgA (with Elise E. Drouin, Carol E. Schrader, and Ulla Hansen), Journal of immunology (Baltimore, Md. : 1950) (2002)

Ig heavy chain class switch recombination (CSR) determines the expression of Ig isotypes. The molecular...

 

Chromatography

Synthesis of a mouse immunoglobulin light chain in a rabbit reticulocyte cell-free system (with R. C. Huang), Nature: New biology (1971)

No abstract provided.

 

Chromosome Deletion

Reticulum cell sarcomas of SJL mice have rearranged immunoglobulin heavy and light chain genes (with J. L. Lasky, N. M. Ponzio, M. P. Scheid, and G. J. Thorbecke), European journal of immunology (1989)

The immunoglobulin (Ig) heavy (H) and light (L) chain gene rearrangements of the high incidence...

 
Mutations, duplication, and deletion of recombined switch regions suggest a role for DNA replication in the immunoglobulin heavy-chain switch (with W. Dunnick and M. Wilson), Molecular and cellular biology (1989)

The heavy-chain switch from immunoglobulin M (IgM) expression to IgA expression is mediated by a...

 

File

Induction of immunoglobulin isotype switching in cultured I.29 B lymphoma cells. Characterization of the accompanying rearrangements of heavy chain genes (with S. Sirlin and J. Abbott), The Journal of experimental medicine (1985)

The murine B cell lymphoma I.29 contains cells expressing surface IgM or IgA with identical...

 
Molecular genetics of immunoglobulin heavy chain switching, Survey of immunologic research (1983)

No abstract provided.

 

Chromosome Mapping

Inhibitors of poly(ADP-ribose) polymerase increase antibody class switching (with P. Shockett), Journal of immunology (Baltimore, Md. : 1950) (1993)

Previous studies suggest that heavy chain isotype switch (S) recombination is directed by cytokine-induced transcription...

 
Genetic structure and origin of t haplotypes of mice, analyzed with H-2 cDNA probes (with H. S. Shin, K. Artzt, and D. Bennett), Cell (1982)

We investigated the genetic organization and evolutionary origin of t chromosomes of mice by examining...

 

Chromosomes

Switch recombination in a transfected plasmid occurs preferentially in a B cell line that undergoes switch recombination of its chromosomal Ig heavy chain genes (with Sean P. Bradley, Norman Rousseau, Todd Pearson, Ananth Shanmugam, Debra J. Waite, Paul R. Rogers, and Amy L. Kenter), Journal of immunology (Baltimore, Md. : 1950) (1999)

Ab class switching is induced upon B cell activation in vivo by immunization or infection...

 
Synthesis of a deoxyribonucleic acid sequence complementary to ovalbumin messenger ribonucleic acid and quantification of ovalbumin genes (with D. Sullivan, R. Palacios, J. M. Taylor, A. J. Faras, M. L. Kiely, N. M. Summers, J. M. Bishop, and R. T. Schimke), The Journal of biological chemistry (1973)

No abstract provided.

 

Clone Cells

I.29 lymphoma cells express a nonmutated VH gene before and after H chain switch (with D. Klein, J. Nietupski, and S. Sirlin), Journal of immunology (Baltimore, Md. : 1950) (1988)

The I.29 B cell lymphoma consists of IgM+ and IgA+ cells which express the same...

 
Surface immunoglobulin light chain expression in pre-B cell leukemias (with B. Koziner, A. Al-Katib, D. Gebhard, A. Mittelman, M. Andreeff, and B. D. Clarkson), Annals of the New York Academy of Sciences (1986)

Cytofluorographic analysis of surface immunoglobulin (sIg) light chain clonal excess (CE), defined as (%kappa+ -...

 
Immunoglobulin heavy chain switching in cultured I.29 murine B lymphoma cells: commitment to an IgA or IgE switch (with J. Abbott and S. Sirlin), Current topics in microbiology and immunology (1984)

No abstract provided.

 
Rearrangements and deletions of immunoglobulin heavy chain genes in the double-producing B cell lymphoma I.29 (with K. B. Marcu, S. Sirlin, B. Alhadeff, and U. Hammerling), Molecular and cellular biology (1982)

The B cell lymphoma I.29 consists of a mixture of cells expressing membrane-bound immunoglobulin M...

 

Cloning, Molecular

Switch recombination in a transfected plasmid occurs preferentially in a B cell line that undergoes switch recombination of its chromosomal Ig heavy chain genes (with Sean P. Bradley, Norman Rousseau, Todd Pearson, Ananth Shanmugam, Debra J. Waite, Paul R. Rogers, and Amy L. Kenter), Journal of immunology (Baltimore, Md. : 1950) (1999)

Ab class switching is induced upon B cell activation in vivo by immunization or infection...

 
Mouse CD6: sequence of cDNA and expression of mRNA (with A. Pal, P. L. Romain, N. G. Singer, and D. Fox), Immunology letters (1996)

No abstract provided.

 
Copy choice mechanism of immunoglobulin heavy-chain switch recombination (with W. Dunnick), Molecular and cellular biology (1990)

The immunoglobulin heavy-chain switch is mediated by a recombination event between DNA switch regions associated...

 
A B-cell-specific nuclear protein that binds to DNA sites 5' to immunoglobulin S alpha tandem repeats is regulated during differentiation (with S. H. Waters and K. U. Saikh), Molecular and cellular biology (1989)

Immunoglobulin heavy-chain switching is effected by recombination events between sites associated with tandemly repeated switch...

 
I.29 lymphoma cells express a nonmutated VH gene before and after H chain switch (with D. Klein, J. Nietupski, and S. Sirlin), Journal of immunology (Baltimore, Md. : 1950) (1988)

The I.29 B cell lymphoma consists of IgM+ and IgA+ cells which express the same...

 

PDF

Aberrant recombination events in B cell lines derived from a kappa-deficient human (with O. Kekish, D. Batter, J. Grenier, I. Balazs, E. Henderson, and B. J. Zegers), Nucleic acids research (1985)

We have analyzed the structure of Ig kappa chain genes in B cell lines derived...

 

File

Induction of immunoglobulin isotype switching in cultured I.29 B lymphoma cells. Characterization of the accompanying rearrangements of heavy chain genes (with S. Sirlin and J. Abbott), The Journal of experimental medicine (1985)

The murine B cell lymphoma I.29 contains cells expressing surface IgM or IgA with identical...

 
Genetic structure and origin of t haplotypes of mice, analyzed with H-2 cDNA probes (with H. S. Shin, K. Artzt, and D. Bennett), Cell (1982)

We investigated the genetic organization and evolutionary origin of t chromosomes of mice by examining...

 

Consensus Sequence

Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50 (with S. Delphin), The Journal of experimental medicine (1995)

A large body of data indicate that antibody class switching is directed by cytokines by...

 

Core Binding Factor Alpha 3 Subunit

Analysis of transforming growth factor-beta1-induced Ig germ-line gamma2b transcription and its implication for IgA isotype switching (with Seok-Rae Park, Goo-Young Seo, Ae-Jin Choi, and Pyeung-Hyeun Kim), European journal of immunology (2005)

Transforming growth factor (TGF)-beta1 directs class switch recombination (CSR) to IgG2b as well as to...

 

Core Binding Factors

CBF alpha3 (AML2) is induced by TGF-beta1 to bind and activate the mouse germline Ig alpha promoter (with M. J. Shi), Journal of immunology (Baltimore, Md. : 1950) (1998)

TGF-beta1 directs class switching to IgA by splenic B cells and by the surface IgM+...

 

Crosses, Genetic

Cognate T cell help for CD40-deficient B cells induces c-myc RNA expression, but DNA synthesis requires an additional signal through surface Ig (with Carol E. Schrader, H. Kikutani, and D. C. Parker), Journal of immunology (Baltimore, Md. : 1950) (1997)

To investigate the role of CD40 ligand in the delivery of help to B cells,...

 

Cyclic AMP

Inhibitors of poly(ADP-ribose) polymerase increase antibody class switching (with P. Shockett), Journal of immunology (Baltimore, Md. : 1950) (1993)

Previous studies suggest that heavy chain isotype switch (S) recombination is directed by cytokine-induced transcription...

 

Cyclic AMP Response Element-Binding

Differential regulation of mouse germline Ig gamma 1 and epsilon promoters by IL-4 and CD40 (with C. S. Mao), Journal of immunology (Baltimore, Md. : 1950) (2001)

Before Ig class switching, RNA transcription through the specific S regions undergoing recombination is induced...

 

Cytidine Deaminase

Mismatch repair converts AID-instigated nicks to double-strand breaks for antibody class-switch recombination (with Carol E. Schrader), Trends in genetics : TIG (2005)

Mismatch repair (MMR) proteins are important for antibody class-switch recombination (CSR), but their roles are...

 
Inducible DNA breaks in Ig S regions are dependent on AID and UNG (with Carol E. Schrader, Erin K. Linehan, Sofia N. Mochegova, and Robert T. Woodland), The Journal of experimental medicine (2005)

Class switch recombination (CSR) occurs by an intrachromosomal deletion whereby the IgM constant region gene...

 
Evolution of isotype switching (with Chris T. Amemiya), Seminars in immunology (2004)

This review discusses evolution of the process of Ig heavy chain class switching, relating it...

 
Antibody class switching: uncoupling S region accessibility from transcription (with Denise A. Kaminski), Trends in genetics : TIG (2004)

Immunogloblin class switch recombination (CSR) is a regulated process that changes antibody effector functions. Recently,...

 
Immunoglobulin genes: generating diversity with AID and UNG (with Ursula Storb), Current biology : CB (2002)

Somatic hypermutation and switch recombination of immunoglobulin genes require the activity of the activation-induced deaminase,...

 
Does activation-induced deaminase initiate antibody diversification by DNA deamination (with Sean P. Bradley), Trends in genetics : TIG (2002)

Activation-induced deaminase (AID) is expressed only in germinal center B cells. There, it is required...

 

Cytidine Deaminase/*metabolism

DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination (with Xiaoming Wu), The Journal of experimental medicine (2007)

Immunoglobulin (Ig) class switch recombination (CSR) is initiated by activation-induced cytidine deaminase (AID), which converts...

 

Cytokines

Immunology. A touch of antibody class, Science (New York, N.Y.) (2000)

When B cells, the antibody producing cells of the body, encounter antigen they switch from...

 
Molecular processes that regulate class switching, Current topics in microbiology and immunology (1999)

No abstract provided.

 

Cytosine/metabolism

DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination (with Xiaoming Wu), The Journal of experimental medicine (2007)

Immunoglobulin (Ig) class switch recombination (CSR) is initiated by activation-induced cytidine deaminase (AID), which converts...

 

Dextrans

Stimuli that enhance IgA class switching increase histone 3 acetylation at S alpha, but poorly stimulate sequential switching from IgG2b (with Denise A. Kaminski), European journal of immunology (2006)

Germ-line (GL) alpha transcription can be induced in mouse splenic B cells by LPS and...

 
Enhanced IgA class switching in marginal zone and B1 B cells relative to follicular/B2 B cells (with Denise A. Kaminski), Journal of immunology (Baltimore, Md. : 1950) (2006)

Mouse splenic marginal zone (MZ) B cells and B1 B cells enriched in the peritoneal...

 

Diploidy

Synthesis of a deoxyribonucleic acid sequence complementary to ovalbumin messenger ribonucleic acid and quantification of ovalbumin genes (with D. Sullivan, R. Palacios, J. M. Taylor, A. J. Faras, M. L. Kiely, N. M. Summers, J. M. Bishop, and R. T. Schimke), The Journal of biological chemistry (1973)

No abstract provided.

 

DNA

Inducible DNA breaks in Ig S regions are dependent on AID and UNG (with Carol E. Schrader, Erin K. Linehan, Sofia N. Mochegova, and Robert T. Woodland), The Journal of experimental medicine (2005)

Class switch recombination (CSR) occurs by an intrachromosomal deletion whereby the IgM constant region gene...

 
Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination (with Carol E. Schrader, Sean P. Bradley, Joycelyn Vardo, Sofia N. Mochegova, and Erin Flanagan), The EMBO journal (2003)

Nucleotide substitutions are found in recombined Ig switch (S) regions and also in unrecombined (germline,...

 
Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions (with Carol E. Schrader and Joycelyn Vardo), The Journal of experimental medicine (2002)

B cells from mice deficient in mismatch repair (MMR) proteins show decreased ability to undergo...

 
The mu switch region tandem repeats are important, but not required, for antibody class switch recombination (with Thomas M. Luby, Carol E. Schrader, and Erik Selsing), The Journal of experimental medicine (2001)

Class switch DNA recombinations change the constant (C) region of the antibody heavy (H) chain...

 
Immunology. A touch of antibody class, Science (New York, N.Y.) (2000)

When B cells, the antibody producing cells of the body, encounter antigen they switch from...

 
Evidence for class-specific factors in immunoglobulin isotype switching (with A. Shanmugam, M. J. Shi, L. Yauch, and A. L. Kenter), The Journal of experimental medicine (2000)

Immunoglobulin class switch recombination (SR) occurs by a B cell-specific, intrachromosomal deletional process between switch...

 
Regulation of the promoter for human immunoglobulin gamma3 germ-line transcription and its interaction with the 3'alpha enhancer (with Q. Pan, C. Petit-Frere, and L. Hammarstrom), European journal of immunology (2000)

The mechanism underlying the differential regulation of switching to human IgG subclasses is still largely...

 
Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription (with Ching-Hung Shen), Molecular and cellular biology (1998)

Signal transducer and activator of transcription 6 (Stat6) and NF-kappaB are widely distributed transcription factors...

 
Antibody class switching, Advances in immunology (1996)

No abstract provided.

 
Regulation of transcription of the germline immunoglobulin alpha constant region gene (with Y. C. Lin and P. Shockett), Current topics in microbiology and immunology (1992)

No abstract provided.

 
Triple helix stabilization, Nature (1991)

No abstract provided.

 
Regulation of the antibody class switch to IgA (with Y. C. Lin and P. Shockett), Immunologic research (1991)

No abstract provided.

 
Copy choice mechanism of immunoglobulin heavy-chain switch recombination (with W. Dunnick), Molecular and cellular biology (1990)

The immunoglobulin heavy-chain switch is mediated by a recombination event between DNA switch regions associated...

 
Structure of germline immunoglobulin heavy-chain gamma 1 transcripts in interleukin 4 treated mouse spleen cells (with M. Xu), Developmental immunology (1990)

Antibody class switching is mediated by a DNA recombination event that replaces the C mu...

 
A B-cell-specific nuclear protein that binds to DNA sites 5' to immunoglobulin S alpha tandem repeats is regulated during differentiation (with S. H. Waters and K. U. Saikh), Molecular and cellular biology (1989)

Immunoglobulin heavy-chain switching is effected by recombination events between sites associated with tandemly repeated switch...

 
Mutations, duplication, and deletion of recombined switch regions suggest a role for DNA replication in the immunoglobulin heavy-chain switch (with W. Dunnick and M. Wilson), Molecular and cellular biology (1989)

The heavy-chain switch from immunoglobulin M (IgM) expression to IgA expression is mediated by a...

 
The J kappa proximal region of the human K locus contains three uncommon V kappa genes which are arranged in opposite transcriptional polarities (with W. Lorenz, K. F. Schable, R. Thiebe, and H. G. Zachau), Molecular immunology (1988)

The structure of one of the V kappa gene-containing regions of the locus coding for...

 

File

Induction of immunoglobulin isotype switching in cultured I.29 B lymphoma cells. Characterization of the accompanying rearrangements of heavy chain genes (with S. Sirlin and J. Abbott), The Journal of experimental medicine (1985)

The murine B cell lymphoma I.29 contains cells expressing surface IgM or IgA with identical...

 
Rearrangements and deletions of immunoglobulin heavy chain genes in the double-producing B cell lymphoma I.29 (with K. B. Marcu, S. Sirlin, B. Alhadeff, and U. Hammerling), Molecular and cellular biology (1982)

The B cell lymphoma I.29 consists of a mixture of cells expressing membrane-bound immunoglobulin M...

 
Genetic structure and origin of t haplotypes of mice, analyzed with H-2 cDNA probes (with H. S. Shin, K. Artzt, and D. Bennett), Cell (1982)

We investigated the genetic organization and evolutionary origin of t chromosomes of mice by examining...

 
Isolation of messenger RNA for an immunoglobulin kappa chain and enumeration of the genes for the constatn region of kappa chain in the mouse (with R. C. Huang, E. Stavnezer, and J. M. Bishop), Journal of molecular biology (1974)

No abstract provided.

 

DNA Glycosylases

Inducible DNA breaks in Ig S regions are dependent on AID and UNG (with Carol E. Schrader, Erin K. Linehan, Sofia N. Mochegova, and Robert T. Woodland), The Journal of experimental medicine (2005)

Class switch recombination (CSR) occurs by an intrachromosomal deletion whereby the IgM constant region gene...

 

DNA Mutational Analysis

Regulation of transcription of immunoglobulin germ-line gamma 1 RNA: analysis of the promoter/enhancer (with M. Z. Xu), The EMBO journal (1992)

Antibody class switching is achieved by recombinations between switch (S) regions which consist of tandemly...

 

DNA Nucleotidylexotransferase

Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination (with Carol E. Schrader, Sean P. Bradley, Joycelyn Vardo, Sofia N. Mochegova, and Erin Flanagan), The EMBO journal (2003)

Nucleotide substitutions are found in recombined Ig switch (S) regions and also in unrecombined (germline,...

 

DNA Nucleotidyltransferases

Synthesis of a deoxyribonucleic acid sequence complementary to ovalbumin messenger ribonucleic acid and quantification of ovalbumin genes (with D. Sullivan, R. Palacios, J. M. Taylor, A. J. Faras, M. L. Kiely, N. M. Summers, J. M. Bishop, and R. T. Schimke), The Journal of biological chemistry (1973)

No abstract provided.

 

DNA Polymerase beta/deficiency/genetics/*physiology

DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination (with Xiaoming Wu), The Journal of experimental medicine (2007)

Immunoglobulin (Ig) class switch recombination (CSR) is initiated by activation-induced cytidine deaminase (AID), which converts...

 

DNA Primers

DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination (with Xiaoming Wu), The Journal of experimental medicine (2007)

Immunoglobulin (Ig) class switch recombination (CSR) is initiated by activation-induced cytidine deaminase (AID), which converts...

 
Shifts in targeting of class switch recombination sites in mice that lack mu switch region tandem repeats or Msh2 (with Irene M. Min, Lisa R. Rothlein, Carol E. Schrader, and Erik Selsing), The Journal of experimental medicine (2005)

The mechanisms that target class switch recombination (CSR) to antibody gene switch (S) regions are...

 
The mu switch region tandem repeats are important, but not required, for antibody class switch recombination (with Thomas M. Luby, Carol E. Schrader, and Erik Selsing), The Journal of experimental medicine (2001)

Class switch DNA recombinations change the constant (C) region of the antibody heavy (H) chain...

 
Evidence for class-specific factors in immunoglobulin isotype switching (with A. Shanmugam, M. J. Shi, L. Yauch, and A. L. Kenter), The Journal of experimental medicine (2000)

Immunoglobulin class switch recombination (SR) occurs by a B cell-specific, intrachromosomal deletional process between switch...

 

DNA Probes

Induction of germ-line immunoglobulin heavy chain transcripts by mitogens and interleukins prior to switch recombination (with E. Severinson and C. Fernandez), European journal of immunology (1990)

It has recently been postulated that immunoglobulin class switching is preceded by transcription from unrearranged...

 

DNA Repair

Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions (with Carol E. Schrader, Joycelyn Vardo, Erin K. Linehan, Michael Z. Twarog, Laura J. Niedernhofer, and Jan H. J. Hoeijmakers), The Journal of experimental medicine (2004)

The structure-specific endonuclease ERCC1-XPF is an essential component of the nucleotide excision DNA repair pathway....

 
Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination (with Carol E. Schrader, Sean P. Bradley, Joycelyn Vardo, Sofia N. Mochegova, and Erin Flanagan), The EMBO journal (2003)

Nucleotide substitutions are found in recombined Ig switch (S) regions and also in unrecombined (germline,...

 
Mlh1 can function in antibody class switch recombination independently of Msh2 (with Carol E. Schrader and Joycelyn Vardo), The Journal of experimental medicine (2003)

Mismatch repair proteins participate in antibody class switch recombination, although their roles are unknown. Previous...

 
Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions (with Carol E. Schrader and Joycelyn Vardo), The Journal of experimental medicine (2002)

B cells from mice deficient in mismatch repair (MMR) proteins show decreased ability to undergo...

 
Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes (with Carol E. Schrader, W. Edelmann, and R. Kucherlapati), The Journal of experimental medicine (1999)

Mice deficient in various mismatch repair (MMR) enzymes were examined to determine whether this repair...

 

DNA Replication

Cognate T cell help for CD40-deficient B cells induces c-myc RNA expression, but DNA synthesis requires an additional signal through surface Ig (with Carol E. Schrader, H. Kikutani, and D. C. Parker), Journal of immunology (Baltimore, Md. : 1950) (1997)

To investigate the role of CD40 ligand in the delivery of help to B cells,...

 

DNA Restriction Enzymes

Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching (with S. Sirlin), The EMBO journal (1986)

IgM+ cells cultured from the I.29 B cell lymphoma can be induced with lipopolysaccharide (LPS)...

 
Rearrangements and deletions of immunoglobulin heavy chain genes in the double-producing B cell lymphoma I.29 (with K. B. Marcu, S. Sirlin, B. Alhadeff, and U. Hammerling), Molecular and cellular biology (1982)

The B cell lymphoma I.29 consists of a mixture of cells expressing membrane-bound immunoglobulin M...

 
Genetic structure and origin of t haplotypes of mice, analyzed with H-2 cDNA probes (with H. S. Shin, K. Artzt, and D. Bennett), Cell (1982)

We investigated the genetic organization and evolutionary origin of t chromosomes of mice by examining...

 

DNA, Bacterial

Isolation of messenger RNA for an immunoglobulin kappa chain and enumeration of the genes for the constatn region of kappa chain in the mouse (with R. C. Huang, E. Stavnezer, and J. M. Bishop), Journal of molecular biology (1974)

No abstract provided.

 

DNA, Complementary

Mouse CD6: sequence of cDNA and expression of mRNA (with A. Pal, P. L. Romain, N. G. Singer, and D. Fox), Immunology letters (1996)

No abstract provided.

 

DNA, Neoplasm

Immunoglobulin heavy chain switching in cultured I.29 murine B lymphoma cells: commitment to an IgA or IgE switch (with J. Abbott and S. Sirlin), Current topics in microbiology and immunology (1984)

No abstract provided.

 

DNA, Recombinant

Structure of germline immunoglobulin heavy-chain gamma 1 transcripts in interleukin 4 treated mouse spleen cells (with M. Xu), Developmental immunology (1990)

Antibody class switching is mediated by a DNA recombination event that replaces the C mu...

 
Molecular defects in a human immunoglobulin kappa chain deficiency (with O. Kekish and B. J. Zegers), Science (New York, N.Y.) (1985)

The molecular basis of a human immunoglobulin deficiency characterized by the complete absence of kappa...

 

DNA, Single-Stranded

Detection and characterization of RNA tumor virus-specific DNA in cells (with H. E. Varmus, E. Medeiros, and J. M. Bishop), Bibliotheca haematologica (1975)

RNA tumor virus-specific DNA in cells can be detected by its capacity to 1) alter...

 
Synthesis of a deoxyribonucleic acid sequence complementary to ovalbumin messenger ribonucleic acid and quantification of ovalbumin genes (with D. Sullivan, R. Palacios, J. M. Taylor, A. J. Faras, M. L. Kiely, N. M. Summers, J. M. Bishop, and R. T. Schimke), The Journal of biological chemistry (1973)

No abstract provided.

 

DNA, Viral

Detection and characterization of RNA tumor virus-specific DNA in cells (with H. E. Varmus, E. Medeiros, and J. M. Bishop), Bibliotheca haematologica (1975)

RNA tumor virus-specific DNA in cells can be detected by its capacity to 1) alter...

 

DNA-Binding Proteins

Shifts in targeting of class switch recombination sites in mice that lack mu switch region tandem repeats or Msh2 (with Irene M. Min, Lisa R. Rothlein, Carol E. Schrader, and Erik Selsing), The Journal of experimental medicine (2005)

The mechanisms that target class switch recombination (CSR) to antibody gene switch (S) regions are...

 
Analysis of transforming growth factor-beta1-induced Ig germ-line gamma2b transcription and its implication for IgA isotype switching (with Seok-Rae Park, Goo-Young Seo, Ae-Jin Choi, and Pyeung-Hyeun Kim), European journal of immunology (2005)

Transforming growth factor (TGF)-beta1 directs class switch recombination (CSR) to IgG2b as well as to...

 
Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions (with Carol E. Schrader, Joycelyn Vardo, Erin K. Linehan, Michael Z. Twarog, Laura J. Niedernhofer, and Jan H. J. Hoeijmakers), The Journal of experimental medicine (2004)

The structure-specific endonuclease ERCC1-XPF is an essential component of the nucleotide excision DNA repair pathway....

 
Mlh1 can function in antibody class switch recombination independently of Msh2 (with Carol E. Schrader and Joycelyn Vardo), The Journal of experimental medicine (2003)

Mismatch repair proteins participate in antibody class switch recombination, although their roles are unknown. Previous...

 
The ubiquitously expressed DNA-binding protein late SV40 factor binds Ig switch regions and represses class switching to IgA (with Elise E. Drouin, Carol E. Schrader, and Ulla Hansen), Journal of immunology (Baltimore, Md. : 1950) (2002)

Ig heavy chain class switch recombination (CSR) determines the expression of Ig isotypes. The molecular...

 
Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions (with Carol E. Schrader and Joycelyn Vardo), The Journal of experimental medicine (2002)

B cells from mice deficient in mismatch repair (MMR) proteins show decreased ability to undergo...

 
Differential regulation of mouse germline Ig gamma 1 and epsilon promoters by IL-4 and CD40 (with C. S. Mao), Journal of immunology (Baltimore, Md. : 1950) (2001)

Before Ig class switching, RNA transcription through the specific S regions undergoing recombination is induced...

 
Roles of Ets proteins, NF-kappa B and nocodazole in regulating induction of transcription of mouse germline Ig alpha RNA by transforming growth factor-beta 1 (with M. J. Shi, S. R. Park, and P. H. Kim), International immunology (2001)

Antibody class switch recombination (CSR) occurs after antigen activation of B cells. CSR is directed...

 
Activation of the mouse Ig germline epsilon promoter by IL-4 is dependent on AP-1 transcription factors (with Ching-Hung Shen), Journal of immunology (Baltimore, Md. : 1950) (2000)

Induction of germline (GL) epsilon transcripts, an essential step preceding Ig isotype switching to IgE,...

 
Regulation of the promoter for human immunoglobulin gamma3 germ-line transcription and its interaction with the 3'alpha enhancer (with Q. Pan, C. Petit-Frere, and L. Hammarstrom), European journal of immunology (2000)

The mechanism underlying the differential regulation of switching to human IgG subclasses is still largely...

 
Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter (with J. Hanai, L. F. Chen, T. Kanno, N. Ohtani-Fujita, W. Y. Kim, W. H. Guo, T. Imamura, Y. Ishidou, M. Fukuchi, M. J. Shi, M. Kawabata, K. Miyazono, and Y. Ito), The Journal of biological chemistry (1999)

Smads are signal transducers for members of the transforming growth factor-beta (TGF-beta) superfamily. Upon ligand...

 
CBF alpha3 (AML2) is induced by TGF-beta1 to bind and activate the mouse germline Ig alpha promoter (with M. J. Shi), Journal of immunology (Baltimore, Md. : 1950) (1998)

TGF-beta1 directs class switching to IgA by splenic B cells and by the surface IgM+...

 
Overexpression of BSAP/Pax-5 inhibits switching to IgA and enhances switching to IgE in the I.29 mu B cell line (with G. Qiu), Journal of immunology (Baltimore, Md. : 1950) (1998)

B cell-specific activator protein (BSAP)/Pax-5 is a paired domain DNA-binding protein expressed in the developing...

 
CD40 cross-linking induces Ig epsilon germline transcripts in B cells via activation of NF-kappaB: synergy with IL-4 induction (with L. A. Iciek and S. A. Delphin), Journal of immunology (Baltimore, Md. : 1950) (1997)

Transcription of unrearranged (germline) Ig heavy chain C region (C(H)) genes is required before Ab...

 
Regulation of antibody class switching to IgE: characterization of an IL-4-responsive region in the immunoglobulin heavy-chain germline epsilon promoter (with S. Delphin), Annals of the New York Academy of Sciences (1995)

A large body of data indicate that antibody class switching is directed by cytokines by...

 
Cell cycle regulation of immunoglobulin class switch recombination and germ-line transcription: potential role of Ets family members (with M. Lundgren, L. Strom, L. O. Bergquist, S. Skog, T. Heiden, and E. Severinson), European journal of immunology (1995)

Previous studies have indicated that transcription of germ-line (GL) CH genes is necessary to obtain...

 
Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50 (with S. Delphin), The Journal of experimental medicine (1995)

A large body of data indicate that antibody class switching is directed by cytokines by...

 
Activation of the Ig germ-line gamma 1 promoter. Involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site (with M. Lundgren, C. Larsson, A. Femino, M. Xu, and E. Severinson), Journal of immunology (Baltimore, Md. : 1950) (1994)

Ig isotype switching in B lymphocytes is preceded by transcription of the corresponding unrearranged, or...

 
A B-cell-specific nuclear protein that binds to DNA sites 5' to immunoglobulin S alpha tandem repeats is regulated during differentiation (with S. H. Waters and K. U. Saikh), Molecular and cellular biology (1989)

Immunoglobulin heavy-chain switching is effected by recombination events between sites associated with tandemly repeated switch...

 

Drug Synergism

Regulation of the promoter for human immunoglobulin gamma3 germ-line transcription and its interaction with the 3'alpha enhancer (with Q. Pan, C. Petit-Frere, and L. Hammarstrom), European journal of immunology (2000)

The mechanism underlying the differential regulation of switching to human IgG subclasses is still largely...

 
Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription (with Ching-Hung Shen), Molecular and cellular biology (1998)

Signal transducer and activator of transcription 6 (Stat6) and NF-kappaB are widely distributed transcription factors...

 

Dysgammaglobulinemia

PDF

Aberrant recombination events in B cell lines derived from a kappa-deficient human (with O. Kekish, D. Batter, J. Grenier, I. Balazs, E. Henderson, and B. J. Zegers), Nucleic acids research (1985)

We have analyzed the structure of Ig kappa chain genes in B cell lines derived...

 

E1A-Associated p300 Protein

Analysis of transforming growth factor-beta1-induced Ig germ-line gamma2b transcription and its implication for IgA isotype switching (with Seok-Rae Park, Goo-Young Seo, Ae-Jin Choi, and Pyeung-Hyeun Kim), European journal of immunology (2005)

Transforming growth factor (TGF)-beta1 directs class switch recombination (CSR) to IgG2b as well as to...

 

Electrophoresis

Synthesis of a mouse immunoglobulin light chain in a rabbit reticulocyte cell-free system (with R. C. Huang), Nature: New biology (1971)

No abstract provided.

 

Electrophoresis, Polyacrylamide Gel

Membrane-bound and secreted IgA contain structurally different alpha-chains (with R. Sitia, H. Kikutani, A. Rubartelli, Y. Bushkin, and U. Hammerling), Journal of immunology (Baltimore, Md. : 1950) (1982)

Three different forms of alpha-chains are synthesized by BF0.3 and 615.2, two cloned cell lines...

 
Isolation of messenger RNA for an immunoglobulin kappa chain and enumeration of the genes for the constatn region of kappa chain in the mouse (with R. C. Huang, E. Stavnezer, and J. M. Bishop), Journal of molecular biology (1974)

No abstract provided.

 
Letter: Translation of messenger RNA for mouse immunoglobulin light chains in living frog oocytes (with M. Smith, R. C. Huang, J. B. Gurdon, and C. D. Lane), Journal of molecular biology (1973)

No abstract provided.

 

Electrophoretic Mobility Shift Assay

Analysis of transforming growth factor-beta1-induced Ig germ-line gamma2b transcription and its implication for IgA isotype switching (with Seok-Rae Park, Goo-Young Seo, Ae-Jin Choi, and Pyeung-Hyeun Kim), European journal of immunology (2005)

Transforming growth factor (TGF)-beta1 directs class switch recombination (CSR) to IgG2b as well as to...

 

Endonucleases

Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions (with Carol E. Schrader, Joycelyn Vardo, Erin K. Linehan, Michael Z. Twarog, Laura J. Niedernhofer, and Jan H. J. Hoeijmakers), The Journal of experimental medicine (2004)

The structure-specific endonuclease ERCC1-XPF is an essential component of the nucleotide excision DNA repair pathway....

 

Enhancer Elements (Genetics)

Regulation of the promoter for human immunoglobulin gamma3 germ-line transcription and its interaction with the 3'alpha enhancer (with Q. Pan, C. Petit-Frere, and L. Hammarstrom), European journal of immunology (2000)

The mechanism underlying the differential regulation of switching to human IgG subclasses is still largely...

 
Regulation of transcription of immunoglobulin germ-line gamma 1 RNA: analysis of the promoter/enhancer (with M. Z. Xu), The EMBO journal (1992)

Antibody class switching is achieved by recombinations between switch (S) regions which consist of tandemly...

 

Enzyme-Linked Immunosorbent Assay

Interleukins 4 and 5: mechanisms of action (with E. Severinson, H. B. Moon, S. Bergstedt-Lindqvist, U. Persson, and C. Heusser), Advances in experimental medicine and biology (1989)

No abstract provided.

 

Escherichia coli

Evidence for class-specific factors in immunoglobulin isotype switching (with A. Shanmugam, M. J. Shi, L. Yauch, and A. L. Kenter), The Journal of experimental medicine (2000)

Immunoglobulin class switch recombination (SR) occurs by a B cell-specific, intrachromosomal deletional process between switch...

 
Isolation of messenger RNA for an immunoglobulin kappa chain and enumeration of the genes for the constatn region of kappa chain in the mouse (with R. C. Huang, E. Stavnezer, and J. M. Bishop), Journal of molecular biology (1974)

No abstract provided.

 

Exons

Ialpha exon-replacement mice synthesize a spliced HPRT-C(alpha) transcript which may explain their ability to switch to IgA. Inhibition of switching to IgG in these mice (with G. Qiu and G. R. Harriman), International immunology (1999)

Antibody class switching is regulated by transcription of unrearranged C(H) genes to produce germline (GL)...

 

Female

Antibody class switching differs among SJL, C57BL/6 and 129 mice (with Denise A. Kaminski), International immunology (2007)

Inbred mouse strains used for gene manipulation studies vary in many respects, including immune system...

 
Cognate T cell help for CD40-deficient B cells induces c-myc RNA expression, but DNA synthesis requires an additional signal through surface Ig (with Carol E. Schrader, H. Kikutani, and D. C. Parker), Journal of immunology (Baltimore, Md. : 1950) (1997)

To investigate the role of CD40 ligand in the delivery of help to B cells,...

 
Cell cycle regulation of immunoglobulin class switch recombination and germ-line transcription: potential role of Ets family members (with M. Lundgren, L. Strom, L. O. Bergquist, S. Skog, T. Heiden, and E. Severinson), European journal of immunology (1995)

Previous studies have indicated that transcription of germ-line (GL) CH genes is necessary to obtain...

 
Induction of germ-line immunoglobulin heavy chain transcripts by mitogens and interleukins prior to switch recombination (with E. Severinson and C. Fernandez), European journal of immunology (1990)

It has recently been postulated that immunoglobulin class switching is preceded by transcription from unrearranged...

 
Synthesis of a deoxyribonucleic acid sequence complementary to ovalbumin messenger ribonucleic acid and quantification of ovalbumin genes (with D. Sullivan, R. Palacios, J. M. Taylor, A. J. Faras, M. L. Kiely, N. M. Summers, J. M. Bishop, and R. T. Schimke), The Journal of biological chemistry (1973)

No abstract provided.

 
Letter: Translation of messenger RNA for mouse immunoglobulin light chains in living frog oocytes (with M. Smith, R. C. Huang, J. B. Gurdon, and C. D. Lane), Journal of molecular biology (1973)

No abstract provided.

 

Flow Cytometry

Antibody class switching differs among SJL, C57BL/6 and 129 mice (with Denise A. Kaminski), International immunology (2007)

Inbred mouse strains used for gene manipulation studies vary in many respects, including immune system...

 
Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes (with Carol E. Schrader, W. Edelmann, and R. Kucherlapati), The Journal of experimental medicine (1999)

Mice deficient in various mismatch repair (MMR) enzymes were examined to determine whether this repair...

 
Surface immunoglobulin light chain expression in pre-B cell leukemias (with B. Koziner, A. Al-Katib, D. Gebhard, A. Mittelman, M. Andreeff, and B. D. Clarkson), Annals of the New York Academy of Sciences (1986)

Cytofluorographic analysis of surface immunoglobulin (sIg) light chain clonal excess (CE), defined as (%kappa+ -...

 
Surface immunoglobulin light-chain expression by the "common" all cell line REH (with B. Koziner and A. Al-Katib), Clinical immunology and immunopathology (1985)

To provide further support of the B-cell lineage of "common" acute lymphoblastic leukemia (ALL), we...

 

Fluorescent Antibody Technique

Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching (with S. Sirlin), The EMBO journal (1986)

IgM+ cells cultured from the I.29 B cell lymphoma can be induced with lipopolysaccharide (LPS)...

 

G-Box Binding Factors

Differential regulation of mouse germline Ig gamma 1 and epsilon promoters by IL-4 and CD40 (with C. S. Mao), Journal of immunology (Baltimore, Md. : 1950) (2001)

Before Ig class switching, RNA transcription through the specific S regions undergoing recombination is induced...

 

gamma-Globulins

Synthesis of a mouse immunoglobulin light chain in a rabbit reticulocyte cell-free system (with R. C. Huang), Nature: New biology (1971)

No abstract provided.

 

Gene Expression

Cell cycle regulation of immunoglobulin class switch recombination and germ-line transcription: potential role of Ets family members (with M. Lundgren, L. Strom, L. O. Bergquist, S. Skog, T. Heiden, and E. Severinson), European journal of immunology (1995)

Previous studies have indicated that transcription of germ-line (GL) CH genes is necessary to obtain...

 

Gene Expression Regulation

Inducible DNA breaks in Ig S regions are dependent on AID and UNG (with Carol E. Schrader, Erin K. Linehan, Sofia N. Mochegova, and Robert T. Woodland), The Journal of experimental medicine (2005)

Class switch recombination (CSR) occurs by an intrachromosomal deletion whereby the IgM constant region gene...

 
Differential regulation of mouse germline Ig gamma 1 and epsilon promoters by IL-4 and CD40 (with C. S. Mao), Journal of immunology (Baltimore, Md. : 1950) (2001)

Before Ig class switching, RNA transcription through the specific S regions undergoing recombination is induced...

 
Roles of Ets proteins, NF-kappa B and nocodazole in regulating induction of transcription of mouse germline Ig alpha RNA by transforming growth factor-beta 1 (with M. J. Shi, S. R. Park, and P. H. Kim), International immunology (2001)

Antibody class switch recombination (CSR) occurs after antigen activation of B cells. CSR is directed...

 
Activation of the mouse Ig germline epsilon promoter by IL-4 is dependent on AP-1 transcription factors (with Ching-Hung Shen), Journal of immunology (Baltimore, Md. : 1950) (2000)

Induction of germline (GL) epsilon transcripts, an essential step preceding Ig isotype switching to IgE,...

 
Ialpha exon-replacement mice synthesize a spliced HPRT-C(alpha) transcript which may explain their ability to switch to IgA. Inhibition of switching to IgG in these mice (with G. Qiu and G. R. Harriman), International immunology (1999)

Antibody class switching is regulated by transcription of unrearranged C(H) genes to produce germline (GL)...

 
CBF alpha3 (AML2) is induced by TGF-beta1 to bind and activate the mouse germline Ig alpha promoter (with M. J. Shi), Journal of immunology (Baltimore, Md. : 1950) (1998)

TGF-beta1 directs class switching to IgA by splenic B cells and by the surface IgM+...

 
Overexpression of BSAP/Pax-5 inhibits switching to IgA and enhances switching to IgE in the I.29 mu B cell line (with G. Qiu), Journal of immunology (Baltimore, Md. : 1950) (1998)

B cell-specific activator protein (BSAP)/Pax-5 is a paired domain DNA-binding protein expressed in the developing...

 
Cognate T cell help for CD40-deficient B cells induces c-myc RNA expression, but DNA synthesis requires an additional signal through surface Ig (with Carol E. Schrader, H. Kikutani, and D. C. Parker), Journal of immunology (Baltimore, Md. : 1950) (1997)

To investigate the role of CD40 ligand in the delivery of help to B cells,...

 
Regulation of antibody class switching to IgE: characterization of an IL-4-responsive region in the immunoglobulin heavy-chain germline epsilon promoter (with S. Delphin), Annals of the New York Academy of Sciences (1995)

A large body of data indicate that antibody class switching is directed by cytokines by...

 
Regulation of transcription of the germ-line Ig alpha constant region gene by an ATF element and by novel transforming growth factor-beta 1-responsive elements (with Y. C. Lin), Journal of immunology (Baltimore, Md. : 1950) (1992)

Inasmuch as transcription of unrearranged, or germ-line, Ig CH genes appears to direct switch recombination,...

 
Regulation of switch recombination to the murine gamma 1 gene (with W. Dunnick, L. Elenich, J. Berry, D. Albrecht, and J. L. Claflin), Current topics in microbiology and immunology (1992)

No abstract provided.

 
Regulation of transcription of the germline immunoglobulin alpha constant region gene (with Y. C. Lin and P. Shockett), Current topics in microbiology and immunology (1992)

No abstract provided.

 
Regulation of the antibody class switch to IgA (with Y. C. Lin and P. Shockett), Immunologic research (1991)

No abstract provided.

 
Induction of germ-line immunoglobulin heavy chain transcripts by mitogens and interleukins prior to switch recombination (with E. Severinson and C. Fernandez), European journal of immunology (1990)

It has recently been postulated that immunoglobulin class switching is preceded by transcription from unrearranged...

 
Specificity of immunoglobulin heavy chain switching by cultured I.29 B lymphoma cells (with G. Radcliffe and E. Severinson), Monographs in allergy (1988)

No abstract provided.

 
Expression of immunoglobulin lambda light chain by the promyelocytic cell line HL-60 (with A. Al-Katib and B. Koziner), Journal of immunology (Baltimore, Md. : 1950) (1986)

The HL-60 cell line, established from a patient with acute promyelocytic leukemia, can be induced...

 
Expression of an antigen receptor on T cells does not require recombination at the immunoglobulin JH-C mu locus (with Y. Cayre, M. A. Palladino, and K. B. Marcu), Proceedings of the National Academy of Sciences of the United States of America (1981)

Considerable evidence has accumulated suggesting that the antigen receptor(s) on T cells is coded for...

 

Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor

Structure of germ line immunoglobulin alpha heavy-chain RNA and its location on polysomes (with G. Radcliffe, Y. C. Lin, M. Julius, and K. B. Marcu), Molecular and cellular biology (1990)

We describe the structure of the major germ line RNA transcribed from unrearranged immunoglobulin alpha...

 

Gene Rearrangement, B-Lymphocyte

Inducible DNA breaks in Ig S regions are dependent on AID and UNG (with Carol E. Schrader, Erin K. Linehan, Sofia N. Mochegova, and Robert T. Woodland), The Journal of experimental medicine (2005)

Class switch recombination (CSR) occurs by an intrachromosomal deletion whereby the IgM constant region gene...

 
Inhibitors of poly(ADP-ribose) polymerase increase antibody class switching (with P. Shockett), Journal of immunology (Baltimore, Md. : 1950) (1993)

Previous studies suggest that heavy chain isotype switch (S) recombination is directed by cytokine-induced transcription...

 

Gene Rearrangement, B-Lymphocyte, Heavy Chain

The mu switch region tandem repeats are important, but not required, for antibody class switch recombination (with Thomas M. Luby, Carol E. Schrader, and Erik Selsing), The Journal of experimental medicine (2001)

Class switch DNA recombinations change the constant (C) region of the antibody heavy (H) chain...

 
Switch recombination in a transfected plasmid occurs preferentially in a B cell line that undergoes switch recombination of its chromosomal Ig heavy chain genes (with Sean P. Bradley, Norman Rousseau, Todd Pearson, Ananth Shanmugam, Debra J. Waite, Paul R. Rogers, and Amy L. Kenter), Journal of immunology (Baltimore, Md. : 1950) (1999)

Ab class switching is induced upon B cell activation in vivo by immunization or infection...

 
Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes (with G. Radcliffe, Y. C. Lin, J. Nietupski, L. Berggren, R. Sitia, and E. Severinson), Proceedings of the National Academy of Sciences of the United States of America (1988)

Immunoglobulin heavy-chain switching is effected by a DNA recombination event that replaces the C mu...

 

Gene Rearrangement, beta-Chain T-Cell Antigen Receptor

Reticulum cell sarcomas of SJL mice have rearranged immunoglobulin heavy and light chain genes (with J. L. Lasky, N. M. Ponzio, M. P. Scheid, and G. J. Thorbecke), European journal of immunology (1989)

The immunoglobulin (Ig) heavy (H) and light (L) chain gene rearrangements of the high incidence...

 

Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor

Reticulum cell sarcomas of SJL mice have rearranged immunoglobulin heavy and light chain genes (with J. L. Lasky, N. M. Ponzio, M. P. Scheid, and G. J. Thorbecke), European journal of immunology (1989)

The immunoglobulin (Ig) heavy (H) and light (L) chain gene rearrangements of the high incidence...

 

Gene Silencing

The ubiquitously expressed DNA-binding protein late SV40 factor binds Ig switch regions and represses class switching to IgA (with Elise E. Drouin, Carol E. Schrader, and Ulla Hansen), Journal of immunology (Baltimore, Md. : 1950) (2002)

Ig heavy chain class switch recombination (CSR) determines the expression of Ig isotypes. The molecular...

 

Genes

Immunoglobulin heavy chain switching in cultured I.29 murine B lymphoma cells: commitment to an IgA or IgE switch (with J. Abbott and S. Sirlin), Current topics in microbiology and immunology (1984)

No abstract provided.

 
Molecular genetics of immunoglobulin heavy chain switching, Survey of immunologic research (1983)

No abstract provided.

 
Expression of an antigen receptor on T cells does not require recombination at the immunoglobulin JH-C mu locus (with Y. Cayre, M. A. Palladino, and K. B. Marcu), Proceedings of the National Academy of Sciences of the United States of America (1981)

Considerable evidence has accumulated suggesting that the antigen receptor(s) on T cells is coded for...

 

Genes, Immunoglobulin

Immunology. A touch of antibody class, Science (New York, N.Y.) (2000)

When B cells, the antibody producing cells of the body, encounter antigen they switch from...

 
Regulation of the promoter for human immunoglobulin gamma3 germ-line transcription and its interaction with the 3'alpha enhancer (with Q. Pan, C. Petit-Frere, and L. Hammarstrom), European journal of immunology (2000)

The mechanism underlying the differential regulation of switching to human IgG subclasses is still largely...

 
Regulation of transcription of the germ-line Ig alpha constant region gene by an ATF element and by novel transforming growth factor-beta 1-responsive elements (with Y. C. Lin), Journal of immunology (Baltimore, Md. : 1950) (1992)

Inasmuch as transcription of unrearranged, or germ-line, Ig CH genes appears to direct switch recombination,...

 
Regulation of the antibody class switch to IgA (with Y. C. Lin and P. Shockett), Immunologic research (1991)

No abstract provided.

 
Mouse antibody response to group A streptococcal carbohydrate (with C. D. Jarvis and L. E. Cannon), Journal of immunology (Baltimore, Md. : 1950) (1989)

In an attempt to more fully understand the generation of antibody diversity to carbohydrate (CHO)...

 

Genes, myc

Cognate T cell help for CD40-deficient B cells induces c-myc RNA expression, but DNA synthesis requires an additional signal through surface Ig (with Carol E. Schrader, H. Kikutani, and D. C. Parker), Journal of immunology (Baltimore, Md. : 1950) (1997)

To investigate the role of CD40 ligand in the delivery of help to B cells,...

 

Genes, Reporter

Activation of the mouse Ig germline epsilon promoter by IL-4 is dependent on AP-1 transcription factors (with Ching-Hung Shen), Journal of immunology (Baltimore, Md. : 1950) (2000)

Induction of germline (GL) epsilon transcripts, an essential step preceding Ig isotype switching to IgE,...

 
CBF alpha3 (AML2) is induced by TGF-beta1 to bind and activate the mouse germline Ig alpha promoter (with M. J. Shi), Journal of immunology (Baltimore, Md. : 1950) (1998)

TGF-beta1 directs class switching to IgA by splenic B cells and by the surface IgM+...

 
The ability of CD40L, but not lipopolysaccharide, to initiate immunoglobulin switching to immunoglobulin G1 is explained by differential induction of NF-kappaB/Rel proteins (with S. C. Lin and H. H. Wortis), Molecular and cellular biology (1998)

Antibodies of the immunoglobulin G1 class are induced in mice by T-cell-dependent antigens but not...

 
Regulation of antibody class switching to IgE: characterization of an IL-4-responsive region in the immunoglobulin heavy-chain germline epsilon promoter (with S. Delphin), Annals of the New York Academy of Sciences (1995)

A large body of data indicate that antibody class switching is directed by cytokines by...

 

Genes, Switch

Activation of the Ig germ-line gamma 1 promoter. Involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site (with M. Lundgren, C. Larsson, A. Femino, M. Xu, and E. Severinson), Journal of immunology (Baltimore, Md. : 1950) (1994)

Ig isotype switching in B lymphocytes is preceded by transcription of the corresponding unrearranged, or...

 
Regulation of transcription of immunoglobulin germ-line gamma 1 RNA: analysis of the promoter/enhancer (with M. Z. Xu), The EMBO journal (1992)

Antibody class switching is achieved by recombinations between switch (S) regions which consist of tandemly...

 
Structure of germline immunoglobulin heavy-chain gamma 1 transcripts in interleukin 4 treated mouse spleen cells (with M. Xu), Developmental immunology (1990)

Antibody class switching is mediated by a DNA recombination event that replaces the C mu...

 

Genetic Code

Isolation of messenger RNA for an immunoglobulin kappa chain and enumeration of the genes for the constatn region of kappa chain in the mouse (with R. C. Huang, E. Stavnezer, and J. M. Bishop), Journal of molecular biology (1974)

No abstract provided.

 

Genetic Engineering

Molecular defects in a human immunoglobulin kappa chain deficiency (with O. Kekish and B. J. Zegers), Science (New York, N.Y.) (1985)

The molecular basis of a human immunoglobulin deficiency characterized by the complete absence of kappa...

 

Germ Cells

Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter (with J. Hanai, L. F. Chen, T. Kanno, N. Ohtani-Fujita, W. Y. Kim, W. H. Guo, T. Imamura, Y. Ishidou, M. Fukuchi, M. J. Shi, M. Kawabata, K. Miyazono, and Y. Ito), The Journal of biological chemistry (1999)

Smads are signal transducers for members of the transforming growth factor-beta (TGF-beta) superfamily. Upon ligand...

 
Ialpha exon-replacement mice synthesize a spliced HPRT-C(alpha) transcript which may explain their ability to switch to IgA. Inhibition of switching to IgG in these mice (with G. Qiu and G. R. Harriman), International immunology (1999)

Antibody class switching is regulated by transcription of unrearranged C(H) genes to produce germline (GL)...

 
Regulation of transcription of immunoglobulin germ-line gamma 1 RNA: analysis of the promoter/enhancer (with M. Z. Xu), The EMBO journal (1992)

Antibody class switching is achieved by recombinations between switch (S) regions which consist of tandemly...

 
I.29 lymphoma cells express a nonmutated VH gene before and after H chain switch (with D. Klein, J. Nietupski, and S. Sirlin), Journal of immunology (Baltimore, Md. : 1950) (1988)

The I.29 B cell lymphoma consists of IgM+ and IgA+ cells which express the same...

 

Germ-Line Mutation

Roles of Ets proteins, NF-kappa B and nocodazole in regulating induction of transcription of mouse germline Ig alpha RNA by transforming growth factor-beta 1 (with M. J. Shi, S. R. Park, and P. H. Kim), International immunology (2001)

Antibody class switch recombination (CSR) occurs after antigen activation of B cells. CSR is directed...

 

Glutamic Acid

The ubiquitously expressed DNA-binding protein late SV40 factor binds Ig switch regions and represses class switching to IgA (with Elise E. Drouin, Carol E. Schrader, and Ulla Hansen), Journal of immunology (Baltimore, Md. : 1950) (2002)

Ig heavy chain class switch recombination (CSR) determines the expression of Ig isotypes. The molecular...

 

Glutamine

The ubiquitously expressed DNA-binding protein late SV40 factor binds Ig switch regions and represses class switching to IgA (with Elise E. Drouin, Carol E. Schrader, and Ulla Hansen), Journal of immunology (Baltimore, Md. : 1950) (2002)

Ig heavy chain class switch recombination (CSR) determines the expression of Ig isotypes. The molecular...

 

Glutathione Transferase

Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription (with Ching-Hung Shen), Molecular and cellular biology (1998)

Signal transducer and activator of transcription 6 (Stat6) and NF-kappaB are widely distributed transcription factors...

 

Goats

Membrane-bound and secreted IgA contain structurally different alpha-chains (with R. Sitia, H. Kikutani, A. Rubartelli, Y. Bushkin, and U. Hammerling), Journal of immunology (Baltimore, Md. : 1950) (1982)

Three different forms of alpha-chains are synthesized by BF0.3 and 615.2, two cloned cell lines...

 

H-2 Antigens

Genetic structure and origin of t haplotypes of mice, analyzed with H-2 cDNA probes (with H. S. Shin, K. Artzt, and D. Bennett), Cell (1982)

We investigated the genetic organization and evolutionary origin of t chromosomes of mice by examining...

 

Half-Life

Activation of the mouse Ig germline epsilon promoter by IL-4 is dependent on AP-1 transcription factors (with Ching-Hung Shen), Journal of immunology (Baltimore, Md. : 1950) (2000)

Induction of germline (GL) epsilon transcripts, an essential step preceding Ig isotype switching to IgE,...

 

Hela Cells

Roles of Ets proteins, NF-kappa B and nocodazole in regulating induction of transcription of mouse germline Ig alpha RNA by transforming growth factor-beta 1 (with M. J. Shi, S. R. Park, and P. H. Kim), International immunology (2001)

Antibody class switch recombination (CSR) occurs after antigen activation of B cells. CSR is directed...

 
Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes (with G. Radcliffe, Y. C. Lin, J. Nietupski, L. Berggren, R. Sitia, and E. Severinson), Proceedings of the National Academy of Sciences of the United States of America (1988)

Immunoglobulin heavy-chain switching is effected by a DNA recombination event that replaces the C mu...

 

Heterozygote

Cell cycle regulation of immunoglobulin class switch recombination and germ-line transcription: potential role of Ets family members (with M. Lundgren, L. Strom, L. O. Bergquist, S. Skog, T. Heiden, and E. Severinson), European journal of immunology (1995)

Previous studies have indicated that transcription of germ-line (GL) CH genes is necessary to obtain...

 

Histone-Lysine

The histone methyltransferase Suv39h1 increases class switch recombination specifically to IgA (with Sean P. Bradley, Denise A. Kaminski, Antoine H. F. M. Peters, and Thomas Jenuwein), Journal of immunology (Baltimore, Md. : 1950) (2006)

Ab class (isotype) switching allows the humoral immune system to adaptively respond to different infectious...

 

Histones

Stimuli that enhance IgA class switching increase histone 3 acetylation at S alpha, but poorly stimulate sequential switching from IgG2b (with Denise A. Kaminski), European journal of immunology (2006)

Germ-line (GL) alpha transcription can be induced in mouse splenic B cells by LPS and...

 
Antibody class switching: uncoupling S region accessibility from transcription (with Denise A. Kaminski), Trends in genetics : TIG (2004)

Immunogloblin class switch recombination (CSR) is a regulated process that changes antibody effector functions. Recently,...

 

Humans

Stimuli that enhance IgA class switching increase histone 3 acetylation at S alpha, but poorly stimulate sequential switching from IgG2b (with Denise A. Kaminski), European journal of immunology (2006)

Germ-line (GL) alpha transcription can be induced in mouse splenic B cells by LPS and...

 
Mismatch repair converts AID-instigated nicks to double-strand breaks for antibody class-switch recombination (with Carol E. Schrader), Trends in genetics : TIG (2005)

Mismatch repair (MMR) proteins are important for antibody class-switch recombination (CSR), but their roles are...

 
Evolution of isotype switching (with Chris T. Amemiya), Seminars in immunology (2004)

This review discusses evolution of the process of Ig heavy chain class switching, relating it...

 
Antibody class switching: uncoupling S region accessibility from transcription (with Denise A. Kaminski), Trends in genetics : TIG (2004)

Immunogloblin class switch recombination (CSR) is a regulated process that changes antibody effector functions. Recently,...

 
Does activation-induced deaminase initiate antibody diversification by DNA deamination (with Sean P. Bradley), Trends in genetics : TIG (2002)

Activation-induced deaminase (AID) is expressed only in germinal center B cells. There, it is required...

 
The ubiquitously expressed DNA-binding protein late SV40 factor binds Ig switch regions and represses class switching to IgA (with Elise E. Drouin, Carol E. Schrader, and Ulla Hansen), Journal of immunology (Baltimore, Md. : 1950) (2002)

Ig heavy chain class switch recombination (CSR) determines the expression of Ig isotypes. The molecular...

 
Roles of Ets proteins, NF-kappa B and nocodazole in regulating induction of transcription of mouse germline Ig alpha RNA by transforming growth factor-beta 1 (with M. J. Shi, S. R. Park, and P. H. Kim), International immunology (2001)

Antibody class switch recombination (CSR) occurs after antigen activation of B cells. CSR is directed...

 
Activation of the mouse Ig germline epsilon promoter by IL-4 is dependent on AP-1 transcription factors (with Ching-Hung Shen), Journal of immunology (Baltimore, Md. : 1950) (2000)

Induction of germline (GL) epsilon transcripts, an essential step preceding Ig isotype switching to IgE,...

 
Regulation of the promoter for human immunoglobulin gamma3 germ-line transcription and its interaction with the 3'alpha enhancer (with Q. Pan, C. Petit-Frere, and L. Hammarstrom), European journal of immunology (2000)

The mechanism underlying the differential regulation of switching to human IgG subclasses is still largely...

 
Molecular processes that regulate class switching, Current topics in microbiology and immunology (1999)

No abstract provided.

 
Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription (with Ching-Hung Shen), Molecular and cellular biology (1998)

Signal transducer and activator of transcription 6 (Stat6) and NF-kappaB are widely distributed transcription factors...

 
Antibody class switching, Advances in immunology (1996)

No abstract provided.

 
Regulation of antibody class switching to IgE: characterization of an IL-4-responsive region in the immunoglobulin heavy-chain germline epsilon promoter (with S. Delphin), Annals of the New York Academy of Sciences (1995)

A large body of data indicate that antibody class switching is directed by cytokines by...

 
Regulation of antibody production and class switching by TGF-beta, Journal of immunology (Baltimore, Md. : 1950) (1995)

No abstract provided.

 
Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50 (with S. Delphin), The Journal of experimental medicine (1995)

A large body of data indicate that antibody class switching is directed by cytokines by...

 
Regulation of transcription of the germline immunoglobulin alpha constant region gene (with Y. C. Lin and P. Shockett), Current topics in microbiology and immunology (1992)

No abstract provided.

 
Regulation of the antibody class switch to IgA (with Y. C. Lin and P. Shockett), Immunologic research (1991)

No abstract provided.

 
Interleukins 4 and 5: mechanisms of action (with E. Severinson, H. B. Moon, S. Bergstedt-Lindqvist, U. Persson, and C. Heusser), Advances in experimental medicine and biology (1989)

No abstract provided.

 
Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes (with G. Radcliffe, Y. C. Lin, J. Nietupski, L. Berggren, R. Sitia, and E. Severinson), Proceedings of the National Academy of Sciences of the United States of America (1988)

Immunoglobulin heavy-chain switching is effected by a DNA recombination event that replaces the C mu...

 
The J kappa proximal region of the human K locus contains three uncommon V kappa genes which are arranged in opposite transcriptional polarities (with W. Lorenz, K. F. Schable, R. Thiebe, and H. G. Zachau), Molecular immunology (1988)

The structure of one of the V kappa gene-containing regions of the locus coding for...

 
Expression of immunoglobulin lambda light chain by the promyelocytic cell line HL-60 (with A. Al-Katib and B. Koziner), Journal of immunology (Baltimore, Md. : 1950) (1986)

The HL-60 cell line, established from a patient with acute promyelocytic leukemia, can be induced...

 

PDF

Presence of a polyadenylated RNA fragment encoding the membrane domain for immunoglobulin alpha chain indicates that mRNAs for both secreted and membrane-bound alpha chains can be produced from the same RNA transcript, Nucleic acids research (1986)

RNA blotting was employed to examine polyadenylated immunoglobulin alpha chain RNAs in a B lymphoma...

 
Surface immunoglobulin light chain expression in pre-B cell leukemias (with B. Koziner, A. Al-Katib, D. Gebhard, A. Mittelman, M. Andreeff, and B. D. Clarkson), Annals of the New York Academy of Sciences (1986)

Cytofluorographic analysis of surface immunoglobulin (sIg) light chain clonal excess (CE), defined as (%kappa+ -...

 
Molecular defects in a human immunoglobulin kappa chain deficiency (with O. Kekish and B. J. Zegers), Science (New York, N.Y.) (1985)

The molecular basis of a human immunoglobulin deficiency characterized by the complete absence of kappa...

 
Surface immunoglobulin light-chain expression by the "common" all cell line REH (with B. Koziner and A. Al-Katib), Clinical immunology and immunopathology (1985)

To provide further support of the B-cell lineage of "common" acute lymphoblastic leukemia (ALL), we...

 

PDF

Aberrant recombination events in B cell lines derived from a kappa-deficient human (with O. Kekish, D. Batter, J. Grenier, I. Balazs, E. Henderson, and B. J. Zegers), Nucleic acids research (1985)

We have analyzed the structure of Ig kappa chain genes in B cell lines derived...

 
Detection and characterization of RNA tumor virus-specific DNA in cells (with H. E. Varmus, E. Medeiros, and J. M. Bishop), Bibliotheca haematologica (1975)

RNA tumor virus-specific DNA in cells can be detected by its capacity to 1) alter...

 

Hybrid Cells

I.29 lymphoma cells express a nonmutated VH gene before and after H chain switch (with D. Klein, J. Nietupski, and S. Sirlin), Journal of immunology (Baltimore, Md. : 1950) (1988)

The I.29 B cell lymphoma consists of IgM+ and IgA+ cells which express the same...

 

Hybridomas

The mu switch region tandem repeats are important, but not required, for antibody class switch recombination (with Thomas M. Luby, Carol E. Schrader, and Erik Selsing), The Journal of experimental medicine (2001)

Class switch DNA recombinations change the constant (C) region of the antibody heavy (H) chain...

 
Mouse antibody response to group A streptococcal carbohydrate (with C. D. Jarvis and L. E. Cannon), Journal of immunology (Baltimore, Md. : 1950) (1989)

In an attempt to more fully understand the generation of antibody diversity to carbohydrate (CHO)...

 
Synthesis and processing of the alpha heavy chains of secreted and membrane-bound IgA (with H. Kikutani, R. Sitia, and R. A. Good), Proceedings of the National Academy of Sciences of the United States of America (1981)

We have compared the synthesis and processing of immunoglobulin alpha chains in two murine cell...

 

Hydroxyurea

Cell cycle regulation of immunoglobulin class switch recombination and germ-line transcription: potential role of Ets family members (with M. Lundgren, L. Strom, L. O. Bergquist, S. Skog, T. Heiden, and E. Severinson), European journal of immunology (1995)

Previous studies have indicated that transcription of germ-line (GL) CH genes is necessary to obtain...

 

Hypoxanthine Phosphoribosyltransferase

Ialpha exon-replacement mice synthesize a spliced HPRT-C(alpha) transcript which may explain their ability to switch to IgA. Inhibition of switching to IgG in these mice (with G. Qiu and G. R. Harriman), International immunology (1999)

Antibody class switching is regulated by transcription of unrearranged C(H) genes to produce germline (GL)...

 

Immunogenetics

Molecular genetics of immunoglobulin heavy chain switching, Survey of immunologic research (1983)

No abstract provided.

 

Immunoglobulin A

Antibody class switching differs among SJL, C57BL/6 and 129 mice (with Denise A. Kaminski), International immunology (2007)

Inbred mouse strains used for gene manipulation studies vary in many respects, including immune system...

 
Stimuli that enhance IgA class switching increase histone 3 acetylation at S alpha, but poorly stimulate sequential switching from IgG2b (with Denise A. Kaminski), European journal of immunology (2006)

Germ-line (GL) alpha transcription can be induced in mouse splenic B cells by LPS and...

 
Enhanced IgA class switching in marginal zone and B1 B cells relative to follicular/B2 B cells (with Denise A. Kaminski), Journal of immunology (Baltimore, Md. : 1950) (2006)

Mouse splenic marginal zone (MZ) B cells and B1 B cells enriched in the peritoneal...

 
The histone methyltransferase Suv39h1 increases class switch recombination specifically to IgA (with Sean P. Bradley, Denise A. Kaminski, Antoine H. F. M. Peters, and Thomas Jenuwein), Journal of immunology (Baltimore, Md. : 1950) (2006)

Ab class (isotype) switching allows the humoral immune system to adaptively respond to different infectious...

 
Analysis of transforming growth factor-beta1-induced Ig germ-line gamma2b transcription and its implication for IgA isotype switching (with Seok-Rae Park, Goo-Young Seo, Ae-Jin Choi, and Pyeung-Hyeun Kim), European journal of immunology (2005)

Transforming growth factor (TGF)-beta1 directs class switch recombination (CSR) to IgG2b as well as to...

 
The ubiquitously expressed DNA-binding protein late SV40 factor binds Ig switch regions and represses class switching to IgA (with Elise E. Drouin, Carol E. Schrader, and Ulla Hansen), Journal of immunology (Baltimore, Md. : 1950) (2002)

Ig heavy chain class switch recombination (CSR) determines the expression of Ig isotypes. The molecular...

 
Roles of Ets proteins, NF-kappa B and nocodazole in regulating induction of transcription of mouse germline Ig alpha RNA by transforming growth factor-beta 1 (with M. J. Shi, S. R. Park, and P. H. Kim), International immunology (2001)

Antibody class switch recombination (CSR) occurs after antigen activation of B cells. CSR is directed...

 
Ialpha exon-replacement mice synthesize a spliced HPRT-C(alpha) transcript which may explain their ability to switch to IgA. Inhibition of switching to IgG in these mice (with G. Qiu and G. R. Harriman), International immunology (1999)

Antibody class switching is regulated by transcription of unrearranged C(H) genes to produce germline (GL)...

 
CBF alpha3 (AML2) is induced by TGF-beta1 to bind and activate the mouse germline Ig alpha promoter (with M. J. Shi), Journal of immunology (Baltimore, Md. : 1950) (1998)

TGF-beta1 directs class switching to IgA by splenic B cells and by the surface IgM+...

 
Overexpression of BSAP/Pax-5 inhibits switching to IgA and enhances switching to IgE in the I.29 mu B cell line (with G. Qiu), Journal of immunology (Baltimore, Md. : 1950) (1998)

B cell-specific activator protein (BSAP)/Pax-5 is a paired domain DNA-binding protein expressed in the developing...

 
Inhibitors of poly(ADP-ribose) polymerase increase antibody class switching (with P. Shockett), Journal of immunology (Baltimore, Md. : 1950) (1993)

Previous studies suggest that heavy chain isotype switch (S) recombination is directed by cytokine-induced transcription...

 
Regulation of transcription of the germ-line Ig alpha constant region gene by an ATF element and by novel transforming growth factor-beta 1-responsive elements (with Y. C. Lin), Journal of immunology (Baltimore, Md. : 1950) (1992)

Inasmuch as transcription of unrearranged, or germ-line, Ig CH genes appears to direct switch recombination,...

 
Effect of cytokines on switching to IgA and alpha germline transcripts in the B lymphoma I.29 mu. Transforming growth factor-beta activates transcription of the unrearranged C alpha gene (with P. Shockett), Journal of immunology (Baltimore, Md. : 1950) (1991)

H chain isotype switch recombination is preceded by the appearance of RNA initiating 5' of...

 
Triple helix stabilization, Nature (1991)

No abstract provided.

 
Regulation of the antibody class switch to IgA (with Y. C. Lin and P. Shockett), Immunologic research (1991)

No abstract provided.

 
Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes (with G. Radcliffe, Y. C. Lin, J. Nietupski, L. Berggren, R. Sitia, and E. Severinson), Proceedings of the National Academy of Sciences of the United States of America (1988)

Immunoglobulin heavy-chain switching is effected by a DNA recombination event that replaces the C mu...

 
I.29 lymphoma cells express a nonmutated VH gene before and after H chain switch (with D. Klein, J. Nietupski, and S. Sirlin), Journal of immunology (Baltimore, Md. : 1950) (1988)

The I.29 B cell lymphoma consists of IgM+ and IgA+ cells which express the same...

 
Specificity of immunoglobulin heavy chain switching by cultured I.29 B lymphoma cells (with G. Radcliffe and E. Severinson), Monographs in allergy (1988)

No abstract provided.

 

PDF

Presence of a polyadenylated RNA fragment encoding the membrane domain for immunoglobulin alpha chain indicates that mRNAs for both secreted and membrane-bound alpha chains can be produced from the same RNA transcript, Nucleic acids research (1986)

RNA blotting was employed to examine polyadenylated immunoglobulin alpha chain RNAs in a B lymphoma...

 
The regulation of membrane-bound and secreted alpha-chain biosynthesis during the differentiation of the B cell lymphoma I.29 (with R. Sitia, A. Rubartelli, H. Kikutani, and U. Hammerling), Journal of immunology (Baltimore, Md. : 1950) (1985)

The regulation of the synthesis of membrane-bound and secreted IgA was investigated in the murine...

 

File

Induction of immunoglobulin isotype switching in cultured I.29 B lymphoma cells. Characterization of the accompanying rearrangements of heavy chain genes (with S. Sirlin and J. Abbott), The Journal of experimental medicine (1985)

The murine B cell lymphoma I.29 contains cells expressing surface IgM or IgA with identical...

 
Immunoglobulin heavy chain switching in cultured I.29 murine B lymphoma cells: commitment to an IgA or IgE switch (with J. Abbott and S. Sirlin), Current topics in microbiology and immunology (1984)

No abstract provided.

 
Rearrangements and deletions of immunoglobulin heavy chain genes in the double-producing B cell lymphoma I.29 (with K. B. Marcu, S. Sirlin, B. Alhadeff, and U. Hammerling), Molecular and cellular biology (1982)

The B cell lymphoma I.29 consists of a mixture of cells expressing membrane-bound immunoglobulin M...

 
Membrane-bound and secreted IgA contain structurally different alpha-chains (with R. Sitia, H. Kikutani, A. Rubartelli, Y. Bushkin, and U. Hammerling), Journal of immunology (Baltimore, Md. : 1950) (1982)

Three different forms of alpha-chains are synthesized by BF0.3 and 615.2, two cloned cell lines...

 
Synthesis and processing of the alpha heavy chains of secreted and membrane-bound IgA (with H. Kikutani, R. Sitia, and R. A. Good), Proceedings of the National Academy of Sciences of the United States of America (1981)

We have compared the synthesis and processing of immunoglobulin alpha chains in two murine cell...

 

Immunoglobulin A, Secretory

The regulation of membrane-bound and secreted alpha-chain biosynthesis during the differentiation of the B cell lymphoma I.29 (with R. Sitia, A. Rubartelli, H. Kikutani, and U. Hammerling), Journal of immunology (Baltimore, Md. : 1950) (1985)

The regulation of the synthesis of membrane-bound and secreted IgA was investigated in the murine...

 

Immunoglobulin A/immunology

DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination (with Xiaoming Wu), The Journal of experimental medicine (2007)

Immunoglobulin (Ig) class switch recombination (CSR) is initiated by activation-induced cytidine deaminase (AID), which converts...

 

Immunoglobulin Allotypes

File

Induction of immunoglobulin isotype switching in cultured I.29 B lymphoma cells. Characterization of the accompanying rearrangements of heavy chain genes (with S. Sirlin and J. Abbott), The Journal of experimental medicine (1985)

The murine B cell lymphoma I.29 contains cells expressing surface IgM or IgA with identical...

 
Rearrangements and deletions of immunoglobulin heavy chain genes in the double-producing B cell lymphoma I.29 (with K. B. Marcu, S. Sirlin, B. Alhadeff, and U. Hammerling), Molecular and cellular biology (1982)

The B cell lymphoma I.29 consists of a mixture of cells expressing membrane-bound immunoglobulin M...

 

Immunoglobulin alpha-Chains

The ubiquitously expressed DNA-binding protein late SV40 factor binds Ig switch regions and represses class switching to IgA (with Elise E. Drouin, Carol E. Schrader, and Ulla Hansen), Journal of immunology (Baltimore, Md. : 1950) (2002)

Ig heavy chain class switch recombination (CSR) determines the expression of Ig isotypes. The molecular...

 
Switch recombination in a transfected plasmid occurs preferentially in a B cell line that undergoes switch recombination of its chromosomal Ig heavy chain genes (with Sean P. Bradley, Norman Rousseau, Todd Pearson, Ananth Shanmugam, Debra J. Waite, Paul R. Rogers, and Amy L. Kenter), Journal of immunology (Baltimore, Md. : 1950) (1999)

Ab class switching is induced upon B cell activation in vivo by immunization or infection...

 
Overexpression of BSAP/Pax-5 inhibits switching to IgA and enhances switching to IgE in the I.29 mu B cell line (with G. Qiu), Journal of immunology (Baltimore, Md. : 1950) (1998)

B cell-specific activator protein (BSAP)/Pax-5 is a paired domain DNA-binding protein expressed in the developing...

 
Regulation of transcription of the germ-line Ig alpha constant region gene by an ATF element and by novel transforming growth factor-beta 1-responsive elements (with Y. C. Lin), Journal of immunology (Baltimore, Md. : 1950) (1992)

Inasmuch as transcription of unrearranged, or germ-line, Ig CH genes appears to direct switch recombination,...

 
Effect of cytokines on switching to IgA and alpha germline transcripts in the B lymphoma I.29 mu. Transforming growth factor-beta activates transcription of the unrearranged C alpha gene (with P. Shockett), Journal of immunology (Baltimore, Md. : 1950) (1991)

H chain isotype switch recombination is preceded by the appearance of RNA initiating 5' of...

 
Structure of germ line immunoglobulin alpha heavy-chain RNA and its location on polysomes (with G. Radcliffe, Y. C. Lin, M. Julius, and K. B. Marcu), Molecular and cellular biology (1990)

We describe the structure of the major germ line RNA transcribed from unrearranged immunoglobulin alpha...

 

PDF

Presence of a polyadenylated RNA fragment encoding the membrane domain for immunoglobulin alpha chain indicates that mRNAs for both secreted and membrane-bound alpha chains can be produced from the same RNA transcript, Nucleic acids research (1986)

RNA blotting was employed to examine polyadenylated immunoglobulin alpha chain RNAs in a B lymphoma...

 
The regulation of membrane-bound and secreted alpha-chain biosynthesis during the differentiation of the B cell lymphoma I.29 (with R. Sitia, A. Rubartelli, H. Kikutani, and U. Hammerling), Journal of immunology (Baltimore, Md. : 1950) (1985)

The regulation of the synthesis of membrane-bound and secreted IgA was investigated in the murine...

 

File

Induction of immunoglobulin isotype switching in cultured I.29 B lymphoma cells. Characterization of the accompanying rearrangements of heavy chain genes (with S. Sirlin and J. Abbott), The Journal of experimental medicine (1985)

The murine B cell lymphoma I.29 contains cells expressing surface IgM or IgA with identical...

 
Rearrangements and deletions of immunoglobulin heavy chain genes in the double-producing B cell lymphoma I.29 (with K. B. Marcu, S. Sirlin, B. Alhadeff, and U. Hammerling), Molecular and cellular biology (1982)

The B cell lymphoma I.29 consists of a mixture of cells expressing membrane-bound immunoglobulin M...

 
Synthesis and processing of the alpha heavy chains of secreted and membrane-bound IgA (with H. Kikutani, R. Sitia, and R. A. Good), Proceedings of the National Academy of Sciences of the United States of America (1981)

We have compared the synthesis and processing of immunoglobulin alpha chains in two murine cell...

 

Immunoglobulin Class Switching

Stimuli that enhance IgA class switching increase histone 3 acetylation at S alpha, but poorly stimulate sequential switching from IgG2b (with Denise A. Kaminski), European journal of immunology (2006)

Germ-line (GL) alpha transcription can be induced in mouse splenic B cells by LPS and...

 
Shifts in targeting of class switch recombination sites in mice that lack mu switch region tandem repeats or Msh2 (with Irene M. Min, Lisa R. Rothlein, Carol E. Schrader, and Erik Selsing), The Journal of experimental medicine (2005)

The mechanisms that target class switch recombination (CSR) to antibody gene switch (S) regions are...

 
Analysis of transforming growth factor-beta1-induced Ig germ-line gamma2b transcription and its implication for IgA isotype switching (with Seok-Rae Park, Goo-Young Seo, Ae-Jin Choi, and Pyeung-Hyeun Kim), European journal of immunology (2005)

Transforming growth factor (TGF)-beta1 directs class switch recombination (CSR) to IgG2b as well as to...

 
Antibody class switching: uncoupling S region accessibility from transcription (with Denise A. Kaminski), Trends in genetics : TIG (2004)

Immunogloblin class switch recombination (CSR) is a regulated process that changes antibody effector functions. Recently,...

 
The Smu tandem repeat region is critical for Ig isotype switching in the absence of Msh2 (with Irene M. Min, Carol E. Schrader, Joycelyn Vardo, Thomas M. Luby, Nicole D'Avirro, and Erik Selsing), Immunity (2003)

Deficiencies of the Msh2 protein or the Smu tandem repeat (SmuTR) sequences each reduce isotype...

 
Mlh1 can function in antibody class switch recombination independently of Msh2 (with Carol E. Schrader and Joycelyn Vardo), The Journal of experimental medicine (2003)

Mismatch repair proteins participate in antibody class switch recombination, although their roles are unknown. Previous...

 
Regulation of the promoter for human immunoglobulin gamma3 germ-line transcription and its interaction with the 3'alpha enhancer (with Q. Pan, C. Petit-Frere, and L. Hammarstrom), European journal of immunology (2000)

The mechanism underlying the differential regulation of switching to human IgG subclasses is still largely...

 
Molecular processes that regulate class switching, Current topics in microbiology and immunology (1999)

No abstract provided.

 
Switch recombination in a transfected plasmid occurs preferentially in a B cell line that undergoes switch recombination of its chromosomal Ig heavy chain genes (with Sean P. Bradley, Norman Rousseau, Todd Pearson, Ananth Shanmugam, Debra J. Waite, Paul R. Rogers, and Amy L. Kenter), Journal of immunology (Baltimore, Md. : 1950) (1999)

Ab class switching is induced upon B cell activation in vivo by immunization or infection...

 
Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes (with Carol E. Schrader, W. Edelmann, and R. Kucherlapati), The Journal of experimental medicine (1999)

Mice deficient in various mismatch repair (MMR) enzymes were examined to determine whether this repair...

 
CBF alpha3 (AML2) is induced by TGF-beta1 to bind and activate the mouse germline Ig alpha promoter (with M. J. Shi), Journal of immunology (Baltimore, Md. : 1950) (1998)

TGF-beta1 directs class switching to IgA by splenic B cells and by the surface IgM+...

 
Overexpression of BSAP/Pax-5 inhibits switching to IgA and enhances switching to IgE in the I.29 mu B cell line (with G. Qiu), Journal of immunology (Baltimore, Md. : 1950) (1998)

B cell-specific activator protein (BSAP)/Pax-5 is a paired domain DNA-binding protein expressed in the developing...

 
The ability of CD40L, but not lipopolysaccharide, to initiate immunoglobulin switching to immunoglobulin G1 is explained by differential induction of NF-kappaB/Rel proteins (with S. C. Lin and H. H. Wortis), Molecular and cellular biology (1998)

Antibodies of the immunoglobulin G1 class are induced in mice by T-cell-dependent antigens but not...

 
Antibody class switching, Advances in immunology (1996)

No abstract provided.

 
Regulation of antibody production and class switching by TGF-beta, Journal of immunology (Baltimore, Md. : 1950) (1995)

No abstract provided.

 

Immunoglobulin Constant Regions

Inducible DNA breaks in Ig S regions are dependent on AID and UNG (with Carol E. Schrader, Erin K. Linehan, Sofia N. Mochegova, and Robert T. Woodland), The Journal of experimental medicine (2005)

Class switch recombination (CSR) occurs by an intrachromosomal deletion whereby the IgM constant region gene...

 
Activation of NF-kappaB/Rel by CD40 engagement induces the mouse germ line immunoglobulin Cgamma1 promoter (with S. C. Lin), Molecular and cellular biology (1996)

Interaction between CD40 on B cells and CD40 ligand (CD40L) on T cells has been...

 
Regulation of antibody class switching to IgE: characterization of an IL-4-responsive region in the immunoglobulin heavy-chain germline epsilon promoter (with S. Delphin), Annals of the New York Academy of Sciences (1995)

A large body of data indicate that antibody class switching is directed by cytokines by...

 
Regulation of transcription of the germ-line Ig alpha constant region gene by an ATF element and by novel transforming growth factor-beta 1-responsive elements (with Y. C. Lin), Journal of immunology (Baltimore, Md. : 1950) (1992)

Inasmuch as transcription of unrearranged, or germ-line, Ig CH genes appears to direct switch recombination,...

 
Effect of cytokines on switching to IgA and alpha germline transcripts in the B lymphoma I.29 mu. Transforming growth factor-beta activates transcription of the unrearranged C alpha gene (with P. Shockett), Journal of immunology (Baltimore, Md. : 1950) (1991)

H chain isotype switch recombination is preceded by the appearance of RNA initiating 5' of...

 
Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes (with G. Radcliffe, Y. C. Lin, J. Nietupski, L. Berggren, R. Sitia, and E. Severinson), Proceedings of the National Academy of Sciences of the United States of America (1988)

Immunoglobulin heavy-chain switching is effected by a DNA recombination event that replaces the C mu...

 

Immunoglobulin E

Overexpression of BSAP/Pax-5 inhibits switching to IgA and enhances switching to IgE in the I.29 mu B cell line (with G. Qiu), Journal of immunology (Baltimore, Md. : 1950) (1998)

B cell-specific activator protein (BSAP)/Pax-5 is a paired domain DNA-binding protein expressed in the developing...

 
CD40 cross-linking induces Ig epsilon germline transcripts in B cells via activation of NF-kappaB: synergy with IL-4 induction (with L. A. Iciek and S. A. Delphin), Journal of immunology (Baltimore, Md. : 1950) (1997)

Transcription of unrearranged (germline) Ig heavy chain C region (C(H)) genes is required before Ab...

 
Regulation of antibody class switching to IgE: characterization of an IL-4-responsive region in the immunoglobulin heavy-chain germline epsilon promoter (with S. Delphin), Annals of the New York Academy of Sciences (1995)

A large body of data indicate that antibody class switching is directed by cytokines by...

 
Interleukins 4 and 5: mechanisms of action (with E. Severinson, H. B. Moon, S. Bergstedt-Lindqvist, U. Persson, and C. Heusser), Advances in experimental medicine and biology (1989)

No abstract provided.

 
Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes (with G. Radcliffe, Y. C. Lin, J. Nietupski, L. Berggren, R. Sitia, and E. Severinson), Proceedings of the National Academy of Sciences of the United States of America (1988)

Immunoglobulin heavy-chain switching is effected by a DNA recombination event that replaces the C mu...

 
Specificity of immunoglobulin heavy chain switching by cultured I.29 B lymphoma cells (with G. Radcliffe and E. Severinson), Monographs in allergy (1988)

No abstract provided.

 

File

Induction of immunoglobulin isotype switching in cultured I.29 B lymphoma cells. Characterization of the accompanying rearrangements of heavy chain genes (with S. Sirlin and J. Abbott), The Journal of experimental medicine (1985)

The murine B cell lymphoma I.29 contains cells expressing surface IgM or IgA with identical...

 
Immunoglobulin heavy chain switching in cultured I.29 murine B lymphoma cells: commitment to an IgA or IgE switch (with J. Abbott and S. Sirlin), Current topics in microbiology and immunology (1984)

No abstract provided.

 

Immunoglobulin epsilon-Chains

Differential regulation of mouse germline Ig gamma 1 and epsilon promoters by IL-4 and CD40 (with C. S. Mao), Journal of immunology (Baltimore, Md. : 1950) (2001)

Before Ig class switching, RNA transcription through the specific S regions undergoing recombination is induced...

 
Activation of the mouse Ig germline epsilon promoter by IL-4 is dependent on AP-1 transcription factors (with Ching-Hung Shen), Journal of immunology (Baltimore, Md. : 1950) (2000)

Induction of germline (GL) epsilon transcripts, an essential step preceding Ig isotype switching to IgE,...

 
Overexpression of BSAP/Pax-5 inhibits switching to IgA and enhances switching to IgE in the I.29 mu B cell line (with G. Qiu), Journal of immunology (Baltimore, Md. : 1950) (1998)

B cell-specific activator protein (BSAP)/Pax-5 is a paired domain DNA-binding protein expressed in the developing...

 
Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50 (with S. Delphin), The Journal of experimental medicine (1995)

A large body of data indicate that antibody class switching is directed by cytokines by...

 

Immunoglobulin G

Antibody class switching differs among SJL, C57BL/6 and 129 mice (with Denise A. Kaminski), International immunology (2007)

Inbred mouse strains used for gene manipulation studies vary in many respects, including immune system...

 
Stimuli that enhance IgA class switching increase histone 3 acetylation at S alpha, but poorly stimulate sequential switching from IgG2b (with Denise A. Kaminski), European journal of immunology (2006)

Germ-line (GL) alpha transcription can be induced in mouse splenic B cells by LPS and...

 
Analysis of transforming growth factor-beta1-induced Ig germ-line gamma2b transcription and its implication for IgA isotype switching (with Seok-Rae Park, Goo-Young Seo, Ae-Jin Choi, and Pyeung-Hyeun Kim), European journal of immunology (2005)

Transforming growth factor (TGF)-beta1 directs class switch recombination (CSR) to IgG2b as well as to...

 
Regulation of the promoter for human immunoglobulin gamma3 germ-line transcription and its interaction with the 3'alpha enhancer (with Q. Pan, C. Petit-Frere, and L. Hammarstrom), European journal of immunology (2000)

The mechanism underlying the differential regulation of switching to human IgG subclasses is still largely...

 
Ialpha exon-replacement mice synthesize a spliced HPRT-C(alpha) transcript which may explain their ability to switch to IgA. Inhibition of switching to IgG in these mice (with G. Qiu and G. R. Harriman), International immunology (1999)

Antibody class switching is regulated by transcription of unrearranged C(H) genes to produce germline (GL)...

 
The ability of CD40L, but not lipopolysaccharide, to initiate immunoglobulin switching to immunoglobulin G1 is explained by differential induction of NF-kappaB/Rel proteins (with S. C. Lin and H. H. Wortis), Molecular and cellular biology (1998)

Antibodies of the immunoglobulin G1 class are induced in mice by T-cell-dependent antigens but not...

 
Activation of NF-kappaB/Rel by CD40 engagement induces the mouse germ line immunoglobulin Cgamma1 promoter (with S. C. Lin), Molecular and cellular biology (1996)

Interaction between CD40 on B cells and CD40 ligand (CD40L) on T cells has been...

 
Specificity of immunoglobulin heavy chain switching by cultured I.29 B lymphoma cells (with G. Radcliffe and E. Severinson), Monographs in allergy (1988)

No abstract provided.

 

Immunoglobulin G/immunology

DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination (with Xiaoming Wu), The Journal of experimental medicine (2007)

Immunoglobulin (Ig) class switch recombination (CSR) is initiated by activation-induced cytidine deaminase (AID), which converts...

 

Immunoglobulin gamma-Chains

Differential regulation of mouse germline Ig gamma 1 and epsilon promoters by IL-4 and CD40 (with C. S. Mao), Journal of immunology (Baltimore, Md. : 1950) (2001)

Before Ig class switching, RNA transcription through the specific S regions undergoing recombination is induced...

 
Cell cycle regulation of immunoglobulin class switch recombination and germ-line transcription: potential role of Ets family members (with M. Lundgren, L. Strom, L. O. Bergquist, S. Skog, T. Heiden, and E. Severinson), European journal of immunology (1995)

Previous studies have indicated that transcription of germ-line (GL) CH genes is necessary to obtain...

 
Activation of the Ig germ-line gamma 1 promoter. Involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site (with M. Lundgren, C. Larsson, A. Femino, M. Xu, and E. Severinson), Journal of immunology (Baltimore, Md. : 1950) (1994)

Ig isotype switching in B lymphocytes is preceded by transcription of the corresponding unrearranged, or...

 
Regulation of transcription of immunoglobulin germ-line gamma 1 RNA: analysis of the promoter/enhancer (with M. Z. Xu), The EMBO journal (1992)

Antibody class switching is achieved by recombinations between switch (S) regions which consist of tandemly...

 
Structure of germline immunoglobulin heavy-chain gamma 1 transcripts in interleukin 4 treated mouse spleen cells (with M. Xu), Developmental immunology (1990)

Antibody class switching is mediated by a DNA recombination event that replaces the C mu...

 

Immunoglobulin Heavy Chains

Immunology. A touch of antibody class, Science (New York, N.Y.) (2000)

When B cells, the antibody producing cells of the body, encounter antigen they switch from...

 
Switch recombination in a transfected plasmid occurs preferentially in a B cell line that undergoes switch recombination of its chromosomal Ig heavy chain genes (with Sean P. Bradley, Norman Rousseau, Todd Pearson, Ananth Shanmugam, Debra J. Waite, Paul R. Rogers, and Amy L. Kenter), Journal of immunology (Baltimore, Md. : 1950) (1999)

Ab class switching is induced upon B cell activation in vivo by immunization or infection...

 
Ialpha exon-replacement mice synthesize a spliced HPRT-C(alpha) transcript which may explain their ability to switch to IgA. Inhibition of switching to IgG in these mice (with G. Qiu and G. R. Harriman), International immunology (1999)

Antibody class switching is regulated by transcription of unrearranged C(H) genes to produce germline (GL)...

 
Antibody class switching, Advances in immunology (1996)

No abstract provided.

 
Regulation of antibody class switching to IgE: characterization of an IL-4-responsive region in the immunoglobulin heavy-chain germline epsilon promoter (with S. Delphin), Annals of the New York Academy of Sciences (1995)

A large body of data indicate that antibody class switching is directed by cytokines by...

 
Induction of germ-line immunoglobulin heavy chain transcripts by mitogens and interleukins prior to switch recombination (with E. Severinson and C. Fernandez), European journal of immunology (1990)

It has recently been postulated that immunoglobulin class switching is preceded by transcription from unrearranged...

 
Copy choice mechanism of immunoglobulin heavy-chain switch recombination (with W. Dunnick), Molecular and cellular biology (1990)

The immunoglobulin heavy-chain switch is mediated by a recombination event between DNA switch regions associated...

 
Structure of germ line immunoglobulin alpha heavy-chain RNA and its location on polysomes (with G. Radcliffe, Y. C. Lin, M. Julius, and K. B. Marcu), Molecular and cellular biology (1990)

We describe the structure of the major germ line RNA transcribed from unrearranged immunoglobulin alpha...

 
Mouse antibody response to group A streptococcal carbohydrate (with C. D. Jarvis and L. E. Cannon), Journal of immunology (Baltimore, Md. : 1950) (1989)

In an attempt to more fully understand the generation of antibody diversity to carbohydrate (CHO)...

 
A B-cell-specific nuclear protein that binds to DNA sites 5' to immunoglobulin S alpha tandem repeats is regulated during differentiation (with S. H. Waters and K. U. Saikh), Molecular and cellular biology (1989)

Immunoglobulin heavy-chain switching is effected by recombination events between sites associated with tandemly repeated switch...

 
Reticulum cell sarcomas of SJL mice have rearranged immunoglobulin heavy and light chain genes (with J. L. Lasky, N. M. Ponzio, M. P. Scheid, and G. J. Thorbecke), European journal of immunology (1989)

The immunoglobulin (Ig) heavy (H) and light (L) chain gene rearrangements of the high incidence...

 
Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes (with G. Radcliffe, Y. C. Lin, J. Nietupski, L. Berggren, R. Sitia, and E. Severinson), Proceedings of the National Academy of Sciences of the United States of America (1988)

Immunoglobulin heavy-chain switching is effected by a DNA recombination event that replaces the C mu...

 
I.29 lymphoma cells express a nonmutated VH gene before and after H chain switch (with D. Klein, J. Nietupski, and S. Sirlin), Journal of immunology (Baltimore, Md. : 1950) (1988)

The I.29 B cell lymphoma consists of IgM+ and IgA+ cells which express the same...

 
Specificity of immunoglobulin heavy chain switching by cultured I.29 B lymphoma cells (with G. Radcliffe and E. Severinson), Monographs in allergy (1988)

No abstract provided.

 

PDF

Presence of a polyadenylated RNA fragment encoding the membrane domain for immunoglobulin alpha chain indicates that mRNAs for both secreted and membrane-bound alpha chains can be produced from the same RNA transcript, Nucleic acids research (1986)

RNA blotting was employed to examine polyadenylated immunoglobulin alpha chain RNAs in a B lymphoma...

 
Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching (with S. Sirlin), The EMBO journal (1986)

IgM+ cells cultured from the I.29 B cell lymphoma can be induced with lipopolysaccharide (LPS)...

 
The regulation of membrane-bound and secreted alpha-chain biosynthesis during the differentiation of the B cell lymphoma I.29 (with R. Sitia, A. Rubartelli, H. Kikutani, and U. Hammerling), Journal of immunology (Baltimore, Md. : 1950) (1985)

The regulation of the synthesis of membrane-bound and secreted IgA was investigated in the murine...

 

File

Induction of immunoglobulin isotype switching in cultured I.29 B lymphoma cells. Characterization of the accompanying rearrangements of heavy chain genes (with S. Sirlin and J. Abbott), The Journal of experimental medicine (1985)

The murine B cell lymphoma I.29 contains cells expressing surface IgM or IgA with identical...

 
Immunoglobulin heavy chain switching in cultured I.29 murine B lymphoma cells: commitment to an IgA or IgE switch (with J. Abbott and S. Sirlin), Current topics in microbiology and immunology (1984)

No abstract provided.

 
Molecular genetics of immunoglobulin heavy chain switching, Survey of immunologic research (1983)

No abstract provided.

 
Rearrangements and deletions of immunoglobulin heavy chain genes in the double-producing B cell lymphoma I.29 (with K. B. Marcu, S. Sirlin, B. Alhadeff, and U. Hammerling), Molecular and cellular biology (1982)

The B cell lymphoma I.29 consists of a mixture of cells expressing membrane-bound immunoglobulin M...

 
Synthesis and processing of the alpha heavy chains of secreted and membrane-bound IgA (with H. Kikutani, R. Sitia, and R. A. Good), Proceedings of the National Academy of Sciences of the United States of America (1981)

We have compared the synthesis and processing of immunoglobulin alpha chains in two murine cell...

 
Expression of an antigen receptor on T cells does not require recombination at the immunoglobulin JH-C mu locus (with Y. Cayre, M. A. Palladino, and K. B. Marcu), Proceedings of the National Academy of Sciences of the United States of America (1981)

Considerable evidence has accumulated suggesting that the antigen receptor(s) on T cells is coded for...

 

Immunoglobulin Idiotypes

File

Induction of immunoglobulin isotype switching in cultured I.29 B lymphoma cells. Characterization of the accompanying rearrangements of heavy chain genes (with S. Sirlin and J. Abbott), The Journal of experimental medicine (1985)

The murine B cell lymphoma I.29 contains cells expressing surface IgM or IgA with identical...

 

Immunoglobulin Isotypes

Stimuli that enhance IgA class switching increase histone 3 acetylation at S alpha, but poorly stimulate sequential switching from IgG2b (with Denise A. Kaminski), European journal of immunology (2006)

Germ-line (GL) alpha transcription can be induced in mouse splenic B cells by LPS and...

 
The Smu tandem repeat region is critical for Ig isotype switching in the absence of Msh2 (with Irene M. Min, Carol E. Schrader, Joycelyn Vardo, Thomas M. Luby, Nicole D'Avirro, and Erik Selsing), Immunity (2003)

Deficiencies of the Msh2 protein or the Smu tandem repeat (SmuTR) sequences each reduce isotype...

 
Evidence for class-specific factors in immunoglobulin isotype switching (with A. Shanmugam, M. J. Shi, L. Yauch, and A. L. Kenter), The Journal of experimental medicine (2000)

Immunoglobulin class switch recombination (SR) occurs by a B cell-specific, intrachromosomal deletional process between switch...

 
Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes (with Carol E. Schrader, W. Edelmann, and R. Kucherlapati), The Journal of experimental medicine (1999)

Mice deficient in various mismatch repair (MMR) enzymes were examined to determine whether this repair...

 
Antibody class switching, Advances in immunology (1996)

No abstract provided.

 
Activation of the Ig germ-line gamma 1 promoter. Involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site (with M. Lundgren, C. Larsson, A. Femino, M. Xu, and E. Severinson), Journal of immunology (Baltimore, Md. : 1950) (1994)

Ig isotype switching in B lymphocytes is preceded by transcription of the corresponding unrearranged, or...

 
Regulation of the antibody class switch to IgA (with Y. C. Lin and P. Shockett), Immunologic research (1991)

No abstract provided.

 
Induction of germ-line immunoglobulin heavy chain transcripts by mitogens and interleukins prior to switch recombination (with E. Severinson and C. Fernandez), European journal of immunology (1990)

It has recently been postulated that immunoglobulin class switching is preceded by transcription from unrearranged...

 

Immunoglobulin J-Chains

PDF

Aberrant recombination events in B cell lines derived from a kappa-deficient human (with O. Kekish, D. Batter, J. Grenier, I. Balazs, E. Henderson, and B. J. Zegers), Nucleic acids research (1985)

We have analyzed the structure of Ig kappa chain genes in B cell lines derived...

 

Immunoglobulin Joining Region

The J kappa proximal region of the human K locus contains three uncommon V kappa genes which are arranged in opposite transcriptional polarities (with W. Lorenz, K. F. Schable, R. Thiebe, and H. G. Zachau), Molecular immunology (1988)

The structure of one of the V kappa gene-containing regions of the locus coding for...

 

Immunoglobulin kappa-Chains

Mouse antibody response to group A streptococcal carbohydrate (with C. D. Jarvis and L. E. Cannon), Journal of immunology (Baltimore, Md. : 1950) (1989)

In an attempt to more fully understand the generation of antibody diversity to carbohydrate (CHO)...

 
Reticulum cell sarcomas of SJL mice have rearranged immunoglobulin heavy and light chain genes (with J. L. Lasky, N. M. Ponzio, M. P. Scheid, and G. J. Thorbecke), European journal of immunology (1989)

The immunoglobulin (Ig) heavy (H) and light (L) chain gene rearrangements of the high incidence...

 
The J kappa proximal region of the human K locus contains three uncommon V kappa genes which are arranged in opposite transcriptional polarities (with W. Lorenz, K. F. Schable, R. Thiebe, and H. G. Zachau), Molecular immunology (1988)

The structure of one of the V kappa gene-containing regions of the locus coding for...

 
Surface immunoglobulin light chain expression in pre-B cell leukemias (with B. Koziner, A. Al-Katib, D. Gebhard, A. Mittelman, M. Andreeff, and B. D. Clarkson), Annals of the New York Academy of Sciences (1986)

Cytofluorographic analysis of surface immunoglobulin (sIg) light chain clonal excess (CE), defined as (%kappa+ -...

 
Molecular defects in a human immunoglobulin kappa chain deficiency (with O. Kekish and B. J. Zegers), Science (New York, N.Y.) (1985)

The molecular basis of a human immunoglobulin deficiency characterized by the complete absence of kappa...

 

PDF

Aberrant recombination events in B cell lines derived from a kappa-deficient human (with O. Kekish, D. Batter, J. Grenier, I. Balazs, E. Henderson, and B. J. Zegers), Nucleic acids research (1985)

We have analyzed the structure of Ig kappa chain genes in B cell lines derived...

 
Synthesis and isolation of DNA complementary to nucleotide sequences encoding the variable region of immunoglobulin kappa chain (with J. M. Bishop), Biochemistry (1977)

No abstract provided.

 

Immunoglobulin lambda-Chains

Surface immunoglobulin light chain expression in pre-B cell leukemias (with B. Koziner, A. Al-Katib, D. Gebhard, A. Mittelman, M. Andreeff, and B. D. Clarkson), Annals of the New York Academy of Sciences (1986)

Cytofluorographic analysis of surface immunoglobulin (sIg) light chain clonal excess (CE), defined as (%kappa+ -...

 

Immunoglobulin Light Chains

Expression of immunoglobulin lambda light chain by the promyelocytic cell line HL-60 (with A. Al-Katib and B. Koziner), Journal of immunology (Baltimore, Md. : 1950) (1986)

The HL-60 cell line, established from a patient with acute promyelocytic leukemia, can be induced...

 
Surface immunoglobulin light chain expression in pre-B cell leukemias (with B. Koziner, A. Al-Katib, D. Gebhard, A. Mittelman, M. Andreeff, and B. D. Clarkson), Annals of the New York Academy of Sciences (1986)

Cytofluorographic analysis of surface immunoglobulin (sIg) light chain clonal excess (CE), defined as (%kappa+ -...

 
Surface immunoglobulin light-chain expression by the "common" all cell line REH (with B. Koziner and A. Al-Katib), Clinical immunology and immunopathology (1985)

To provide further support of the B-cell lineage of "common" acute lymphoblastic leukemia (ALL), we...

 

PDF

Aberrant recombination events in B cell lines derived from a kappa-deficient human (with O. Kekish, D. Batter, J. Grenier, I. Balazs, E. Henderson, and B. J. Zegers), Nucleic acids research (1985)

We have analyzed the structure of Ig kappa chain genes in B cell lines derived...

 
Synthesis and isolation of DNA complementary to nucleotide sequences encoding the variable region of immunoglobulin kappa chain (with J. M. Bishop), Biochemistry (1977)

No abstract provided.

 

Immunoglobulin M

Antibody class switching differs among SJL, C57BL/6 and 129 mice (with Denise A. Kaminski), International immunology (2007)

Inbred mouse strains used for gene manipulation studies vary in many respects, including immune system...

 
Does activation-induced deaminase initiate antibody diversification by DNA deamination (with Sean P. Bradley), Trends in genetics : TIG (2002)

Activation-induced deaminase (AID) is expressed only in germinal center B cells. There, it is required...

 
CBF alpha3 (AML2) is induced by TGF-beta1 to bind and activate the mouse germline Ig alpha promoter (with M. J. Shi), Journal of immunology (Baltimore, Md. : 1950) (1998)

TGF-beta1 directs class switching to IgA by splenic B cells and by the surface IgM+...

 
Regulation of transcription of immunoglobulin germ-line gamma 1 RNA: analysis of the promoter/enhancer (with M. Z. Xu), The EMBO journal (1992)

Antibody class switching is achieved by recombinations between switch (S) regions which consist of tandemly...

 
Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes (with G. Radcliffe, Y. C. Lin, J. Nietupski, L. Berggren, R. Sitia, and E. Severinson), Proceedings of the National Academy of Sciences of the United States of America (1988)

Immunoglobulin heavy-chain switching is effected by a DNA recombination event that replaces the C mu...

 
I.29 lymphoma cells express a nonmutated VH gene before and after H chain switch (with D. Klein, J. Nietupski, and S. Sirlin), Journal of immunology (Baltimore, Md. : 1950) (1988)

The I.29 B cell lymphoma consists of IgM+ and IgA+ cells which express the same...

 
Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching (with S. Sirlin), The EMBO journal (1986)

IgM+ cells cultured from the I.29 B cell lymphoma can be induced with lipopolysaccharide (LPS)...

 

File

Induction of immunoglobulin isotype switching in cultured I.29 B lymphoma cells. Characterization of the accompanying rearrangements of heavy chain genes (with S. Sirlin and J. Abbott), The Journal of experimental medicine (1985)

The murine B cell lymphoma I.29 contains cells expressing surface IgM or IgA with identical...

 
Rearrangements and deletions of immunoglobulin heavy chain genes in the double-producing B cell lymphoma I.29 (with K. B. Marcu, S. Sirlin, B. Alhadeff, and U. Hammerling), Molecular and cellular biology (1982)

The B cell lymphoma I.29 consists of a mixture of cells expressing membrane-bound immunoglobulin M...

 

Immunoglobulin mu-Chains

Inducible DNA breaks in Ig S regions are dependent on AID and UNG (with Carol E. Schrader, Erin K. Linehan, Sofia N. Mochegova, and Robert T. Woodland), The Journal of experimental medicine (2005)

Class switch recombination (CSR) occurs by an intrachromosomal deletion whereby the IgM constant region gene...

 
The ubiquitously expressed DNA-binding protein late SV40 factor binds Ig switch regions and represses class switching to IgA (with Elise E. Drouin, Carol E. Schrader, and Ulla Hansen), Journal of immunology (Baltimore, Md. : 1950) (2002)

Ig heavy chain class switch recombination (CSR) determines the expression of Ig isotypes. The molecular...

 
Switch recombination in a transfected plasmid occurs preferentially in a B cell line that undergoes switch recombination of its chromosomal Ig heavy chain genes (with Sean P. Bradley, Norman Rousseau, Todd Pearson, Ananth Shanmugam, Debra J. Waite, Paul R. Rogers, and Amy L. Kenter), Journal of immunology (Baltimore, Md. : 1950) (1999)

Ab class switching is induced upon B cell activation in vivo by immunization or infection...

 
Overexpression of BSAP/Pax-5 inhibits switching to IgA and enhances switching to IgE in the I.29 mu B cell line (with G. Qiu), Journal of immunology (Baltimore, Md. : 1950) (1998)

B cell-specific activator protein (BSAP)/Pax-5 is a paired domain DNA-binding protein expressed in the developing...

 
Cell cycle regulation of immunoglobulin class switch recombination and germ-line transcription: potential role of Ets family members (with M. Lundgren, L. Strom, L. O. Bergquist, S. Skog, T. Heiden, and E. Severinson), European journal of immunology (1995)

Previous studies have indicated that transcription of germ-line (GL) CH genes is necessary to obtain...

 

File

Induction of immunoglobulin isotype switching in cultured I.29 B lymphoma cells. Characterization of the accompanying rearrangements of heavy chain genes (with S. Sirlin and J. Abbott), The Journal of experimental medicine (1985)

The murine B cell lymphoma I.29 contains cells expressing surface IgM or IgA with identical...

 
Rearrangements and deletions of immunoglobulin heavy chain genes in the double-producing B cell lymphoma I.29 (with K. B. Marcu, S. Sirlin, B. Alhadeff, and U. Hammerling), Molecular and cellular biology (1982)

The B cell lymphoma I.29 consists of a mixture of cells expressing membrane-bound immunoglobulin M...

 
Expression of an antigen receptor on T cells does not require recombination at the immunoglobulin JH-C mu locus (with Y. Cayre, M. A. Palladino, and K. B. Marcu), Proceedings of the National Academy of Sciences of the United States of America (1981)

Considerable evidence has accumulated suggesting that the antigen receptor(s) on T cells is coded for...

 

Immunoglobulin Switch Region

Shifts in targeting of class switch recombination sites in mice that lack mu switch region tandem repeats or Msh2 (with Irene M. Min, Lisa R. Rothlein, Carol E. Schrader, and Erik Selsing), The Journal of experimental medicine (2005)

The mechanisms that target class switch recombination (CSR) to antibody gene switch (S) regions are...

 
Antibody class switching: uncoupling S region accessibility from transcription (with Denise A. Kaminski), Trends in genetics : TIG (2004)

Immunogloblin class switch recombination (CSR) is a regulated process that changes antibody effector functions. Recently,...

 
Switch recombination in a transfected plasmid occurs preferentially in a B cell line that undergoes switch recombination of its chromosomal Ig heavy chain genes (with Sean P. Bradley, Norman Rousseau, Todd Pearson, Ananth Shanmugam, Debra J. Waite, Paul R. Rogers, and Amy L. Kenter), Journal of immunology (Baltimore, Md. : 1950) (1999)

Ab class switching is induced upon B cell activation in vivo by immunization or infection...

 
Inhibitors of poly(ADP-ribose) polymerase increase antibody class switching (with P. Shockett), Journal of immunology (Baltimore, Md. : 1950) (1993)

Previous studies suggest that heavy chain isotype switch (S) recombination is directed by cytokine-induced transcription...

 
Effect of cytokines on switching to IgA and alpha germline transcripts in the B lymphoma I.29 mu. Transforming growth factor-beta activates transcription of the unrearranged C alpha gene (with P. Shockett), Journal of immunology (Baltimore, Md. : 1950) (1991)

H chain isotype switch recombination is preceded by the appearance of RNA initiating 5' of...

 
Triple helix stabilization, Nature (1991)

No abstract provided.

 
Induction of germ-line immunoglobulin heavy chain transcripts by mitogens and interleukins prior to switch recombination (with E. Severinson and C. Fernandez), European journal of immunology (1990)

It has recently been postulated that immunoglobulin class switching is preceded by transcription from unrearranged...

 
Mutations, duplication, and deletion of recombined switch regions suggest a role for DNA replication in the immunoglobulin heavy-chain switch (with W. Dunnick and M. Wilson), Molecular and cellular biology (1989)

The heavy-chain switch from immunoglobulin M (IgM) expression to IgA expression is mediated by a...

 
I.29 lymphoma cells express a nonmutated VH gene before and after H chain switch (with D. Klein, J. Nietupski, and S. Sirlin), Journal of immunology (Baltimore, Md. : 1950) (1988)

The I.29 B cell lymphoma consists of IgM+ and IgA+ cells which express the same...

 

Immunoglobulin Switch Region/*genetics/immunology

DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination (with Xiaoming Wu), The Journal of experimental medicine (2007)

Immunoglobulin (Ig) class switch recombination (CSR) is initiated by activation-induced cytidine deaminase (AID), which converts...

 

Immunoglobulin Variable Region

Does activation-induced deaminase initiate antibody diversification by DNA deamination (with Sean P. Bradley), Trends in genetics : TIG (2002)

Activation-induced deaminase (AID) is expressed only in germinal center B cells. There, it is required...

 
Mouse antibody response to group A streptococcal carbohydrate (with C. D. Jarvis and L. E. Cannon), Journal of immunology (Baltimore, Md. : 1950) (1989)

In an attempt to more fully understand the generation of antibody diversity to carbohydrate (CHO)...

 
The J kappa proximal region of the human K locus contains three uncommon V kappa genes which are arranged in opposite transcriptional polarities (with W. Lorenz, K. F. Schable, R. Thiebe, and H. G. Zachau), Molecular immunology (1988)

The structure of one of the V kappa gene-containing regions of the locus coding for...

 
I.29 lymphoma cells express a nonmutated VH gene before and after H chain switch (with D. Klein, J. Nietupski, and S. Sirlin), Journal of immunology (Baltimore, Md. : 1950) (1988)

The I.29 B cell lymphoma consists of IgM+ and IgA+ cells which express the same...

 

PDF

Aberrant recombination events in B cell lines derived from a kappa-deficient human (with O. Kekish, D. Batter, J. Grenier, I. Balazs, E. Henderson, and B. J. Zegers), Nucleic acids research (1985)

We have analyzed the structure of Ig kappa chain genes in B cell lines derived...

 

Immunoglobulins

Evolution of isotype switching (with Chris T. Amemiya), Seminars in immunology (2004)

This review discusses evolution of the process of Ig heavy chain class switching, relating it...

 
Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter (with J. Hanai, L. F. Chen, T. Kanno, N. Ohtani-Fujita, W. Y. Kim, W. H. Guo, T. Imamura, Y. Ishidou, M. Fukuchi, M. J. Shi, M. Kawabata, K. Miyazono, and Y. Ito), The Journal of biological chemistry (1999)

Smads are signal transducers for members of the transforming growth factor-beta (TGF-beta) superfamily. Upon ligand...

 
Immunoglobulin class switching, Current opinion in immunology (1996)

Antibody class switching is induced by B-cell activators in the presence of cytokines. The identity...

 

File

Induction of immunoglobulin isotype switching in cultured I.29 B lymphoma cells. Characterization of the accompanying rearrangements of heavy chain genes (with S. Sirlin and J. Abbott), The Journal of experimental medicine (1985)

The murine B cell lymphoma I.29 contains cells expressing surface IgM or IgA with identical...

 
Synthesis of a mouse immunoglobulin light chain in a rabbit reticulocyte cell-free system (with R. C. Huang), Nature: New biology (1971)

No abstract provided.

 

Immunologic Deficiency Syndromes

Induction of germ-line immunoglobulin heavy chain transcripts by mitogens and interleukins prior to switch recombination (with E. Severinson and C. Fernandez), European journal of immunology (1990)

It has recently been postulated that immunoglobulin class switching is preceded by transcription from unrearranged...

 
Molecular defects in a human immunoglobulin kappa chain deficiency (with O. Kekish and B. J. Zegers), Science (New York, N.Y.) (1985)

The molecular basis of a human immunoglobulin deficiency characterized by the complete absence of kappa...

 

Immunophenotyping

Antibody class switching differs among SJL, C57BL/6 and 129 mice (with Denise A. Kaminski), International immunology (2007)

Inbred mouse strains used for gene manipulation studies vary in many respects, including immune system...

 

Immunosuppressive Agents

Overexpression of BSAP/Pax-5 inhibits switching to IgA and enhances switching to IgE in the I.29 mu B cell line (with G. Qiu), Journal of immunology (Baltimore, Md. : 1950) (1998)

B cell-specific activator protein (BSAP)/Pax-5 is a paired domain DNA-binding protein expressed in the developing...

 

inhibitors

Activation of the mouse Ig germline epsilon promoter by IL-4 is dependent on AP-1 transcription factors (with Ching-Hung Shen), Journal of immunology (Baltimore, Md. : 1950) (2000)

Induction of germline (GL) epsilon transcripts, an essential step preceding Ig isotype switching to IgE,...

 

Interferon Type II

Effect of cytokines on switching to IgA and alpha germline transcripts in the B lymphoma I.29 mu. Transforming growth factor-beta activates transcription of the unrearranged C alpha gene (with P. Shockett), Journal of immunology (Baltimore, Md. : 1950) (1991)

H chain isotype switch recombination is preceded by the appearance of RNA initiating 5' of...

 
Induction of germ-line immunoglobulin heavy chain transcripts by mitogens and interleukins prior to switch recombination (with E. Severinson and C. Fernandez), European journal of immunology (1990)

It has recently been postulated that immunoglobulin class switching is preceded by transcription from unrearranged...

 

Interleukin-4

Antibody class switching differs among SJL, C57BL/6 and 129 mice (with Denise A. Kaminski), International immunology (2007)

Inbred mouse strains used for gene manipulation studies vary in many respects, including immune system...

 
Stimuli that enhance IgA class switching increase histone 3 acetylation at S alpha, but poorly stimulate sequential switching from IgG2b (with Denise A. Kaminski), European journal of immunology (2006)

Germ-line (GL) alpha transcription can be induced in mouse splenic B cells by LPS and...

 
Enhanced IgA class switching in marginal zone and B1 B cells relative to follicular/B2 B cells (with Denise A. Kaminski), Journal of immunology (Baltimore, Md. : 1950) (2006)

Mouse splenic marginal zone (MZ) B cells and B1 B cells enriched in the peritoneal...

 
Differential regulation of mouse germline Ig gamma 1 and epsilon promoters by IL-4 and CD40 (with C. S. Mao), Journal of immunology (Baltimore, Md. : 1950) (2001)

Before Ig class switching, RNA transcription through the specific S regions undergoing recombination is induced...

 
Activation of the mouse Ig germline epsilon promoter by IL-4 is dependent on AP-1 transcription factors (with Ching-Hung Shen), Journal of immunology (Baltimore, Md. : 1950) (2000)

Induction of germline (GL) epsilon transcripts, an essential step preceding Ig isotype switching to IgE,...

 
Regulation of the promoter for human immunoglobulin gamma3 germ-line transcription and its interaction with the 3'alpha enhancer (with Q. Pan, C. Petit-Frere, and L. Hammarstrom), European journal of immunology (2000)

The mechanism underlying the differential regulation of switching to human IgG subclasses is still largely...

 
The ability of CD40L, but not lipopolysaccharide, to initiate immunoglobulin switching to immunoglobulin G1 is explained by differential induction of NF-kappaB/Rel proteins (with S. C. Lin and H. H. Wortis), Molecular and cellular biology (1998)

Antibodies of the immunoglobulin G1 class are induced in mice by T-cell-dependent antigens but not...

 
Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription (with Ching-Hung Shen), Molecular and cellular biology (1998)

Signal transducer and activator of transcription 6 (Stat6) and NF-kappaB are widely distributed transcription factors...

 
CD40 cross-linking induces Ig epsilon germline transcripts in B cells via activation of NF-kappaB: synergy with IL-4 induction (with L. A. Iciek and S. A. Delphin), Journal of immunology (Baltimore, Md. : 1950) (1997)

Transcription of unrearranged (germline) Ig heavy chain C region (C(H)) genes is required before Ab...

 
Regulation of antibody class switching to IgE: characterization of an IL-4-responsive region in the immunoglobulin heavy-chain germline epsilon promoter (with S. Delphin), Annals of the New York Academy of Sciences (1995)

A large body of data indicate that antibody class switching is directed by cytokines by...

 
Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50 (with S. Delphin), The Journal of experimental medicine (1995)

A large body of data indicate that antibody class switching is directed by cytokines by...

 
Regulation of transcription of immunoglobulin germ-line gamma 1 RNA: analysis of the promoter/enhancer (with M. Z. Xu), The EMBO journal (1992)

Antibody class switching is achieved by recombinations between switch (S) regions which consist of tandemly...

 
Effect of cytokines on switching to IgA and alpha germline transcripts in the B lymphoma I.29 mu. Transforming growth factor-beta activates transcription of the unrearranged C alpha gene (with P. Shockett), Journal of immunology (Baltimore, Md. : 1950) (1991)

H chain isotype switch recombination is preceded by the appearance of RNA initiating 5' of...

 
Induction of germ-line immunoglobulin heavy chain transcripts by mitogens and interleukins prior to switch recombination (with E. Severinson and C. Fernandez), European journal of immunology (1990)

It has recently been postulated that immunoglobulin class switching is preceded by transcription from unrearranged...

 
Structure of germline immunoglobulin heavy-chain gamma 1 transcripts in interleukin 4 treated mouse spleen cells (with M. Xu), Developmental immunology (1990)

Antibody class switching is mediated by a DNA recombination event that replaces the C mu...

 
Interleukins 4 and 5: mechanisms of action (with E. Severinson, H. B. Moon, S. Bergstedt-Lindqvist, U. Persson, and C. Heusser), Advances in experimental medicine and biology (1989)

No abstract provided.

 
Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes (with G. Radcliffe, Y. C. Lin, J. Nietupski, L. Berggren, R. Sitia, and E. Severinson), Proceedings of the National Academy of Sciences of the United States of America (1988)

Immunoglobulin heavy-chain switching is effected by a DNA recombination event that replaces the C mu...

 

Interleukin-5

Antibody class switching differs among SJL, C57BL/6 and 129 mice (with Denise A. Kaminski), International immunology (2007)

Inbred mouse strains used for gene manipulation studies vary in many respects, including immune system...

 
Stimuli that enhance IgA class switching increase histone 3 acetylation at S alpha, but poorly stimulate sequential switching from IgG2b (with Denise A. Kaminski), European journal of immunology (2006)

Germ-line (GL) alpha transcription can be induced in mouse splenic B cells by LPS and...

 
Enhanced IgA class switching in marginal zone and B1 B cells relative to follicular/B2 B cells (with Denise A. Kaminski), Journal of immunology (Baltimore, Md. : 1950) (2006)

Mouse splenic marginal zone (MZ) B cells and B1 B cells enriched in the peritoneal...

 
Induction of germ-line immunoglobulin heavy chain transcripts by mitogens and interleukins prior to switch recombination (with E. Severinson and C. Fernandez), European journal of immunology (1990)

It has recently been postulated that immunoglobulin class switching is preceded by transcription from unrearranged...

 
Interleukins 4 and 5: mechanisms of action (with E. Severinson, H. B. Moon, S. Bergstedt-Lindqvist, U. Persson, and C. Heusser), Advances in experimental medicine and biology (1989)

No abstract provided.

 
Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes (with G. Radcliffe, Y. C. Lin, J. Nietupski, L. Berggren, R. Sitia, and E. Severinson), Proceedings of the National Academy of Sciences of the United States of America (1988)

Immunoglobulin heavy-chain switching is effected by a DNA recombination event that replaces the C mu...

 

Interleukins

Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes (with G. Radcliffe, Y. C. Lin, J. Nietupski, L. Berggren, R. Sitia, and E. Severinson), Proceedings of the National Academy of Sciences of the United States of America (1988)

Immunoglobulin heavy-chain switching is effected by a DNA recombination event that replaces the C mu...

 

Introns

The Smu tandem repeat region is critical for Ig isotype switching in the absence of Msh2 (with Irene M. Min, Carol E. Schrader, Joycelyn Vardo, Thomas M. Luby, Nicole D'Avirro, and Erik Selsing), Immunity (2003)

Deficiencies of the Msh2 protein or the Smu tandem repeat (SmuTR) sequences each reduce isotype...

 

Kinetics

Activation of the mouse Ig germline epsilon promoter by IL-4 is dependent on AP-1 transcription factors (with Ching-Hung Shen), Journal of immunology (Baltimore, Md. : 1950) (2000)

Induction of germline (GL) epsilon transcripts, an essential step preceding Ig isotype switching to IgE,...

 
Induction of germ-line immunoglobulin heavy chain transcripts by mitogens and interleukins prior to switch recombination (with E. Severinson and C. Fernandez), European journal of immunology (1990)

It has recently been postulated that immunoglobulin class switching is preceded by transcription from unrearranged...

 
Synthesis and isolation of DNA complementary to nucleotide sequences encoding the variable region of immunoglobulin kappa chain (with J. M. Bishop), Biochemistry (1977)

No abstract provided.

 

Leucine

The ubiquitously expressed DNA-binding protein late SV40 factor binds Ig switch regions and represses class switching to IgA (with Elise E. Drouin, Carol E. Schrader, and Ulla Hansen), Journal of immunology (Baltimore, Md. : 1950) (2002)

Ig heavy chain class switch recombination (CSR) determines the expression of Ig isotypes. The molecular...

 
Letter: Translation of messenger RNA for mouse immunoglobulin light chains in living frog oocytes (with M. Smith, R. C. Huang, J. B. Gurdon, and C. D. Lane), Journal of molecular biology (1973)

No abstract provided.

 
Synthesis of a mouse immunoglobulin light chain in a rabbit reticulocyte cell-free system (with R. C. Huang), Nature: New biology (1971)

No abstract provided.

 

Leukemia

Surface immunoglobulin light chain expression in pre-B cell leukemias (with B. Koziner, A. Al-Katib, D. Gebhard, A. Mittelman, M. Andreeff, and B. D. Clarkson), Annals of the New York Academy of Sciences (1986)

Cytofluorographic analysis of surface immunoglobulin (sIg) light chain clonal excess (CE), defined as (%kappa+ -...

 

Leukemia, Lymphocytic

Surface immunoglobulin light-chain expression by the "common" all cell line REH (with B. Koziner and A. Al-Katib), Clinical immunology and immunopathology (1985)

To provide further support of the B-cell lineage of "common" acute lymphoblastic leukemia (ALL), we...

 

Leukemia, Myelocytic, Acute

Expression of immunoglobulin lambda light chain by the promyelocytic cell line HL-60 (with A. Al-Katib and B. Koziner), Journal of immunology (Baltimore, Md. : 1950) (1986)

The HL-60 cell line, established from a patient with acute promyelocytic leukemia, can be induced...

 

Lipopolysaccharides

Antibody class switching differs among SJL, C57BL/6 and 129 mice (with Denise A. Kaminski), International immunology (2007)

Inbred mouse strains used for gene manipulation studies vary in many respects, including immune system...

 
Enhanced IgA class switching in marginal zone and B1 B cells relative to follicular/B2 B cells (with Denise A. Kaminski), Journal of immunology (Baltimore, Md. : 1950) (2006)

Mouse splenic marginal zone (MZ) B cells and B1 B cells enriched in the peritoneal...

 
The ability of CD40L, but not lipopolysaccharide, to initiate immunoglobulin switching to immunoglobulin G1 is explained by differential induction of NF-kappaB/Rel proteins (with S. C. Lin and H. H. Wortis), Molecular and cellular biology (1998)

Antibodies of the immunoglobulin G1 class are induced in mice by T-cell-dependent antigens but not...

 
Inhibitors of poly(ADP-ribose) polymerase increase antibody class switching (with P. Shockett), Journal of immunology (Baltimore, Md. : 1950) (1993)

Previous studies suggest that heavy chain isotype switch (S) recombination is directed by cytokine-induced transcription...

 
Effect of cytokines on switching to IgA and alpha germline transcripts in the B lymphoma I.29 mu. Transforming growth factor-beta activates transcription of the unrearranged C alpha gene (with P. Shockett), Journal of immunology (Baltimore, Md. : 1950) (1991)

H chain isotype switch recombination is preceded by the appearance of RNA initiating 5' of...

 
Induction of germ-line immunoglobulin heavy chain transcripts by mitogens and interleukins prior to switch recombination (with E. Severinson and C. Fernandez), European journal of immunology (1990)

It has recently been postulated that immunoglobulin class switching is preceded by transcription from unrearranged...

 
Interleukins 4 and 5: mechanisms of action (with E. Severinson, H. B. Moon, S. Bergstedt-Lindqvist, U. Persson, and C. Heusser), Advances in experimental medicine and biology (1989)

No abstract provided.

 
The regulation of membrane-bound and secreted alpha-chain biosynthesis during the differentiation of the B cell lymphoma I.29 (with R. Sitia, A. Rubartelli, H. Kikutani, and U. Hammerling), Journal of immunology (Baltimore, Md. : 1950) (1985)

The regulation of the synthesis of membrane-bound and secreted IgA was investigated in the murine...

 

File

Induction of immunoglobulin isotype switching in cultured I.29 B lymphoma cells. Characterization of the accompanying rearrangements of heavy chain genes (with S. Sirlin and J. Abbott), The Journal of experimental medicine (1985)

The murine B cell lymphoma I.29 contains cells expressing surface IgM or IgA with identical...

 
Immunoglobulin heavy chain switching in cultured I.29 murine B lymphoma cells: commitment to an IgA or IgE switch (with J. Abbott and S. Sirlin), Current topics in microbiology and immunology (1984)

No abstract provided.

 

Lipopolysaccharides/pharmacology

DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination (with Xiaoming Wu), The Journal of experimental medicine (2007)

Immunoglobulin (Ig) class switch recombination (CSR) is initiated by activation-induced cytidine deaminase (AID), which converts...

 

Liver

I.29 lymphoma cells express a nonmutated VH gene before and after H chain switch (with D. Klein, J. Nietupski, and S. Sirlin), Journal of immunology (Baltimore, Md. : 1950) (1988)

The I.29 B cell lymphoma consists of IgM+ and IgA+ cells which express the same...

 
Isolation of messenger RNA for an immunoglobulin kappa chain and enumeration of the genes for the constatn region of kappa chain in the mouse (with R. C. Huang, E. Stavnezer, and J. M. Bishop), Journal of molecular biology (1974)

No abstract provided.

 
Synthesis of a deoxyribonucleic acid sequence complementary to ovalbumin messenger ribonucleic acid and quantification of ovalbumin genes (with D. Sullivan, R. Palacios, J. M. Taylor, A. J. Faras, M. L. Kiely, N. M. Summers, J. M. Bishop, and R. T. Schimke), The Journal of biological chemistry (1973)

No abstract provided.

 

Luciferases

The ability of CD40L, but not lipopolysaccharide, to initiate immunoglobulin switching to immunoglobulin G1 is explained by differential induction of NF-kappaB/Rel proteins (with S. C. Lin and H. H. Wortis), Molecular and cellular biology (1998)

Antibodies of the immunoglobulin G1 class are induced in mice by T-cell-dependent antigens but not...

 
Regulation of antibody class switching to IgE: characterization of an IL-4-responsive region in the immunoglobulin heavy-chain germline epsilon promoter (with S. Delphin), Annals of the New York Academy of Sciences (1995)

A large body of data indicate that antibody class switching is directed by cytokines by...

 
Regulation of transcription of immunoglobulin germ-line gamma 1 RNA: analysis of the promoter/enhancer (with M. Z. Xu), The EMBO journal (1992)

Antibody class switching is achieved by recombinations between switch (S) regions which consist of tandemly...

 

Lymphocyte Activation

Antibody class switching differs among SJL, C57BL/6 and 129 mice (with Denise A. Kaminski), International immunology (2007)

Inbred mouse strains used for gene manipulation studies vary in many respects, including immune system...

 
Stimuli that enhance IgA class switching increase histone 3 acetylation at S alpha, but poorly stimulate sequential switching from IgG2b (with Denise A. Kaminski), European journal of immunology (2006)

Germ-line (GL) alpha transcription can be induced in mouse splenic B cells by LPS and...

 
Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination (with Carol E. Schrader, Sean P. Bradley, Joycelyn Vardo, Sofia N. Mochegova, and Erin Flanagan), The EMBO journal (2003)

Nucleotide substitutions are found in recombined Ig switch (S) regions and also in unrecombined (germline,...

 
Roles of Ets proteins, NF-kappa B and nocodazole in regulating induction of transcription of mouse germline Ig alpha RNA by transforming growth factor-beta 1 (with M. J. Shi, S. R. Park, and P. H. Kim), International immunology (2001)

Antibody class switch recombination (CSR) occurs after antigen activation of B cells. CSR is directed...

 
Activation of the mouse Ig germline epsilon promoter by IL-4 is dependent on AP-1 transcription factors (with Ching-Hung Shen), Journal of immunology (Baltimore, Md. : 1950) (2000)

Induction of germline (GL) epsilon transcripts, an essential step preceding Ig isotype switching to IgE,...

 
Cognate T cell help for CD40-deficient B cells induces c-myc RNA expression, but DNA synthesis requires an additional signal through surface Ig (with Carol E. Schrader, H. Kikutani, and D. C. Parker), Journal of immunology (Baltimore, Md. : 1950) (1997)

To investigate the role of CD40 ligand in the delivery of help to B cells,...

 
Activation of NF-kappaB/Rel by CD40 engagement induces the mouse germ line immunoglobulin Cgamma1 promoter (with S. C. Lin), Molecular and cellular biology (1996)

Interaction between CD40 on B cells and CD40 ligand (CD40L) on T cells has been...

 

Lymphocytes

Regulation of antibody production and class switching by TGF-beta, Journal of immunology (Baltimore, Md. : 1950) (1995)

No abstract provided.

 

Lymphoma

I.29 lymphoma cells express a nonmutated VH gene before and after H chain switch (with D. Klein, J. Nietupski, and S. Sirlin), Journal of immunology (Baltimore, Md. : 1950) (1988)

The I.29 B cell lymphoma consists of IgM+ and IgA+ cells which express the same...

 
Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching (with S. Sirlin), The EMBO journal (1986)

IgM+ cells cultured from the I.29 B cell lymphoma can be induced with lipopolysaccharide (LPS)...

 
The regulation of membrane-bound and secreted alpha-chain biosynthesis during the differentiation of the B cell lymphoma I.29 (with R. Sitia, A. Rubartelli, H. Kikutani, and U. Hammerling), Journal of immunology (Baltimore, Md. : 1950) (1985)

The regulation of the synthesis of membrane-bound and secreted IgA was investigated in the murine...

 

File

Induction of immunoglobulin isotype switching in cultured I.29 B lymphoma cells. Characterization of the accompanying rearrangements of heavy chain genes (with S. Sirlin and J. Abbott), The Journal of experimental medicine (1985)

The murine B cell lymphoma I.29 contains cells expressing surface IgM or IgA with identical...

 
Immunoglobulin heavy chain switching in cultured I.29 murine B lymphoma cells: commitment to an IgA or IgE switch (with J. Abbott and S. Sirlin), Current topics in microbiology and immunology (1984)

No abstract provided.

 
Rearrangements and deletions of immunoglobulin heavy chain genes in the double-producing B cell lymphoma I.29 (with K. B. Marcu, S. Sirlin, B. Alhadeff, and U. Hammerling), Molecular and cellular biology (1982)

The B cell lymphoma I.29 consists of a mixture of cells expressing membrane-bound immunoglobulin M...

 
Membrane-bound and secreted IgA contain structurally different alpha-chains (with R. Sitia, H. Kikutani, A. Rubartelli, Y. Bushkin, and U. Hammerling), Journal of immunology (Baltimore, Md. : 1950) (1982)

Three different forms of alpha-chains are synthesized by BF0.3 and 615.2, two cloned cell lines...

 
Synthesis and processing of the alpha heavy chains of secreted and membrane-bound IgA (with H. Kikutani, R. Sitia, and R. A. Good), Proceedings of the National Academy of Sciences of the United States of America (1981)

We have compared the synthesis and processing of immunoglobulin alpha chains in two murine cell...

 

Lymphoma, B-Cell

The ubiquitously expressed DNA-binding protein late SV40 factor binds Ig switch regions and represses class switching to IgA (with Elise E. Drouin, Carol E. Schrader, and Ulla Hansen), Journal of immunology (Baltimore, Md. : 1950) (2002)

Ig heavy chain class switch recombination (CSR) determines the expression of Ig isotypes. The molecular...

 
CBF alpha3 (AML2) is induced by TGF-beta1 to bind and activate the mouse germline Ig alpha promoter (with M. J. Shi), Journal of immunology (Baltimore, Md. : 1950) (1998)

TGF-beta1 directs class switching to IgA by splenic B cells and by the surface IgM+...

 
Overexpression of BSAP/Pax-5 inhibits switching to IgA and enhances switching to IgE in the I.29 mu B cell line (with G. Qiu), Journal of immunology (Baltimore, Md. : 1950) (1998)

B cell-specific activator protein (BSAP)/Pax-5 is a paired domain DNA-binding protein expressed in the developing...

 
Effect of cytokines on switching to IgA and alpha germline transcripts in the B lymphoma I.29 mu. Transforming growth factor-beta activates transcription of the unrearranged C alpha gene (with P. Shockett), Journal of immunology (Baltimore, Md. : 1950) (1991)

H chain isotype switch recombination is preceded by the appearance of RNA initiating 5' of...

 

Lymphoma, Large-Cell

Reticulum cell sarcomas of SJL mice have rearranged immunoglobulin heavy and light chain genes (with J. L. Lasky, N. M. Ponzio, M. P. Scheid, and G. J. Thorbecke), European journal of immunology (1989)

The immunoglobulin (Ig) heavy (H) and light (L) chain gene rearrangements of the high incidence...

 

Lysine

The ubiquitously expressed DNA-binding protein late SV40 factor binds Ig switch regions and represses class switching to IgA (with Elise E. Drouin, Carol E. Schrader, and Ulla Hansen), Journal of immunology (Baltimore, Md. : 1950) (2002)

Ig heavy chain class switch recombination (CSR) determines the expression of Ig isotypes. The molecular...

 

Macromolecular Substances

CBF alpha3 (AML2) is induced by TGF-beta1 to bind and activate the mouse germline Ig alpha promoter (with M. J. Shi), Journal of immunology (Baltimore, Md. : 1950) (1998)

TGF-beta1 directs class switching to IgA by splenic B cells and by the surface IgM+...

 
Activation of the Ig germ-line gamma 1 promoter. Involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site (with M. Lundgren, C. Larsson, A. Femino, M. Xu, and E. Severinson), Journal of immunology (Baltimore, Md. : 1950) (1994)

Ig isotype switching in B lymphocytes is preceded by transcription of the corresponding unrearranged, or...

 

Male

Antibody class switching differs among SJL, C57BL/6 and 129 mice (with Denise A. Kaminski), International immunology (2007)

Inbred mouse strains used for gene manipulation studies vary in many respects, including immune system...

 
Cell cycle regulation of immunoglobulin class switch recombination and germ-line transcription: potential role of Ets family members (with M. Lundgren, L. Strom, L. O. Bergquist, S. Skog, T. Heiden, and E. Severinson), European journal of immunology (1995)

Previous studies have indicated that transcription of germ-line (GL) CH genes is necessary to obtain...

 
Induction of germ-line immunoglobulin heavy chain transcripts by mitogens and interleukins prior to switch recombination (with E. Severinson and C. Fernandez), European journal of immunology (1990)

It has recently been postulated that immunoglobulin class switching is preceded by transcription from unrearranged...

 
Expression of immunoglobulin lambda light chain by the promyelocytic cell line HL-60 (with A. Al-Katib and B. Koziner), Journal of immunology (Baltimore, Md. : 1950) (1986)

The HL-60 cell line, established from a patient with acute promyelocytic leukemia, can be induced...

 
Synthesis of a deoxyribonucleic acid sequence complementary to ovalbumin messenger ribonucleic acid and quantification of ovalbumin genes (with D. Sullivan, R. Palacios, J. M. Taylor, A. J. Faras, M. L. Kiely, N. M. Summers, J. M. Bishop, and R. T. Schimke), The Journal of biological chemistry (1973)

No abstract provided.

 

Mammary Tumor Virus, Mouse

Detection and characterization of RNA tumor virus-specific DNA in cells (with H. E. Varmus, E. Medeiros, and J. M. Bishop), Bibliotheca haematologica (1975)

RNA tumor virus-specific DNA in cells can be detected by its capacity to 1) alter...

 

Membrane Glycoproteins

The ability of CD40L, but not lipopolysaccharide, to initiate immunoglobulin switching to immunoglobulin G1 is explained by differential induction of NF-kappaB/Rel proteins (with S. C. Lin and H. H. Wortis), Molecular and cellular biology (1998)

Antibodies of the immunoglobulin G1 class are induced in mice by T-cell-dependent antigens but not...

 
CD40 cross-linking induces Ig epsilon germline transcripts in B cells via activation of NF-kappaB: synergy with IL-4 induction (with L. A. Iciek and S. A. Delphin), Journal of immunology (Baltimore, Md. : 1950) (1997)

Transcription of unrearranged (germline) Ig heavy chain C region (C(H)) genes is required before Ab...

 
Activation of NF-kappaB/Rel by CD40 engagement induces the mouse germ line immunoglobulin Cgamma1 promoter (with S. C. Lin), Molecular and cellular biology (1996)

Interaction between CD40 on B cells and CD40 ligand (CD40L) on T cells has been...

 

Membrane Proteins

The Smu tandem repeat region is critical for Ig isotype switching in the absence of Msh2 (with Irene M. Min, Carol E. Schrader, Joycelyn Vardo, Thomas M. Luby, Nicole D'Avirro, and Erik Selsing), Immunity (2003)

Deficiencies of the Msh2 protein or the Smu tandem repeat (SmuTR) sequences each reduce isotype...

 

Methylation

A B-cell-specific nuclear protein that binds to DNA sites 5' to immunoglobulin S alpha tandem repeats is regulated during differentiation (with S. H. Waters and K. U. Saikh), Molecular and cellular biology (1989)

Immunoglobulin heavy-chain switching is effected by recombination events between sites associated with tandemly repeated switch...

 

Methyltransferases

The histone methyltransferase Suv39h1 increases class switch recombination specifically to IgA (with Sean P. Bradley, Denise A. Kaminski, Antoine H. F. M. Peters, and Thomas Jenuwein), Journal of immunology (Baltimore, Md. : 1950) (2006)

Ab class (isotype) switching allows the humoral immune system to adaptively respond to different infectious...

 

Mice

DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination (with Xiaoming Wu), The Journal of experimental medicine (2007)

Immunoglobulin (Ig) class switch recombination (CSR) is initiated by activation-induced cytidine deaminase (AID), which converts...

 
Antibody class switching differs among SJL, C57BL/6 and 129 mice (with Denise A. Kaminski), International immunology (2007)

Inbred mouse strains used for gene manipulation studies vary in many respects, including immune system...

 
Stimuli that enhance IgA class switching increase histone 3 acetylation at S alpha, but poorly stimulate sequential switching from IgG2b (with Denise A. Kaminski), European journal of immunology (2006)

Germ-line (GL) alpha transcription can be induced in mouse splenic B cells by LPS and...

 
Enhanced IgA class switching in marginal zone and B1 B cells relative to follicular/B2 B cells (with Denise A. Kaminski), Journal of immunology (Baltimore, Md. : 1950) (2006)

Mouse splenic marginal zone (MZ) B cells and B1 B cells enriched in the peritoneal...

 
The histone methyltransferase Suv39h1 increases class switch recombination specifically to IgA (with Sean P. Bradley, Denise A. Kaminski, Antoine H. F. M. Peters, and Thomas Jenuwein), Journal of immunology (Baltimore, Md. : 1950) (2006)

Ab class (isotype) switching allows the humoral immune system to adaptively respond to different infectious...

 
Mismatch repair converts AID-instigated nicks to double-strand breaks for antibody class-switch recombination (with Carol E. Schrader), Trends in genetics : TIG (2005)

Mismatch repair (MMR) proteins are important for antibody class-switch recombination (CSR), but their roles are...

 
Inducible DNA breaks in Ig S regions are dependent on AID and UNG (with Carol E. Schrader, Erin K. Linehan, Sofia N. Mochegova, and Robert T. Woodland), The Journal of experimental medicine (2005)

Class switch recombination (CSR) occurs by an intrachromosomal deletion whereby the IgM constant region gene...

 
Shifts in targeting of class switch recombination sites in mice that lack mu switch region tandem repeats or Msh2 (with Irene M. Min, Lisa R. Rothlein, Carol E. Schrader, and Erik Selsing), The Journal of experimental medicine (2005)

The mechanisms that target class switch recombination (CSR) to antibody gene switch (S) regions are...

 
Analysis of transforming growth factor-beta1-induced Ig germ-line gamma2b transcription and its implication for IgA isotype switching (with Seok-Rae Park, Goo-Young Seo, Ae-Jin Choi, and Pyeung-Hyeun Kim), European journal of immunology (2005)

Transforming growth factor (TGF)-beta1 directs class switch recombination (CSR) to IgG2b as well as to...

 
Evolution of isotype switching (with Chris T. Amemiya), Seminars in immunology (2004)

This review discusses evolution of the process of Ig heavy chain class switching, relating it...

 
Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions (with Carol E. Schrader, Joycelyn Vardo, Erin K. Linehan, Michael Z. Twarog, Laura J. Niedernhofer, and Jan H. J. Hoeijmakers), The Journal of experimental medicine (2004)

The structure-specific endonuclease ERCC1-XPF is an essential component of the nucleotide excision DNA repair pathway....

 
Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination (with Carol E. Schrader, Sean P. Bradley, Joycelyn Vardo, Sofia N. Mochegova, and Erin Flanagan), The EMBO journal (2003)

Nucleotide substitutions are found in recombined Ig switch (S) regions and also in unrecombined (germline,...

 
The Smu tandem repeat region is critical for Ig isotype switching in the absence of Msh2 (with Irene M. Min, Carol E. Schrader, Joycelyn Vardo, Thomas M. Luby, Nicole D'Avirro, and Erik Selsing), Immunity (2003)

Deficiencies of the Msh2 protein or the Smu tandem repeat (SmuTR) sequences each reduce isotype...

 
Mlh1 can function in antibody class switch recombination independently of Msh2 (with Carol E. Schrader and Joycelyn Vardo), The Journal of experimental medicine (2003)

Mismatch repair proteins participate in antibody class switch recombination, although their roles are unknown. Previous...

 
Immunoglobulin genes: generating diversity with AID and UNG (with Ursula Storb), Current biology : CB (2002)

Somatic hypermutation and switch recombination of immunoglobulin genes require the activity of the activation-induced deaminase,...

 
The ubiquitously expressed DNA-binding protein late SV40 factor binds Ig switch regions and represses class switching to IgA (with Elise E. Drouin, Carol E. Schrader, and Ulla Hansen), Journal of immunology (Baltimore, Md. : 1950) (2002)

Ig heavy chain class switch recombination (CSR) determines the expression of Ig isotypes. The molecular...

 
Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions (with Carol E. Schrader and Joycelyn Vardo), The Journal of experimental medicine (2002)

B cells from mice deficient in mismatch repair (MMR) proteins show decreased ability to undergo...

 
Differential regulation of mouse germline Ig gamma 1 and epsilon promoters by IL-4 and CD40 (with C. S. Mao), Journal of immunology (Baltimore, Md. : 1950) (2001)

Before Ig class switching, RNA transcription through the specific S regions undergoing recombination is induced...

 
Roles of Ets proteins, NF-kappa B and nocodazole in regulating induction of transcription of mouse germline Ig alpha RNA by transforming growth factor-beta 1 (with M. J. Shi, S. R. Park, and P. H. Kim), International immunology (2001)

Antibody class switch recombination (CSR) occurs after antigen activation of B cells. CSR is directed...

 
The mu switch region tandem repeats are important, but not required, for antibody class switch recombination (with Thomas M. Luby, Carol E. Schrader, and Erik Selsing), The Journal of experimental medicine (2001)

Class switch DNA recombinations change the constant (C) region of the antibody heavy (H) chain...

 
Activation of the mouse Ig germline epsilon promoter by IL-4 is dependent on AP-1 transcription factors (with Ching-Hung Shen), Journal of immunology (Baltimore, Md. : 1950) (2000)

Induction of germline (GL) epsilon transcripts, an essential step preceding Ig isotype switching to IgE,...

 
Immunology. A touch of antibody class, Science (New York, N.Y.) (2000)

When B cells, the antibody producing cells of the body, encounter antigen they switch from...

 
Evidence for class-specific factors in immunoglobulin isotype switching (with A. Shanmugam, M. J. Shi, L. Yauch, and A. L. Kenter), The Journal of experimental medicine (2000)

Immunoglobulin class switch recombination (SR) occurs by a B cell-specific, intrachromosomal deletional process between switch...

 
Switch recombination in a transfected plasmid occurs preferentially in a B cell line that undergoes switch recombination of its chromosomal Ig heavy chain genes (with Sean P. Bradley, Norman Rousseau, Todd Pearson, Ananth Shanmugam, Debra J. Waite, Paul R. Rogers, and Amy L. Kenter), Journal of immunology (Baltimore, Md. : 1950) (1999)

Ab class switching is induced upon B cell activation in vivo by immunization or infection...

 
Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes (with Carol E. Schrader, W. Edelmann, and R. Kucherlapati), The Journal of experimental medicine (1999)

Mice deficient in various mismatch repair (MMR) enzymes were examined to determine whether this repair...

 
Ialpha exon-replacement mice synthesize a spliced HPRT-C(alpha) transcript which may explain their ability to switch to IgA. Inhibition of switching to IgG in these mice (with G. Qiu and G. R. Harriman), International immunology (1999)

Antibody class switching is regulated by transcription of unrearranged C(H) genes to produce germline (GL)...

 
CBF alpha3 (AML2) is induced by TGF-beta1 to bind and activate the mouse germline Ig alpha promoter (with M. J. Shi), Journal of immunology (Baltimore, Md. : 1950) (1998)

TGF-beta1 directs class switching to IgA by splenic B cells and by the surface IgM+...

 
Overexpression of BSAP/Pax-5 inhibits switching to IgA and enhances switching to IgE in the I.29 mu B cell line (with G. Qiu), Journal of immunology (Baltimore, Md. : 1950) (1998)

B cell-specific activator protein (BSAP)/Pax-5 is a paired domain DNA-binding protein expressed in the developing...

 
The ability of CD40L, but not lipopolysaccharide, to initiate immunoglobulin switching to immunoglobulin G1 is explained by differential induction of NF-kappaB/Rel proteins (with S. C. Lin and H. H. Wortis), Molecular and cellular biology (1998)

Antibodies of the immunoglobulin G1 class are induced in mice by T-cell-dependent antigens but not...

 
CD40 cross-linking induces Ig epsilon germline transcripts in B cells via activation of NF-kappaB: synergy with IL-4 induction (with L. A. Iciek and S. A. Delphin), Journal of immunology (Baltimore, Md. : 1950) (1997)

Transcription of unrearranged (germline) Ig heavy chain C region (C(H)) genes is required before Ab...

 
Cognate T cell help for CD40-deficient B cells induces c-myc RNA expression, but DNA synthesis requires an additional signal through surface Ig (with Carol E. Schrader, H. Kikutani, and D. C. Parker), Journal of immunology (Baltimore, Md. : 1950) (1997)

To investigate the role of CD40 ligand in the delivery of help to B cells,...

 
Activation of NF-kappaB/Rel by CD40 engagement induces the mouse germ line immunoglobulin Cgamma1 promoter (with S. C. Lin), Molecular and cellular biology (1996)

Interaction between CD40 on B cells and CD40 ligand (CD40L) on T cells has been...

 
Mouse CD6: sequence of cDNA and expression of mRNA (with A. Pal, P. L. Romain, N. G. Singer, and D. Fox), Immunology letters (1996)

No abstract provided.

 
Regulation of antibody class switching to IgE: characterization of an IL-4-responsive region in the immunoglobulin heavy-chain germline epsilon promoter (with S. Delphin), Annals of the New York Academy of Sciences (1995)

A large body of data indicate that antibody class switching is directed by cytokines by...

 
Cell cycle regulation of immunoglobulin class switch recombination and germ-line transcription: potential role of Ets family members (with M. Lundgren, L. Strom, L. O. Bergquist, S. Skog, T. Heiden, and E. Severinson), European journal of immunology (1995)

Previous studies have indicated that transcription of germ-line (GL) CH genes is necessary to obtain...

 
Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50 (with S. Delphin), The Journal of experimental medicine (1995)

A large body of data indicate that antibody class switching is directed by cytokines by...

 
Activation of the Ig germ-line gamma 1 promoter. Involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site (with M. Lundgren, C. Larsson, A. Femino, M. Xu, and E. Severinson), Journal of immunology (Baltimore, Md. : 1950) (1994)

Ig isotype switching in B lymphocytes is preceded by transcription of the corresponding unrearranged, or...

 
Inhibitors of poly(ADP-ribose) polymerase increase antibody class switching (with P. Shockett), Journal of immunology (Baltimore, Md. : 1950) (1993)

Previous studies suggest that heavy chain isotype switch (S) recombination is directed by cytokine-induced transcription...

 
Regulation of transcription of the germ-line Ig alpha constant region gene by an ATF element and by novel transforming growth factor-beta 1-responsive elements (with Y. C. Lin), Journal of immunology (Baltimore, Md. : 1950) (1992)

Inasmuch as transcription of unrearranged, or germ-line, Ig CH genes appears to direct switch recombination,...

 
Regulation of switch recombination to the murine gamma 1 gene (with W. Dunnick, L. Elenich, J. Berry, D. Albrecht, and J. L. Claflin), Current topics in microbiology and immunology (1992)

No abstract provided.

 
Regulation of transcription of immunoglobulin germ-line gamma 1 RNA: analysis of the promoter/enhancer (with M. Z. Xu), The EMBO journal (1992)

Antibody class switching is achieved by recombinations between switch (S) regions which consist of tandemly...

 
Regulation of transcription of the germline immunoglobulin alpha constant region gene (with Y. C. Lin and P. Shockett), Current topics in microbiology and immunology (1992)

No abstract provided.

 
Effect of cytokines on switching to IgA and alpha germline transcripts in the B lymphoma I.29 mu. Transforming growth factor-beta activates transcription of the unrearranged C alpha gene (with P. Shockett), Journal of immunology (Baltimore, Md. : 1950) (1991)

H chain isotype switch recombination is preceded by the appearance of RNA initiating 5' of...

 
Induction of germ-line immunoglobulin heavy chain transcripts by mitogens and interleukins prior to switch recombination (with E. Severinson and C. Fernandez), European journal of immunology (1990)

It has recently been postulated that immunoglobulin class switching is preceded by transcription from unrearranged...

 
Copy choice mechanism of immunoglobulin heavy-chain switch recombination (with W. Dunnick), Molecular and cellular biology (1990)

The immunoglobulin heavy-chain switch is mediated by a recombination event between DNA switch regions associated...

 
Structure of germ line immunoglobulin alpha heavy-chain RNA and its location on polysomes (with G. Radcliffe, Y. C. Lin, M. Julius, and K. B. Marcu), Molecular and cellular biology (1990)

We describe the structure of the major germ line RNA transcribed from unrearranged immunoglobulin alpha...

 
Structure of germline immunoglobulin heavy-chain gamma 1 transcripts in interleukin 4 treated mouse spleen cells (with M. Xu), Developmental immunology (1990)

Antibody class switching is mediated by a DNA recombination event that replaces the C mu...

 
Mouse antibody response to group A streptococcal carbohydrate (with C. D. Jarvis and L. E. Cannon), Journal of immunology (Baltimore, Md. : 1950) (1989)

In an attempt to more fully understand the generation of antibody diversity to carbohydrate (CHO)...

 
Reticulum cell sarcomas of SJL mice have rearranged immunoglobulin heavy and light chain genes (with J. L. Lasky, N. M. Ponzio, M. P. Scheid, and G. J. Thorbecke), European journal of immunology (1989)

The immunoglobulin (Ig) heavy (H) and light (L) chain gene rearrangements of the high incidence...

 
Mutations, duplication, and deletion of recombined switch regions suggest a role for DNA replication in the immunoglobulin heavy-chain switch (with W. Dunnick and M. Wilson), Molecular and cellular biology (1989)

The heavy-chain switch from immunoglobulin M (IgM) expression to IgA expression is mediated by a...

 
Interleukins 4 and 5: mechanisms of action (with E. Severinson, H. B. Moon, S. Bergstedt-Lindqvist, U. Persson, and C. Heusser), Advances in experimental medicine and biology (1989)

No abstract provided.

 
I.29 lymphoma cells express a nonmutated VH gene before and after H chain switch (with D. Klein, J. Nietupski, and S. Sirlin), Journal of immunology (Baltimore, Md. : 1950) (1988)

The I.29 B cell lymphoma consists of IgM+ and IgA+ cells which express the same...

 
Specificity of immunoglobulin heavy chain switching by cultured I.29 B lymphoma cells (with G. Radcliffe and E. Severinson), Monographs in allergy (1988)

No abstract provided.

 
Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching (with S. Sirlin), The EMBO journal (1986)

IgM+ cells cultured from the I.29 B cell lymphoma can be induced with lipopolysaccharide (LPS)...

 
The regulation of membrane-bound and secreted alpha-chain biosynthesis during the differentiation of the B cell lymphoma I.29 (with R. Sitia, A. Rubartelli, H. Kikutani, and U. Hammerling), Journal of immunology (Baltimore, Md. : 1950) (1985)

The regulation of the synthesis of membrane-bound and secreted IgA was investigated in the murine...

 

File

Induction of immunoglobulin isotype switching in cultured I.29 B lymphoma cells. Characterization of the accompanying rearrangements of heavy chain genes (with S. Sirlin and J. Abbott), The Journal of experimental medicine (1985)

The murine B cell lymphoma I.29 contains cells expressing surface IgM or IgA with identical...

 
Immunoglobulin heavy chain switching in cultured I.29 murine B lymphoma cells: commitment to an IgA or IgE switch (with J. Abbott and S. Sirlin), Current topics in microbiology and immunology (1984)

No abstract provided.

 
Molecular genetics of immunoglobulin heavy chain switching, Survey of immunologic research (1983)

No abstract provided.

 
Rearrangements and deletions of immunoglobulin heavy chain genes in the double-producing B cell lymphoma I.29 (with K. B. Marcu, S. Sirlin, B. Alhadeff, and U. Hammerling), Molecular and cellular biology (1982)

The B cell lymphoma I.29 consists of a mixture of cells expressing membrane-bound immunoglobulin M...

 
Genetic structure and origin of t haplotypes of mice, analyzed with H-2 cDNA probes (with H. S. Shin, K. Artzt, and D. Bennett), Cell (1982)

We investigated the genetic organization and evolutionary origin of t chromosomes of mice by examining...

 
Membrane-bound and secreted IgA contain structurally different alpha-chains (with R. Sitia, H. Kikutani, A. Rubartelli, Y. Bushkin, and U. Hammerling), Journal of immunology (Baltimore, Md. : 1950) (1982)

Three different forms of alpha-chains are synthesized by BF0.3 and 615.2, two cloned cell lines...

 
Synthesis and processing of the alpha heavy chains of secreted and membrane-bound IgA (with H. Kikutani, R. Sitia, and R. A. Good), Proceedings of the National Academy of Sciences of the United States of America (1981)

We have compared the synthesis and processing of immunoglobulin alpha chains in two murine cell...

 
Expression of an antigen receptor on T cells does not require recombination at the immunoglobulin JH-C mu locus (with Y. Cayre, M. A. Palladino, and K. B. Marcu), Proceedings of the National Academy of Sciences of the United States of America (1981)

Considerable evidence has accumulated suggesting that the antigen receptor(s) on T cells is coded for...

 
Detection and characterization of RNA tumor virus-specific DNA in cells (with H. E. Varmus, E. Medeiros, and J. M. Bishop), Bibliotheca haematologica (1975)

RNA tumor virus-specific DNA in cells can be detected by its capacity to 1) alter...

 
Isolation of messenger RNA for an immunoglobulin kappa chain and enumeration of the genes for the constatn region of kappa chain in the mouse (with R. C. Huang, E. Stavnezer, and J. M. Bishop), Journal of molecular biology (1974)

No abstract provided.

 
Synthesis of a mouse immunoglobulin light chain in a rabbit reticulocyte cell-free system (with R. C. Huang), Nature: New biology (1971)

No abstract provided.

 

Mice, Inbred A

Mouse antibody response to group A streptococcal carbohydrate (with C. D. Jarvis and L. E. Cannon), Journal of immunology (Baltimore, Md. : 1950) (1989)

In an attempt to more fully understand the generation of antibody diversity to carbohydrate (CHO)...

 

Mice, Inbred BALB C

Analysis of transforming growth factor-beta1-induced Ig germ-line gamma2b transcription and its implication for IgA isotype switching (with Seok-Rae Park, Goo-Young Seo, Ae-Jin Choi, and Pyeung-Hyeun Kim), European journal of immunology (2005)

Transforming growth factor (TGF)-beta1 directs class switch recombination (CSR) to IgG2b as well as to...

 
Differential regulation of mouse germline Ig gamma 1 and epsilon promoters by IL-4 and CD40 (with C. S. Mao), Journal of immunology (Baltimore, Md. : 1950) (2001)

Before Ig class switching, RNA transcription through the specific S regions undergoing recombination is induced...

 
Activation of the mouse Ig germline epsilon promoter by IL-4 is dependent on AP-1 transcription factors (with Ching-Hung Shen), Journal of immunology (Baltimore, Md. : 1950) (2000)

Induction of germline (GL) epsilon transcripts, an essential step preceding Ig isotype switching to IgE,...

 
Evidence for class-specific factors in immunoglobulin isotype switching (with A. Shanmugam, M. J. Shi, L. Yauch, and A. L. Kenter), The Journal of experimental medicine (2000)

Immunoglobulin class switch recombination (SR) occurs by a B cell-specific, intrachromosomal deletional process between switch...

 
Switch recombination in a transfected plasmid occurs preferentially in a B cell line that undergoes switch recombination of its chromosomal Ig heavy chain genes (with Sean P. Bradley, Norman Rousseau, Todd Pearson, Ananth Shanmugam, Debra J. Waite, Paul R. Rogers, and Amy L. Kenter), Journal of immunology (Baltimore, Md. : 1950) (1999)

Ab class switching is induced upon B cell activation in vivo by immunization or infection...

 
The ability of CD40L, but not lipopolysaccharide, to initiate immunoglobulin switching to immunoglobulin G1 is explained by differential induction of NF-kappaB/Rel proteins (with S. C. Lin and H. H. Wortis), Molecular and cellular biology (1998)

Antibodies of the immunoglobulin G1 class are induced in mice by T-cell-dependent antigens but not...

 
Cognate T cell help for CD40-deficient B cells induces c-myc RNA expression, but DNA synthesis requires an additional signal through surface Ig (with Carol E. Schrader, H. Kikutani, and D. C. Parker), Journal of immunology (Baltimore, Md. : 1950) (1997)

To investigate the role of CD40 ligand in the delivery of help to B cells,...

 
Inhibitors of poly(ADP-ribose) polymerase increase antibody class switching (with P. Shockett), Journal of immunology (Baltimore, Md. : 1950) (1993)

Previous studies suggest that heavy chain isotype switch (S) recombination is directed by cytokine-induced transcription...

 
Structure of germline immunoglobulin heavy-chain gamma 1 transcripts in interleukin 4 treated mouse spleen cells (with M. Xu), Developmental immunology (1990)

Antibody class switching is mediated by a DNA recombination event that replaces the C mu...

 
Mouse antibody response to group A streptococcal carbohydrate (with C. D. Jarvis and L. E. Cannon), Journal of immunology (Baltimore, Md. : 1950) (1989)

In an attempt to more fully understand the generation of antibody diversity to carbohydrate (CHO)...

 
Isolation of messenger RNA for an immunoglobulin kappa chain and enumeration of the genes for the constatn region of kappa chain in the mouse (with R. C. Huang, E. Stavnezer, and J. M. Bishop), Journal of molecular biology (1974)

No abstract provided.

 

Mice, Inbred C57BL

DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination (with Xiaoming Wu), The Journal of experimental medicine (2007)

Immunoglobulin (Ig) class switch recombination (CSR) is initiated by activation-induced cytidine deaminase (AID), which converts...

 
Antibody class switching differs among SJL, C57BL/6 and 129 mice (with Denise A. Kaminski), International immunology (2007)

Inbred mouse strains used for gene manipulation studies vary in many respects, including immune system...

 
Stimuli that enhance IgA class switching increase histone 3 acetylation at S alpha, but poorly stimulate sequential switching from IgG2b (with Denise A. Kaminski), European journal of immunology (2006)

Germ-line (GL) alpha transcription can be induced in mouse splenic B cells by LPS and...

 
The histone methyltransferase Suv39h1 increases class switch recombination specifically to IgA (with Sean P. Bradley, Denise A. Kaminski, Antoine H. F. M. Peters, and Thomas Jenuwein), Journal of immunology (Baltimore, Md. : 1950) (2006)

Ab class (isotype) switching allows the humoral immune system to adaptively respond to different infectious...

 
Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions (with Carol E. Schrader, Joycelyn Vardo, Erin K. Linehan, Michael Z. Twarog, Laura J. Niedernhofer, and Jan H. J. Hoeijmakers), The Journal of experimental medicine (2004)

The structure-specific endonuclease ERCC1-XPF is an essential component of the nucleotide excision DNA repair pathway....

 
The ubiquitously expressed DNA-binding protein late SV40 factor binds Ig switch regions and represses class switching to IgA (with Elise E. Drouin, Carol E. Schrader, and Ulla Hansen), Journal of immunology (Baltimore, Md. : 1950) (2002)

Ig heavy chain class switch recombination (CSR) determines the expression of Ig isotypes. The molecular...

 
Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions (with Carol E. Schrader and Joycelyn Vardo), The Journal of experimental medicine (2002)

B cells from mice deficient in mismatch repair (MMR) proteins show decreased ability to undergo...

 
Differential regulation of mouse germline Ig gamma 1 and epsilon promoters by IL-4 and CD40 (with C. S. Mao), Journal of immunology (Baltimore, Md. : 1950) (2001)

Before Ig class switching, RNA transcription through the specific S regions undergoing recombination is induced...

 
Cell cycle regulation of immunoglobulin class switch recombination and germ-line transcription: potential role of Ets family members (with M. Lundgren, L. Strom, L. O. Bergquist, S. Skog, T. Heiden, and E. Severinson), European journal of immunology (1995)

Previous studies have indicated that transcription of germ-line (GL) CH genes is necessary to obtain...

 

File

Induction of immunoglobulin isotype switching in cultured I.29 B lymphoma cells. Characterization of the accompanying rearrangements of heavy chain genes (with S. Sirlin and J. Abbott), The Journal of experimental medicine (1985)

The murine B cell lymphoma I.29 contains cells expressing surface IgM or IgA with identical...

 

Mice, Inbred CBA

Cell cycle regulation of immunoglobulin class switch recombination and germ-line transcription: potential role of Ets family members (with M. Lundgren, L. Strom, L. O. Bergquist, S. Skog, T. Heiden, and E. Severinson), European journal of immunology (1995)

Previous studies have indicated that transcription of germ-line (GL) CH genes is necessary to obtain...

 

Mice, Inbred DBA

Cognate T cell help for CD40-deficient B cells induces c-myc RNA expression, but DNA synthesis requires an additional signal through surface Ig (with Carol E. Schrader, H. Kikutani, and D. C. Parker), Journal of immunology (Baltimore, Md. : 1950) (1997)

To investigate the role of CD40 ligand in the delivery of help to B cells,...

 

Mice, Inbred Strains

Antibody class switching differs among SJL, C57BL/6 and 129 mice (with Denise A. Kaminski), International immunology (2007)

Inbred mouse strains used for gene manipulation studies vary in many respects, including immune system...

 
Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching (with S. Sirlin), The EMBO journal (1986)

IgM+ cells cultured from the I.29 B cell lymphoma can be induced with lipopolysaccharide (LPS)...

 
Membrane-bound and secreted IgA contain structurally different alpha-chains (with R. Sitia, H. Kikutani, A. Rubartelli, Y. Bushkin, and U. Hammerling), Journal of immunology (Baltimore, Md. : 1950) (1982)

Three different forms of alpha-chains are synthesized by BF0.3 and 615.2, two cloned cell lines...

 
Expression of an antigen receptor on T cells does not require recombination at the immunoglobulin JH-C mu locus (with Y. Cayre, M. A. Palladino, and K. B. Marcu), Proceedings of the National Academy of Sciences of the United States of America (1981)

Considerable evidence has accumulated suggesting that the antigen receptor(s) on T cells is coded for...

 

Mice, Knockout

The histone methyltransferase Suv39h1 increases class switch recombination specifically to IgA (with Sean P. Bradley, Denise A. Kaminski, Antoine H. F. M. Peters, and Thomas Jenuwein), Journal of immunology (Baltimore, Md. : 1950) (2006)

Ab class (isotype) switching allows the humoral immune system to adaptively respond to different infectious...

 
Shifts in targeting of class switch recombination sites in mice that lack mu switch region tandem repeats or Msh2 (with Irene M. Min, Lisa R. Rothlein, Carol E. Schrader, and Erik Selsing), The Journal of experimental medicine (2005)

The mechanisms that target class switch recombination (CSR) to antibody gene switch (S) regions are...

 
Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination (with Carol E. Schrader, Sean P. Bradley, Joycelyn Vardo, Sofia N. Mochegova, and Erin Flanagan), The EMBO journal (2003)

Nucleotide substitutions are found in recombined Ig switch (S) regions and also in unrecombined (germline,...

 
Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions (with Carol E. Schrader and Joycelyn Vardo), The Journal of experimental medicine (2002)

B cells from mice deficient in mismatch repair (MMR) proteins show decreased ability to undergo...

 
The mu switch region tandem repeats are important, but not required, for antibody class switch recombination (with Thomas M. Luby, Carol E. Schrader, and Erik Selsing), The Journal of experimental medicine (2001)

Class switch DNA recombinations change the constant (C) region of the antibody heavy (H) chain...

 
Ialpha exon-replacement mice synthesize a spliced HPRT-C(alpha) transcript which may explain their ability to switch to IgA. Inhibition of switching to IgG in these mice (with G. Qiu and G. R. Harriman), International immunology (1999)

Antibody class switching is regulated by transcription of unrearranged C(H) genes to produce germline (GL)...

 

Mice, Mutant Strains

Inducible DNA breaks in Ig S regions are dependent on AID and UNG (with Carol E. Schrader, Erin K. Linehan, Sofia N. Mochegova, and Robert T. Woodland), The Journal of experimental medicine (2005)

Class switch recombination (CSR) occurs by an intrachromosomal deletion whereby the IgM constant region gene...

 
Cognate T cell help for CD40-deficient B cells induces c-myc RNA expression, but DNA synthesis requires an additional signal through surface Ig (with Carol E. Schrader, H. Kikutani, and D. C. Parker), Journal of immunology (Baltimore, Md. : 1950) (1997)

To investigate the role of CD40 ligand in the delivery of help to B cells,...

 
Genetic structure and origin of t haplotypes of mice, analyzed with H-2 cDNA probes (with H. S. Shin, K. Artzt, and D. Bennett), Cell (1982)

We investigated the genetic organization and evolutionary origin of t chromosomes of mice by examining...

 

Mice, Nude

Evidence for class-specific factors in immunoglobulin isotype switching (with A. Shanmugam, M. J. Shi, L. Yauch, and A. L. Kenter), The Journal of experimental medicine (2000)

Immunoglobulin class switch recombination (SR) occurs by a B cell-specific, intrachromosomal deletional process between switch...

 

Mice, Transgenic

Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination (with Carol E. Schrader, Sean P. Bradley, Joycelyn Vardo, Sofia N. Mochegova, and Erin Flanagan), The EMBO journal (2003)

Nucleotide substitutions are found in recombined Ig switch (S) regions and also in unrecombined (germline,...

 
Immunology. A touch of antibody class, Science (New York, N.Y.) (2000)

When B cells, the antibody producing cells of the body, encounter antigen they switch from...

 
Regulation of switch recombination to the murine gamma 1 gene (with W. Dunnick, L. Elenich, J. Berry, D. Albrecht, and J. L. Claflin), Current topics in microbiology and immunology (1992)

No abstract provided.

 

Models, Genetic

Mismatch repair converts AID-instigated nicks to double-strand breaks for antibody class-switch recombination (with Carol E. Schrader), Trends in genetics : TIG (2005)

Mismatch repair (MMR) proteins are important for antibody class-switch recombination (CSR), but their roles are...

 
Immunology. A touch of antibody class, Science (New York, N.Y.) (2000)

When B cells, the antibody producing cells of the body, encounter antigen they switch from...

 
Molecular genetics of immunoglobulin heavy chain switching, Survey of immunologic research (1983)

No abstract provided.

 

Molecular Sequence Data

Analysis of transforming growth factor-beta1-induced Ig germ-line gamma2b transcription and its implication for IgA isotype switching (with Seok-Rae Park, Goo-Young Seo, Ae-Jin Choi, and Pyeung-Hyeun Kim), European journal of immunology (2005)

Transforming growth factor (TGF)-beta1 directs class switch recombination (CSR) to IgG2b as well as to...

 
Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination (with Carol E. Schrader, Sean P. Bradley, Joycelyn Vardo, Sofia N. Mochegova, and Erin Flanagan), The EMBO journal (2003)

Nucleotide substitutions are found in recombined Ig switch (S) regions and also in unrecombined (germline,...

 
Mlh1 can function in antibody class switch recombination independently of Msh2 (with Carol E. Schrader and Joycelyn Vardo), The Journal of experimental medicine (2003)

Mismatch repair proteins participate in antibody class switch recombination, although their roles are unknown. Previous...

 
The ubiquitously expressed DNA-binding protein late SV40 factor binds Ig switch regions and represses class switching to IgA (with Elise E. Drouin, Carol E. Schrader, and Ulla Hansen), Journal of immunology (Baltimore, Md. : 1950) (2002)

Ig heavy chain class switch recombination (CSR) determines the expression of Ig isotypes. The molecular...

 
Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions (with Carol E. Schrader and Joycelyn Vardo), The Journal of experimental medicine (2002)

B cells from mice deficient in mismatch repair (MMR) proteins show decreased ability to undergo...

 
Differential regulation of mouse germline Ig gamma 1 and epsilon promoters by IL-4 and CD40 (with C. S. Mao), Journal of immunology (Baltimore, Md. : 1950) (2001)

Before Ig class switching, RNA transcription through the specific S regions undergoing recombination is induced...

 
Roles of Ets proteins, NF-kappa B and nocodazole in regulating induction of transcription of mouse germline Ig alpha RNA by transforming growth factor-beta 1 (with M. J. Shi, S. R. Park, and P. H. Kim), International immunology (2001)

Antibody class switch recombination (CSR) occurs after antigen activation of B cells. CSR is directed...

 
The mu switch region tandem repeats are important, but not required, for antibody class switch recombination (with Thomas M. Luby, Carol E. Schrader, and Erik Selsing), The Journal of experimental medicine (2001)

Class switch DNA recombinations change the constant (C) region of the antibody heavy (H) chain...

 
Activation of the mouse Ig germline epsilon promoter by IL-4 is dependent on AP-1 transcription factors (with Ching-Hung Shen), Journal of immunology (Baltimore, Md. : 1950) (2000)

Induction of germline (GL) epsilon transcripts, an essential step preceding Ig isotype switching to IgE,...

 
Evidence for class-specific factors in immunoglobulin isotype switching (with A. Shanmugam, M. J. Shi, L. Yauch, and A. L. Kenter), The Journal of experimental medicine (2000)

Immunoglobulin class switch recombination (SR) occurs by a B cell-specific, intrachromosomal deletional process between switch...

 
Regulation of the promoter for human immunoglobulin gamma3 germ-line transcription and its interaction with the 3'alpha enhancer (with Q. Pan, C. Petit-Frere, and L. Hammarstrom), European journal of immunology (2000)

The mechanism underlying the differential regulation of switching to human IgG subclasses is still largely...

 
Switch recombination in a transfected plasmid occurs preferentially in a B cell line that undergoes switch recombination of its chromosomal Ig heavy chain genes (with Sean P. Bradley, Norman Rousseau, Todd Pearson, Ananth Shanmugam, Debra J. Waite, Paul R. Rogers, and Amy L. Kenter), Journal of immunology (Baltimore, Md. : 1950) (1999)

Ab class switching is induced upon B cell activation in vivo by immunization or infection...

 
Overexpression of BSAP/Pax-5 inhibits switching to IgA and enhances switching to IgE in the I.29 mu B cell line (with G. Qiu), Journal of immunology (Baltimore, Md. : 1950) (1998)

B cell-specific activator protein (BSAP)/Pax-5 is a paired domain DNA-binding protein expressed in the developing...

 
CD40 cross-linking induces Ig epsilon germline transcripts in B cells via activation of NF-kappaB: synergy with IL-4 induction (with L. A. Iciek and S. A. Delphin), Journal of immunology (Baltimore, Md. : 1950) (1997)

Transcription of unrearranged (germline) Ig heavy chain C region (C(H)) genes is required before Ab...

 
Activation of NF-kappaB/Rel by CD40 engagement induces the mouse germ line immunoglobulin Cgamma1 promoter (with S. C. Lin), Molecular and cellular biology (1996)

Interaction between CD40 on B cells and CD40 ligand (CD40L) on T cells has been...

 
Antibody class switching, Advances in immunology (1996)

No abstract provided.

 
Mouse CD6: sequence of cDNA and expression of mRNA (with A. Pal, P. L. Romain, N. G. Singer, and D. Fox), Immunology letters (1996)

No abstract provided.

 
Regulation of antibody class switching to IgE: characterization of an IL-4-responsive region in the immunoglobulin heavy-chain germline epsilon promoter (with S. Delphin), Annals of the New York Academy of Sciences (1995)

A large body of data indicate that antibody class switching is directed by cytokines by...

 
Cell cycle regulation of immunoglobulin class switch recombination and germ-line transcription: potential role of Ets family members (with M. Lundgren, L. Strom, L. O. Bergquist, S. Skog, T. Heiden, and E. Severinson), European journal of immunology (1995)

Previous studies have indicated that transcription of germ-line (GL) CH genes is necessary to obtain...

 
Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50 (with S. Delphin), The Journal of experimental medicine (1995)

A large body of data indicate that antibody class switching is directed by cytokines by...

 
Activation of the Ig germ-line gamma 1 promoter. Involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site (with M. Lundgren, C. Larsson, A. Femino, M. Xu, and E. Severinson), Journal of immunology (Baltimore, Md. : 1950) (1994)

Ig isotype switching in B lymphocytes is preceded by transcription of the corresponding unrearranged, or...

 
Regulation of transcription of the germ-line Ig alpha constant region gene by an ATF element and by novel transforming growth factor-beta 1-responsive elements (with Y. C. Lin), Journal of immunology (Baltimore, Md. : 1950) (1992)

Inasmuch as transcription of unrearranged, or germ-line, Ig CH genes appears to direct switch recombination,...

 
Regulation of transcription of immunoglobulin germ-line gamma 1 RNA: analysis of the promoter/enhancer (with M. Z. Xu), The EMBO journal (1992)

Antibody class switching is achieved by recombinations between switch (S) regions which consist of tandemly...

 
Regulation of transcription of the germline immunoglobulin alpha constant region gene (with Y. C. Lin and P. Shockett), Current topics in microbiology and immunology (1992)

No abstract provided.

 
Triple helix stabilization, Nature (1991)

No abstract provided.

 
Copy choice mechanism of immunoglobulin heavy-chain switch recombination (with W. Dunnick), Molecular and cellular biology (1990)

The immunoglobulin heavy-chain switch is mediated by a recombination event between DNA switch regions associated...

 
Structure of germ line immunoglobulin alpha heavy-chain RNA and its location on polysomes (with G. Radcliffe, Y. C. Lin, M. Julius, and K. B. Marcu), Molecular and cellular biology (1990)

We describe the structure of the major germ line RNA transcribed from unrearranged immunoglobulin alpha...

 
Structure of germline immunoglobulin heavy-chain gamma 1 transcripts in interleukin 4 treated mouse spleen cells (with M. Xu), Developmental immunology (1990)

Antibody class switching is mediated by a DNA recombination event that replaces the C mu...

 
Mouse antibody response to group A streptococcal carbohydrate (with C. D. Jarvis and L. E. Cannon), Journal of immunology (Baltimore, Md. : 1950) (1989)

In an attempt to more fully understand the generation of antibody diversity to carbohydrate (CHO)...

 
A B-cell-specific nuclear protein that binds to DNA sites 5' to immunoglobulin S alpha tandem repeats is regulated during differentiation (with S. H. Waters and K. U. Saikh), Molecular and cellular biology (1989)

Immunoglobulin heavy-chain switching is effected by recombination events between sites associated with tandemly repeated switch...

 
Mutations, duplication, and deletion of recombined switch regions suggest a role for DNA replication in the immunoglobulin heavy-chain switch (with W. Dunnick and M. Wilson), Molecular and cellular biology (1989)

The heavy-chain switch from immunoglobulin M (IgM) expression to IgA expression is mediated by a...

 
The J kappa proximal region of the human K locus contains three uncommon V kappa genes which are arranged in opposite transcriptional polarities (with W. Lorenz, K. F. Schable, R. Thiebe, and H. G. Zachau), Molecular immunology (1988)

The structure of one of the V kappa gene-containing regions of the locus coding for...

 
I.29 lymphoma cells express a nonmutated VH gene before and after H chain switch (with D. Klein, J. Nietupski, and S. Sirlin), Journal of immunology (Baltimore, Md. : 1950) (1988)

The I.29 B cell lymphoma consists of IgM+ and IgA+ cells which express the same...

 

Molecular Weight

Synthesis and processing of the alpha heavy chains of secreted and membrane-bound IgA (with H. Kikutani, R. Sitia, and R. A. Good), Proceedings of the National Academy of Sciences of the United States of America (1981)

We have compared the synthesis and processing of immunoglobulin alpha chains in two murine cell...

 
Isolation of messenger RNA for an immunoglobulin kappa chain and enumeration of the genes for the constatn region of kappa chain in the mouse (with R. C. Huang, E. Stavnezer, and J. M. Bishop), Journal of molecular biology (1974)

No abstract provided.

 
Synthesis of a mouse immunoglobulin light chain in a rabbit reticulocyte cell-free system (with R. C. Huang), Nature: New biology (1971)

No abstract provided.

 

Multigene Family

Activation of the mouse Ig germline epsilon promoter by IL-4 is dependent on AP-1 transcription factors (with Ching-Hung Shen), Journal of immunology (Baltimore, Md. : 1950) (2000)

Induction of germline (GL) epsilon transcripts, an essential step preceding Ig isotype switching to IgE,...

 

Mutagenesis, Insertional

Regulation of the promoter for human immunoglobulin gamma3 germ-line transcription and its interaction with the 3'alpha enhancer (with Q. Pan, C. Petit-Frere, and L. Hammarstrom), European journal of immunology (2000)

The mechanism underlying the differential regulation of switching to human IgG subclasses is still largely...

 

Mutagenesis, Site-Directed

Regulation of antibody class switching to IgE: characterization of an IL-4-responsive region in the immunoglobulin heavy-chain germline epsilon promoter (with S. Delphin), Annals of the New York Academy of Sciences (1995)

A large body of data indicate that antibody class switching is directed by cytokines by...

 
Regulation of transcription of the germ-line Ig alpha constant region gene by an ATF element and by novel transforming growth factor-beta 1-responsive elements (with Y. C. Lin), Journal of immunology (Baltimore, Md. : 1950) (1992)

Inasmuch as transcription of unrearranged, or germ-line, Ig CH genes appears to direct switch recombination,...

 

Mutation

DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination (with Xiaoming Wu), The Journal of experimental medicine (2007)

Immunoglobulin (Ig) class switch recombination (CSR) is initiated by activation-induced cytidine deaminase (AID), which converts...

 
Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions (with Carol E. Schrader, Joycelyn Vardo, Erin K. Linehan, Michael Z. Twarog, Laura J. Niedernhofer, and Jan H. J. Hoeijmakers), The Journal of experimental medicine (2004)

The structure-specific endonuclease ERCC1-XPF is an essential component of the nucleotide excision DNA repair pathway....

 
Switch recombination in a transfected plasmid occurs preferentially in a B cell line that undergoes switch recombination of its chromosomal Ig heavy chain genes (with Sean P. Bradley, Norman Rousseau, Todd Pearson, Ananth Shanmugam, Debra J. Waite, Paul R. Rogers, and Amy L. Kenter), Journal of immunology (Baltimore, Md. : 1950) (1999)

Ab class switching is induced upon B cell activation in vivo by immunization or infection...

 
Mutations, duplication, and deletion of recombined switch regions suggest a role for DNA replication in the immunoglobulin heavy-chain switch (with W. Dunnick and M. Wilson), Molecular and cellular biology (1989)

The heavy-chain switch from immunoglobulin M (IgM) expression to IgA expression is mediated by a...

 
I.29 lymphoma cells express a nonmutated VH gene before and after H chain switch (with D. Klein, J. Nietupski, and S. Sirlin), Journal of immunology (Baltimore, Md. : 1950) (1988)

The I.29 B cell lymphoma consists of IgM+ and IgA+ cells which express the same...

 

MutS Homolog 2 Protein

Shifts in targeting of class switch recombination sites in mice that lack mu switch region tandem repeats or Msh2 (with Irene M. Min, Lisa R. Rothlein, Carol E. Schrader, and Erik Selsing), The Journal of experimental medicine (2005)

The mechanisms that target class switch recombination (CSR) to antibody gene switch (S) regions are...

 
Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions (with Carol E. Schrader, Joycelyn Vardo, Erin K. Linehan, Michael Z. Twarog, Laura J. Niedernhofer, and Jan H. J. Hoeijmakers), The Journal of experimental medicine (2004)

The structure-specific endonuclease ERCC1-XPF is an essential component of the nucleotide excision DNA repair pathway....

 
Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination (with Carol E. Schrader, Sean P. Bradley, Joycelyn Vardo, Sofia N. Mochegova, and Erin Flanagan), The EMBO journal (2003)

Nucleotide substitutions are found in recombined Ig switch (S) regions and also in unrecombined (germline,...

 
The Smu tandem repeat region is critical for Ig isotype switching in the absence of Msh2 (with Irene M. Min, Carol E. Schrader, Joycelyn Vardo, Thomas M. Luby, Nicole D'Avirro, and Erik Selsing), Immunity (2003)

Deficiencies of the Msh2 protein or the Smu tandem repeat (SmuTR) sequences each reduce isotype...

 
Mlh1 can function in antibody class switch recombination independently of Msh2 (with Carol E. Schrader and Joycelyn Vardo), The Journal of experimental medicine (2003)

Mismatch repair proteins participate in antibody class switch recombination, although their roles are unknown. Previous...

 
Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions (with Carol E. Schrader and Joycelyn Vardo), The Journal of experimental medicine (2002)

B cells from mice deficient in mismatch repair (MMR) proteins show decreased ability to undergo...

 

Myeloma Proteins

Letter: Translation of messenger RNA for mouse immunoglobulin light chains in living frog oocytes (with M. Smith, R. C. Huang, J. B. Gurdon, and C. D. Lane), Journal of molecular biology (1973)

No abstract provided.

 

N-Glycosyl Hydrolases

Immunoglobulin genes: generating diversity with AID and UNG (with Ursula Storb), Current biology : CB (2002)

Somatic hypermutation and switch recombination of immunoglobulin genes require the activity of the activation-induced deaminase,...

 

N-Methyltransferase

The histone methyltransferase Suv39h1 increases class switch recombination specifically to IgA (with Sean P. Bradley, Denise A. Kaminski, Antoine H. F. M. Peters, and Thomas Jenuwein), Journal of immunology (Baltimore, Md. : 1950) (2006)

Ab class (isotype) switching allows the humoral immune system to adaptively respond to different infectious...

 

Neoplasm Proteins

Mlh1 can function in antibody class switch recombination independently of Msh2 (with Carol E. Schrader and Joycelyn Vardo), The Journal of experimental medicine (2003)

Mismatch repair proteins participate in antibody class switch recombination, although their roles are unknown. Previous...

 
Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions (with Carol E. Schrader and Joycelyn Vardo), The Journal of experimental medicine (2002)

B cells from mice deficient in mismatch repair (MMR) proteins show decreased ability to undergo...

 
Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes (with Carol E. Schrader, W. Edelmann, and R. Kucherlapati), The Journal of experimental medicine (1999)

Mice deficient in various mismatch repair (MMR) enzymes were examined to determine whether this repair...

 
Regulation of transcription of the germ-line Ig alpha constant region gene by an ATF element and by novel transforming growth factor-beta 1-responsive elements (with Y. C. Lin), Journal of immunology (Baltimore, Md. : 1950) (1992)

Inasmuch as transcription of unrearranged, or germ-line, Ig CH genes appears to direct switch recombination,...

 

Neoplasms, Experimental

Rearrangements and deletions of immunoglobulin heavy chain genes in the double-producing B cell lymphoma I.29 (with K. B. Marcu, S. Sirlin, B. Alhadeff, and U. Hammerling), Molecular and cellular biology (1982)

The B cell lymphoma I.29 consists of a mixture of cells expressing membrane-bound immunoglobulin M...

 
Synthesis of a mouse immunoglobulin light chain in a rabbit reticulocyte cell-free system (with R. C. Huang), Nature: New biology (1971)

No abstract provided.

 

Neprilysin

Surface immunoglobulin light chain expression in pre-B cell leukemias (with B. Koziner, A. Al-Katib, D. Gebhard, A. Mittelman, M. Andreeff, and B. D. Clarkson), Annals of the New York Academy of Sciences (1986)

Cytofluorographic analysis of surface immunoglobulin (sIg) light chain clonal excess (CE), defined as (%kappa+ -...

 

NF-kappa B

Differential regulation of mouse germline Ig gamma 1 and epsilon promoters by IL-4 and CD40 (with C. S. Mao), Journal of immunology (Baltimore, Md. : 1950) (2001)

Before Ig class switching, RNA transcription through the specific S regions undergoing recombination is induced...

 
Roles of Ets proteins, NF-kappa B and nocodazole in regulating induction of transcription of mouse germline Ig alpha RNA by transforming growth factor-beta 1 (with M. J. Shi, S. R. Park, and P. H. Kim), International immunology (2001)

Antibody class switch recombination (CSR) occurs after antigen activation of B cells. CSR is directed...

 
Regulation of the promoter for human immunoglobulin gamma3 germ-line transcription and its interaction with the 3'alpha enhancer (with Q. Pan, C. Petit-Frere, and L. Hammarstrom), European journal of immunology (2000)

The mechanism underlying the differential regulation of switching to human IgG subclasses is still largely...

 
The ability of CD40L, but not lipopolysaccharide, to initiate immunoglobulin switching to immunoglobulin G1 is explained by differential induction of NF-kappaB/Rel proteins (with S. C. Lin and H. H. Wortis), Molecular and cellular biology (1998)

Antibodies of the immunoglobulin G1 class are induced in mice by T-cell-dependent antigens but not...

 
Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription (with Ching-Hung Shen), Molecular and cellular biology (1998)

Signal transducer and activator of transcription 6 (Stat6) and NF-kappaB are widely distributed transcription factors...

 
CD40 cross-linking induces Ig epsilon germline transcripts in B cells via activation of NF-kappaB: synergy with IL-4 induction (with L. A. Iciek and S. A. Delphin), Journal of immunology (Baltimore, Md. : 1950) (1997)

Transcription of unrearranged (germline) Ig heavy chain C region (C(H)) genes is required before Ab...

 
Activation of NF-kappaB/Rel by CD40 engagement induces the mouse germ line immunoglobulin Cgamma1 promoter (with S. C. Lin), Molecular and cellular biology (1996)

Interaction between CD40 on B cells and CD40 ligand (CD40L) on T cells has been...

 
Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50 (with S. Delphin), The Journal of experimental medicine (1995)

A large body of data indicate that antibody class switching is directed by cytokines by...

 

NF-kappa B p50 Subunit

Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription (with Ching-Hung Shen), Molecular and cellular biology (1998)

Signal transducer and activator of transcription 6 (Stat6) and NF-kappaB are widely distributed transcription factors...

 

Niacinamide

Inhibitors of poly(ADP-ribose) polymerase increase antibody class switching (with P. Shockett), Journal of immunology (Baltimore, Md. : 1950) (1993)

Previous studies suggest that heavy chain isotype switch (S) recombination is directed by cytokine-induced transcription...

 

Nocodazole

Roles of Ets proteins, NF-kappa B and nocodazole in regulating induction of transcription of mouse germline Ig alpha RNA by transforming growth factor-beta 1 (with M. J. Shi, S. R. Park, and P. H. Kim), International immunology (2001)

Antibody class switch recombination (CSR) occurs after antigen activation of B cells. CSR is directed...

 

Nuclear Proteins

Analysis of transforming growth factor-beta1-induced Ig germ-line gamma2b transcription and its implication for IgA isotype switching (with Seok-Rae Park, Goo-Young Seo, Ae-Jin Choi, and Pyeung-Hyeun Kim), European journal of immunology (2005)

Transforming growth factor (TGF)-beta1 directs class switch recombination (CSR) to IgG2b as well as to...

 
Mlh1 can function in antibody class switch recombination independently of Msh2 (with Carol E. Schrader and Joycelyn Vardo), The Journal of experimental medicine (2003)

Mismatch repair proteins participate in antibody class switch recombination, although their roles are unknown. Previous...

 
Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions (with Carol E. Schrader and Joycelyn Vardo), The Journal of experimental medicine (2002)

B cells from mice deficient in mismatch repair (MMR) proteins show decreased ability to undergo...

 
Roles of Ets proteins, NF-kappa B and nocodazole in regulating induction of transcription of mouse germline Ig alpha RNA by transforming growth factor-beta 1 (with M. J. Shi, S. R. Park, and P. H. Kim), International immunology (2001)

Antibody class switch recombination (CSR) occurs after antigen activation of B cells. CSR is directed...

 
Regulation of the promoter for human immunoglobulin gamma3 germ-line transcription and its interaction with the 3'alpha enhancer (with Q. Pan, C. Petit-Frere, and L. Hammarstrom), European journal of immunology (2000)

The mechanism underlying the differential regulation of switching to human IgG subclasses is still largely...

 
Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes (with Carol E. Schrader, W. Edelmann, and R. Kucherlapati), The Journal of experimental medicine (1999)

Mice deficient in various mismatch repair (MMR) enzymes were examined to determine whether this repair...

 
Overexpression of BSAP/Pax-5 inhibits switching to IgA and enhances switching to IgE in the I.29 mu B cell line (with G. Qiu), Journal of immunology (Baltimore, Md. : 1950) (1998)

B cell-specific activator protein (BSAP)/Pax-5 is a paired domain DNA-binding protein expressed in the developing...

 
Cell cycle regulation of immunoglobulin class switch recombination and germ-line transcription: potential role of Ets family members (with M. Lundgren, L. Strom, L. O. Bergquist, S. Skog, T. Heiden, and E. Severinson), European journal of immunology (1995)

Previous studies have indicated that transcription of germ-line (GL) CH genes is necessary to obtain...

 
Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50 (with S. Delphin), The Journal of experimental medicine (1995)

A large body of data indicate that antibody class switching is directed by cytokines by...

 
Activation of the Ig germ-line gamma 1 promoter. Involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site (with M. Lundgren, C. Larsson, A. Femino, M. Xu, and E. Severinson), Journal of immunology (Baltimore, Md. : 1950) (1994)

Ig isotype switching in B lymphocytes is preceded by transcription of the corresponding unrearranged, or...

 
A B-cell-specific nuclear protein that binds to DNA sites 5' to immunoglobulin S alpha tandem repeats is regulated during differentiation (with S. H. Waters and K. U. Saikh), Molecular and cellular biology (1989)

Immunoglobulin heavy-chain switching is effected by recombination events between sites associated with tandemly repeated switch...

 

Nucleic Acid Denaturation

Synthesis and isolation of DNA complementary to nucleotide sequences encoding the variable region of immunoglobulin kappa chain (with J. M. Bishop), Biochemistry (1977)

No abstract provided.

 
Isolation of messenger RNA for an immunoglobulin kappa chain and enumeration of the genes for the constatn region of kappa chain in the mouse (with R. C. Huang, E. Stavnezer, and J. M. Bishop), Journal of molecular biology (1974)

No abstract provided.

 

Nucleic Acid Heteroduplexes

Triple helix stabilization, Nature (1991)

No abstract provided.

 

Nucleic Acid Hybridization

Surface immunoglobulin light chain expression in pre-B cell leukemias (with B. Koziner, A. Al-Katib, D. Gebhard, A. Mittelman, M. Andreeff, and B. D. Clarkson), Annals of the New York Academy of Sciences (1986)

Cytofluorographic analysis of surface immunoglobulin (sIg) light chain clonal excess (CE), defined as (%kappa+ -...

 
Immunoglobulin heavy chain switching in cultured I.29 murine B lymphoma cells: commitment to an IgA or IgE switch (with J. Abbott and S. Sirlin), Current topics in microbiology and immunology (1984)

No abstract provided.

 
Genetic structure and origin of t haplotypes of mice, analyzed with H-2 cDNA probes (with H. S. Shin, K. Artzt, and D. Bennett), Cell (1982)

We investigated the genetic organization and evolutionary origin of t chromosomes of mice by examining...

 
Synthesis and processing of the alpha heavy chains of secreted and membrane-bound IgA (with H. Kikutani, R. Sitia, and R. A. Good), Proceedings of the National Academy of Sciences of the United States of America (1981)

We have compared the synthesis and processing of immunoglobulin alpha chains in two murine cell...

 
Expression of an antigen receptor on T cells does not require recombination at the immunoglobulin JH-C mu locus (with Y. Cayre, M. A. Palladino, and K. B. Marcu), Proceedings of the National Academy of Sciences of the United States of America (1981)

Considerable evidence has accumulated suggesting that the antigen receptor(s) on T cells is coded for...

 
Synthesis and isolation of DNA complementary to nucleotide sequences encoding the variable region of immunoglobulin kappa chain (with J. M. Bishop), Biochemistry (1977)

No abstract provided.

 
Detection and characterization of RNA tumor virus-specific DNA in cells (with H. E. Varmus, E. Medeiros, and J. M. Bishop), Bibliotheca haematologica (1975)

RNA tumor virus-specific DNA in cells can be detected by its capacity to 1) alter...

 
Isolation of messenger RNA for an immunoglobulin kappa chain and enumeration of the genes for the constatn region of kappa chain in the mouse (with R. C. Huang, E. Stavnezer, and J. M. Bishop), Journal of molecular biology (1974)

No abstract provided.

 
Synthesis of a deoxyribonucleic acid sequence complementary to ovalbumin messenger ribonucleic acid and quantification of ovalbumin genes (with D. Sullivan, R. Palacios, J. M. Taylor, A. J. Faras, M. L. Kiely, N. M. Summers, J. M. Bishop, and R. T. Schimke), The Journal of biological chemistry (1973)

No abstract provided.

 

Nucleotide Mapping

A B-cell-specific nuclear protein that binds to DNA sites 5' to immunoglobulin S alpha tandem repeats is regulated during differentiation (with S. H. Waters and K. U. Saikh), Molecular and cellular biology (1989)

Immunoglobulin heavy-chain switching is effected by recombination events between sites associated with tandemly repeated switch...

 

Oligodeoxyribonucleotides

Cell cycle regulation of immunoglobulin class switch recombination and germ-line transcription: potential role of Ets family members (with M. Lundgren, L. Strom, L. O. Bergquist, S. Skog, T. Heiden, and E. Severinson), European journal of immunology (1995)

Previous studies have indicated that transcription of germ-line (GL) CH genes is necessary to obtain...

 
Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50 (with S. Delphin), The Journal of experimental medicine (1995)

A large body of data indicate that antibody class switching is directed by cytokines by...

 

Oligonucleotide Probes

Regulation of transcription of the germ-line Ig alpha constant region gene by an ATF element and by novel transforming growth factor-beta 1-responsive elements (with Y. C. Lin), Journal of immunology (Baltimore, Md. : 1950) (1992)

Inasmuch as transcription of unrearranged, or germ-line, Ig CH genes appears to direct switch recombination,...

 

Open Reading Frames

Structure of germline immunoglobulin heavy-chain gamma 1 transcripts in interleukin 4 treated mouse spleen cells (with M. Xu), Developmental immunology (1990)

Antibody class switching is mediated by a DNA recombination event that replaces the C mu...

 

Organ Specificity

Synthesis of a deoxyribonucleic acid sequence complementary to ovalbumin messenger ribonucleic acid and quantification of ovalbumin genes (with D. Sullivan, R. Palacios, J. M. Taylor, A. J. Faras, M. L. Kiely, N. M. Summers, J. M. Bishop, and R. T. Schimke), The Journal of biological chemistry (1973)

No abstract provided.

 

Ovalbumin

Synthesis of a deoxyribonucleic acid sequence complementary to ovalbumin messenger ribonucleic acid and quantification of ovalbumin genes (with D. Sullivan, R. Palacios, J. M. Taylor, A. J. Faras, M. L. Kiely, N. M. Summers, J. M. Bishop, and R. T. Schimke), The Journal of biological chemistry (1973)

No abstract provided.

 

Oviducts

Synthesis of a deoxyribonucleic acid sequence complementary to ovalbumin messenger ribonucleic acid and quantification of ovalbumin genes (with D. Sullivan, R. Palacios, J. M. Taylor, A. J. Faras, M. L. Kiely, N. M. Summers, J. M. Bishop, and R. T. Schimke), The Journal of biological chemistry (1973)

No abstract provided.

 

Ovum

Letter: Translation of messenger RNA for mouse immunoglobulin light chains in living frog oocytes (with M. Smith, R. C. Huang, J. B. Gurdon, and C. D. Lane), Journal of molecular biology (1973)

No abstract provided.

 

Pedigree

Molecular defects in a human immunoglobulin kappa chain deficiency (with O. Kekish and B. J. Zegers), Science (New York, N.Y.) (1985)

The molecular basis of a human immunoglobulin deficiency characterized by the complete absence of kappa...

 

Peptides

Synthesis of a mouse immunoglobulin light chain in a rabbit reticulocyte cell-free system (with R. C. Huang), Nature: New biology (1971)

No abstract provided.

 

Peritoneum

Enhanced IgA class switching in marginal zone and B1 B cells relative to follicular/B2 B cells (with Denise A. Kaminski), Journal of immunology (Baltimore, Md. : 1950) (2006)

Mouse splenic marginal zone (MZ) B cells and B1 B cells enriched in the peritoneal...

 

Peyer's Patches

Antibody class switching differs among SJL, C57BL/6 and 129 mice (with Denise A. Kaminski), International immunology (2007)

Inbred mouse strains used for gene manipulation studies vary in many respects, including immune system...

 

Phenotype

Surface immunoglobulin light-chain expression by the "common" all cell line REH (with B. Koziner and A. Al-Katib), Clinical immunology and immunopathology (1985)

To provide further support of the B-cell lineage of "common" acute lymphoblastic leukemia (ALL), we...

 

Phorbol 12,13-Dibutyrate

Regulation of the promoter for human immunoglobulin gamma3 germ-line transcription and its interaction with the 3'alpha enhancer (with Q. Pan, C. Petit-Frere, and L. Hammarstrom), European journal of immunology (2000)

The mechanism underlying the differential regulation of switching to human IgG subclasses is still largely...

 

Plasmacytoma

Switch recombination in a transfected plasmid occurs preferentially in a B cell line that undergoes switch recombination of its chromosomal Ig heavy chain genes (with Sean P. Bradley, Norman Rousseau, Todd Pearson, Ananth Shanmugam, Debra J. Waite, Paul R. Rogers, and Amy L. Kenter), Journal of immunology (Baltimore, Md. : 1950) (1999)

Ab class switching is induced upon B cell activation in vivo by immunization or infection...

 
Isolation of messenger RNA for an immunoglobulin kappa chain and enumeration of the genes for the constatn region of kappa chain in the mouse (with R. C. Huang, E. Stavnezer, and J. M. Bishop), Journal of molecular biology (1974)

No abstract provided.

 
Synthesis of a mouse immunoglobulin light chain in a rabbit reticulocyte cell-free system (with R. C. Huang), Nature: New biology (1971)

No abstract provided.

 

Plasmids

The histone methyltransferase Suv39h1 increases class switch recombination specifically to IgA (with Sean P. Bradley, Denise A. Kaminski, Antoine H. F. M. Peters, and Thomas Jenuwein), Journal of immunology (Baltimore, Md. : 1950) (2006)

Ab class (isotype) switching allows the humoral immune system to adaptively respond to different infectious...

 
Activation of the mouse Ig germline epsilon promoter by IL-4 is dependent on AP-1 transcription factors (with Ching-Hung Shen), Journal of immunology (Baltimore, Md. : 1950) (2000)

Induction of germline (GL) epsilon transcripts, an essential step preceding Ig isotype switching to IgE,...

 
Evidence for class-specific factors in immunoglobulin isotype switching (with A. Shanmugam, M. J. Shi, L. Yauch, and A. L. Kenter), The Journal of experimental medicine (2000)

Immunoglobulin class switch recombination (SR) occurs by a B cell-specific, intrachromosomal deletional process between switch...

 
Switch recombination in a transfected plasmid occurs preferentially in a B cell line that undergoes switch recombination of its chromosomal Ig heavy chain genes (with Sean P. Bradley, Norman Rousseau, Todd Pearson, Ananth Shanmugam, Debra J. Waite, Paul R. Rogers, and Amy L. Kenter), Journal of immunology (Baltimore, Md. : 1950) (1999)

Ab class switching is induced upon B cell activation in vivo by immunization or infection...

 

Poly A

Induction of germ-line immunoglobulin heavy chain transcripts by mitogens and interleukins prior to switch recombination (with E. Severinson and C. Fernandez), European journal of immunology (1990)

It has recently been postulated that immunoglobulin class switching is preceded by transcription from unrearranged...

 
Expression of immunoglobulin lambda light chain by the promyelocytic cell line HL-60 (with A. Al-Katib and B. Koziner), Journal of immunology (Baltimore, Md. : 1950) (1986)

The HL-60 cell line, established from a patient with acute promyelocytic leukemia, can be induced...

 

PDF

Presence of a polyadenylated RNA fragment encoding the membrane domain for immunoglobulin alpha chain indicates that mRNAs for both secreted and membrane-bound alpha chains can be produced from the same RNA transcript, Nucleic acids research (1986)

RNA blotting was employed to examine polyadenylated immunoglobulin alpha chain RNAs in a B lymphoma...

 
Immunoglobulin heavy chain switching in cultured I.29 murine B lymphoma cells: commitment to an IgA or IgE switch (with J. Abbott and S. Sirlin), Current topics in microbiology and immunology (1984)

No abstract provided.

 

Poly(ADP-ribose) Polymerases

Inhibitors of poly(ADP-ribose) polymerase increase antibody class switching (with P. Shockett), Journal of immunology (Baltimore, Md. : 1950) (1993)

Previous studies suggest that heavy chain isotype switch (S) recombination is directed by cytokine-induced transcription...

 

Polymerase Chain Reaction

Shifts in targeting of class switch recombination sites in mice that lack mu switch region tandem repeats or Msh2 (with Irene M. Min, Lisa R. Rothlein, Carol E. Schrader, and Erik Selsing), The Journal of experimental medicine (2005)

The mechanisms that target class switch recombination (CSR) to antibody gene switch (S) regions are...

 
Evidence for class-specific factors in immunoglobulin isotype switching (with A. Shanmugam, M. J. Shi, L. Yauch, and A. L. Kenter), The Journal of experimental medicine (2000)

Immunoglobulin class switch recombination (SR) occurs by a B cell-specific, intrachromosomal deletional process between switch...

 
Switch recombination in a transfected plasmid occurs preferentially in a B cell line that undergoes switch recombination of its chromosomal Ig heavy chain genes (with Sean P. Bradley, Norman Rousseau, Todd Pearson, Ananth Shanmugam, Debra J. Waite, Paul R. Rogers, and Amy L. Kenter), Journal of immunology (Baltimore, Md. : 1950) (1999)

Ab class switching is induced upon B cell activation in vivo by immunization or infection...

 

Polymorphism, Genetic

Genetic structure and origin of t haplotypes of mice, analyzed with H-2 cDNA probes (with H. S. Shin, K. Artzt, and D. Bennett), Cell (1982)

We investigated the genetic organization and evolutionary origin of t chromosomes of mice by examining...

 

Polynucleotides

Synthesis of a deoxyribonucleic acid sequence complementary to ovalbumin messenger ribonucleic acid and quantification of ovalbumin genes (with D. Sullivan, R. Palacios, J. M. Taylor, A. J. Faras, M. L. Kiely, N. M. Summers, J. M. Bishop, and R. T. Schimke), The Journal of biological chemistry (1973)

No abstract provided.

 

Polyribosomes

Structure of germ line immunoglobulin alpha heavy-chain RNA and its location on polysomes (with G. Radcliffe, Y. C. Lin, M. Julius, and K. B. Marcu), Molecular and cellular biology (1990)

We describe the structure of the major germ line RNA transcribed from unrearranged immunoglobulin alpha...

 

Polysaccharides, Bacterial

Mouse antibody response to group A streptococcal carbohydrate (with C. D. Jarvis and L. E. Cannon), Journal of immunology (Baltimore, Md. : 1950) (1989)

In an attempt to more fully understand the generation of antibody diversity to carbohydrate (CHO)...

 

Precipitin Tests

Letter: Translation of messenger RNA for mouse immunoglobulin light chains in living frog oocytes (with M. Smith, R. C. Huang, J. B. Gurdon, and C. D. Lane), Journal of molecular biology (1973)

No abstract provided.

 
Synthesis of a mouse immunoglobulin light chain in a rabbit reticulocyte cell-free system (with R. C. Huang), Nature: New biology (1971)

No abstract provided.

 

Promoter Regions (Genetics)

Analysis of transforming growth factor-beta1-induced Ig germ-line gamma2b transcription and its implication for IgA isotype switching (with Seok-Rae Park, Goo-Young Seo, Ae-Jin Choi, and Pyeung-Hyeun Kim), European journal of immunology (2005)

Transforming growth factor (TGF)-beta1 directs class switch recombination (CSR) to IgG2b as well as to...

 
Differential regulation of mouse germline Ig gamma 1 and epsilon promoters by IL-4 and CD40 (with C. S. Mao), Journal of immunology (Baltimore, Md. : 1950) (2001)

Before Ig class switching, RNA transcription through the specific S regions undergoing recombination is induced...

 
Roles of Ets proteins, NF-kappa B and nocodazole in regulating induction of transcription of mouse germline Ig alpha RNA by transforming growth factor-beta 1 (with M. J. Shi, S. R. Park, and P. H. Kim), International immunology (2001)

Antibody class switch recombination (CSR) occurs after antigen activation of B cells. CSR is directed...

 
Activation of the mouse Ig germline epsilon promoter by IL-4 is dependent on AP-1 transcription factors (with Ching-Hung Shen), Journal of immunology (Baltimore, Md. : 1950) (2000)

Induction of germline (GL) epsilon transcripts, an essential step preceding Ig isotype switching to IgE,...

 
Regulation of the promoter for human immunoglobulin gamma3 germ-line transcription and its interaction with the 3'alpha enhancer (with Q. Pan, C. Petit-Frere, and L. Hammarstrom), European journal of immunology (2000)

The mechanism underlying the differential regulation of switching to human IgG subclasses is still largely...

 
Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter (with J. Hanai, L. F. Chen, T. Kanno, N. Ohtani-Fujita, W. Y. Kim, W. H. Guo, T. Imamura, Y. Ishidou, M. Fukuchi, M. J. Shi, M. Kawabata, K. Miyazono, and Y. Ito), The Journal of biological chemistry (1999)

Smads are signal transducers for members of the transforming growth factor-beta (TGF-beta) superfamily. Upon ligand...

 
Overexpression of BSAP/Pax-5 inhibits switching to IgA and enhances switching to IgE in the I.29 mu B cell line (with G. Qiu), Journal of immunology (Baltimore, Md. : 1950) (1998)

B cell-specific activator protein (BSAP)/Pax-5 is a paired domain DNA-binding protein expressed in the developing...

 
Cell cycle regulation of immunoglobulin class switch recombination and germ-line transcription: potential role of Ets family members (with M. Lundgren, L. Strom, L. O. Bergquist, S. Skog, T. Heiden, and E. Severinson), European journal of immunology (1995)

Previous studies have indicated that transcription of germ-line (GL) CH genes is necessary to obtain...

 
Regulation of transcription of the germ-line Ig alpha constant region gene by an ATF element and by novel transforming growth factor-beta 1-responsive elements (with Y. C. Lin), Journal of immunology (Baltimore, Md. : 1950) (1992)

Inasmuch as transcription of unrearranged, or germ-line, Ig CH genes appears to direct switch recombination,...

 
Regulation of transcription of immunoglobulin germ-line gamma 1 RNA: analysis of the promoter/enhancer (with M. Z. Xu), The EMBO journal (1992)

Antibody class switching is achieved by recombinations between switch (S) regions which consist of tandemly...

 
Regulation of transcription of the germline immunoglobulin alpha constant region gene (with Y. C. Lin and P. Shockett), Current topics in microbiology and immunology (1992)

No abstract provided.

 

Protein

Differential regulation of mouse germline Ig gamma 1 and epsilon promoters by IL-4 and CD40 (with C. S. Mao), Journal of immunology (Baltimore, Md. : 1950) (2001)

Before Ig class switching, RNA transcription through the specific S regions undergoing recombination is induced...

 

Protein Binding

Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter (with J. Hanai, L. F. Chen, T. Kanno, N. Ohtani-Fujita, W. Y. Kim, W. H. Guo, T. Imamura, Y. Ishidou, M. Fukuchi, M. J. Shi, M. Kawabata, K. Miyazono, and Y. Ito), The Journal of biological chemistry (1999)

Smads are signal transducers for members of the transforming growth factor-beta (TGF-beta) superfamily. Upon ligand...

 
Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription (with Ching-Hung Shen), Molecular and cellular biology (1998)

Signal transducer and activator of transcription 6 (Stat6) and NF-kappaB are widely distributed transcription factors...

 

Protein Biosynthesis

Synthesis and processing of the alpha heavy chains of secreted and membrane-bound IgA (with H. Kikutani, R. Sitia, and R. A. Good), Proceedings of the National Academy of Sciences of the United States of America (1981)

We have compared the synthesis and processing of immunoglobulin alpha chains in two murine cell...

 

Protein-Serine-Threonine Kinases

Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter (with J. Hanai, L. F. Chen, T. Kanno, N. Ohtani-Fujita, W. Y. Kim, W. H. Guo, T. Imamura, Y. Ishidou, M. Fukuchi, M. J. Shi, M. Kawabata, K. Miyazono, and Y. Ito), The Journal of biological chemistry (1999)

Smads are signal transducers for members of the transforming growth factor-beta (TGF-beta) superfamily. Upon ligand...

 

Proteins

Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes (with Carol E. Schrader, W. Edelmann, and R. Kucherlapati), The Journal of experimental medicine (1999)

Mice deficient in various mismatch repair (MMR) enzymes were examined to determine whether this repair...

 

Proto-Oncogene Proteins

Shifts in targeting of class switch recombination sites in mice that lack mu switch region tandem repeats or Msh2 (with Irene M. Min, Lisa R. Rothlein, Carol E. Schrader, and Erik Selsing), The Journal of experimental medicine (2005)

The mechanisms that target class switch recombination (CSR) to antibody gene switch (S) regions are...

 
Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions (with Carol E. Schrader, Joycelyn Vardo, Erin K. Linehan, Michael Z. Twarog, Laura J. Niedernhofer, and Jan H. J. Hoeijmakers), The Journal of experimental medicine (2004)

The structure-specific endonuclease ERCC1-XPF is an essential component of the nucleotide excision DNA repair pathway....

 
Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination (with Carol E. Schrader, Sean P. Bradley, Joycelyn Vardo, Sofia N. Mochegova, and Erin Flanagan), The EMBO journal (2003)

Nucleotide substitutions are found in recombined Ig switch (S) regions and also in unrecombined (germline,...

 
The Smu tandem repeat region is critical for Ig isotype switching in the absence of Msh2 (with Irene M. Min, Carol E. Schrader, Joycelyn Vardo, Thomas M. Luby, Nicole D'Avirro, and Erik Selsing), Immunity (2003)

Deficiencies of the Msh2 protein or the Smu tandem repeat (SmuTR) sequences each reduce isotype...

 
Mlh1 can function in antibody class switch recombination independently of Msh2 (with Carol E. Schrader and Joycelyn Vardo), The Journal of experimental medicine (2003)

Mismatch repair proteins participate in antibody class switch recombination, although their roles are unknown. Previous...

 
Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions (with Carol E. Schrader and Joycelyn Vardo), The Journal of experimental medicine (2002)

B cells from mice deficient in mismatch repair (MMR) proteins show decreased ability to undergo...

 
Roles of Ets proteins, NF-kappa B and nocodazole in regulating induction of transcription of mouse germline Ig alpha RNA by transforming growth factor-beta 1 (with M. J. Shi, S. R. Park, and P. H. Kim), International immunology (2001)

Antibody class switch recombination (CSR) occurs after antigen activation of B cells. CSR is directed...

 
The ability of CD40L, but not lipopolysaccharide, to initiate immunoglobulin switching to immunoglobulin G1 is explained by differential induction of NF-kappaB/Rel proteins (with S. C. Lin and H. H. Wortis), Molecular and cellular biology (1998)

Antibodies of the immunoglobulin G1 class are induced in mice by T-cell-dependent antigens but not...

 
Activation of NF-kappaB/Rel by CD40 engagement induces the mouse germ line immunoglobulin Cgamma1 promoter (with S. C. Lin), Molecular and cellular biology (1996)

Interaction between CD40 on B cells and CD40 ligand (CD40L) on T cells has been...

 
Cell cycle regulation of immunoglobulin class switch recombination and germ-line transcription: potential role of Ets family members (with M. Lundgren, L. Strom, L. O. Bergquist, S. Skog, T. Heiden, and E. Severinson), European journal of immunology (1995)

Previous studies have indicated that transcription of germ-line (GL) CH genes is necessary to obtain...

 

Proto-Oncogene Proteins c-ets

Roles of Ets proteins, NF-kappa B and nocodazole in regulating induction of transcription of mouse germline Ig alpha RNA by transforming growth factor-beta 1 (with M. J. Shi, S. R. Park, and P. H. Kim), International immunology (2001)

Antibody class switch recombination (CSR) occurs after antigen activation of B cells. CSR is directed...

 
Cell cycle regulation of immunoglobulin class switch recombination and germ-line transcription: potential role of Ets family members (with M. Lundgren, L. Strom, L. O. Bergquist, S. Skog, T. Heiden, and E. Severinson), European journal of immunology (1995)

Previous studies have indicated that transcription of germ-line (GL) CH genes is necessary to obtain...

 

Proto-Oncogene Proteins c-fos

Activation of the mouse Ig germline epsilon promoter by IL-4 is dependent on AP-1 transcription factors (with Ching-Hung Shen), Journal of immunology (Baltimore, Md. : 1950) (2000)

Induction of germline (GL) epsilon transcripts, an essential step preceding Ig isotype switching to IgE,...

 

Proto-Oncogene Proteins c-jun

Activation of the mouse Ig germline epsilon promoter by IL-4 is dependent on AP-1 transcription factors (with Ching-Hung Shen), Journal of immunology (Baltimore, Md. : 1950) (2000)

Induction of germline (GL) epsilon transcripts, an essential step preceding Ig isotype switching to IgE,...

 

Proto-Oncogene Proteins c-myc

Cognate T cell help for CD40-deficient B cells induces c-myc RNA expression, but DNA synthesis requires an additional signal through surface Ig (with Carol E. Schrader, H. Kikutani, and D. C. Parker), Journal of immunology (Baltimore, Md. : 1950) (1997)

To investigate the role of CD40 ligand in the delivery of help to B cells,...

 

Proto-Oncogene Proteins c-rel

The ability of CD40L, but not lipopolysaccharide, to initiate immunoglobulin switching to immunoglobulin G1 is explained by differential induction of NF-kappaB/Rel proteins (with S. C. Lin and H. H. Wortis), Molecular and cellular biology (1998)

Antibodies of the immunoglobulin G1 class are induced in mice by T-cell-dependent antigens but not...

 
Activation of NF-kappaB/Rel by CD40 engagement induces the mouse germ line immunoglobulin Cgamma1 promoter (with S. C. Lin), Molecular and cellular biology (1996)

Interaction between CD40 on B cells and CD40 ligand (CD40L) on T cells has been...

 

Pseudogenes

The J kappa proximal region of the human K locus contains three uncommon V kappa genes which are arranged in opposite transcriptional polarities (with W. Lorenz, K. F. Schable, R. Thiebe, and H. G. Zachau), Molecular immunology (1988)

The structure of one of the V kappa gene-containing regions of the locus coding for...

 

Rabbits

Molecular defects in a human immunoglobulin kappa chain deficiency (with O. Kekish and B. J. Zegers), Science (New York, N.Y.) (1985)

The molecular basis of a human immunoglobulin deficiency characterized by the complete absence of kappa...

 

Receptors, Antigen, B-Cell

Molecular processes that regulate class switching, Current topics in microbiology and immunology (1999)

No abstract provided.

 
CBF alpha3 (AML2) is induced by TGF-beta1 to bind and activate the mouse germline Ig alpha promoter (with M. J. Shi), Journal of immunology (Baltimore, Md. : 1950) (1998)

TGF-beta1 directs class switching to IgA by splenic B cells and by the surface IgM+...

 
Cognate T cell help for CD40-deficient B cells induces c-myc RNA expression, but DNA synthesis requires an additional signal through surface Ig (with Carol E. Schrader, H. Kikutani, and D. C. Parker), Journal of immunology (Baltimore, Md. : 1950) (1997)

To investigate the role of CD40 ligand in the delivery of help to B cells,...

 

PDF

Presence of a polyadenylated RNA fragment encoding the membrane domain for immunoglobulin alpha chain indicates that mRNAs for both secreted and membrane-bound alpha chains can be produced from the same RNA transcript, Nucleic acids research (1986)

RNA blotting was employed to examine polyadenylated immunoglobulin alpha chain RNAs in a B lymphoma...

 
Surface immunoglobulin light chain expression in pre-B cell leukemias (with B. Koziner, A. Al-Katib, D. Gebhard, A. Mittelman, M. Andreeff, and B. D. Clarkson), Annals of the New York Academy of Sciences (1986)

Cytofluorographic analysis of surface immunoglobulin (sIg) light chain clonal excess (CE), defined as (%kappa+ -...

 
Surface immunoglobulin light-chain expression by the "common" all cell line REH (with B. Koziner and A. Al-Katib), Clinical immunology and immunopathology (1985)

To provide further support of the B-cell lineage of "common" acute lymphoblastic leukemia (ALL), we...

 
The regulation of membrane-bound and secreted alpha-chain biosynthesis during the differentiation of the B cell lymphoma I.29 (with R. Sitia, A. Rubartelli, H. Kikutani, and U. Hammerling), Journal of immunology (Baltimore, Md. : 1950) (1985)

The regulation of the synthesis of membrane-bound and secreted IgA was investigated in the murine...

 
Rearrangements and deletions of immunoglobulin heavy chain genes in the double-producing B cell lymphoma I.29 (with K. B. Marcu, S. Sirlin, B. Alhadeff, and U. Hammerling), Molecular and cellular biology (1982)

The B cell lymphoma I.29 consists of a mixture of cells expressing membrane-bound immunoglobulin M...

 
Membrane-bound and secreted IgA contain structurally different alpha-chains (with R. Sitia, H. Kikutani, A. Rubartelli, Y. Bushkin, and U. Hammerling), Journal of immunology (Baltimore, Md. : 1950) (1982)

Three different forms of alpha-chains are synthesized by BF0.3 and 615.2, two cloned cell lines...

 

Receptors, Antigen, T-Cell

Reticulum cell sarcomas of SJL mice have rearranged immunoglobulin heavy and light chain genes (with J. L. Lasky, N. M. Ponzio, M. P. Scheid, and G. J. Thorbecke), European journal of immunology (1989)

The immunoglobulin (Ig) heavy (H) and light (L) chain gene rearrangements of the high incidence...

 
Expression of an antigen receptor on T cells does not require recombination at the immunoglobulin JH-C mu locus (with Y. Cayre, M. A. Palladino, and K. B. Marcu), Proceedings of the National Academy of Sciences of the United States of America (1981)

Considerable evidence has accumulated suggesting that the antigen receptor(s) on T cells is coded for...

 

Receptors, Transforming Growth Factor beta

Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter (with J. Hanai, L. F. Chen, T. Kanno, N. Ohtani-Fujita, W. Y. Kim, W. H. Guo, T. Imamura, Y. Ishidou, M. Fukuchi, M. J. Shi, M. Kawabata, K. Miyazono, and Y. Ito), The Journal of biological chemistry (1999)

Smads are signal transducers for members of the transforming growth factor-beta (TGF-beta) superfamily. Upon ligand...

 
Regulation of antibody production and class switching by TGF-beta, Journal of immunology (Baltimore, Md. : 1950) (1995)

No abstract provided.

 

Recombinant Fusion Proteins

The ability of CD40L, but not lipopolysaccharide, to initiate immunoglobulin switching to immunoglobulin G1 is explained by differential induction of NF-kappaB/Rel proteins (with S. C. Lin and H. H. Wortis), Molecular and cellular biology (1998)

Antibodies of the immunoglobulin G1 class are induced in mice by T-cell-dependent antigens but not...

 
Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription (with Ching-Hung Shen), Molecular and cellular biology (1998)

Signal transducer and activator of transcription 6 (Stat6) and NF-kappaB are widely distributed transcription factors...

 
Regulation of transcription of immunoglobulin germ-line gamma 1 RNA: analysis of the promoter/enhancer (with M. Z. Xu), The EMBO journal (1992)

Antibody class switching is achieved by recombinations between switch (S) regions which consist of tandemly...

 

Recombinant Proteins

Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination (with Carol E. Schrader, Sean P. Bradley, Joycelyn Vardo, Sofia N. Mochegova, and Erin Flanagan), The EMBO journal (2003)

Nucleotide substitutions are found in recombined Ig switch (S) regions and also in unrecombined (germline,...

 
Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes (with G. Radcliffe, Y. C. Lin, J. Nietupski, L. Berggren, R. Sitia, and E. Severinson), Proceedings of the National Academy of Sciences of the United States of America (1988)

Immunoglobulin heavy-chain switching is effected by a DNA recombination event that replaces the C mu...

 

Recombination, Genetic

Mismatch repair converts AID-instigated nicks to double-strand breaks for antibody class-switch recombination (with Carol E. Schrader), Trends in genetics : TIG (2005)

Mismatch repair (MMR) proteins are important for antibody class-switch recombination (CSR), but their roles are...

 
Inducible DNA breaks in Ig S regions are dependent on AID and UNG (with Carol E. Schrader, Erin K. Linehan, Sofia N. Mochegova, and Robert T. Woodland), The Journal of experimental medicine (2005)

Class switch recombination (CSR) occurs by an intrachromosomal deletion whereby the IgM constant region gene...

 
Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions (with Carol E. Schrader and Joycelyn Vardo), The Journal of experimental medicine (2002)

B cells from mice deficient in mismatch repair (MMR) proteins show decreased ability to undergo...

 
The mu switch region tandem repeats are important, but not required, for antibody class switch recombination (with Thomas M. Luby, Carol E. Schrader, and Erik Selsing), The Journal of experimental medicine (2001)

Class switch DNA recombinations change the constant (C) region of the antibody heavy (H) chain...

 
Immunology. A touch of antibody class, Science (New York, N.Y.) (2000)

When B cells, the antibody producing cells of the body, encounter antigen they switch from...

 
Molecular processes that regulate class switching, Current topics in microbiology and immunology (1999)

No abstract provided.

 
Ialpha exon-replacement mice synthesize a spliced HPRT-C(alpha) transcript which may explain their ability to switch to IgA. Inhibition of switching to IgG in these mice (with G. Qiu and G. R. Harriman), International immunology (1999)

Antibody class switching is regulated by transcription of unrearranged C(H) genes to produce germline (GL)...

 
Antibody class switching, Advances in immunology (1996)

No abstract provided.

 
Cell cycle regulation of immunoglobulin class switch recombination and germ-line transcription: potential role of Ets family members (with M. Lundgren, L. Strom, L. O. Bergquist, S. Skog, T. Heiden, and E. Severinson), European journal of immunology (1995)

Previous studies have indicated that transcription of germ-line (GL) CH genes is necessary to obtain...

 
Regulation of switch recombination to the murine gamma 1 gene (with W. Dunnick, L. Elenich, J. Berry, D. Albrecht, and J. L. Claflin), Current topics in microbiology and immunology (1992)

No abstract provided.

 
Regulation of the antibody class switch to IgA (with Y. C. Lin and P. Shockett), Immunologic research (1991)

No abstract provided.

 
Induction of germ-line immunoglobulin heavy chain transcripts by mitogens and interleukins prior to switch recombination (with E. Severinson and C. Fernandez), European journal of immunology (1990)

It has recently been postulated that immunoglobulin class switching is preceded by transcription from unrearranged...

 
A B-cell-specific nuclear protein that binds to DNA sites 5' to immunoglobulin S alpha tandem repeats is regulated during differentiation (with S. H. Waters and K. U. Saikh), Molecular and cellular biology (1989)

Immunoglobulin heavy-chain switching is effected by recombination events between sites associated with tandemly repeated switch...

 
Mutations, duplication, and deletion of recombined switch regions suggest a role for DNA replication in the immunoglobulin heavy-chain switch (with W. Dunnick and M. Wilson), Molecular and cellular biology (1989)

The heavy-chain switch from immunoglobulin M (IgM) expression to IgA expression is mediated by a...

 

File

Induction of immunoglobulin isotype switching in cultured I.29 B lymphoma cells. Characterization of the accompanying rearrangements of heavy chain genes (with S. Sirlin and J. Abbott), The Journal of experimental medicine (1985)

The murine B cell lymphoma I.29 contains cells expressing surface IgM or IgA with identical...

 
Genetic structure and origin of t haplotypes of mice, analyzed with H-2 cDNA probes (with H. S. Shin, K. Artzt, and D. Bennett), Cell (1982)

We investigated the genetic organization and evolutionary origin of t chromosomes of mice by examining...

 
Expression of an antigen receptor on T cells does not require recombination at the immunoglobulin JH-C mu locus (with Y. Cayre, M. A. Palladino, and K. B. Marcu), Proceedings of the National Academy of Sciences of the United States of America (1981)

Considerable evidence has accumulated suggesting that the antigen receptor(s) on T cells is coded for...

 

Regulatory Sequences, Nucleic Acid

Activation of NF-kappaB/Rel by CD40 engagement induces the mouse germ line immunoglobulin Cgamma1 promoter (with S. C. Lin), Molecular and cellular biology (1996)

Interaction between CD40 on B cells and CD40 ligand (CD40L) on T cells has been...

 
Regulation of transcription of immunoglobulin germ-line gamma 1 RNA: analysis of the promoter/enhancer (with M. Z. Xu), The EMBO journal (1992)

Antibody class switching is achieved by recombinations between switch (S) regions which consist of tandemly...

 

Repressor Proteins

The histone methyltransferase Suv39h1 increases class switch recombination specifically to IgA (with Sean P. Bradley, Denise A. Kaminski, Antoine H. F. M. Peters, and Thomas Jenuwein), Journal of immunology (Baltimore, Md. : 1950) (2006)

Ab class (isotype) switching allows the humoral immune system to adaptively respond to different infectious...

 
The ubiquitously expressed DNA-binding protein late SV40 factor binds Ig switch regions and represses class switching to IgA (with Elise E. Drouin, Carol E. Schrader, and Ulla Hansen), Journal of immunology (Baltimore, Md. : 1950) (2002)

Ig heavy chain class switch recombination (CSR) determines the expression of Ig isotypes. The molecular...

 

Response Elements

Differential regulation of mouse germline Ig gamma 1 and epsilon promoters by IL-4 and CD40 (with C. S. Mao), Journal of immunology (Baltimore, Md. : 1950) (2001)

Before Ig class switching, RNA transcription through the specific S regions undergoing recombination is induced...

 
Regulation of the promoter for human immunoglobulin gamma3 germ-line transcription and its interaction with the 3'alpha enhancer (with Q. Pan, C. Petit-Frere, and L. Hammarstrom), European journal of immunology (2000)

The mechanism underlying the differential regulation of switching to human IgG subclasses is still largely...

 

Restriction Mapping

Regulation of transcription of the germ-line Ig alpha constant region gene by an ATF element and by novel transforming growth factor-beta 1-responsive elements (with Y. C. Lin), Journal of immunology (Baltimore, Md. : 1950) (1992)

Inasmuch as transcription of unrearranged, or germ-line, Ig CH genes appears to direct switch recombination,...

 
Copy choice mechanism of immunoglobulin heavy-chain switch recombination (with W. Dunnick), Molecular and cellular biology (1990)

The immunoglobulin heavy-chain switch is mediated by a recombination event between DNA switch regions associated...

 
Structure of germ line immunoglobulin alpha heavy-chain RNA and its location on polysomes (with G. Radcliffe, Y. C. Lin, M. Julius, and K. B. Marcu), Molecular and cellular biology (1990)

We describe the structure of the major germ line RNA transcribed from unrearranged immunoglobulin alpha...

 
A B-cell-specific nuclear protein that binds to DNA sites 5' to immunoglobulin S alpha tandem repeats is regulated during differentiation (with S. H. Waters and K. U. Saikh), Molecular and cellular biology (1989)

Immunoglobulin heavy-chain switching is effected by recombination events between sites associated with tandemly repeated switch...

 
Mutations, duplication, and deletion of recombined switch regions suggest a role for DNA replication in the immunoglobulin heavy-chain switch (with W. Dunnick and M. Wilson), Molecular and cellular biology (1989)

The heavy-chain switch from immunoglobulin M (IgM) expression to IgA expression is mediated by a...

 

Reverse Transcriptase Polymerase Chain Reaction

DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination (with Xiaoming Wu), The Journal of experimental medicine (2007)

Immunoglobulin (Ig) class switch recombination (CSR) is initiated by activation-induced cytidine deaminase (AID), which converts...

 
Analysis of transforming growth factor-beta1-induced Ig germ-line gamma2b transcription and its implication for IgA isotype switching (with Seok-Rae Park, Goo-Young Seo, Ae-Jin Choi, and Pyeung-Hyeun Kim), European journal of immunology (2005)

Transforming growth factor (TGF)-beta1 directs class switch recombination (CSR) to IgG2b as well as to...

 

Ribonuclease H, Calf Thymus

Immunology. A touch of antibody class, Science (New York, N.Y.) (2000)

When B cells, the antibody producing cells of the body, encounter antigen they switch from...

 

RNA

Roles of Ets proteins, NF-kappa B and nocodazole in regulating induction of transcription of mouse germline Ig alpha RNA by transforming growth factor-beta 1 (with M. J. Shi, S. R. Park, and P. H. Kim), International immunology (2001)

Antibody class switch recombination (CSR) occurs after antigen activation of B cells. CSR is directed...

 
Immunology. A touch of antibody class, Science (New York, N.Y.) (2000)

When B cells, the antibody producing cells of the body, encounter antigen they switch from...

 
Structure of germline immunoglobulin heavy-chain gamma 1 transcripts in interleukin 4 treated mouse spleen cells (with M. Xu), Developmental immunology (1990)

Antibody class switching is mediated by a DNA recombination event that replaces the C mu...

 
Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes (with G. Radcliffe, Y. C. Lin, J. Nietupski, L. Berggren, R. Sitia, and E. Severinson), Proceedings of the National Academy of Sciences of the United States of America (1988)

Immunoglobulin heavy-chain switching is effected by a DNA recombination event that replaces the C mu...

 
Surface immunoglobulin light chain expression in pre-B cell leukemias (with B. Koziner, A. Al-Katib, D. Gebhard, A. Mittelman, M. Andreeff, and B. D. Clarkson), Annals of the New York Academy of Sciences (1986)

Cytofluorographic analysis of surface immunoglobulin (sIg) light chain clonal excess (CE), defined as (%kappa+ -...

 
Surface immunoglobulin light-chain expression by the "common" all cell line REH (with B. Koziner and A. Al-Katib), Clinical immunology and immunopathology (1985)

To provide further support of the B-cell lineage of "common" acute lymphoblastic leukemia (ALL), we...

 

File

Induction of immunoglobulin isotype switching in cultured I.29 B lymphoma cells. Characterization of the accompanying rearrangements of heavy chain genes (with S. Sirlin and J. Abbott), The Journal of experimental medicine (1985)

The murine B cell lymphoma I.29 contains cells expressing surface IgM or IgA with identical...

 

RNA Polymerase II

Antibody class switching: uncoupling S region accessibility from transcription (with Denise A. Kaminski), Trends in genetics : TIG (2004)

Immunogloblin class switch recombination (CSR) is a regulated process that changes antibody effector functions. Recently,...

 

RNA Probes

Induction of germ-line immunoglobulin heavy chain transcripts by mitogens and interleukins prior to switch recombination (with E. Severinson and C. Fernandez), European journal of immunology (1990)

It has recently been postulated that immunoglobulin class switching is preceded by transcription from unrearranged...

 

RNA Processing, Post-Transcriptional

PDF

Presence of a polyadenylated RNA fragment encoding the membrane domain for immunoglobulin alpha chain indicates that mRNAs for both secreted and membrane-bound alpha chains can be produced from the same RNA transcript, Nucleic acids research (1986)

RNA blotting was employed to examine polyadenylated immunoglobulin alpha chain RNAs in a B lymphoma...

 

RNA Splicing

Immunology. A touch of antibody class, Science (New York, N.Y.) (2000)

When B cells, the antibody producing cells of the body, encounter antigen they switch from...

 

RNA Viruses

Detection and characterization of RNA tumor virus-specific DNA in cells (with H. E. Varmus, E. Medeiros, and J. M. Bishop), Bibliotheca haematologica (1975)

RNA tumor virus-specific DNA in cells can be detected by its capacity to 1) alter...

 

RNA, Messenger

Regulation of the promoter for human immunoglobulin gamma3 germ-line transcription and its interaction with the 3'alpha enhancer (with Q. Pan, C. Petit-Frere, and L. Hammarstrom), European journal of immunology (2000)

The mechanism underlying the differential regulation of switching to human IgG subclasses is still largely...

 
Cognate T cell help for CD40-deficient B cells induces c-myc RNA expression, but DNA synthesis requires an additional signal through surface Ig (with Carol E. Schrader, H. Kikutani, and D. C. Parker), Journal of immunology (Baltimore, Md. : 1950) (1997)

To investigate the role of CD40 ligand in the delivery of help to B cells,...

 
Mouse CD6: sequence of cDNA and expression of mRNA (with A. Pal, P. L. Romain, N. G. Singer, and D. Fox), Immunology letters (1996)

No abstract provided.

 
Cell cycle regulation of immunoglobulin class switch recombination and germ-line transcription: potential role of Ets family members (with M. Lundgren, L. Strom, L. O. Bergquist, S. Skog, T. Heiden, and E. Severinson), European journal of immunology (1995)

Previous studies have indicated that transcription of germ-line (GL) CH genes is necessary to obtain...

 
Induction of germ-line immunoglobulin heavy chain transcripts by mitogens and interleukins prior to switch recombination (with E. Severinson and C. Fernandez), European journal of immunology (1990)

It has recently been postulated that immunoglobulin class switching is preceded by transcription from unrearranged...

 
Structure of germ line immunoglobulin alpha heavy-chain RNA and its location on polysomes (with G. Radcliffe, Y. C. Lin, M. Julius, and K. B. Marcu), Molecular and cellular biology (1990)

We describe the structure of the major germ line RNA transcribed from unrearranged immunoglobulin alpha...

 
Interleukins 4 and 5: mechanisms of action (with E. Severinson, H. B. Moon, S. Bergstedt-Lindqvist, U. Persson, and C. Heusser), Advances in experimental medicine and biology (1989)

No abstract provided.

 
Expression of immunoglobulin lambda light chain by the promyelocytic cell line HL-60 (with A. Al-Katib and B. Koziner), Journal of immunology (Baltimore, Md. : 1950) (1986)

The HL-60 cell line, established from a patient with acute promyelocytic leukemia, can be induced...

 

PDF

Presence of a polyadenylated RNA fragment encoding the membrane domain for immunoglobulin alpha chain indicates that mRNAs for both secreted and membrane-bound alpha chains can be produced from the same RNA transcript, Nucleic acids research (1986)

RNA blotting was employed to examine polyadenylated immunoglobulin alpha chain RNAs in a B lymphoma...

 
Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching (with S. Sirlin), The EMBO journal (1986)

IgM+ cells cultured from the I.29 B cell lymphoma can be induced with lipopolysaccharide (LPS)...

 
The regulation of membrane-bound and secreted alpha-chain biosynthesis during the differentiation of the B cell lymphoma I.29 (with R. Sitia, A. Rubartelli, H. Kikutani, and U. Hammerling), Journal of immunology (Baltimore, Md. : 1950) (1985)

The regulation of the synthesis of membrane-bound and secreted IgA was investigated in the murine...

 
Immunoglobulin heavy chain switching in cultured I.29 murine B lymphoma cells: commitment to an IgA or IgE switch (with J. Abbott and S. Sirlin), Current topics in microbiology and immunology (1984)

No abstract provided.

 
Synthesis and processing of the alpha heavy chains of secreted and membrane-bound IgA (with H. Kikutani, R. Sitia, and R. A. Good), Proceedings of the National Academy of Sciences of the United States of America (1981)

We have compared the synthesis and processing of immunoglobulin alpha chains in two murine cell...

 
Isolation of messenger RNA for an immunoglobulin kappa chain and enumeration of the genes for the constatn region of kappa chain in the mouse (with R. C. Huang, E. Stavnezer, and J. M. Bishop), Journal of molecular biology (1974)

No abstract provided.

 
Synthesis of a mouse immunoglobulin light chain in a rabbit reticulocyte cell-free system (with R. C. Huang), Nature: New biology (1971)

No abstract provided.

 

RNA, Neoplasm

The regulation of membrane-bound and secreted alpha-chain biosynthesis during the differentiation of the B cell lymphoma I.29 (with R. Sitia, A. Rubartelli, H. Kikutani, and U. Hammerling), Journal of immunology (Baltimore, Md. : 1950) (1985)

The regulation of the synthesis of membrane-bound and secreted IgA was investigated in the murine...

 

RNA-Binding Proteins

The ubiquitously expressed DNA-binding protein late SV40 factor binds Ig switch regions and represses class switching to IgA (with Elise E. Drouin, Carol E. Schrader, and Ulla Hansen), Journal of immunology (Baltimore, Md. : 1950) (2002)

Ig heavy chain class switch recombination (CSR) determines the expression of Ig isotypes. The molecular...

 

RNA-Directed DNA Polymerase

Detection and characterization of RNA tumor virus-specific DNA in cells (with H. E. Varmus, E. Medeiros, and J. M. Bishop), Bibliotheca haematologica (1975)

RNA tumor virus-specific DNA in cells can be detected by its capacity to 1) alter...

 

Sarcoma, Experimental

Reticulum cell sarcomas of SJL mice have rearranged immunoglobulin heavy and light chain genes (with J. L. Lasky, N. M. Ponzio, M. P. Scheid, and G. J. Thorbecke), European journal of immunology (1989)

The immunoglobulin (Ig) heavy (H) and light (L) chain gene rearrangements of the high incidence...

 
Detection and characterization of RNA tumor virus-specific DNA in cells (with H. E. Varmus, E. Medeiros, and J. M. Bishop), Bibliotheca haematologica (1975)

RNA tumor virus-specific DNA in cells can be detected by its capacity to 1) alter...

 

Sequence Alignment

Regulation of antibody class switching to IgE: characterization of an IL-4-responsive region in the immunoglobulin heavy-chain germline epsilon promoter (with S. Delphin), Annals of the New York Academy of Sciences (1995)

A large body of data indicate that antibody class switching is directed by cytokines by...

 
Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50 (with S. Delphin), The Journal of experimental medicine (1995)

A large body of data indicate that antibody class switching is directed by cytokines by...

 

Sequence Analysis, DNA

Ialpha exon-replacement mice synthesize a spliced HPRT-C(alpha) transcript which may explain their ability to switch to IgA. Inhibition of switching to IgG in these mice (with G. Qiu and G. R. Harriman), International immunology (1999)

Antibody class switching is regulated by transcription of unrearranged C(H) genes to produce germline (GL)...

 
Mouse CD6: sequence of cDNA and expression of mRNA (with A. Pal, P. L. Romain, N. G. Singer, and D. Fox), Immunology letters (1996)

No abstract provided.

 

Sequence Deletion

The mu switch region tandem repeats are important, but not required, for antibody class switch recombination (with Thomas M. Luby, Carol E. Schrader, and Erik Selsing), The Journal of experimental medicine (2001)

Class switch DNA recombinations change the constant (C) region of the antibody heavy (H) chain...

 

Sequence Homology, Amino Acid

Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50 (with S. Delphin), The Journal of experimental medicine (1995)

A large body of data indicate that antibody class switching is directed by cytokines by...

 

Sequence Homology, Nucleic Acid

Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions (with Carol E. Schrader and Joycelyn Vardo), The Journal of experimental medicine (2002)

B cells from mice deficient in mismatch repair (MMR) proteins show decreased ability to undergo...

 
The mu switch region tandem repeats are important, but not required, for antibody class switch recombination (with Thomas M. Luby, Carol E. Schrader, and Erik Selsing), The Journal of experimental medicine (2001)

Class switch DNA recombinations change the constant (C) region of the antibody heavy (H) chain...

 
Regulation of antibody class switching to IgE: characterization of an IL-4-responsive region in the immunoglobulin heavy-chain germline epsilon promoter (with S. Delphin), Annals of the New York Academy of Sciences (1995)

A large body of data indicate that antibody class switching is directed by cytokines by...

 
Regulation of transcription of the germ-line Ig alpha constant region gene by an ATF element and by novel transforming growth factor-beta 1-responsive elements (with Y. C. Lin), Journal of immunology (Baltimore, Md. : 1950) (1992)

Inasmuch as transcription of unrearranged, or germ-line, Ig CH genes appears to direct switch recombination,...

 

Signal Transduction

Differential regulation of mouse germline Ig gamma 1 and epsilon promoters by IL-4 and CD40 (with C. S. Mao), Journal of immunology (Baltimore, Md. : 1950) (2001)

Before Ig class switching, RNA transcription through the specific S regions undergoing recombination is induced...

 
Activation of the mouse Ig germline epsilon promoter by IL-4 is dependent on AP-1 transcription factors (with Ching-Hung Shen), Journal of immunology (Baltimore, Md. : 1950) (2000)

Induction of germline (GL) epsilon transcripts, an essential step preceding Ig isotype switching to IgE,...

 
Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter (with J. Hanai, L. F. Chen, T. Kanno, N. Ohtani-Fujita, W. Y. Kim, W. H. Guo, T. Imamura, Y. Ishidou, M. Fukuchi, M. J. Shi, M. Kawabata, K. Miyazono, and Y. Ito), The Journal of biological chemistry (1999)

Smads are signal transducers for members of the transforming growth factor-beta (TGF-beta) superfamily. Upon ligand...

 
Molecular processes that regulate class switching, Current topics in microbiology and immunology (1999)

No abstract provided.

 
Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription (with Ching-Hung Shen), Molecular and cellular biology (1998)

Signal transducer and activator of transcription 6 (Stat6) and NF-kappaB are widely distributed transcription factors...

 
CD40 cross-linking induces Ig epsilon germline transcripts in B cells via activation of NF-kappaB: synergy with IL-4 induction (with L. A. Iciek and S. A. Delphin), Journal of immunology (Baltimore, Md. : 1950) (1997)

Transcription of unrearranged (germline) Ig heavy chain C region (C(H)) genes is required before Ab...

 
Cognate T cell help for CD40-deficient B cells induces c-myc RNA expression, but DNA synthesis requires an additional signal through surface Ig (with Carol E. Schrader, H. Kikutani, and D. C. Parker), Journal of immunology (Baltimore, Md. : 1950) (1997)

To investigate the role of CD40 ligand in the delivery of help to B cells,...

 
Regulation of antibody production and class switching by TGF-beta, Journal of immunology (Baltimore, Md. : 1950) (1995)

No abstract provided.

 

Smad3 Protein

Analysis of transforming growth factor-beta1-induced Ig germ-line gamma2b transcription and its implication for IgA isotype switching (with Seok-Rae Park, Goo-Young Seo, Ae-Jin Choi, and Pyeung-Hyeun Kim), European journal of immunology (2005)

Transforming growth factor (TGF)-beta1 directs class switch recombination (CSR) to IgG2b as well as to...

 
Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter (with J. Hanai, L. F. Chen, T. Kanno, N. Ohtani-Fujita, W. Y. Kim, W. H. Guo, T. Imamura, Y. Ishidou, M. Fukuchi, M. J. Shi, M. Kawabata, K. Miyazono, and Y. Ito), The Journal of biological chemistry (1999)

Smads are signal transducers for members of the transforming growth factor-beta (TGF-beta) superfamily. Upon ligand...

 

Smad4 Protein

Analysis of transforming growth factor-beta1-induced Ig germ-line gamma2b transcription and its implication for IgA isotype switching (with Seok-Rae Park, Goo-Young Seo, Ae-Jin Choi, and Pyeung-Hyeun Kim), European journal of immunology (2005)

Transforming growth factor (TGF)-beta1 directs class switch recombination (CSR) to IgG2b as well as to...

 

Somatic Hypermutation, Immunoglobulin

Inducible DNA breaks in Ig S regions are dependent on AID and UNG (with Carol E. Schrader, Erin K. Linehan, Sofia N. Mochegova, and Robert T. Woodland), The Journal of experimental medicine (2005)

Class switch recombination (CSR) occurs by an intrachromosomal deletion whereby the IgM constant region gene...

 

Species Specificity

Antibody class switching differs among SJL, C57BL/6 and 129 mice (with Denise A. Kaminski), International immunology (2007)

Inbred mouse strains used for gene manipulation studies vary in many respects, including immune system...

 

Spermatozoa

Synthesis of a deoxyribonucleic acid sequence complementary to ovalbumin messenger ribonucleic acid and quantification of ovalbumin genes (with D. Sullivan, R. Palacios, J. M. Taylor, A. J. Faras, M. L. Kiely, N. M. Summers, J. M. Bishop, and R. T. Schimke), The Journal of biological chemistry (1973)

No abstract provided.

 

Spleen

Antibody class switching differs among SJL, C57BL/6 and 129 mice (with Denise A. Kaminski), International immunology (2007)

Inbred mouse strains used for gene manipulation studies vary in many respects, including immune system...

 
Stimuli that enhance IgA class switching increase histone 3 acetylation at S alpha, but poorly stimulate sequential switching from IgG2b (with Denise A. Kaminski), European journal of immunology (2006)

Germ-line (GL) alpha transcription can be induced in mouse splenic B cells by LPS and...

 
Enhanced IgA class switching in marginal zone and B1 B cells relative to follicular/B2 B cells (with Denise A. Kaminski), Journal of immunology (Baltimore, Md. : 1950) (2006)

Mouse splenic marginal zone (MZ) B cells and B1 B cells enriched in the peritoneal...

 
Inducible DNA breaks in Ig S regions are dependent on AID and UNG (with Carol E. Schrader, Erin K. Linehan, Sofia N. Mochegova, and Robert T. Woodland), The Journal of experimental medicine (2005)

Class switch recombination (CSR) occurs by an intrachromosomal deletion whereby the IgM constant region gene...

 
The ubiquitously expressed DNA-binding protein late SV40 factor binds Ig switch regions and represses class switching to IgA (with Elise E. Drouin, Carol E. Schrader, and Ulla Hansen), Journal of immunology (Baltimore, Md. : 1950) (2002)

Ig heavy chain class switch recombination (CSR) determines the expression of Ig isotypes. The molecular...

 
Differential regulation of mouse germline Ig gamma 1 and epsilon promoters by IL-4 and CD40 (with C. S. Mao), Journal of immunology (Baltimore, Md. : 1950) (2001)

Before Ig class switching, RNA transcription through the specific S regions undergoing recombination is induced...

 
Roles of Ets proteins, NF-kappa B and nocodazole in regulating induction of transcription of mouse germline Ig alpha RNA by transforming growth factor-beta 1 (with M. J. Shi, S. R. Park, and P. H. Kim), International immunology (2001)

Antibody class switch recombination (CSR) occurs after antigen activation of B cells. CSR is directed...

 
Activation of the mouse Ig germline epsilon promoter by IL-4 is dependent on AP-1 transcription factors (with Ching-Hung Shen), Journal of immunology (Baltimore, Md. : 1950) (2000)

Induction of germline (GL) epsilon transcripts, an essential step preceding Ig isotype switching to IgE,...

 
Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes (with Carol E. Schrader, W. Edelmann, and R. Kucherlapati), The Journal of experimental medicine (1999)

Mice deficient in various mismatch repair (MMR) enzymes were examined to determine whether this repair...

 
CBF alpha3 (AML2) is induced by TGF-beta1 to bind and activate the mouse germline Ig alpha promoter (with M. J. Shi), Journal of immunology (Baltimore, Md. : 1950) (1998)

TGF-beta1 directs class switching to IgA by splenic B cells and by the surface IgM+...

 
The ability of CD40L, but not lipopolysaccharide, to initiate immunoglobulin switching to immunoglobulin G1 is explained by differential induction of NF-kappaB/Rel proteins (with S. C. Lin and H. H. Wortis), Molecular and cellular biology (1998)

Antibodies of the immunoglobulin G1 class are induced in mice by T-cell-dependent antigens but not...

 
Induction of germ-line immunoglobulin heavy chain transcripts by mitogens and interleukins prior to switch recombination (with E. Severinson and C. Fernandez), European journal of immunology (1990)

It has recently been postulated that immunoglobulin class switching is preceded by transcription from unrearranged...

 
Structure of germline immunoglobulin heavy-chain gamma 1 transcripts in interleukin 4 treated mouse spleen cells (with M. Xu), Developmental immunology (1990)

Antibody class switching is mediated by a DNA recombination event that replaces the C mu...

 

STAT6 Transcription Factor

Differential regulation of mouse germline Ig gamma 1 and epsilon promoters by IL-4 and CD40 (with C. S. Mao), Journal of immunology (Baltimore, Md. : 1950) (2001)

Before Ig class switching, RNA transcription through the specific S regions undergoing recombination is induced...

 
Activation of the mouse Ig germline epsilon promoter by IL-4 is dependent on AP-1 transcription factors (with Ching-Hung Shen), Journal of immunology (Baltimore, Md. : 1950) (2000)

Induction of germline (GL) epsilon transcripts, an essential step preceding Ig isotype switching to IgE,...

 
Regulation of the promoter for human immunoglobulin gamma3 germ-line transcription and its interaction with the 3'alpha enhancer (with Q. Pan, C. Petit-Frere, and L. Hammarstrom), European journal of immunology (2000)

The mechanism underlying the differential regulation of switching to human IgG subclasses is still largely...

 
Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription (with Ching-Hung Shen), Molecular and cellular biology (1998)

Signal transducer and activator of transcription 6 (Stat6) and NF-kappaB are widely distributed transcription factors...

 
CD40 cross-linking induces Ig epsilon germline transcripts in B cells via activation of NF-kappaB: synergy with IL-4 induction (with L. A. Iciek and S. A. Delphin), Journal of immunology (Baltimore, Md. : 1950) (1997)

Transcription of unrearranged (germline) Ig heavy chain C region (C(H)) genes is required before Ab...

 

Streptococcus pyogenes

Mouse antibody response to group A streptococcal carbohydrate (with C. D. Jarvis and L. E. Cannon), Journal of immunology (Baltimore, Md. : 1950) (1989)

In an attempt to more fully understand the generation of antibody diversity to carbohydrate (CHO)...

 

Structure-Activity Relationship

Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50 (with S. Delphin), The Journal of experimental medicine (1995)

A large body of data indicate that antibody class switching is directed by cytokines by...

 

T-Lymphocytes

Switch recombination in a transfected plasmid occurs preferentially in a B cell line that undergoes switch recombination of its chromosomal Ig heavy chain genes (with Sean P. Bradley, Norman Rousseau, Todd Pearson, Ananth Shanmugam, Debra J. Waite, Paul R. Rogers, and Amy L. Kenter), Journal of immunology (Baltimore, Md. : 1950) (1999)

Ab class switching is induced upon B cell activation in vivo by immunization or infection...

 
The ability of CD40L, but not lipopolysaccharide, to initiate immunoglobulin switching to immunoglobulin G1 is explained by differential induction of NF-kappaB/Rel proteins (with S. C. Lin and H. H. Wortis), Molecular and cellular biology (1998)

Antibodies of the immunoglobulin G1 class are induced in mice by T-cell-dependent antigens but not...

 
Cognate T cell help for CD40-deficient B cells induces c-myc RNA expression, but DNA synthesis requires an additional signal through surface Ig (with Carol E. Schrader, H. Kikutani, and D. C. Parker), Journal of immunology (Baltimore, Md. : 1950) (1997)

To investigate the role of CD40 ligand in the delivery of help to B cells,...

 
Mouse antibody response to group A streptococcal carbohydrate (with C. D. Jarvis and L. E. Cannon), Journal of immunology (Baltimore, Md. : 1950) (1989)

In an attempt to more fully understand the generation of antibody diversity to carbohydrate (CHO)...

 
Interleukins 4 and 5: mechanisms of action (with E. Severinson, H. B. Moon, S. Bergstedt-Lindqvist, U. Persson, and C. Heusser), Advances in experimental medicine and biology (1989)

No abstract provided.

 
Expression of an antigen receptor on T cells does not require recombination at the immunoglobulin JH-C mu locus (with Y. Cayre, M. A. Palladino, and K. B. Marcu), Proceedings of the National Academy of Sciences of the United States of America (1981)

Considerable evidence has accumulated suggesting that the antigen receptor(s) on T cells is coded for...

 

Tandem Repeat Sequences

Shifts in targeting of class switch recombination sites in mice that lack mu switch region tandem repeats or Msh2 (with Irene M. Min, Lisa R. Rothlein, Carol E. Schrader, and Erik Selsing), The Journal of experimental medicine (2005)

The mechanisms that target class switch recombination (CSR) to antibody gene switch (S) regions are...

 

Templates, Genetic

Immunology. A touch of antibody class, Science (New York, N.Y.) (2000)

When B cells, the antibody producing cells of the body, encounter antigen they switch from...

 
Synthesis of a deoxyribonucleic acid sequence complementary to ovalbumin messenger ribonucleic acid and quantification of ovalbumin genes (with D. Sullivan, R. Palacios, J. M. Taylor, A. J. Faras, M. L. Kiely, N. M. Summers, J. M. Bishop, and R. T. Schimke), The Journal of biological chemistry (1973)

No abstract provided.

 
Synthesis of a mouse immunoglobulin light chain in a rabbit reticulocyte cell-free system (with R. C. Huang), Nature: New biology (1971)

No abstract provided.

 

Tetracycline

Overexpression of BSAP/Pax-5 inhibits switching to IgA and enhances switching to IgE in the I.29 mu B cell line (with G. Qiu), Journal of immunology (Baltimore, Md. : 1950) (1998)

B cell-specific activator protein (BSAP)/Pax-5 is a paired domain DNA-binding protein expressed in the developing...

 

Tetradecanoylphorbol Acetate

Regulation of transcription of immunoglobulin germ-line gamma 1 RNA: analysis of the promoter/enhancer (with M. Z. Xu), The EMBO journal (1992)

Antibody class switching is achieved by recombinations between switch (S) regions which consist of tandemly...

 
Expression of immunoglobulin lambda light chain by the promyelocytic cell line HL-60 (with A. Al-Katib and B. Koziner), Journal of immunology (Baltimore, Md. : 1950) (1986)

The HL-60 cell line, established from a patient with acute promyelocytic leukemia, can be induced...

 
Surface immunoglobulin light-chain expression by the "common" all cell line REH (with B. Koziner and A. Al-Katib), Clinical immunology and immunopathology (1985)

To provide further support of the B-cell lineage of "common" acute lymphoblastic leukemia (ALL), we...

 

Thymus Gland

Synthesis of a deoxyribonucleic acid sequence complementary to ovalbumin messenger ribonucleic acid and quantification of ovalbumin genes (with D. Sullivan, R. Palacios, J. M. Taylor, A. J. Faras, M. L. Kiely, N. M. Summers, J. M. Bishop, and R. T. Schimke), The Journal of biological chemistry (1973)

No abstract provided.

 

Trans-Activation (Genetics)

Differential regulation of mouse germline Ig gamma 1 and epsilon promoters by IL-4 and CD40 (with C. S. Mao), Journal of immunology (Baltimore, Md. : 1950) (2001)

Before Ig class switching, RNA transcription through the specific S regions undergoing recombination is induced...

 
Regulation of the promoter for human immunoglobulin gamma3 germ-line transcription and its interaction with the 3'alpha enhancer (with Q. Pan, C. Petit-Frere, and L. Hammarstrom), European journal of immunology (2000)

The mechanism underlying the differential regulation of switching to human IgG subclasses is still largely...

 

Trans-Activators

Analysis of transforming growth factor-beta1-induced Ig germ-line gamma2b transcription and its implication for IgA isotype switching (with Seok-Rae Park, Goo-Young Seo, Ae-Jin Choi, and Pyeung-Hyeun Kim), European journal of immunology (2005)

Transforming growth factor (TGF)-beta1 directs class switch recombination (CSR) to IgG2b as well as to...

 
Differential regulation of mouse germline Ig gamma 1 and epsilon promoters by IL-4 and CD40 (with C. S. Mao), Journal of immunology (Baltimore, Md. : 1950) (2001)

Before Ig class switching, RNA transcription through the specific S regions undergoing recombination is induced...

 
Activation of the mouse Ig germline epsilon promoter by IL-4 is dependent on AP-1 transcription factors (with Ching-Hung Shen), Journal of immunology (Baltimore, Md. : 1950) (2000)

Induction of germline (GL) epsilon transcripts, an essential step preceding Ig isotype switching to IgE,...

 
Regulation of the promoter for human immunoglobulin gamma3 germ-line transcription and its interaction with the 3'alpha enhancer (with Q. Pan, C. Petit-Frere, and L. Hammarstrom), European journal of immunology (2000)

The mechanism underlying the differential regulation of switching to human IgG subclasses is still largely...

 
Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter (with J. Hanai, L. F. Chen, T. Kanno, N. Ohtani-Fujita, W. Y. Kim, W. H. Guo, T. Imamura, Y. Ishidou, M. Fukuchi, M. J. Shi, M. Kawabata, K. Miyazono, and Y. Ito), The Journal of biological chemistry (1999)

Smads are signal transducers for members of the transforming growth factor-beta (TGF-beta) superfamily. Upon ligand...

 
Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription (with Ching-Hung Shen), Molecular and cellular biology (1998)

Signal transducer and activator of transcription 6 (Stat6) and NF-kappaB are widely distributed transcription factors...

 
CD40 cross-linking induces Ig epsilon germline transcripts in B cells via activation of NF-kappaB: synergy with IL-4 induction (with L. A. Iciek and S. A. Delphin), Journal of immunology (Baltimore, Md. : 1950) (1997)

Transcription of unrearranged (germline) Ig heavy chain C region (C(H)) genes is required before Ab...

 

Transcription Factor AP-1

Activation of the mouse Ig germline epsilon promoter by IL-4 is dependent on AP-1 transcription factors (with Ching-Hung Shen), Journal of immunology (Baltimore, Md. : 1950) (2000)

Induction of germline (GL) epsilon transcripts, an essential step preceding Ig isotype switching to IgE,...

 

Transcription Factor AP-2

Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter (with J. Hanai, L. F. Chen, T. Kanno, N. Ohtani-Fujita, W. Y. Kim, W. H. Guo, T. Imamura, Y. Ishidou, M. Fukuchi, M. J. Shi, M. Kawabata, K. Miyazono, and Y. Ito), The Journal of biological chemistry (1999)

Smads are signal transducers for members of the transforming growth factor-beta (TGF-beta) superfamily. Upon ligand...

 

Transcription Factor RelA

Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription (with Ching-Hung Shen), Molecular and cellular biology (1998)

Signal transducer and activator of transcription 6 (Stat6) and NF-kappaB are widely distributed transcription factors...

 

Transcription Factors

Analysis of transforming growth factor-beta1-induced Ig germ-line gamma2b transcription and its implication for IgA isotype switching (with Seok-Rae Park, Goo-Young Seo, Ae-Jin Choi, and Pyeung-Hyeun Kim), European journal of immunology (2005)

Transforming growth factor (TGF)-beta1 directs class switch recombination (CSR) to IgG2b as well as to...

 
The ubiquitously expressed DNA-binding protein late SV40 factor binds Ig switch regions and represses class switching to IgA (with Elise E. Drouin, Carol E. Schrader, and Ulla Hansen), Journal of immunology (Baltimore, Md. : 1950) (2002)

Ig heavy chain class switch recombination (CSR) determines the expression of Ig isotypes. The molecular...

 
Differential regulation of mouse germline Ig gamma 1 and epsilon promoters by IL-4 and CD40 (with C. S. Mao), Journal of immunology (Baltimore, Md. : 1950) (2001)

Before Ig class switching, RNA transcription through the specific S regions undergoing recombination is induced...

 
Roles of Ets proteins, NF-kappa B and nocodazole in regulating induction of transcription of mouse germline Ig alpha RNA by transforming growth factor-beta 1 (with M. J. Shi, S. R. Park, and P. H. Kim), International immunology (2001)

Antibody class switch recombination (CSR) occurs after antigen activation of B cells. CSR is directed...

 
Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter (with J. Hanai, L. F. Chen, T. Kanno, N. Ohtani-Fujita, W. Y. Kim, W. H. Guo, T. Imamura, Y. Ishidou, M. Fukuchi, M. J. Shi, M. Kawabata, K. Miyazono, and Y. Ito), The Journal of biological chemistry (1999)

Smads are signal transducers for members of the transforming growth factor-beta (TGF-beta) superfamily. Upon ligand...

 
CBF alpha3 (AML2) is induced by TGF-beta1 to bind and activate the mouse germline Ig alpha promoter (with M. J. Shi), Journal of immunology (Baltimore, Md. : 1950) (1998)

TGF-beta1 directs class switching to IgA by splenic B cells and by the surface IgM+...

 
The ability of CD40L, but not lipopolysaccharide, to initiate immunoglobulin switching to immunoglobulin G1 is explained by differential induction of NF-kappaB/Rel proteins (with S. C. Lin and H. H. Wortis), Molecular and cellular biology (1998)

Antibodies of the immunoglobulin G1 class are induced in mice by T-cell-dependent antigens but not...

 
Regulation of antibody class switching to IgE: characterization of an IL-4-responsive region in the immunoglobulin heavy-chain germline epsilon promoter (with S. Delphin), Annals of the New York Academy of Sciences (1995)

A large body of data indicate that antibody class switching is directed by cytokines by...

 
Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50 (with S. Delphin), The Journal of experimental medicine (1995)

A large body of data indicate that antibody class switching is directed by cytokines by...

 
Regulation of transcription of the germ-line Ig alpha constant region gene by an ATF element and by novel transforming growth factor-beta 1-responsive elements (with Y. C. Lin), Journal of immunology (Baltimore, Md. : 1950) (1992)

Inasmuch as transcription of unrearranged, or germ-line, Ig CH genes appears to direct switch recombination,...

 

Transcription, Genetic

Antibody class switching: uncoupling S region accessibility from transcription (with Denise A. Kaminski), Trends in genetics : TIG (2004)

Immunogloblin class switch recombination (CSR) is a regulated process that changes antibody effector functions. Recently,...

 
The ubiquitously expressed DNA-binding protein late SV40 factor binds Ig switch regions and represses class switching to IgA (with Elise E. Drouin, Carol E. Schrader, and Ulla Hansen), Journal of immunology (Baltimore, Md. : 1950) (2002)

Ig heavy chain class switch recombination (CSR) determines the expression of Ig isotypes. The molecular...

 
Immunology. A touch of antibody class, Science (New York, N.Y.) (2000)

When B cells, the antibody producing cells of the body, encounter antigen they switch from...

 
Evidence for class-specific factors in immunoglobulin isotype switching (with A. Shanmugam, M. J. Shi, L. Yauch, and A. L. Kenter), The Journal of experimental medicine (2000)

Immunoglobulin class switch recombination (SR) occurs by a B cell-specific, intrachromosomal deletional process between switch...

 
Regulation of the promoter for human immunoglobulin gamma3 germ-line transcription and its interaction with the 3'alpha enhancer (with Q. Pan, C. Petit-Frere, and L. Hammarstrom), European journal of immunology (2000)

The mechanism underlying the differential regulation of switching to human IgG subclasses is still largely...

 
Molecular processes that regulate class switching, Current topics in microbiology and immunology (1999)

No abstract provided.

 
Switch recombination in a transfected plasmid occurs preferentially in a B cell line that undergoes switch recombination of its chromosomal Ig heavy chain genes (with Sean P. Bradley, Norman Rousseau, Todd Pearson, Ananth Shanmugam, Debra J. Waite, Paul R. Rogers, and Amy L. Kenter), Journal of immunology (Baltimore, Md. : 1950) (1999)

Ab class switching is induced upon B cell activation in vivo by immunization or infection...

 
The ability of CD40L, but not lipopolysaccharide, to initiate immunoglobulin switching to immunoglobulin G1 is explained by differential induction of NF-kappaB/Rel proteins (with S. C. Lin and H. H. Wortis), Molecular and cellular biology (1998)

Antibodies of the immunoglobulin G1 class are induced in mice by T-cell-dependent antigens but not...

 
CD40 cross-linking induces Ig epsilon germline transcripts in B cells via activation of NF-kappaB: synergy with IL-4 induction (with L. A. Iciek and S. A. Delphin), Journal of immunology (Baltimore, Md. : 1950) (1997)

Transcription of unrearranged (germline) Ig heavy chain C region (C(H)) genes is required before Ab...

 
Activation of NF-kappaB/Rel by CD40 engagement induces the mouse germ line immunoglobulin Cgamma1 promoter (with S. C. Lin), Molecular and cellular biology (1996)

Interaction between CD40 on B cells and CD40 ligand (CD40L) on T cells has been...

 
Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50 (with S. Delphin), The Journal of experimental medicine (1995)

A large body of data indicate that antibody class switching is directed by cytokines by...

 
Regulation of transcription of the germ-line Ig alpha constant region gene by an ATF element and by novel transforming growth factor-beta 1-responsive elements (with Y. C. Lin), Journal of immunology (Baltimore, Md. : 1950) (1992)

Inasmuch as transcription of unrearranged, or germ-line, Ig CH genes appears to direct switch recombination,...

 
Regulation of switch recombination to the murine gamma 1 gene (with W. Dunnick, L. Elenich, J. Berry, D. Albrecht, and J. L. Claflin), Current topics in microbiology and immunology (1992)

No abstract provided.

 
Regulation of transcription of the germline immunoglobulin alpha constant region gene (with Y. C. Lin and P. Shockett), Current topics in microbiology and immunology (1992)

No abstract provided.

 
Effect of cytokines on switching to IgA and alpha germline transcripts in the B lymphoma I.29 mu. Transforming growth factor-beta activates transcription of the unrearranged C alpha gene (with P. Shockett), Journal of immunology (Baltimore, Md. : 1950) (1991)

H chain isotype switch recombination is preceded by the appearance of RNA initiating 5' of...

 
Regulation of the antibody class switch to IgA (with Y. C. Lin and P. Shockett), Immunologic research (1991)

No abstract provided.

 
Structure of germline immunoglobulin heavy-chain gamma 1 transcripts in interleukin 4 treated mouse spleen cells (with M. Xu), Developmental immunology (1990)

Antibody class switching is mediated by a DNA recombination event that replaces the C mu...

 
Specificity of immunoglobulin heavy chain switching by cultured I.29 B lymphoma cells (with G. Radcliffe and E. Severinson), Monographs in allergy (1988)

No abstract provided.

 

PDF

Presence of a polyadenylated RNA fragment encoding the membrane domain for immunoglobulin alpha chain indicates that mRNAs for both secreted and membrane-bound alpha chains can be produced from the same RNA transcript, Nucleic acids research (1986)

RNA blotting was employed to examine polyadenylated immunoglobulin alpha chain RNAs in a B lymphoma...

 
Synthesis and processing of the alpha heavy chains of secreted and membrane-bound IgA (with H. Kikutani, R. Sitia, and R. A. Good), Proceedings of the National Academy of Sciences of the United States of America (1981)

We have compared the synthesis and processing of immunoglobulin alpha chains in two murine cell...

 
Isolation of messenger RNA for an immunoglobulin kappa chain and enumeration of the genes for the constatn region of kappa chain in the mouse (with R. C. Huang, E. Stavnezer, and J. M. Bishop), Journal of molecular biology (1974)

No abstract provided.

 

Transfection

Analysis of transforming growth factor-beta1-induced Ig germ-line gamma2b transcription and its implication for IgA isotype switching (with Seok-Rae Park, Goo-Young Seo, Ae-Jin Choi, and Pyeung-Hyeun Kim), European journal of immunology (2005)

Transforming growth factor (TGF)-beta1 directs class switch recombination (CSR) to IgG2b as well as to...

 
Activation of the mouse Ig germline epsilon promoter by IL-4 is dependent on AP-1 transcription factors (with Ching-Hung Shen), Journal of immunology (Baltimore, Md. : 1950) (2000)

Induction of germline (GL) epsilon transcripts, an essential step preceding Ig isotype switching to IgE,...

 
Evidence for class-specific factors in immunoglobulin isotype switching (with A. Shanmugam, M. J. Shi, L. Yauch, and A. L. Kenter), The Journal of experimental medicine (2000)

Immunoglobulin class switch recombination (SR) occurs by a B cell-specific, intrachromosomal deletional process between switch...

 
Switch recombination in a transfected plasmid occurs preferentially in a B cell line that undergoes switch recombination of its chromosomal Ig heavy chain genes (with Sean P. Bradley, Norman Rousseau, Todd Pearson, Ananth Shanmugam, Debra J. Waite, Paul R. Rogers, and Amy L. Kenter), Journal of immunology (Baltimore, Md. : 1950) (1999)

Ab class switching is induced upon B cell activation in vivo by immunization or infection...

 
Overexpression of BSAP/Pax-5 inhibits switching to IgA and enhances switching to IgE in the I.29 mu B cell line (with G. Qiu), Journal of immunology (Baltimore, Md. : 1950) (1998)

B cell-specific activator protein (BSAP)/Pax-5 is a paired domain DNA-binding protein expressed in the developing...

 
The ability of CD40L, but not lipopolysaccharide, to initiate immunoglobulin switching to immunoglobulin G1 is explained by differential induction of NF-kappaB/Rel proteins (with S. C. Lin and H. H. Wortis), Molecular and cellular biology (1998)

Antibodies of the immunoglobulin G1 class are induced in mice by T-cell-dependent antigens but not...

 
Regulation of transcription of the germ-line Ig alpha constant region gene by an ATF element and by novel transforming growth factor-beta 1-responsive elements (with Y. C. Lin), Journal of immunology (Baltimore, Md. : 1950) (1992)

Inasmuch as transcription of unrearranged, or germ-line, Ig CH genes appears to direct switch recombination,...

 
Regulation of transcription of immunoglobulin germ-line gamma 1 RNA: analysis of the promoter/enhancer (with M. Z. Xu), The EMBO journal (1992)

Antibody class switching is achieved by recombinations between switch (S) regions which consist of tandemly...

 

Transformation, Genetic

Evidence for class-specific factors in immunoglobulin isotype switching (with A. Shanmugam, M. J. Shi, L. Yauch, and A. L. Kenter), The Journal of experimental medicine (2000)

Immunoglobulin class switch recombination (SR) occurs by a B cell-specific, intrachromosomal deletional process between switch...

 

Transforming Growth Factor beta

Antibody class switching differs among SJL, C57BL/6 and 129 mice (with Denise A. Kaminski), International immunology (2007)

Inbred mouse strains used for gene manipulation studies vary in many respects, including immune system...

 
Enhanced IgA class switching in marginal zone and B1 B cells relative to follicular/B2 B cells (with Denise A. Kaminski), Journal of immunology (Baltimore, Md. : 1950) (2006)

Mouse splenic marginal zone (MZ) B cells and B1 B cells enriched in the peritoneal...

 
Analysis of transforming growth factor-beta1-induced Ig germ-line gamma2b transcription and its implication for IgA isotype switching (with Seok-Rae Park, Goo-Young Seo, Ae-Jin Choi, and Pyeung-Hyeun Kim), European journal of immunology (2005)

Transforming growth factor (TGF)-beta1 directs class switch recombination (CSR) to IgG2b as well as to...

 
Roles of Ets proteins, NF-kappa B and nocodazole in regulating induction of transcription of mouse germline Ig alpha RNA by transforming growth factor-beta 1 (with M. J. Shi, S. R. Park, and P. H. Kim), International immunology (2001)

Antibody class switch recombination (CSR) occurs after antigen activation of B cells. CSR is directed...

 
Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter (with J. Hanai, L. F. Chen, T. Kanno, N. Ohtani-Fujita, W. Y. Kim, W. H. Guo, T. Imamura, Y. Ishidou, M. Fukuchi, M. J. Shi, M. Kawabata, K. Miyazono, and Y. Ito), The Journal of biological chemistry (1999)

Smads are signal transducers for members of the transforming growth factor-beta (TGF-beta) superfamily. Upon ligand...

 
CBF alpha3 (AML2) is induced by TGF-beta1 to bind and activate the mouse germline Ig alpha promoter (with M. J. Shi), Journal of immunology (Baltimore, Md. : 1950) (1998)

TGF-beta1 directs class switching to IgA by splenic B cells and by the surface IgM+...

 
Regulation of antibody production and class switching by TGF-beta, Journal of immunology (Baltimore, Md. : 1950) (1995)

No abstract provided.

 
Inhibitors of poly(ADP-ribose) polymerase increase antibody class switching (with P. Shockett), Journal of immunology (Baltimore, Md. : 1950) (1993)

Previous studies suggest that heavy chain isotype switch (S) recombination is directed by cytokine-induced transcription...

 
Regulation of transcription of the germ-line Ig alpha constant region gene by an ATF element and by novel transforming growth factor-beta 1-responsive elements (with Y. C. Lin), Journal of immunology (Baltimore, Md. : 1950) (1992)

Inasmuch as transcription of unrearranged, or germ-line, Ig CH genes appears to direct switch recombination,...

 
Regulation of transcription of the germline immunoglobulin alpha constant region gene (with Y. C. Lin and P. Shockett), Current topics in microbiology and immunology (1992)

No abstract provided.

 
Effect of cytokines on switching to IgA and alpha germline transcripts in the B lymphoma I.29 mu. Transforming growth factor-beta activates transcription of the unrearranged C alpha gene (with P. Shockett), Journal of immunology (Baltimore, Md. : 1950) (1991)

H chain isotype switch recombination is preceded by the appearance of RNA initiating 5' of...

 
Regulation of the antibody class switch to IgA (with Y. C. Lin and P. Shockett), Immunologic research (1991)

No abstract provided.

 

Tritium

Isolation of messenger RNA for an immunoglobulin kappa chain and enumeration of the genes for the constatn region of kappa chain in the mouse (with R. C. Huang, E. Stavnezer, and J. M. Bishop), Journal of molecular biology (1974)

No abstract provided.

 
Synthesis of a deoxyribonucleic acid sequence complementary to ovalbumin messenger ribonucleic acid and quantification of ovalbumin genes (with D. Sullivan, R. Palacios, J. M. Taylor, A. J. Faras, M. L. Kiely, N. M. Summers, J. M. Bishop, and R. T. Schimke), The Journal of biological chemistry (1973)

No abstract provided.

 
Letter: Translation of messenger RNA for mouse immunoglobulin light chains in living frog oocytes (with M. Smith, R. C. Huang, J. B. Gurdon, and C. D. Lane), Journal of molecular biology (1973)

No abstract provided.

 
Synthesis of a mouse immunoglobulin light chain in a rabbit reticulocyte cell-free system (with R. C. Huang), Nature: New biology (1971)

No abstract provided.

 

Tumor Cells, Cultured

The ubiquitously expressed DNA-binding protein late SV40 factor binds Ig switch regions and represses class switching to IgA (with Elise E. Drouin, Carol E. Schrader, and Ulla Hansen), Journal of immunology (Baltimore, Md. : 1950) (2002)

Ig heavy chain class switch recombination (CSR) determines the expression of Ig isotypes. The molecular...

 
Differential regulation of mouse germline Ig gamma 1 and epsilon promoters by IL-4 and CD40 (with C. S. Mao), Journal of immunology (Baltimore, Md. : 1950) (2001)

Before Ig class switching, RNA transcription through the specific S regions undergoing recombination is induced...

 
Roles of Ets proteins, NF-kappa B and nocodazole in regulating induction of transcription of mouse germline Ig alpha RNA by transforming growth factor-beta 1 (with M. J. Shi, S. R. Park, and P. H. Kim), International immunology (2001)

Antibody class switch recombination (CSR) occurs after antigen activation of B cells. CSR is directed...

 
Activation of the mouse Ig germline epsilon promoter by IL-4 is dependent on AP-1 transcription factors (with Ching-Hung Shen), Journal of immunology (Baltimore, Md. : 1950) (2000)

Induction of germline (GL) epsilon transcripts, an essential step preceding Ig isotype switching to IgE,...

 
Regulation of the promoter for human immunoglobulin gamma3 germ-line transcription and its interaction with the 3'alpha enhancer (with Q. Pan, C. Petit-Frere, and L. Hammarstrom), European journal of immunology (2000)

The mechanism underlying the differential regulation of switching to human IgG subclasses is still largely...

 
Switch recombination in a transfected plasmid occurs preferentially in a B cell line that undergoes switch recombination of its chromosomal Ig heavy chain genes (with Sean P. Bradley, Norman Rousseau, Todd Pearson, Ananth Shanmugam, Debra J. Waite, Paul R. Rogers, and Amy L. Kenter), Journal of immunology (Baltimore, Md. : 1950) (1999)

Ab class switching is induced upon B cell activation in vivo by immunization or infection...

 
CBF alpha3 (AML2) is induced by TGF-beta1 to bind and activate the mouse germline Ig alpha promoter (with M. J. Shi), Journal of immunology (Baltimore, Md. : 1950) (1998)

TGF-beta1 directs class switching to IgA by splenic B cells and by the surface IgM+...

 
Overexpression of BSAP/Pax-5 inhibits switching to IgA and enhances switching to IgE in the I.29 mu B cell line (with G. Qiu), Journal of immunology (Baltimore, Md. : 1950) (1998)

B cell-specific activator protein (BSAP)/Pax-5 is a paired domain DNA-binding protein expressed in the developing...

 
Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription (with Ching-Hung Shen), Molecular and cellular biology (1998)

Signal transducer and activator of transcription 6 (Stat6) and NF-kappaB are widely distributed transcription factors...

 
Reticulum cell sarcomas of SJL mice have rearranged immunoglobulin heavy and light chain genes (with J. L. Lasky, N. M. Ponzio, M. P. Scheid, and G. J. Thorbecke), European journal of immunology (1989)

The immunoglobulin (Ig) heavy (H) and light (L) chain gene rearrangements of the high incidence...

 
Specificity of immunoglobulin heavy chain switching by cultured I.29 B lymphoma cells (with G. Radcliffe and E. Severinson), Monographs in allergy (1988)

No abstract provided.

 

Tunicamycin

Membrane-bound and secreted IgA contain structurally different alpha-chains (with R. Sitia, H. Kikutani, A. Rubartelli, Y. Bushkin, and U. Hammerling), Journal of immunology (Baltimore, Md. : 1950) (1982)

Three different forms of alpha-chains are synthesized by BF0.3 and 615.2, two cloned cell lines...

 

Up-Regulation

Stimuli that enhance IgA class switching increase histone 3 acetylation at S alpha, but poorly stimulate sequential switching from IgG2b (with Denise A. Kaminski), European journal of immunology (2006)

Germ-line (GL) alpha transcription can be induced in mouse splenic B cells by LPS and...

 

Uracil-DNA Glycosidase

Inducible DNA breaks in Ig S regions are dependent on AID and UNG (with Carol E. Schrader, Erin K. Linehan, Sofia N. Mochegova, and Robert T. Woodland), The Journal of experimental medicine (2005)

Class switch recombination (CSR) occurs by an intrachromosomal deletion whereby the IgM constant region gene...

 
Immunoglobulin genes: generating diversity with AID and UNG (with Ursula Storb), Current biology : CB (2002)

Somatic hypermutation and switch recombination of immunoglobulin genes require the activity of the activation-induced deaminase,...

 

Uracil-DNA Glycosidase/*metabolism

DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination (with Xiaoming Wu), The Journal of experimental medicine (2007)

Immunoglobulin (Ig) class switch recombination (CSR) is initiated by activation-induced cytidine deaminase (AID), which converts...

 

Uracil/metabolism

DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination (with Xiaoming Wu), The Journal of experimental medicine (2007)

Immunoglobulin (Ig) class switch recombination (CSR) is initiated by activation-induced cytidine deaminase (AID), which converts...

 

Variation (Genetics)

Evolution of isotype switching (with Chris T. Amemiya), Seminars in immunology (2004)

This review discusses evolution of the process of Ig heavy chain class switching, relating it...

 

Vertebrates

Evolution of isotype switching (with Chris T. Amemiya), Seminars in immunology (2004)

This review discusses evolution of the process of Ig heavy chain class switching, relating it...

 

Xanthines

Inhibitors of poly(ADP-ribose) polymerase increase antibody class switching (with P. Shockett), Journal of immunology (Baltimore, Md. : 1950) (1993)

Previous studies suggest that heavy chain isotype switch (S) recombination is directed by cytokine-induced transcription...

 

Xenopus

Letter: Translation of messenger RNA for mouse immunoglobulin light chains in living frog oocytes (with M. Smith, R. C. Huang, J. B. Gurdon, and C. D. Lane), Journal of molecular biology (1973)

No abstract provided.