Articles
DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination (with Xiaoming Wu), The Journal of experimental medicine (2007)
Immunoglobulin (Ig) class switch recombination (CSR) is initiated by activation-induced cytidine deaminase (AID), which converts...
Antibody class switching differs among SJL, C57BL/6 and 129 mice (with Denise A. Kaminski), International immunology (2007)
Inbred mouse strains used for gene manipulation studies vary in many respects, including immune system...
Stimuli that enhance IgA class switching increase histone 3 acetylation at S alpha, but poorly stimulate sequential switching from IgG2b (with Denise A. Kaminski), European journal of immunology (2006)
Germ-line (GL) alpha transcription can be induced in mouse splenic B cells by LPS and...
Enhanced IgA class switching in marginal zone and B1 B cells relative to follicular/B2 B cells (with Denise A. Kaminski), Journal of immunology (Baltimore, Md. : 1950) (2006)
Mouse splenic marginal zone (MZ) B cells and B1 B cells enriched in the peritoneal...
The histone methyltransferase Suv39h1 increases class switch recombination specifically to IgA (with Sean P. Bradley, Denise A. Kaminski, Antoine H. F. M. Peters, and Thomas Jenuwein), Journal of immunology (Baltimore, Md. : 1950) (2006)
Ab class (isotype) switching allows the humoral immune system to adaptively respond to different infectious...
Mismatch repair converts AID-instigated nicks to double-strand breaks for antibody class-switch recombination (with Carol E. Schrader), Trends in genetics : TIG (2005)
Mismatch repair (MMR) proteins are important for antibody class-switch recombination (CSR), but their roles are...
Inducible DNA breaks in Ig S regions are dependent on AID and UNG (with Carol E. Schrader, Erin K. Linehan, Sofia N. Mochegova, and Robert T. Woodland), The Journal of experimental medicine (2005)
Class switch recombination (CSR) occurs by an intrachromosomal deletion whereby the IgM constant region gene...
Shifts in targeting of class switch recombination sites in mice that lack mu switch region tandem repeats or Msh2 (with Irene M. Min, Lisa R. Rothlein, Carol E. Schrader, and Erik Selsing), The Journal of experimental medicine (2005)
The mechanisms that target class switch recombination (CSR) to antibody gene switch (S) regions are...
Analysis of transforming growth factor-beta1-induced Ig germ-line gamma2b transcription and its implication for IgA isotype switching (with Seok-Rae Park, Goo-Young Seo, Ae-Jin Choi, and Pyeung-Hyeun Kim), European journal of immunology (2005)
Transforming growth factor (TGF)-beta1 directs class switch recombination (CSR) to IgG2b as well as to...
Evolution of isotype switching (with Chris T. Amemiya), Seminars in immunology (2004)
This review discusses evolution of the process of Ig heavy chain class switching, relating it...
Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions (with Carol E. Schrader, Joycelyn Vardo, Erin K. Linehan, Michael Z. Twarog, Laura J. Niedernhofer, and Jan H. J. Hoeijmakers), The Journal of experimental medicine (2004)
The structure-specific endonuclease ERCC1-XPF is an essential component of the nucleotide excision DNA repair pathway....
Antibody class switching: uncoupling S region accessibility from transcription (with Denise A. Kaminski), Trends in genetics : TIG (2004)
Immunogloblin class switch recombination (CSR) is a regulated process that changes antibody effector functions. Recently,...
Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination (with Carol E. Schrader, Sean P. Bradley, Joycelyn Vardo, Sofia N. Mochegova, and Erin Flanagan), The EMBO journal (2003)
Nucleotide substitutions are found in recombined Ig switch (S) regions and also in unrecombined (germline,...
The Smu tandem repeat region is critical for Ig isotype switching in the absence of Msh2 (with Irene M. Min, Carol E. Schrader, Joycelyn Vardo, Thomas M. Luby, Nicole D'Avirro, and Erik Selsing), Immunity (2003)
Deficiencies of the Msh2 protein or the Smu tandem repeat (SmuTR) sequences each reduce isotype...
Mlh1 can function in antibody class switch recombination independently of Msh2 (with Carol E. Schrader and Joycelyn Vardo), The Journal of experimental medicine (2003)
Mismatch repair proteins participate in antibody class switch recombination, although their roles are unknown. Previous...
Immunoglobulin genes: generating diversity with AID and UNG (with Ursula Storb), Current biology : CB (2002)
Somatic hypermutation and switch recombination of immunoglobulin genes require the activity of the activation-induced deaminase,...
Does activation-induced deaminase initiate antibody diversification by DNA deamination (with Sean P. Bradley), Trends in genetics : TIG (2002)
Activation-induced deaminase (AID) is expressed only in germinal center B cells. There, it is required...
The ubiquitously expressed DNA-binding protein late SV40 factor binds Ig switch regions and represses class switching to IgA (with Elise E. Drouin, Carol E. Schrader, and Ulla Hansen), Journal of immunology (Baltimore, Md. : 1950) (2002)
Ig heavy chain class switch recombination (CSR) determines the expression of Ig isotypes. The molecular...
Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions (with Carol E. Schrader and Joycelyn Vardo), The Journal of experimental medicine (2002)
B cells from mice deficient in mismatch repair (MMR) proteins show decreased ability to undergo...
Differential regulation of mouse germline Ig gamma 1 and epsilon promoters by IL-4 and CD40 (with C. S. Mao), Journal of immunology (Baltimore, Md. : 1950) (2001)
Before Ig class switching, RNA transcription through the specific S regions undergoing recombination is induced...
Roles of Ets proteins, NF-kappa B and nocodazole in regulating induction of transcription of mouse germline Ig alpha RNA by transforming growth factor-beta 1 (with M. J. Shi, S. R. Park, and P. H. Kim), International immunology (2001)
Antibody class switch recombination (CSR) occurs after antigen activation of B cells. CSR is directed...
The mu switch region tandem repeats are important, but not required, for antibody class switch recombination (with Thomas M. Luby, Carol E. Schrader, and Erik Selsing), The Journal of experimental medicine (2001)
Class switch DNA recombinations change the constant (C) region of the antibody heavy (H) chain...
Activation of the mouse Ig germline epsilon promoter by IL-4 is dependent on AP-1 transcription factors (with Ching-Hung Shen), Journal of immunology (Baltimore, Md. : 1950) (2000)
Induction of germline (GL) epsilon transcripts, an essential step preceding Ig isotype switching to IgE,...
Immunology. A touch of antibody class, Science (New York, N.Y.) (2000)
When B cells, the antibody producing cells of the body, encounter antigen they switch from...
Evidence for class-specific factors in immunoglobulin isotype switching (with A. Shanmugam, M. J. Shi, L. Yauch, and A. L. Kenter), The Journal of experimental medicine (2000)
Immunoglobulin class switch recombination (SR) occurs by a B cell-specific, intrachromosomal deletional process between switch...
Regulation of the promoter for human immunoglobulin gamma3 germ-line transcription and its interaction with the 3'alpha enhancer (with Q. Pan, C. Petit-Frere, and L. Hammarstrom), European journal of immunology (2000)
The mechanism underlying the differential regulation of switching to human IgG subclasses is still largely...
Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter (with J. Hanai, L. F. Chen, T. Kanno, N. Ohtani-Fujita, W. Y. Kim, W. H. Guo, T. Imamura, Y. Ishidou, M. Fukuchi, M. J. Shi, M. Kawabata, K. Miyazono, and Y. Ito), The Journal of biological chemistry (1999)
Smads are signal transducers for members of the transforming growth factor-beta (TGF-beta) superfamily. Upon ligand...
Molecular processes that regulate class switching, Current topics in microbiology and immunology (1999)
No abstract provided.
Switch recombination in a transfected plasmid occurs preferentially in a B cell line that undergoes switch recombination of its chromosomal Ig heavy chain genes (with Sean P. Bradley, Norman Rousseau, Todd Pearson, Ananth Shanmugam, Debra J. Waite, Paul R. Rogers, and Amy L. Kenter), Journal of immunology (Baltimore, Md. : 1950) (1999)
Ab class switching is induced upon B cell activation in vivo by immunization or infection...
Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes (with Carol E. Schrader, W. Edelmann, and R. Kucherlapati), The Journal of experimental medicine (1999)
Mice deficient in various mismatch repair (MMR) enzymes were examined to determine whether this repair...
Ialpha exon-replacement mice synthesize a spliced HPRT-C(alpha) transcript which may explain their ability to switch to IgA. Inhibition of switching to IgG in these mice (with G. Qiu and G. R. Harriman), International immunology (1999)
Antibody class switching is regulated by transcription of unrearranged C(H) genes to produce germline (GL)...
CBF alpha3 (AML2) is induced by TGF-beta1 to bind and activate the mouse germline Ig alpha promoter (with M. J. Shi), Journal of immunology (Baltimore, Md. : 1950) (1998)
TGF-beta1 directs class switching to IgA by splenic B cells and by the surface IgM+...
Overexpression of BSAP/Pax-5 inhibits switching to IgA and enhances switching to IgE in the I.29 mu B cell line (with G. Qiu), Journal of immunology (Baltimore, Md. : 1950) (1998)
B cell-specific activator protein (BSAP)/Pax-5 is a paired domain DNA-binding protein expressed in the developing...
The ability of CD40L, but not lipopolysaccharide, to initiate immunoglobulin switching to immunoglobulin G1 is explained by differential induction of NF-kappaB/Rel proteins (with S. C. Lin and H. H. Wortis), Molecular and cellular biology (1998)
Antibodies of the immunoglobulin G1 class are induced in mice by T-cell-dependent antigens but not...
Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription (with Ching-Hung Shen), Molecular and cellular biology (1998)
Signal transducer and activator of transcription 6 (Stat6) and NF-kappaB are widely distributed transcription factors...
CD40 cross-linking induces Ig epsilon germline transcripts in B cells via activation of NF-kappaB: synergy with IL-4 induction (with L. A. Iciek and S. A. Delphin), Journal of immunology (Baltimore, Md. : 1950) (1997)
Transcription of unrearranged (germline) Ig heavy chain C region (C(H)) genes is required before Ab...
Cognate T cell help for CD40-deficient B cells induces c-myc RNA expression, but DNA synthesis requires an additional signal through surface Ig (with Carol E. Schrader, H. Kikutani, and D. C. Parker), Journal of immunology (Baltimore, Md. : 1950) (1997)
To investigate the role of CD40 ligand in the delivery of help to B cells,...
Activation of NF-kappaB/Rel by CD40 engagement induces the mouse germ line immunoglobulin Cgamma1 promoter (with S. C. Lin), Molecular and cellular biology (1996)
Interaction between CD40 on B cells and CD40 ligand (CD40L) on T cells has been...
Immunoglobulin class switching, Current opinion in immunology (1996)
Antibody class switching is induced by B-cell activators in the presence of cytokines. The identity...
Mouse CD6: sequence of cDNA and expression of mRNA (with A. Pal, P. L. Romain, N. G. Singer, and D. Fox), Immunology letters (1996)
No abstract provided.
Regulation of antibody class switching to IgE: characterization of an IL-4-responsive region in the immunoglobulin heavy-chain germline epsilon promoter (with S. Delphin), Annals of the New York Academy of Sciences (1995)
A large body of data indicate that antibody class switching is directed by cytokines by...
Regulation of antibody production and class switching by TGF-beta, Journal of immunology (Baltimore, Md. : 1950) (1995)
No abstract provided.
Cell cycle regulation of immunoglobulin class switch recombination and germ-line transcription: potential role of Ets family members (with M. Lundgren, L. Strom, L. O. Bergquist, S. Skog, T. Heiden, and E. Severinson), European journal of immunology (1995)
Previous studies have indicated that transcription of germ-line (GL) CH genes is necessary to obtain...
Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50 (with S. Delphin), The Journal of experimental medicine (1995)
A large body of data indicate that antibody class switching is directed by cytokines by...
Activation of the Ig germ-line gamma 1 promoter. Involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site (with M. Lundgren, C. Larsson, A. Femino, M. Xu, and E. Severinson), Journal of immunology (Baltimore, Md. : 1950) (1994)
Ig isotype switching in B lymphocytes is preceded by transcription of the corresponding unrearranged, or...
Inhibitors of poly(ADP-ribose) polymerase increase antibody class switching (with P. Shockett), Journal of immunology (Baltimore, Md. : 1950) (1993)
Previous studies suggest that heavy chain isotype switch (S) recombination is directed by cytokine-induced transcription...
Regulation of transcription of the germ-line Ig alpha constant region gene by an ATF element and by novel transforming growth factor-beta 1-responsive elements (with Y. C. Lin), Journal of immunology (Baltimore, Md. : 1950) (1992)
Inasmuch as transcription of unrearranged, or germ-line, Ig CH genes appears to direct switch recombination,...
Regulation of switch recombination to the murine gamma 1 gene (with W. Dunnick, L. Elenich, J. Berry, D. Albrecht, and J. L. Claflin), Current topics in microbiology and immunology (1992)
No abstract provided.
Regulation of transcription of immunoglobulin germ-line gamma 1 RNA: analysis of the promoter/enhancer (with M. Z. Xu), The EMBO journal (1992)
Antibody class switching is achieved by recombinations between switch (S) regions which consist of tandemly...
Regulation of transcription of the germline immunoglobulin alpha constant region gene (with Y. C. Lin and P. Shockett), Current topics in microbiology and immunology (1992)
No abstract provided.
Effect of cytokines on switching to IgA and alpha germline transcripts in the B lymphoma I.29 mu. Transforming growth factor-beta activates transcription of the unrearranged C alpha gene (with P. Shockett), Journal of immunology (Baltimore, Md. : 1950) (1991)
H chain isotype switch recombination is preceded by the appearance of RNA initiating 5' of...
Regulation of the antibody class switch to IgA (with Y. C. Lin and P. Shockett), Immunologic research (1991)
No abstract provided.
Induction of germ-line immunoglobulin heavy chain transcripts by mitogens and interleukins prior to switch recombination (with E. Severinson and C. Fernandez), European journal of immunology (1990)
It has recently been postulated that immunoglobulin class switching is preceded by transcription from unrearranged...
Copy choice mechanism of immunoglobulin heavy-chain switch recombination (with W. Dunnick), Molecular and cellular biology (1990)
The immunoglobulin heavy-chain switch is mediated by a recombination event between DNA switch regions associated...
Structure of germ line immunoglobulin alpha heavy-chain RNA and its location on polysomes (with G. Radcliffe, Y. C. Lin, M. Julius, and K. B. Marcu), Molecular and cellular biology (1990)
We describe the structure of the major germ line RNA transcribed from unrearranged immunoglobulin alpha...
Structure of germline immunoglobulin heavy-chain gamma 1 transcripts in interleukin 4 treated mouse spleen cells (with M. Xu), Developmental immunology (1990)
Antibody class switching is mediated by a DNA recombination event that replaces the C mu...
Mouse antibody response to group A streptococcal carbohydrate (with C. D. Jarvis and L. E. Cannon), Journal of immunology (Baltimore, Md. : 1950) (1989)
In an attempt to more fully understand the generation of antibody diversity to carbohydrate (CHO)...
A B-cell-specific nuclear protein that binds to DNA sites 5' to immunoglobulin S alpha tandem repeats is regulated during differentiation (with S. H. Waters and K. U. Saikh), Molecular and cellular biology (1989)
Immunoglobulin heavy-chain switching is effected by recombination events between sites associated with tandemly repeated switch...
Reticulum cell sarcomas of SJL mice have rearranged immunoglobulin heavy and light chain genes (with J. L. Lasky, N. M. Ponzio, M. P. Scheid, and G. J. Thorbecke), European journal of immunology (1989)
The immunoglobulin (Ig) heavy (H) and light (L) chain gene rearrangements of the high incidence...
Mutations, duplication, and deletion of recombined switch regions suggest a role for DNA replication in the immunoglobulin heavy-chain switch (with W. Dunnick and M. Wilson), Molecular and cellular biology (1989)
The heavy-chain switch from immunoglobulin M (IgM) expression to IgA expression is mediated by a...
Interleukins 4 and 5: mechanisms of action (with E. Severinson, H. B. Moon, S. Bergstedt-Lindqvist, U. Persson, and C. Heusser), Advances in experimental medicine and biology (1989)
No abstract provided.
Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes (with G. Radcliffe, Y. C. Lin, J. Nietupski, L. Berggren, R. Sitia, and E. Severinson), Proceedings of the National Academy of Sciences of the United States of America (1988)
Immunoglobulin heavy-chain switching is effected by a DNA recombination event that replaces the C mu...
The J kappa proximal region of the human K locus contains three uncommon V kappa genes which are arranged in opposite transcriptional polarities (with W. Lorenz, K. F. Schable, R. Thiebe, and H. G. Zachau), Molecular immunology (1988)
The structure of one of the V kappa gene-containing regions of the locus coding for...
I.29 lymphoma cells express a nonmutated VH gene before and after H chain switch (with D. Klein, J. Nietupski, and S. Sirlin), Journal of immunology (Baltimore, Md. : 1950) (1988)
The I.29 B cell lymphoma consists of IgM+ and IgA+ cells which express the same...
Specificity of immunoglobulin heavy chain switching by cultured I.29 B lymphoma cells (with G. Radcliffe and E. Severinson), Monographs in allergy (1988)
No abstract provided.
Expression of immunoglobulin lambda light chain by the promyelocytic cell line HL-60 (with A. Al-Katib and B. Koziner), Journal of immunology (Baltimore, Md. : 1950) (1986)
The HL-60 cell line, established from a patient with acute promyelocytic leukemia, can be induced...
Presence of a polyadenylated RNA fragment encoding the membrane domain for immunoglobulin alpha chain indicates that mRNAs for both secreted and membrane-bound alpha chains can be produced from the same RNA transcript, Nucleic acids research (1986)
RNA blotting was employed to examine polyadenylated immunoglobulin alpha chain RNAs in a B lymphoma...
Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching (with S. Sirlin), The EMBO journal (1986)
IgM+ cells cultured from the I.29 B cell lymphoma can be induced with lipopolysaccharide (LPS)...
Surface immunoglobulin light chain expression in pre-B cell leukemias (with B. Koziner, A. Al-Katib, D. Gebhard, A. Mittelman, M. Andreeff, and B. D. Clarkson), Annals of the New York Academy of Sciences (1986)
Cytofluorographic analysis of surface immunoglobulin (sIg) light chain clonal excess (CE), defined as (%kappa+ -...
Molecular defects in a human immunoglobulin kappa chain deficiency (with O. Kekish and B. J. Zegers), Science (New York, N.Y.) (1985)
The molecular basis of a human immunoglobulin deficiency characterized by the complete absence of kappa...
Surface immunoglobulin light-chain expression by the "common" all cell line REH (with B. Koziner and A. Al-Katib), Clinical immunology and immunopathology (1985)
To provide further support of the B-cell lineage of "common" acute lymphoblastic leukemia (ALL), we...
The regulation of membrane-bound and secreted alpha-chain biosynthesis during the differentiation of the B cell lymphoma I.29 (with R. Sitia, A. Rubartelli, H. Kikutani, and U. Hammerling), Journal of immunology (Baltimore, Md. : 1950) (1985)
The regulation of the synthesis of membrane-bound and secreted IgA was investigated in the murine...
Aberrant recombination events in B cell lines derived from a kappa-deficient human (with O. Kekish, D. Batter, J. Grenier, I. Balazs, E. Henderson, and B. J. Zegers), Nucleic acids research (1985)
We have analyzed the structure of Ig kappa chain genes in B cell lines derived...
Induction of immunoglobulin isotype switching in cultured I.29 B lymphoma cells. Characterization of the accompanying rearrangements of heavy chain genes (with S. Sirlin and J. Abbott), The Journal of experimental medicine (1985)
The murine B cell lymphoma I.29 contains cells expressing surface IgM or IgA with identical...
Immunoglobulin heavy chain switching in cultured I.29 murine B lymphoma cells: commitment to an IgA or IgE switch (with J. Abbott and S. Sirlin), Current topics in microbiology and immunology (1984)
No abstract provided.
Molecular genetics of immunoglobulin heavy chain switching, Survey of immunologic research (1983)
No abstract provided.
Rearrangements and deletions of immunoglobulin heavy chain genes in the double-producing B cell lymphoma I.29 (with K. B. Marcu, S. Sirlin, B. Alhadeff, and U. Hammerling), Molecular and cellular biology (1982)
The B cell lymphoma I.29 consists of a mixture of cells expressing membrane-bound immunoglobulin M...
Genetic structure and origin of t haplotypes of mice, analyzed with H-2 cDNA probes (with H. S. Shin, K. Artzt, and D. Bennett), Cell (1982)
We investigated the genetic organization and evolutionary origin of t chromosomes of mice by examining...
Membrane-bound and secreted IgA contain structurally different alpha-chains (with R. Sitia, H. Kikutani, A. Rubartelli, Y. Bushkin, and U. Hammerling), Journal of immunology (Baltimore, Md. : 1950) (1982)
Three different forms of alpha-chains are synthesized by BF0.3 and 615.2, two cloned cell lines...
Synthesis and processing of the alpha heavy chains of secreted and membrane-bound IgA (with H. Kikutani, R. Sitia, and R. A. Good), Proceedings of the National Academy of Sciences of the United States of America (1981)
We have compared the synthesis and processing of immunoglobulin alpha chains in two murine cell...
Expression of an antigen receptor on T cells does not require recombination at the immunoglobulin JH-C mu locus (with Y. Cayre, M. A. Palladino, and K. B. Marcu), Proceedings of the National Academy of Sciences of the United States of America (1981)
Considerable evidence has accumulated suggesting that the antigen receptor(s) on T cells is coded for...
Synthesis and isolation of DNA complementary to nucleotide sequences encoding the variable region of immunoglobulin kappa chain (with J. M. Bishop), Biochemistry (1977)
No abstract provided.
Detection and characterization of RNA tumor virus-specific DNA in cells (with H. E. Varmus, E. Medeiros, and J. M. Bishop), Bibliotheca haematologica (1975)
RNA tumor virus-specific DNA in cells can be detected by its capacity to 1) alter...
Isolation of messenger RNA for an immunoglobulin kappa chain and enumeration of the genes for the constatn region of kappa chain in the mouse (with R. C. Huang, E. Stavnezer, and J. M. Bishop), Journal of molecular biology (1974)
No abstract provided.
Synthesis of a deoxyribonucleic acid sequence complementary to ovalbumin messenger ribonucleic acid and quantification of ovalbumin genes (with D. Sullivan, R. Palacios, J. M. Taylor, A. J. Faras, M. L. Kiely, N. M. Summers, J. M. Bishop, and R. T. Schimke), The Journal of biological chemistry (1973)
No abstract provided.
Letter: Translation of messenger RNA for mouse immunoglobulin light chains in living frog oocytes (with M. Smith, R. C. Huang, J. B. Gurdon, and C. D. Lane), Journal of molecular biology (1973)
No abstract provided.
Synthesis of a mouse immunoglobulin light chain in a rabbit reticulocyte cell-free system (with R. C. Huang), Nature: New biology (1971)
No abstract provided.