Immunoglobulin genes: generating diversity with AID and UNG
Abstract
Somatic hypermutation and switch recombination of immunoglobulin genes require the activity of the activation-induced deaminase, AID. Recent studies of mice deficient for the uracil-DNA glycosylase UNG, which removes U from DNA, suggest that AID catalyses the deamination of dC to dU during antibody diversification.
Suggested Citation
Ursula Storb and Janet Stavnezer. "Immunoglobulin genes: generating diversity with AID and UNG" Current biology : CB 12.21 (2002).
Available at: http://works.bepress.com/stavnezerj/23
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