Effect of Potassium on Plasma Renin Concentration in the Presence and Absence of ADH (Brattleboro Rat Model)

Emma Fernandez-Repollet, University of Puerto Rico - School of Medicine
Susan C. Opava-Stitzer, University of Puerto Rico - School of Medicine
Manuel Martinez-Maldonado, University of Puerto Rico - School of Medicine

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http:dx.doi.org/10.1111/j.1749-6632.1982.tb37433.x

NOTE: At the time of publication, the author Susan C. Opava-Stitzer was affiliated with the University of Puerto Rico School of Medicine - San Juan, Puerto Rico. Currently, May 2008, she is Dean of Research and Graduate Programs at California Polytechnic State University - San Luis Obispo.

Abstract

Rats with hereditary hypothalamic diabetes insipidus (so-called DI rats) have elevated plasma renin levels. Although the mechanism responsible for this condition has not be elucidated, it seems reasonable to postulate that the absence of ADH and/or the hypokalemia previously reported in these rats might contribute to the elevation of plasma renin concentration (PRC). Evidence in favor of this hypothesis emerges from studies in which both ADH and potassium have been shown to inhibit renin release. In an attempt to examine the relative roles of ADH and potassium in the regulation of renin secretion, PRC was measured in DI rats maintained on a potassium-free, normal potassium, or high potassium diet in the presence and absence of ADH treatment.