Articles

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Modeling the collagen fibril network of biological tissues as a nonlinearly elastic material using a continuous volume fraction distribution function (with Reza Shirazi, Pasquale Vena, and Robert L. Sah), Mathematics and Mechanics of Solids (2011)

Despite distinct mechanical functions, biological soft tissues have a common microstructure in which a ground...

 

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Contribution of Proteoglycan Osmotic Swelling Pressure to the Compressive Properties of Articular Cartilage (with EunHee Han, Silvia S. Chen, and Robert L. Sah), Biophysical Journal (2011)

The negatively charged proteoglycans (PG) provide compressive resistance to articular cartilage by means of their...

 

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Differential Regulation of Immature Articular Cartilage Compressive Moduli and Poisson's Ratios by in Vitro Stimulation with IGF-1 and TGF-β1 (with Gregory M. Williams, Kristin J. Dills, Christian R. Flores, Michael E. Stender, Kevin M. Stewart, Lauren M. Nelson, Albert C. Chen, Koichi Masuda, Scott J. Hazelwood, and Robert L. Sah), Journal of Biomechanics (2010)

Mechanisms of articular cartilage growth and maturation have been elucidated by studying composition-function dynamics during...

 

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Differential Regulation of Immature Articular Cartilage Compressive Moduli and Poisson’s Ratios by in vitro Stimulation With IGF-1 and TGF-β1 (with Gregory M. Williams, Kristin J. Dills, Christian R. Flores, Michael E. Stender, Kevin M. Stewart, Lauren M. Nelson, Albert C. Chen, Koichi Masuda, Scott J. Hazelwood, and Robert L. Sah), Journal of Biomechanics (2010)

Mechanisms of articular cartilage growth and maturation have been elucidated by studying composition-function dynamics during...

 

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A Nonlinear Constituent Based Viscoelastic Model for Articular Cartilage and Analysis of Tissue Remodeling Due to Altered Glycosaminoglycan-Collagen Interactions (with Gregory C. Thomas, Anna Asanbaeva, Pasquale Vena, and Robert L. Sah), Journal of Biomechanical Engineering (2009)

A constituent based nonlinear viscoelastic (VE) model was modified from a previous study (Vena, et...

 

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Simulating the Growth of Articular Cartilage Explants in a Permeation Bioreactor to Aid in Experimental Protocol Design (with Timothy P. Ficklin and Andrew Davol), Journal of Biomechanical Engineering (2009)

Recently a cartilage growth finite element model (CGFEM) was developed to solve nonhomogeneous and time-dependent...

 

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A Nonlinear Finite Element Model of Cartilage Growth (with Andrew Davol, Michael S. Bingham, and Robert L. Sah), Biomechanics and Modeling in Mechanobiology (2008)

The long range objective of this work is to develop a cartilage growth finite element...

 

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Regulation of immature cartilage growth by IGF-I, TGF- β 1, BMP-7, and PDGF-AB: role of metabolic balance between fixed charge and collagen network (with Anna Asanbaeva, Koichi Masuda, Eugene J-M.A. Thonar, and Robert L. Sah), Biomechanics and Modeling in Mechanobiology (2008)

Cartilage growth may involve alterations in the balance between the swelling tendency of proteoglycans and...

 

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A Cartilage Growth Mixture Model With Collagen Remodeling: Validation Protocols (with Anna Asanbaeva, Sevan R. Oungoulian, Koichi Masuda, Eugene J.-MA. Thonar, Andrew Davol, and Robert L. Sah), Journal of Biomechanical Engineering (2008)

A cartilage growth mixture (CGM) model is proposed to address limitations of a model used...

 

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Articular Cartilage Tensile Integrity: Modulation by matrix depletion is maturation-dependent (with Anna Asanbaeva, Johnny Tam, Barbara L. Schumacher, Koichi Masuda, and Robert L. Sah), Archives of Biochemistry and Biophysics (2008)

Articular cartilage function depends on the molecular composition and structure of its extracellular matrix (ECM)....

 

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Bioengineering Cartilage Growth, Maturation, and Form (with Gregory M. Williams and Robert L. Sah), Pediatric Research (2008)

Cartilage of articular joints grows and matures to achieve characteristic sizes, forms, and functional properties....

 

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Cartilage growth and remodeling: modulation of balance between proteoglycan and collagen network in vitro with β-aminopropionitrile (with Anna Asanbaeva, Koichi Masuda, Eugene J-M.A. Thonar, and Robert L. Sah), Osteoarthritis and Cartilage (2008)

Objective

To examine the effect of β-aminopropionitrile (BAPN), an inhibitor of lysyl oxidase, on growth...

 

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Articular Cartilage Mechanical and Biochemical Property Relations Before and After In Vitro Growth (with Timothy Ficklin, Gregory Thomas, James C. Barthel, Anna Asanbaeva, Eugene J. Thonar, Koichi Masuda, Albert C. Chen, Robert L. Sah, and Andrew Davol), Journal of Biomechanics (2007)

The aim of this study was to design in vitro growth protocols that can comprehensively...

 

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A Bimodular Polyconvex Anisotropic Strain Energy Function for Articular Cartilage, Journal of Biomechanical Engineering (2007)

A strain energy function for finite deformations is developed that has the capability to describe...

 

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A Bimodular Theory for Finite Deformations: Comparison of orthotropic second-order and exponential stress constitutive equations for articular cartilage, Biomechanics and Modeling in Mechanobiology (2006)

Cartilaginous tissues, such as articular cartilage and the annulus fibrosus, exhibit orthotropic behavior with highly...

 

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A cartilage growth mixture model for infinitesimal strains: solutions of boundary-value problems related to in vitro growth experiments (with Robert L. Sah and Anne Hoger), Biomechanics and Modeling in Mechanobiology (2005)

A cartilage growth mixture (CGM) model is linearized for infinitesimal elastic and growth strains. Parametric...

 

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Volumetric Growth of Thermoelastic Materials and Mixtures (with Anne Hoger), Mathematics and Mechanics of Solids (2003)

The proteoglycan and collagen constituents of cartilage serve distinct mechanical roles. Changes to the mechanical...

 

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A Growth Mixture Theory for Cartilage With Application to Growth-Related Experiments on Cartilage Explants (with Silvia S. Chen, Robert L. Sah, and Anne Hoger), Journal of Biomechanical Engineering (2003)

In this paper, we present a growth mixture model for cartilage. The main features of...

 

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A Mixture of Elastic Materials with Different Constituent Temperatures and Internal Constraints, International Journal of Engineering Science (2002)

A novel treatment of the 2nd Law of Thermodynamics and the development of general thermomechanical...

 

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A Theory of Volumetric Growth for Compressible Elastic Biological Materials (with Timothy J. Van Dyke and Anne Hoger), Mathematics and Mechanics of Solids (2001)

A general theory of volumetric growth for compressible elastic materials is presented. The authors derive...

 

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A Special Theory of Biphasic Mixtures and Experimental Results for Human Annulus Fibrosus Tested in Confined Compression (with Jeffrey C. Lotz), Journal of Biomechanical Engineering (2000)

A finite deformation mixture theory is used to quantify the mechanical properties of the annulus...

 

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Internally Constrained Mixtures of Elastic Continua, Mathematics and Mechanics of Solids (1999)

A treatment of internally constrained mixtures of elastic continua at a common temperature is developed....

 

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Application of a fiber-reinforced continuum theory to multiple deformations of the annulus fibrosus (with Jeffrey C. Lotz), Journal of Biomechanics (1999)

Accurate tissue stress predictions for the annulus fibrosus are essential for understanding the factors that...

 

Conference Proceedings

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A Growth Mixture Theory for Cartilage (with Robert L. Sah and Anne Hoger), Mechanics in Biology: Proceedings of the 2000 ASME International Mechanical Engineering Congress and Exposition: Orlando, FL (2000)

In this paper we present a model of growth for cartilaginous tissues in which there...