Articles

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Differential Regulation of Articular Cartilage Tensile Properties by IGF-1 and TGF-β1 during In Vitro Growth (with M. E. Stender, N. T. Balcom, B. Berg-Johansen, K. J. Dills, D. Dyk, A. C. Chen, R. L. Sah, and S. M. Klisch), 4th International Conference on the Mechanics of Biomaterials and Tissues: Waikoloa, HI (2011)
 

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The Biomechanics of Varied Proximal Locking Screw Configurations in a Synthetic Model of Proximal Third Tibial Fracture Fixation (with Philip R. Wolinsky, Douglas Dennis, Brett D. Crist, and Shane Curtiss), Journal of Orthopaedic Trauma (2011)

Objective: To determine if 1) angularly stable devices created by compressing (‘‘locking’’) proximal locking screws...

 

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The effect of Cox-2 specific inhibition on direct fracture healing in the rabbit tibia (with David J. Hak, Kurt S. Schulz, and Behrang Khoie), The Journal of Orthopaedic Science (2011)

Objective: The purpose of this study was to evaluate the effect of Cox-2 administration on...

 

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Differential Regulation of Immature Articular Cartilage Compressive Moduli and Poisson's Ratios by in Vitro Stimulation with IGF-1 and TGF-β1 (with Gregory M. Williams, Kristin J. Dills, Christian R. Flores, Michael E. Stender, Kevin M. Stewart, Lauren M. Nelson, Albert C. Chen, Koichi Masuda, Stephen M. Klisch, and Robert L. Sah), Journal of Biomechanics (2010)

Mechanisms of articular cartilage growth and maturation have been elucidated by studying composition-function dynamics during...

 

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Differential Regulation of Immature Articular Cartilage Compressive Moduli and Poisson’s Ratios by in vitro Stimulation With IGF-1 and TGF-β1 (with Gregory M. Williams, Kristin J. Dills, Christian R. Flores, Michael E. Stender, Kevin M. Stewart, Lauren M. Nelson, Albert C. Chen, Koichi Masuda, Stephen M. Klisch, and Robert L. Sah), Journal of Biomechanics (2010)

Mechanisms of articular cartilage growth and maturation have been elucidated by studying composition-function dynamics during...

 

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Locked Plate Fixation of Osteoporotic Humeral Shaft Fractures: Are Two Locking Screws Per Segment Enough? (with David J. Hak and Peter Althausen), Journal of Orthopaedic Trauma (2010)

Objective: The purpose of this study was to compare the biomechanical behavior of using two...

 

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Morphological Assessment of Basic Multicellular Unit Resorption Parameters in Dogs Shows Additional Mechanisms of Bisphosphonate Effects on Bone (with Matthew R. Allen, Antonia M. Erickson, Xiang Wang, David B. Burr, and R. Bruce Martin), Calcified Tissue Internatioanl (2010)

Bisphosphonates (BPs) slow bone loss by reducing initiation of new basic multicellular units (BMUs). Whether...

 

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A Biomechanical Comparison of Locked Plate Fixation With Percutaneous Insertion Capability Versus the Angled Blade Plate in a Subtrochanteric Fracture Gap Model (with Brett D. Crist, Afshin Khalafi, and Mark A. Lee), Journal of Orthopaedic Trauma (2009)

Objectives: The angled blade plate has been the historical standard in fixed-angle extramedullary subtrochanteric femur...

 

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Compliance Calibration for Fracture Testing of Anisotropic Biological Materials (with J. A. Creel, S. M. Stover, R. B. Martin, D. P. Fyhrie, and J. C. Gibeling), Journal of the Mechanical Behavior of Biomedical Materials (2009)

The compliance technique has been used to monitor crack length during fracture and fatigue testing...

 

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Material Properties are Related to Stress Fracture Callus and Porosity of Cortical Bone Tissue at Affected and Unaffected Sites (with Rachel C. Entwistle,; Sara C. Sammons; Robert F. Bigley; David P. Fyhrie; Jeffery C. Gibeling; and Susan M. Stover), Journal of Orthopaedic Research (2009)

Stress fractures are overuse injuries of bone that affect elite athletes and military recruits. One...

 

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Theoretical Analysis of Alendronate and Risedronate Effects on Canine Vertebral Remodeling and Microdamage (with Xiang Wang, Antonia M. Erickson, Matthew R. Allen, David B. Burr, and R. Bruce Martin), Journal of Biomechanics (2009)

Bisphosphonates suppress bone remodeling activity, increase bone volume, and significantly reduce fracture risk in individuals...

 

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Alterations in Femoral Strain Following Hip Resurfacing and Total Hip Replacement (with C. R. Deuel, A. A. Jamali, and S. M. Stover), Journal of Bone and Joint Surgery - British (2009)

Bone surface strains were measured in cadaver femora during loading prior to and after resurfacing...

 

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Volume Effects on Yield Strength of Equine Cortical Bone (with R. F. Bigley, J. C. Gibeling, S. M. Stover, D. P. Fyhrie, and R. B. Martin), Journal of the Mechanical Behavior of Biomedical Materials (2008)

Volume effects are a fundamental determinant of structural failure. A material exhibits a volume effect...

 

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Simulated Effects of Marathon Training on Bone Density, Remodeling, and Microdamage Accumulation of the Femur (with Alesha B. Castillo), International Journal of Fatigue (2007)

Stress fractures are mechanically induced injuries resulting from fatigue damage to bone due to repetitive...

 

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The Use of Hinged External Fixation to Provide Additional Stabilization for Fractures of the Distal Humerus (with Christopher R. Deuel, Philip Wolinsky, and Eric Shepherd), Journal of Orthopaedic Trauma (2007)

Objective: To assess improvements in fixation stability when a hinged unilateral external fixator is used...

 

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Quantitative Regional Associations Between Remodeling, Modeling, and Osteocyte Apoptosis and Density in Rabbit Tibial Midshafts (with Nicole L. Hedgecock, Tamer Hadi, Andrew A. Chen, Shane B. Curtiss, and R. Bruce Martin), Bone (2007)

Evidence suggests that osteocyte apoptosis is involved in the adaptive response of bone, although the...

 

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Biomechanics of the Rabbit Knee and Ankle: Muscle, Ligament, and Joint Contact Force Predictions (with Dustin M. Grover and Andrew A. Chen), Journal of Biomechanics (2007)

Mathematical models of small animals that predict in vivo forces acting on the lower extremities...

 

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Two in Vivo Surgical Approaches for Lumbar Corpectomy Using Allograft and a Metallic Implant: A Controlled Clinical and Biomechanical Study (with Philbert Huang, Munish C. Gupta, and Nesrin Sarigul-Klijn), The Spine Journal (2006)

Background context: Both bone graft and metallic implants have been used in combination with the...

 

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The Effect of Plate Rotation on the Stiffness of Femoral LISS: A Mechanical Study (with Afshin Khalafi, Shane Curtiss, and Philip Wolinsky), Journal of Orthopaedic Trauma (2006)

Objective: Malposition of the femoral Less Invasive Stabilization System (LISS) plate may alter its biomechanical...

 

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Effect of Low Molecular Weight Heparin on Fracture Healing in a Stabilized Rat Femur Fracture Model (with David J. Hak and Rena L. Stewart), Journal of Orthopaedic Research (2006)

The purpose of this studywas to evaluate the effect of low molecular weight heparin (LMWH)...

 

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Osteonal Effects on Elastic Modulus and Fatigue Life in Equine Bone (with V. A. Gibson, S. M. Stover, J. C. Gibeling, and R. B. Martin), Journal of Biomechanics (2006)

We hypothesized that recently formed, incompletely mineralized, and thus, relatively deformable osteons in the equine...

 

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Predictions on Preserving Bone Mass in Knee Arthroplasty With Bisphosphonates (with Jeffry S. Nyman, Juan J. Rodrigo, Oscar C. Yeh, and R. Bruce Martin), The Journal of Arthroplasty (2006)

Using a computational model of bone adaptation, we investigated the long-term ability of bisphosphonates to...

 

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Recombinant Human BMP-7 Effectively Prevents Non-Union in Both Young and Old Rats (with David J. Hak, Takeshi Makino, Takahiro Niikura, Shane Curtiss, and A. Hari Reddi), Journal of Orthopaedic Research (2006)

The purpose of this study was to evaluate the influence of age on the effectiveness...

 

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Coronal Fractures of the Distal Femoral Condyle: A Biomechanical Evaluation of Four Internal Fixation Constructs (with David J. Hak, James Nguyen, and Shane Curtiss), Injury (2005)

This study evaluated different fixation methods in posterior femoral condyle coronal fractures. A standardised osteotomy...

 

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Prevention of Atrophic Nonunion Development by Recombinant Human Bone Morphogenetic Protein-7 (with Takeshi Makino, David J. Hak, Shane Curtiss, and A. Hari Reddi), Journal of Orthopaedic Research (2005)

Severe periosteal and soft tissue disruption at the time of fracture may result in the...

 

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Do Microcracks Decrease or Increase Fatigue Resistance in Cortical Bone? (with O. S. Sobelman, J. C. Gibeling, S. M. Stover, O. C. Yeh, D. R. Shelton, and R. B. Martin), Journal of Biomechanics (2004)

Fatigue of cortical bone produces microcracks; it has been hypothesized that these cracks are analogous...

 

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A Theoretical Analysis of Long-Term Bisphosphonate Effects on Trabecular Bone Volume and Microdamage (with Jeffry S. Nyman, Oscar C. Yeh, and R. Bruce Martin), Bone (2004)

Bisphosphonates increase bone mass and reduce fracture risk, but their anti-resorptive action may lead to...

 

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Long Stemmed Total Knee Arthroplasty With Interlocking Screws: A Computational Bone Adaptation Study (with Jeffry S. Nyman, Juan J. Rodrigo, R. Bruce Martin, and Oscar C. Yeh), Journal of Orthopaedic Research (2004)

The ability of an interlocking screw fixation technique to minimize bone loss related to stress...

 

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Development of an Atrophic Nonunion Model and Comparison to a Closed Healing Fracture in Rat Femur (with Takeshi Kokubu, David J. Hak, and A. Hari Reddi), Journal of Orthopaedic Research (2003)

Although most fractures heal, some fail to heal and become nonunions. Many animal models have...

 

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Osteon Pullout in the Equine Third Metacarpal Bone: Effects of Ex Vivo Fatigue (with L. P. Hiller, S. M. Stover, V. A. Gibson, J. C. Gibeling, C. S. Prater, O. C. Yeh, and R. B. Martin), Journal of Orthopaedic Research (2003)

An important concept in bone mechanics is that osteons influence mechanical properties in several ways,...

 

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A Mechanistic Model for Internal Bone Remodeling Exhibits Different Dynamic Responses in Disuse and Overload (with R. Bruce Martin, Mark M. Rashid, and Juan J. Rodrigo), Journal of Biomechanics (2001)

Bone is a dynamic tissue which, through the process of bone remodeling in the mature...

 

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The Relationship Between Basic Multicellular Unit Activation and Origination in Cancellous Bone (with C. J. Hernandez and R. B. Martin), Bone (1999)

Activation frequency is often used as a measure of basic multicellular unit (BMU) activity in...