Medicinal Chemistry and Chemical Biology
Characterization of a Reductively-Activated Elimination Pathway Relevant to the Biological Chemistry of the Kinamycins and Lomaiviticins, Chemical Science (2012)
The lomaiviticins (1 and 2) and kinamycins (3–5) are bacterial metabolites with potent antimicrobial and...
Discovery of a Strongly Apoptotic Ruthenium Complex Through Combinatorial Coordination Chemistry, Dalton Transactions (2010)
A strategy for combinatorial parallel coordination chemistry is introduced that provides access to libraries of...
Organic Synthesis and Methodology
Synthesis and cyclometalation of a pyrido[3,2-e]-2,10b-diaza-cyclopenta[c]fluorene-1,3-dione scaffold, Tetrahedron Letters (2006)
The synthesis of a pyrido[3,2-e]-2,10b-diaza-cyclopenta[c]fluorene-1,3-dione scaffold is disclosed, which was synthesized using a Suzuki cross-coupling...
Extension of β-chloroenals to ethyl 5-chloro-2,4-pentadienoates using Wadsworth–Emmons reactions: subsequent conversions to 5-aryl-5-chloro-2,4-pentadienoic acids and 5-aryl-2-penten-4-ynoic acids, Tetrahedron (2004)
Convenient routes from (Z)-3-aryl-3-chloroenals to (2E,4Z)-5-aryl-5-chloro-2,4-pentadienoates and (2E)-5-aryl-2-penten-4-ynoates are described. The stereochemical assignments are based...
Articles
Chiral Salicyloxazolines as Auxiliaries for the Asymmetric Synthesis of Ruthenium Polypyridyl Complexes, Inorganic Chemistry (2010)
Chiral auxiliaries are promising emerging tools for the asymmetric synthesis of octahedral metal complexes. We...
Chiral-Auxiliary-Mediated Asymmetric Synthesis of Tris-Heteroleptic Ruthenium Polypyridyl Complexes, Journal of the American Chemical Society (2009)
A strategy for the asymmetric synthesis of chiral-at-metal [Ru(pp)(pp′)(pp′′)]2+ complexes, where pp, pp′, and pp′′...
Strategy for the Stereochemical Assignment of Tris-Heteroleptic Ru(II) Complexes by NMR Spectroscopy, Inorganic Chemistry (2008)
The relative stereochemistry of tris-heteroleptic ruthenium complexes [Ru(pp)(pp′)(pp′′)](PF6)2, where pp = 1,10-phenanthroline-4-carboxamide, pp′ = 5,6-dimethyl-1,10-phenanthroline,...
Solid-Phase Synthesis of Tris-heteroleptic Ruthenium(II) Complexes and Application to Acetylcholinesterase Inhibition, Inorganic Chemistry (2008)
A synthetic route with two consecutive coordination chemistry steps on a solid support affords tris-heteroleptic...