Cancer biologist with extensive research experience in the fields of osteoblast
biology and hematopoiesis and a longstanding interest in exploring genetic and epigenetic
mechanisms that control onset and progression of the cancer phenotype, especially in
myelogenous leukemia.
Gene Regulation
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Chromatin immunoprecipitation assays: application of ChIP-on-chip for defining dynamic transcriptional mechanisms in bone cells (with Margaretha Van der Deen, Mohammad Q. Hassan, Jitesh Pratap, Nadiya M. Teplyuk, Daniel W. Young, Amjad Javed, Jane B. Lian, Martin A. Montecino, Janet L. Stein, Gary S. Stein, and Andre J. Van Wijnen), Methods in molecular biology (Clifton, N.J.) (2008)
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Structural coupling of Smad and Runx2 for execution of the BMP2 osteogenic signal (with Amjad Javed, Jong-Sup Bae, Faiza Afzal, Soraya E. Gutierrez, Jitesh Pratap, Yang Lou, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein, and Jane B. Lian), The Journal of biological chemistry (2008)
Link
Analysis of in vivo gene expression using epitope-tagged proteins (with Amjad Javed, Soraya E. Gutierrez, Christopher J. Lengner, Kimberly Stacy Harrington, Hayk Hovhannisyan, Brian C. Cho, Jitesh Pratap, Shirwin M. Pockwinse, Martin Montecino, Andre J. Van Wijnen, Jane B. Lian, Janet L. Stein, and Gary S. Stein), Methods in molecular biology (Clifton, N.J.) (2004)
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Chromatin immunoprecipitation (with Amjad Javed, Soraya E. Gutierrez, Christopher J. Lengner, Kimberly Stacy Harrington, Hayk Hovhannisyan, Brian C. Cho, Jitesh Pratap, Shirwin M. Pockwinse, Martin Montecino, Andre J. Van Wijnen, Jane B. Lian, Janet L. Stein, and Gary S. Stein), Methods in molecular biology (Clifton, N.J.) (2004)
Link
Immunofluorescence analysis using epitope-tagged proteins: in vitro system (with Amjad Javed, Soraya E. Gutierrez, Christopher J. Lengner, Kimberly Stacy Harrington, Hayk Hovhannisyan, Brian C. Cho, Jitesh Pratap, Shirwin M. Pockwinse, Martin A. Montecino, Andre J. Van Wijnen, Jane B. Lian, Janet L. Stein, and Gary S. Stein), Methods in molecular biology (Clifton, N.J.) (2004)
Epigenetic Regulation
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Transcription-factor-mediated epigenetic control of cell fate and lineage commitment (with Gary S. Stein, Janet L. Stein, Jane B. Lian, Andre J. Van Wijnen, Martin A. Montecino, Daniel W. Young, Amjad Javed, Jitesh Pratap, Je-Yong Choi, Syed A. Ali, Sandhya Pande, and Mohammad Q. Hassan), Biochemistry and cell biology = Biochimie et biologie cellulaire (2009)
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Phenotypic transcription factors epigenetically mediate cell growth control (with Syed A. Ali, Caroline S. Dacwag, Nunciada Salma, Daniel W. Young, A. Rauf Shakoori, Martin A. Montecino, Jane B. Lian, Andre J. Van Wijnen, Anthony N. Imbalzano, Gary S. Stein, and Janet L. Stein), Proceedings of the National Academy of Sciences of the United States of America (2008)
Link
Mitotic retention of gene expression patterns by the cell fate-determining transcription factor Runx2 (with Daniel W. Young, Mohammad Q. Hassan, Xiaoqing Yang, Mario Galindo, Amjad Javed, Paul S. Furcinitti, David S. Lapointe, Martin A. Montecino, Jane B. Lian, Janet L. Stein, Andre J. Van Wijnen, and Gary S. Stein), Proceedings of the National Academy of Sciences of the United States of America (2007)
Link
Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2 (with Daniel W. Young, Mohammad Q. Hassan, Jitesh Pratap, Mario Galindo, Suk Hee Lee, Xiaoqing Yang, Ronglin Xie, Amjad Javed, Jean. M. Underwood, Paul S. Furcinitti, Anthony N. Imbalzano, Sheldon Penman, Jeffrey A. Nickerson, Martin A. Montecino, Jane B. Lian, Janet L. Stein, Andre J. Van Wijnen, and Gary S. Stein), Nature (2007)
Nuclear Organization
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Genetic and epigenetic regulation in nuclear microenvironments for biological control in cancer (with Gary S. Stein, Janet L. Stein, Jane B. Lian, Andre J. Van Wijnen, Martin A. Montecino, Daniel W. Young, Amjad Javed, Jitesh Pratap, Je-Yong Choi, Syed A. Ali, Sandhya Pande, and Mohammad Q. Hassan), Journal of cellular biochemistry (2008)
Link
In situ nuclear organization of regulatory machinery (with Shirwin M. Pockwinse, Ricardo F. Medina, Rachit Bakshi, Krishna P. Kota, Syed A. Ali, Daniel W. Young, Jeffrey A. Nickerson, Amjad Javed, Martin A. Montecino, Andre J. Van Wijnen, Jane B. Lian, Janet L. Stein, and Gary S. Stein), Methods in molecular biology (Clifton, N.J.) (2008)
Osteogenesis
Acute Myeloid Leukemia
MicroRNAs
Cell Proliferation
Multiprotein Complexes
Phenotype
Mammals
Intranuclear Space
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Subnuclear localization and intranuclear trafficking of transcription factors (with Ricardo F. Medina, Shirwin M. Pockwinse, Rachit Bakshi, Krishna P. Kota, Syed A. Ali, Daniel W. Young, Jeffrey A. Nickerson, Amjad Javed, Martin A. Montecino, Andre J. Van Wijnen, Jane B. Lian, Janet L. Stein, and Gary S. Stein), Methods in molecular biology (Clifton, N.J.) (2010)
Cell Line, Tumor
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Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation (with Christopher R. Dowdy, Ronglin Xie, Dana Frederick, Sadiq Hussain, Diana Vradii, Amjad Javed, Xiangen Li, Stephen N. Jones, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, and Gary S. Stein), Human molecular genetics (2010)
Humans
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Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation (with Christopher R. Dowdy, Ronglin Xie, Dana Frederick, Sadiq Hussain, Diana Vradii, Amjad Javed, Xiangen Li, Stephen N. Jones, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, and Gary S. Stein), Human molecular genetics (2010)
*Epigenesis, Genetic
RNA, Untranslated
Cell Differentiation
Epigenesis, Genetic
Adenosine Triphosphatases
*Neoplasms
Mitosis
Gene Expression Regulation
Promoter Regions, Genetic
DNA Methylation
RNA, Ribosomal
DNA-Binding Proteins
Repressor Proteins
Nucleolus Organizer Region
Protein Processing, Post-Translational
Immunoprecipitation
*Transcription, Genetic
Models, Genetic
Transcription Factors
Animals
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Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation (with Christopher R. Dowdy, Ronglin Xie, Dana Frederick, Sadiq Hussain, Diana Vradii, Amjad Javed, Xiangen Li, Stephen N. Jones, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, and Gary S. Stein), Human molecular genetics (2010)
Microscopy, Fluorescence
Histones
*Gene Expression Regulation
Core Binding Factor Alpha 2 Subunit
Link
Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation (with Christopher R. Dowdy, Ronglin Xie, Dana Frederick, Sadiq Hussain, Diana Vradii, Amjad Javed, Xiangen Li, Stephen N. Jones, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, and Gary S. Stein), Human molecular genetics (2010)
Cell Nucleus
Link
Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation (with Christopher R. Dowdy, Ronglin Xie, Dana Frederick, Sadiq Hussain, Diana Vradii, Amjad Javed, Xiangen Li, Stephen N. Jones, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, and Gary S. Stein), Human molecular genetics (2010)
Female
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Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation (with Christopher R. Dowdy, Ronglin Xie, Dana Frederick, Sadiq Hussain, Diana Vradii, Amjad Javed, Xiangen Li, Stephen N. Jones, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, and Gary S. Stein), Human molecular genetics (2010)
Mutation
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Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation (with Christopher R. Dowdy, Ronglin Xie, Dana Frederick, Sadiq Hussain, Diana Vradii, Amjad Javed, Xiangen Li, Stephen N. Jones, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, and Gary S. Stein), Human molecular genetics (2010)
Genotype
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Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation (with Christopher R. Dowdy, Ronglin Xie, Dana Frederick, Sadiq Hussain, Diana Vradii, Amjad Javed, Xiangen Li, Stephen N. Jones, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, and Gary S. Stein), Human molecular genetics (2010)
Transcriptional Activation
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Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation (with Christopher R. Dowdy, Ronglin Xie, Dana Frederick, Sadiq Hussain, Diana Vradii, Amjad Javed, Xiangen Li, Stephen N. Jones, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, and Gary S. Stein), Human molecular genetics (2010)
Male
Link
Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation (with Christopher R. Dowdy, Ronglin Xie, Dana Frederick, Sadiq Hussain, Diana Vradii, Amjad Javed, Xiangen Li, Stephen N. Jones, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, and Gary S. Stein), Human molecular genetics (2010)
Structure-Activity Relationship
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Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation (with Christopher R. Dowdy, Ronglin Xie, Dana Frederick, Sadiq Hussain, Diana Vradii, Amjad Javed, Xiangen Li, Stephen N. Jones, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, and Gary S. Stein), Human molecular genetics (2010)
Mutant Proteins
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Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation (with Christopher R. Dowdy, Ronglin Xie, Dana Frederick, Sadiq Hussain, Diana Vradii, Amjad Javed, Xiangen Li, Stephen N. Jones, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, and Gary S. Stein), Human molecular genetics (2010)
Gene Expression Regulation, Developmental
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Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation (with Christopher R. Dowdy, Ronglin Xie, Dana Frederick, Sadiq Hussain, Diana Vradii, Amjad Javed, Xiangen Li, Stephen N. Jones, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, and Gary S. Stein), Human molecular genetics (2010)
Mice
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Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation (with Christopher R. Dowdy, Ronglin Xie, Dana Frederick, Sadiq Hussain, Diana Vradii, Amjad Javed, Xiangen Li, Stephen N. Jones, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, and Gary S. Stein), Human molecular genetics (2010)
Protein Binding
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Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation (with Christopher R. Dowdy, Ronglin Xie, Dana Frederick, Sadiq Hussain, Diana Vradii, Amjad Javed, Xiangen Li, Stephen N. Jones, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, and Gary S. Stein), Human molecular genetics (2010)
*Hematopoiesis
Link
Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation (with Christopher R. Dowdy, Ronglin Xie, Dana Frederick, Sadiq Hussain, Diana Vradii, Amjad Javed, Xiangen Li, Stephen N. Jones, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, and Gary S. Stein), Human molecular genetics (2010)
Hematopoietic Stem Cells
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Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation (with Christopher R. Dowdy, Ronglin Xie, Dana Frederick, Sadiq Hussain, Diana Vradii, Amjad Javed, Xiangen Li, Stephen N. Jones, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, and Gary S. Stein), Human molecular genetics (2010)
Embryo, Mammalian
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Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation (with Christopher R. Dowdy, Ronglin Xie, Dana Frederick, Sadiq Hussain, Diana Vradii, Amjad Javed, Xiangen Li, Stephen N. Jones, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, and Gary S. Stein), Human molecular genetics (2010)
Protein Structure, Tertiary
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Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation (with Christopher R. Dowdy, Ronglin Xie, Dana Frederick, Sadiq Hussain, Diana Vradii, Amjad Javed, Xiangen Li, Stephen N. Jones, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, and Gary S. Stein), Human molecular genetics (2010)
Heterozygote
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Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation (with Christopher R. Dowdy, Ronglin Xie, Dana Frederick, Sadiq Hussain, Diana Vradii, Amjad Javed, Xiangen Li, Stephen N. Jones, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, and Gary S. Stein), Human molecular genetics (2010)
Crosses, Genetic
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Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation (with Christopher R. Dowdy, Ronglin Xie, Dana Frederick, Sadiq Hussain, Diana Vradii, Amjad Javed, Xiangen Li, Stephen N. Jones, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, and Gary S. Stein), Human molecular genetics (2010)
Protein Transport
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Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation (with Christopher R. Dowdy, Ronglin Xie, Dana Frederick, Sadiq Hussain, Diana Vradii, Amjad Javed, Xiangen Li, Stephen N. Jones, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, and Gary S. Stein), Human molecular genetics (2010)
Intracellular Space
